As an urban fringe district, the Ecorse River watershed is faced with increased impervious area caused by urban expansion. Effects of Green Infrastructure (GI) practice implementation were simulated with the Long-Term Hydrologic Impact Assessment-Low Impact Development 2.1 model (L-THIA-LID 2.1). Suitable locations of each GI practice were identified, based on construction condition requirements and demand on GI practices in the study area. Using the data of 2011, various GI practice combination scenarios were explored according to the cost-efficiency of each GI practice. GI practice implementation scenarios in 2050 were also simulated based on projected land use and rainfall data. Results show that grassed swales, rain barrels (residential areas) and dry ponds were the top three most cost-efficient GI practices, with the cost at $1.5/m³/yr, $3.0/m³/yr and $3.4/m³/yr, respectively. Green roofs with rain cisterns (industrial and commercial area) were the most expensive GI practices, with the cost at $92.9/m³/yr. With the increase of investment in GI practices, the changing curves of the annual runoff volume, Total Nitrogen (TN) load and Total Phosphorus (TP) load reduction ratios match the law of diminishing marginal utility. The scenario with grassed swales, rain barrels, dry ponds and porous pavement would be the most cost-efficient scenario for runoff water quantity reduction. In addition, the scenario with additional wet ponds would be the most cost-efficient one for TN load and TP load reduction. GI practices in each scenario for expected 2050 conditions show better effectiveness on water quantity and quality management.