Load Reduction Research Articles

Liposomal Ozonated Oil Ensures a Further Reduction in the Microbial Load Before Intravitreal Injection: the "OPERA" Study.

This was a prospective study to investigate the antimicrobial efficacy of a novel ophthalmic solution comprising ozonated sunflower oil in liposomes plus hypromellose in conjunction with liposomal foam (BlefOX), in patients undergoing intravitreal injection, in comparison to povidone iodine 5%. The study employed a paired-eye design with n = 195 patients and a total of n = 390 eyes divided into two groups. Conjunctival swabs were collected from both eyes of each patient at baseline (T0-3 days before the injection). The study group underwent home therapy, which included instilling two drops of an isotonic ophthalmic solution containing 0.5% ozonated sunflower oil in liposomes plus hypromellose (Ozodrop) four times daily and applying liposomal foam twice daily to the eye undergoing intravitreal injections. In contrast, the control group (contralateral eyes) received treatment with povidone iodine 5%. This treatment regimen was maintained for 3days. At T1 (10min before injection), all patients instilled one drop of a topical solution of povidone iodine 5% into the conjunctival sac of both eyes. After 30seconds had elapsed, a conjunctival swab was obtained for each eye in both study groups. The results, derived from conjunctival swabs, exhibited a significant reduction in the microbial load of the study group on both chocolate agar and blood agar (p ≤ 0.007). The study demonstrated that the combination of povidone iodine 5% + Ozodrop + BlefOX provides a greater reduction in microbial load than povidone iodine 5% alone on both chocolate agar (141 [72.31%] vs. 98 [50.26%], p < 0.0001) and blood agar (130 [66.67%] vs. 97 [49.74%], p = 0.0007). The combination of povidone iodine 5% + Ozodrop + BlefOX resulted in the killing of approximately 41% to 49% of bacteria compared to povidone iodine 5% alone on the chocolate agar and blood agar, respectively. Liposomal ozonated oil treatment, coupled with liposomal foam, in patients undergoing intravitreal injection led to a substantial reduction in conjunctival microbial load compared to eyes treated solely with povidone iodine 5%.

Cyclic pitch control for aerodynamic load reductions of floating offshore wind turbines under pitch motions

Floating offshore wind turbines suffer severe aerodynamics under platform motions. Novel control methods are urgently needed to improve power and load performances. A mechanical cyclic pitch control strategy is introduced in this paper, and the load reduction effect on the NREL 5-MW wind turbine is investigated under dominant pitch motions. The simulation is performed by the standalone Aerodyn_Driver code. Results show that the relative airflow under pitch motions can be equated to a linear sheared flow and is only related to wind velocity and pitch angular velocity. Cyclic pitch control hardly affects power and thrust but significantly changes aerodynamic moments. The resultant moment and moment axis azimuth are defined, and they are controlled respectively by pitch amplitude and phase. The optimal pitch parameter equations to minimize pitching and yawing moments are derived from fitting and derivation, and the standard deviations of aerodynamic moments are reduced by over 70 % under the sinusoidal pitch motion and steady inflow below rated operation. This paper provides a new idea for the individual pitch control structure, and the mechanism study for aerodynamic control is important and instructive to fill the technological gap in mature pitch control strategies for floating offshore wind turbines.

The Influence and Mechanism of Curing Methods and Curing Age on the Mechanical Properties of Yellow River Sand Engineered Cementitious Composites.

This study investigates the potential use of Yellow River sand (YRS) sourced from the lower reaches of the Yellow River in China as a sustainable and cost-effective substitute for quartz sand in Engineered Cementitious Composites (ECC). With an annual accumulation of approximately 400 million tons in this region, YRS presents a substantial resource. ECC specimens with 100% YRS replacement with quartz sand were subjected to various curing methods: natural, steam, standard, and sprinkler. Extensive mechanical testing including flexural, compressive, uniaxial tensile, and four-point flexural tests was conducted. Additionally, Scanning Electron Microscope (SEM) and Mercury Intrusion Porosimetry (MIP) analyses investigated microscopic mechanisms influencing macroscopic mechanical properties. Finally, the mechanical properties of the YRS-ECC test block after 14 days of standard curing and the traditional sand ECC test block were compared and analyzed. The results indicate that ECC specimens with 100% YRS substitution under natural curing show an optimal ultimate tensile strain of more than 4%, providing the best resistance to the reduction in ultimate flexural load and deflection due to aging. Steam curing enhances flexural and compressive strength, achieving an ultimate flexural load of 5 kN and a maximum deflection of 4.42 mm at 90 days. SEM analysis revealed lower C-S-H gel density under natural curing and higher under steam curing, enhancing fiber pull-out in steam-cured specimens. The MIP tests demonstrated that natural curing had the highest porosity (32.86%) and average pore size (51.69 nm), whereas steam curing resulted in the smallest average pore size, with 44% of pores under 50 nm. Compared with traditional sand, it is found that the ultimate bending load and deflection of YRS-ECC are 5.7% and 9.4% higher than those of traditional sand ECC, respectively, and its ultimate tensile strength and strain are also improved. These findings highlight YRS as a sustainable alternative to natural sand in ECC, with natural curing proving the most effective for superior mechanical performance, including tensile strain, crack resistance, and durability.

Overview of Large Helical Device experiments of basic plasma physics for solving crucial issues in reaching burning plasma conditions

Abstract Recently, experiments on basic plasma physics issues for solving future problems in fusion energy have been performed on a Large Helical Device. There are several problems to be solved in future devices for fusion energy. Emerging issues in burning plasma are: alpha-channeling (ion heating by alpha particles), turbulence and transport in electron dominant heating helium ash exhaust, reduction of the divertor heat load. To solve these problems, understanding the basic plasma physics of (1) wave–particle interaction through (inverse) Landau damping, (2) characteristics of electron-scale (high-k) turbulence, (3) ion mixing and the isotope effect, and (4) turbulence spreading and detachment, is necessary. This overview discusses the experimental studies on these issues and turbulent transport in multi-ion plasma and other issues in the appendix.

Factors affecting the tensile strength of bituminous geomembrane seams

The tensile shear strength, break location, and constant tensile load failure times are examined for seams made from one 4 mm-thick bituminous geomembrane (BGM) product, with corresponding observations specific to that material. In short-term tests, failure is observed within the sheet material once the seam strength exceeded 0.8 times that of the sheet material. The effects of seam thickness reduction and overlap width on seam strength are examined for two methods of seaming. Seams with a short-term strength meeting or exceeding 80% of the sheet strength are subjected to constant tensile loads between 18 and 55% of sheet ultimate strength and the time to failure is reported. The relationship between short-term seam strength and time to failure under sustained load and thickness reduction and squeeze-out is investigated. Constant tensile load testing is proposed as a construction quality assurance procedure to assess the degree of geotextile engagement of field seams.

Impacts of climate change and best management practices on nitrate loading to a eutrophic coastal lagoon

Anthropogenic climate change and associated increasing nutrient loading to coasts will worsen coastal eutrophication on a global scale. Basin Head is a coastal lagoon located in northeastern Prince Edward Island, Canada, with a federally protected ecosystem. Nitrate-nitrogen (NO3-N) is conveyed from agricultural fields in the watershed to the eutrophic lagoon via intertidal groundwater springs and groundwater-dominated tributaries. A field program focused on four main tributaries that discharge into the lagoon was conducted to measure year-round NO3-N loading. These measurements were used to calibrate a SWAT+ hydrologic model capable of simulating hydrologic and NO3-N loads to the lagoon. Several climate change scenarios incorporating different agricultural best management practices (BMPs) were simulated to better understand potential future NO3-N loading dynamics. Results indicate that all climate change scenarios produced increased annual NO3-N loading to the lagoon when comparing historical (1990–2020) to end of century time periods (2070–2100); however, only one climate scenario (MRI-ESM2-0 SSP5-8.5) resulted in a statistically significant (p-value &amp;lt;0.05) increase. Enlarged buffer strips and delayed tillage BMP simulations produced small (0%–8%) effects on loading, while changing the crop rotation from potato-barley-clover to potato-soybean-barley yielded a small reduction in NO3-N loading between the historical period and the end of the century (26%–33%). Modeling revealed changes in seasonal loading dynamics under climate change where NO3-N loads remained more consistent throughout the year as opposed to current conditions where the dominant load is in the spring. An increase in baseflow contributions to streamflow was also noted under climate change, with the largest change occurring in the winter (e.g., up to a five-fold increase in February). These findings have direct implications for coastal management in groundwater-dominated agricultural watersheds in a changing climate.

Anti-tropical cyclone load reduction control of wind turbines based on deep neural network yaw algorithm

Rapid changes in the wind field of tropical cyclones can cause excessive loads and threaten the safety of offshore wind turbines. This paper designs a wind turbine yaw optimization strategy based on the deep neural network to reduce the structural loads of wind turbines caused by tropical cyclones. Firstly, the high-precision tropical cyclone data is used to analyze the characteristics of the wind field. Then, a pseudo-Monte Carlo experiment is designed to compensate for the incompleteness of the observed data. Furthermore, a robust nonlinear coupling model between the wind characteristics and the loads of the wind turbine is constructed by a deep neural network, and the optimal yaw angle is searched in real time based on this model. The simulation results show that the proposed deep neural network model based on pseudo-Monte Carlo scenario generation can robustly calculate the structural loads of wind turbines with a calculation error of less than 8 %. After applying this model to the real-time optimization control loop, the corresponding optimized yaw angle can be obtained according to the operating data of the wind turbine under tropical cyclone conditions so that the structural loads of the wind turbine are reduced. Compared with the no-yaw and traditional yaw strategies, the load suppression effect is 1 %–9 % under different working conditions. The proposed data-driven structural load model and load suppression algorithm will effectively improve the operating safety of wind turbines under tropical cyclone conditions.

Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis.

Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune-mediated tissue damage. Depending on the anatomic setting, a chronic inflammatory disease can exert unique local and systemic influences, which provide an exceptional opportunity for understanding disease mechanism and testing therapeutic interventions. The oral cavity is an easily accessible environment that allows for protective interventions aiming at modulating the immune response to control disease processes driven by a breakdown of host-microbe homeostasis. Periodontal disease (PD) is a prevalent condition in which quantitative and qualitative changes of the oral microbiota (dysbiosis) trigger nonresolving chronic inflammation, progressive bone loss, and ultimately tooth loss. Here, we demonstrate the therapeutic benefit of local sustained delivery of the myeloid-recruiting chemokine (C-C motif) ligand 2 (CCL2) in murine ligature-induced PD using clinically relevant models as a preventive, interventional, or reparative therapy. Local delivery of CCL2 into the periodontium inhibited bone loss and accelerated bone gain that could be ascribed to reduced osteoclasts numbers. CCL2 treatment up-regulated M2-macrophage and downregulated proinflammatory and pro-osteoclastic markers. Furthermore, single-cell ribonucleic acid (RNA) sequencing indicated that CCL2 therapy reversed disease-associated transcriptomic profiles of murine gingival macrophages via inhibiting the triggering receptor expressed on myeloid cells-1 (TREM-1) signaling in classically activated macrophages and inducing protein kinase A (PKA) signaling in infiltrating macrophages. Finally, 16S ribosomal ribonucleic acid (rRNA) sequencing showed mitigation of microbial dysbiosis in the periodontium that correlated with a reduction in microbial load in CCL2-treated mice. This study reveals a novel protective effect of CCL2 local delivery in PD as a model for chronic inflammatory diseases caused by a disturbance in host-microbe homeostasis.

B-cell depletion limits HTLV-1-infected T-cell expansion and ameliorate HTLV-1-associated myelopathy.

Human T-cell leukemia virus type 1-associated myelopathy (HAM) is a chronic, progressive, inflammatory disease with unclear pathogenesis and no effective treatments. We aimed to investigate a novel mechanistic theory and treat HAM patients with rituximab, which can deplete CD20+ B lymphocytes in circulation. Single-cell RNA sequencing (scRNA-seq) data was analyzed to identify HTLV-1-associated B cells and their effect on Tcells. An observational analysis of our HAM cohort was conducted to elucidate changes in the immunological microenvironment of these patients. Peripheral blood mononuclear cells (PBMC) from HAM patients were isolated to explore the efficacy of B cell depletion in vitro. To assess the effect of B-cell depletion on HAM patients, eligible participants in our cohort received rituximab therapy (NCT04004819). ScRNA-seq results suggest a significant effect of HTLV-1-associated B cells on Tcells. Additionally, HTLV-1 was found to infect B cells and depletion of B cells inhibited the proliferation of Tcells. Number of B cells in HAM patients had positive correlation with the proviral load and infected cell counts. Depletion of B cells led to a reduction in HTLV-1 proviral load in vitro. Furthermore, in clinical trial, 14 HAM patients were enrolled. Three patients (21.4%) who received rituximab failed to achieve remission, compared to 24 (85.7%) patients received any other therapy that failed to achieve remission. With a low level of circulating B cells, the proportion of Ki67-positive cells in CD4+ Tcells fell. This study provided evidence that depleting B-lymphocytes is an innovative strategy for treating patients with HAM and broadens the understanding of the role of B cells in infectious immunity.

Efficacy and safety of Ibalizumab for the treatment of HIV-1 infected patients: A systematic review

Objectives: Human immunodeficiency virus (HIV) infection is a significant global health concern, due to the emerging complexity in the management of infection. The emergence of novel therapeutic agents, such as ibalizumab, has provided a ray of hope for individuals living with HIV. This systematic review provides a comprehensive analysis of the efficacy and safety of ibalizumab for the treatment of HIV-1-infected patients. Material and Methods: Using online medical literature databases and the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines, four of the 86 articles met the acceptance criteria to be analyzed. Details such as author name, year of publication, demographic characteristics, mode, and dose of drug administration, duration of treatment, comparator if any, baseline CD4 counts, and viral load, change in CD4 count and viral load, and the adverse events were noted in the studies. Results: The total number of patients enrolled in each study ranged from 22 to 82 with a median age ranging from 39 to 53. Except for the open-label dose-ranging cohort study, baseline CD4 counts and post-intervention CD4 counts were assessed in all the studies. The patients who received a higher dose of ibalizumab showed an early significant rise in CD4+T-cell count at week 16 and week 48. Although the viral reduction after ibalizumab injection increases from the dose of 3 mg/kg, it was noted that beyond 10mg/kg the viral load reduction was not increasing proportionately with 25 mg/kg. The adverse effects encountered among the four studies ranged from 45% to 91%. The commonly observed adverse effects were headache, diarrhea, nausea, fatigue, somnolence, and rash. Conclusion: Ibalizumab demonstrates promise as a therapeutic option for individuals with multidrug-resistant HIV-1. Its unique mechanism of action and positive impact on viral load reduction and CD4 cell counts make it a valuable addition to the armamentarium of HIV treatment options.

Runoff Control Performance of Three Typical Low-Impact Development Facilities: A Case Study of a Community in Beijing

The development of sponge cities advocates for sustainable urban rainwater management, effectively alleviating urban flood disasters, reducing non-point-source pollution, and promoting the recycling of rainwater resources. Low-Impact Development (LID) serves as a key strategy in this context, providing essential support for urban rainwater control and pollution reduction. To investigate the runoff control effects of LID measures and to reveal the relationship between facility runoff control performance and installation scale, this study focuses on a sponge community in Beijing. A SWMM model was constructed to analyze the rainwater flood control and pollutant load reduction effects of different LID facilities, including bio-retention cells, green roofs, and permeable pavements. Using evaluation indicators such as surface runoff, node overflow, and pollutant control rates, this study examined how facility performance varies with installation scale under different rainfall conditions. The combination scheme of LID equipment optimal configuration is designed by using multiple criteria decision analysis (MCDA) and cost–benefit theory. The results indicate significant differences in performance among the various LID facilities across different rainfall scenarios. Specifically, the optimal installation proportion for runoff and overflow control of permeable pavements were found to be between 30% and 70%. Green roofs demonstrate superior performance in handling extreme rainfall events, while bio-retention cells exhibit significant effectiveness in controlling Total Suspended Solids (TSSs). Through comprehensive performance evaluation, this study identified the optimal combination scale under a 3-year rainfall recurrence interval as 30% permeable pavements, 20% green roof, and 60% bio-retention cells. This combination effectively leverages the strengths of each facility, ensuring system stability and efficiency while also demonstrating optimal management efficiency in cost–benefit analyses. The findings of this research provide valuable insights for future urban water management and infrastructure development.

Performance and mechanism of adaptive pitch control in a floating vertical axis wind turbine with a surge motion

Floating vertical axis wind turbines are bearing complex aerodynamic fatigue loads due to the movement of the platform and the reciprocating variations in the angle of attack and the blade relative wind speed. To explore the effect of the surge motion of the platform and verify the performance and acting mechanism of adaptive pitch control on reducing the fatigue loads and improving the power coefficient, a floating vertical axis wind turbine with three motion forms (non-surge, pure surge, and surge-adaptive pitch) is investigated in the condition of a low tip speed ratio with a high incoming wind speed. The results show that the surge motion enhances the fatigue loads, with the power coefficient less affected. The adaptive pitch control reduces the enhanced fatigue loads and improves the power coefficient by nearly twice. Vorticity and pressure distributions verify that the fluctuation ranges of the angle of attack and the blade relative wind speed are expanded by the surge motion, and the angle of attack is reduced by the adaptive pitch control especially in the upwind section, with the flow separation mitigated. However, the effects of the surge motion and the pitch variation are also influenced by the shedding vortex and the flow separation reattachment. For the upwind part of the blade aerodynamic forces, with the surge amplitude increase or the surge period decrease, the global amplitudes are increased gradually by the surge motion and then reduced by the pitch control, with the load reduction performance enhanced gradually.

Multi-objective optimization design of aerothermal performance for turbine blade squealer tip with inclined suction-side rim

To optimize the inclined rim design, multi-objective optimization was numerically conducted on the suction-side rim of the squealer tip in the GE-E3 rotor blade. The RANS equations, incorporating with the standard k-ω model, were numerically solved. Through the implementation of a Kriging surrogate model coupled with the NSGA-II evolutionary optimization technique, six geometric parameters on the suction-side rim went through iterative optimization. This process yielded three optimized squealer tip geometries on the Pareto front: Structure 1 with minimum total pressure loss, Structure 2 with optimal comprehensive aerothermal performance, and Structure 3 with minimum tip heat load. Comparative analysis revealed that with the inner and external wall inclined toward the cavity and passage respectively, the optimization results in a 3 %–11 % reduction in tip heat load, accompanied by an 8.5 %–10.2 % reduction in aerodynamic loss, facilitated by an attenuated upper passage vortex (UPV) and strengthened tip leakage vortex (TLV). The critical inclined region of the external rim wall, spanning 7 %–80 %, influences the exit total pressure loss distribution. The inclined inner wall upstream of 50 % Cax obstructs coolant jets from exiting the cavity, reducing the heat load on the cavity bottom. However, the inclined external wall from 66 % to 90 % Cax amplifies the impingement of the scraping vortex (SV), increasing local heat transfer. The thermal behavior of Structure 1 is sensitive to changes in tip clearance, whereas Structure 2 and 3 show more robust advantages. As the clearance increased, the aerodynamic losses associated with the TLV rise for all three optimized tips, but losses from the UPV remain similar. This study provides a novel approach for designing efficient squealer tip geometries incorporating an inclined rim.

Optimization of multi-vehicle charging and discharging efficiency under time constraints based on reinforcement learning

In the Vehicle-to-Grid (V2G) scenario, a multitude of coordinated electric vehicles (EVs) equipped with high-capacity batteries actively participate in power grid dispatching as energy carriers, aiming to achieve a tripartite objective encompassing peak load reduction and valley filling, enhanced utilization of renewable energy sources, and added benefits for electric vehicle owners. To address the existing limitations in the charging–discharging decision-making process for electric vehicles based on V2G, such as the lack of consideration for charging pile constraints, EV profitability, EV transportation timeliness, and high costs associated with central servers, we proposed a reinforcement learning-based Multi-vehicle Joint Routing and Charging–Discharging Decision algorithm (MJRCDD). Firstly, the Markov decision process (MDP) was established to describe the problem, and the route selection and charging–discharging behavior of the vehicle were innovatively integrated in the vehicle action space. Secondly, the multi-vehicle joint route planning and charging–discharging decision problem was solved by multi-agent reinforcement learning. Finally, the effectiveness of MJRCDD was verified by simulation and comparison experiments based on PeMS.

Development of quaternized agar-based materials for the coronavirus inactivation

The COVID-19 pandemic has revealed weaknesses in healthcare systems and underscored the need for advanced antimicrobial materials. This study investigates the quaternization of agar, a seaweed-derived polysaccharide, and the development of electrospun membranes for air filtration in facemasks and biomedical applications. Using the betacoronavirus MHV-3 as a model, quaternized agar and membranes achieved a 90–99.99 % reduction in viral load, without associated cytotoxicity. The quaternization process reduced the viscosity of the solution from 1.19 ± 0.005 to 0.64 ± 0.005 Pa.s and consequently the electrospun fiber diameter ranged from 360 to 185 nm. Membranes synthesized based on polyvinyl alcohol and thermally cross-linked with citric acid exhibited lower water permeability. Avoiding organic solvents in the electrospinning technique ensured eco-friendly production. This approach offers a promising way to develop biocompatible and functional materials for healthcare and environmental applications.

End of rope or phoenix nirvana? Exploring the evolutionary paths of coal resource-based cities in China

Coal resource-based cities (CRBCs) face a complex transformation of the urban system due to the adjustment of the global energy structure and the need for sustainable development worldwide. Considering the urban system as the combination of urban carriers and urban loads, this study proposed a framework to illustrate the evolution of CRBCs using resources and environmental carrying capacity (RECC). Taking 30 CRBCs in China as research objects, the EWM-TOPSIS method and the Geographically and Temporally Weighted Regression (GTWR) model were introduced to assess the comprehensive performance and identify the influencing factors from 2011 to 2020. With most CRBCs becoming more sustainable in the past decade, the results showed two evolutionary paths: urban carrier expansion and urban load reduction. Furthermore, urban conditions and evolutions were spatially agglomerated, and the natural resources sustainability in urban carriers and the environmental pollution in urban loads were the main factors affecting the two paths mentioned above, while the declining population was the major challenge for the shrinking CRBCs. These findings offered valuable insights to guide the sustainable transformation of CRBCs in different situations.

Intranasal Administration of Recombinant Newcastle Disease Virus Expressing SARS-CoV-2 Spike Protein Protects hACE2 TG Mice against Lethal SARS-CoV-2 Infection.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged as a global outbreak in 2019, profoundly affecting both human health and the global economy. Various vaccine modalities were developed and commercialized to overcome this challenge, including inactivated vaccines, mRNA vaccines, adenovirus vector-based vaccines, and subunit vaccines. While intramuscular vaccines induce high IgG levels, they often fail to stimulate significant mucosal immunity in the respiratory system. We employed the Newcastle disease virus (NDV) vector expressing the spike protein of the SARS-CoV-2 Beta variant (rK148/beta-S), and evaluated the efficacy of intranasal vaccination with rK148/beta-S in K18-hACE2 transgenic mice. Intranasal vaccination with a low dose (106.0 EID50) resulted in an 86% survival rate after challenge with the SARS-CoV-2 Beta variant. Administration at a high dose (107.0 EID50) led to a reduction in lung viral load and 100% survival against the SARS-CoV-2 Beta and Delta variants. A high level of the SARS-CoV-2 spike-specific IgA was also induced in vaccinated mice lungs following the SARS-CoV-2 challenge. Our findings suggest that rK148/beta-S holds promise as an intranasal vaccine candidate that effectively induces mucosal immunity against SARS-CoV-2.

Intramuscular Botulinum Toxin as an Adjunct to Arthrocentesis with Viscosupplementation in Temporomandibular Disorders: A Proof-of-Concept Case-Control Investigation.

The reduction in joint load is a potential beneficial factor in managing osteoarthritis of the temporomandibular joint (TMJ). This paper aims to compare the effectiveness of the intramuscular injection of botulinum toxin (BTX-A) as an adjunct to TMJ arthrocentesis plus viscosupplementation with arthrocentesis plus viscosupplementation alone in the management of TMJ osteoarthritis. A pilot clinical retrospective study examined TMJ osteoarthritis treatments. Patients were divided into two groups: Group A received BTX-A injections and arthrocentesis with viscosupplementation, while Group B received only arthrocentesis with viscosupplementation. The study assessed outcomes based on mouth opening (MO), pain at rest (PR), pain at mastication (PF), and masticatory efficiency (ME) at various time points (baseline (T0), 1 week (T1), 2 weeks (T2), 3 weeks (T3), and 4 weeks (T4)) up to 2 months after treatment. The study included two groups, each with five patients. Group A received five weekly sessions of arthrocentesis plus viscosupplementation and a single BTX-A injection during the first arthrocentesis appointment. Group B underwent the five-session protocol of arthrocentesis plus viscosupplementation alone. MO, PF, PR, and ME improved quickly in T2 in both groups, but the improvement was of greater importance over the following weeks and lasted longer in Group A. Arthrocentesis with viscosupplementation associated with BTX-A was found to be more effective than arthrocentesis alone in improving clinical outcomes. This suggests that patients with TMJ osteoarthritis and myofascial pain may benefit from reduced muscle tone and joint load.

Characteristics of the Evolution of Resource and Environmental Carrying Capacity in Shaanxi Province

This paper constructs a resource and environmental carrying capacity index system based on the DPSIR model, and adopts the entropy weight TOPSIS method to analyze the resource and environmental carrying capacity of Shaanxi Province in terms of time series and spatial distribution. The results show that from 2010 to 2020, the resource environmental carrying capacity of Shaanxi Province in general shows a fluctuating upward trend, and on the whole there is a small decrease in 2017 compared with 2016 and 2020 compared with 2019, and an increase in 2019 compared with 2018; in terms of the characterization value of the resource environmental carrying capacity of each city, Yan'an City is in the first place for a long period of time, and it is stable in the top three with Yulin and Xi'an; each The resource environmental carrying capacity of each city shows a gradual convergence state, indicating that the difference between their carrying capacity gradually decreases. Finally, this paper makes corresponding suggestions for the improvement of the resource and environmental carrying capacity of Shaanxi Province from five aspects: economic development, low-carbon development, resource and environmental load reduction, population growth, and environmental infrastructure construction.

Early Versus Late Rapid Force Production During Single-Joint Isometric Hamstring Assessment Using Force Plates.

Ripley, NJ, Barber, R, Fahey, JT, and Comfort, P. Early versus late rapid force production during single-joint isometric hamstring assessment using force plates. J Strength Cond Res XX(X): 000-000, 2024-The aim of this study was to assess differences in time-matched early versus late rapid force (RF) development in female soccer players in the 90-90 isometric hamstring assessment. Twenty-one elite female soccer players (age: 20.7 ± 4.7 years; height: 168.2 ± 5.5 cm; body mass: 62.8 ± 7.0 kg), with no recent (>6 months) history of hamstring strain injury, volunteered to participate in the study. Following a standardized warm-up, each subject performed 3 maximal isometric unilateral hamstring contractions, with their heel resting on a force plate, elevated on a box, to ensure that their hips and knees were at 90°. Data were analyzed to determine peak force, early RF (ERF) 0-100 milliseconds and late RF (LRF) 100-200 milliseconds. Significant and large differences were observed in the percentage of peak force achieved between ERF (52.85 ± 11.53%; 54.99 ± 9.80%) and LRF (15.82 ± 5.58%; 15.25 ± 3.91%) for the left and right limbs, respectively (p < 0.001, g = 2.13-3.06). The large differences between ERF and LRF can be used by practitioners to streamline performance assessment, which in turn will allow practitioners to act upon data collected more effectively. Additionally, regular monitoring ERF production could inform practitioners of any interventions that maybe required, such as reduction of load or introduction of specific recovery modalities and during return to play protocols.