Reduction In Fatality Rate Research Articles

Tocilizumab: A promising treatment for COVID-19 patients

A novel Coronavirus was identified in China as SARS-CoV-2 in December 2019 and was later declared a pandemic by the World Health Organization [1]. In most patients, COVID-19 presents with mild or moderate symptoms such as fever, cough, fatigue, and myalgia. However, around 10% of patients develop more severe symptoms such as pneumonia and multiorgan failure, which can result in death [1-2]. Until vaccines are widely available, the only way to reduce fatality rates is to treat affected patients with existing drugs and therapy options.

The Effect of Probiotics in Stroke Treatment.

Objective We conducted a systematic review and meta-analysis to evaluate the curative effect of probiotics combined with enteral nutrition (EN) in patients with stroke. Methods We retrieved randomized controlled trials and case-controlled trials on the use of probiotics for stroke treatment from PubMed, Web of Science, CNKI, Wanfang, and Weipu databases. Retrieval times were from the databases' inception to November 6, 2020. Two researchers conducted a strict evaluation of the literature quality and extracted the data, which were then entered into RevMan 5.3 for meta-analysis. Results Twenty-three articles were included, including 1,816 patients. The meta-analysis revealed that probiotics combined with EN did not reduce NIHSS scores of patients with stroke (P > 0.05). However, it did shorten hospital stays and bedrest periods (P < 0.05). Probiotics combined with EN also improved patients' nutritional status and increased hemoglobin, albumin, serum total protein, and physical and chemical properties of prealbumin (P < 0.05). In terms of relieving inflammation, we found that probiotics combined with EN reduced neither high-sensitivity C-reactive protein nor procalcitonin (P > 0.05). However, it did cause a significant reduction in TNF-α, IL-6, and IL-10. Probiotics combined with EN significantly reduced esophageal reflux, bloating, constipation, diarrhea, gastric retention, and gastrointestinal bleeding. It relieved intestinal stress and reduced the occurrence of adverse reactions such as esophageal reflux, bloating, constipation, diarrhea, gastric retention, and gastrointestinal bleeding (P < 0.05). In terms of reducing stroke complications, probiotics combined with EN reduced the incidence of lung, gastrointestinal, and urinary tract infections (P < 0.05). It also reduced fatality rates and intestinal flora imbalance rates (P < 0.05). Conclusion The probiotics combined with EN group's therapeutic effects were superior to those of the EN alone. Thus, probiotics combined with EN is worthy of both clinical application and promotion in stroke treatment.

Forgotten fatalities: British military, mining and maritime accidents since 1900.

BackgroundComparative long-term trends in fatal accident rates in the UK’s most hazardous occupations have not been reported.AimsTo compare trends in fatal accident rates in six of the most hazardous occupations (the three armed forces, merchant shipping, sea fishing and coal mining) and the general British workforce during peacetime years since 1900.MethodsExaminations of annual mortality reports, returns, inquiry files and statistics. The main outcome measure was the fatal accident rate per 100 000 population employed.ResultsThese six occupations accounted for ~40% of all fatal accidents in the British workforce. Fatal accident rates were highest in merchant shipping to 1914 (400–600 per 100 000) and in the Royal Air Force and sea fishing by the early 1920s (around 300 per 100 000). Since the 1950s sea fishing has remained the most hazardous occupation (50–200). Widespread reductions in fatal accident rates for each occupation have been greatest in recent years in the three armed forces and merchant shipping. Compared with the general workforce, relative risks of fatalities have increased in recent decades in all these occupations except shipping.ConclusionsAll six occupations still have high fatal accident rates. The greatly increased fatalities in sea fishing generally and in the Royal Air Force during its early years reflect, for different reasons, cultures of extreme risk-taking in these two sectors. Reductions in fatality rates in the armed forces over the last 20 years are due largely to decreases in land transport accidents.

Direct Detection of Streptococcus suis from Cerebrospinal Fluid, Positive Hemoculture, and Simultaneous Differentiation of Serotypes 1, 1/2, 2, and 14 within Single Reaction.

Streptococcus suis is an emerging zoonotic bacterium causing septicemia and meningitis in humans. Due to rapid disease progression, high mortality rate, and many underdiagnosed cases by time-consuming routine identification methods, alternative diagnostic testing is essential. Among 29 broadly accepted S. suis serotypes, serotypes 2 and 14 are high prevalent; however, many PCR assays showed an inability to differentiate serotype 2 from 1/2, and 1 from 14. In this study, we developed and validated a new multiplex PCR assay that facilitates the identification of only the 29 true serotypes of S. suis and simultaneously differentiates serotypes 1, 1/2, 2, and 14 within a single reaction. Importantly, the multiplex PCR could detect S. suis directly from positive hemocultures and CSF. The results revealed high sensitivity, specificity, and 100% accuracy with almost perfect agreement (κ = 1.0) compared to culture and serotyping methods. Direct detection enables a decrease in overall diagnosis time, rapid and efficient treatment, reduced fatality rates, and proficient disease control. This multiplex PCR offers a rapid, easy, and cost-effective method that can be applied in a routine laboratory. Furthermore, it is promising for developing point-of-care testing (POCT) for S. suis detection in the future.

COVID-19 vaccinations are associated with reduced fatality rates: Evidence from cross-country quasi-experiments.

BackgroundScientists have demonstrated the efficacy of vaccines against severe acute respiratory syndrome coronavirus 2 in randomized controlled trials. However, the extent to which reductions in COVID-19 case fatality ratio (CFR) are attributable to mass vaccination in the real world remains unclear. This study evaluated the association of COVID-19 vaccine coverage with CFR on a global scale.MethodsThe sample was a longitudinal data set of 90 countries over 25 weeks, from the first week of November 2020 to the third week of April 2021. CFR was measured in deaths per 100 COVID-19 confirmed cases; vaccine coverage was defined as the number of people who received at least one vaccine dose per 10 people in the total population. Data were retrieved from open-access databases, including Our World in Data and the Oxford COVID-19 Government Response Tracker. A country-level random effects model was used; a comprehensive set of variables for country characteristics and nonpharmaceutical interventions were included.ResultsA 10% increase in vaccine coverage was associated with a 7.6% reduction in the CFR (95% confidence interval (CI = -12.6 to -2.7%, P = 0.002). This association was stronger in countries with more effective governments (-8.3%; 95% CI = -13.6 to -3.1%, P = 0.002) and higher transport infrastructure quality (-8.1%; 95% CI = -13.3 to -2.9%, P = 0.002). Moreover, the vaccine coverage was associated with a reduced CFR in a dose-dependent manner. When vaccine coverage achieved 0.8 to 1.6, 1.6 to 3.2 and ≥3.2 per 10 people, the CFR reduced by 12.7% (95 CI = -21.8 to -3.6%, P = 0.006), 21.2% (95 CI = -33.9 to -8.5%, P = 0.001) and 31.3% (95 CI = -51.5 to -11.0%, P = 0.002), respectively as compared with no vaccination.ConclusionsOur results provide supporting evidence that vaccination is critical to preventing deaths among infected people. Vaccination programmes have yielded significant health benefits in certain countries. However, globally, a large gap remains between observed and achievable fatality reductions. Continuous improvement in vaccine coverage will be critical to transforming efficacious vaccines into desired health outcomes.

High health expenditures and low exposure of population to air pollution as critical factors that can reduce fatality rate in COVID-19 pandemic crisis: a global analysis

One of the problems hardly clarified in Coronavirus Disease 2019 (COVID-19) pandemic crisis is to identify factors associated with a lower mortality of COVID-19 between countries to design strategies to cope with future pandemics in society. The study here confronts this problem by developing a global analysis based on more than 160 countries. This paper proposes that Gross Domestic Product (GDP) per capita, healthcare spending and air pollution of nations are critical factors associated with fatality rate of COVID-19. The statistical evidence seems in general to support that countries with a low average COVID-19 fatality rate have high expenditures in health sector >7.5% of GDP, high health expenditures per capita >$2,300 and a lower exposure of population to days exceeding safe levels of particulate matter (PM2.5). Another relevant finding here is that these countries have lower case fatality rates (CFRs) of COVID-19, regardless a higher percentage of population aged more than 65 years. Overall, then, this study finds that an effective and proactive strategy to reduce the negative impact of future pandemics, driven by novel viral agents, has to be based on a planning of enhancement of healthcare sector and of environmental sustainability that can reduce fatality rate of infectious diseases in society.

Using Machine Learning to Reduce Fatality Rate of Scuba Diving..

Using Machine Learning to Reduce Fatality Rate of Scuba Diving..

Lessons Learned from COVID-19 Pandemic Crisis to Reduce Mortality of Future Infectious Diseases in Society

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of novel coronavirus that causes Coronavirus disease 2019 (COVID-19) that generates high number of infected cases and deaths worldwide. The fundamental question in this field of research is how countries can reduce fatality rates of COVID-19. This study confronts this question here by developing the first global analysis (based on more than 160 countries), which endeavors to analyze the socioeconomic sources of the reduction of mortality rates of COVID-19 in society. Results suggest that a low average fatality rate of COVID-19 is associated with countries having high level of current health expenditure expressed as a percentage of GDP, high domestic general government health expenditure per capita and a reduced exposure of population to days exceeding safe levels of particulate matter (PM2.5). These findings are important, very important to support an effective strategy to cope with future epidemics similar to COVID-19 that has to be based on high investments in health sector and environmental policy that reduces air pollution in order to be able to minimize fatality rates of future infectious diseases.

PIN17 Healthcare Resource Utilization and Cost in Patients with Inpatient Mortality Due to COVID-19 Infection

Patients with severe SARS-CoV-2 infection require significant hospital resources. However, since the disease was first identified, treatments have evolved rapidly, reducing fatality rates. This study was designed to evaluate changes in healthcare utilization and cost in patients with in-hospital mortality, from earliest time of disease identification to May 2020.

Detection of Atrial Fibrillation Using a Machine Learning Approach

The atrial fibrillation (AF) is one of the most well-known cardiac arrhythmias in clinical practice, with a prevalence of 1–2% in the community, which can increase the risk of stroke and myocardial infarction. The detection of AF electrocardiogram (ECG) can improve the early detection of diagnosis. In this paper, we have further developed a framework for processing the ECG signal in order to determine the AF episodes. We have implemented machine learning and deep learning algorithms to detect AF. Moreover, the experimental results show that better performance can be achieved with long short-term memory (LSTM) as compared to other algorithms. The initial experimental results illustrate that the deep learning algorithms, such as LSTM and convolutional neural network (CNN), achieved better performance (10%) as compared to machine learning classifiers, such as support vectors, logistic regression, etc. This preliminary work can help clinicians in AF detection with high accuracy and less probability of errors, which can ultimately result in reduction in fatality rate.

Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate

The world is desperately seeking for a sustainable solution to combat the coronavirus strain SARS-CoV-2 (COVID-19). Recent research indicated that optimizing Vitamin D blood levels could offer a solution approach that promises a heavily reduced fatality rate as well as solving the public health problem of counteracting the general vitamin D deficiency. This paper dived into the immunoregulatory effects of supplementing Vitamin D3 by elaborating a causal loop diagram. Together with D3, vitamin K2 and magnesium should be supplemented to prevent long-term health risks. Follow up clinical randomized trials are required to verify the current circumstantial evidence.

Paint it black: Efficacy of increased wind turbine rotor blade visibility to reduce avian fatalities.

As wind energy deployment increases and larger wind‐power plants are considered, bird fatalities through collision with moving turbine rotor blades are expected to increase. However, few (cost‐) effective deterrent or mitigation measures have so far been developed to reduce the risk of collision. Provision of “passive” visual cues may enhance the visibility of the rotor blades enabling birds to take evasive action in due time. Laboratory experiments have indicated that painting one of three rotor blades black minimizes motion smear (Hodos 2003, Minimization of motion smear: Reducing avian collisions with wind turbines). We tested the hypothesis that painting would increase the visibility of the blades, and that this would reduce fatality rates in situ, at the Smøla wind‐power plant in Norway, using a Before–After–Control–Impact approach employing fatality searches. The annual fatality rate was significantly reduced at the turbines with a painted blade by over 70%, relative to the neighboring control (i.e., unpainted) turbines. The treatment had the largest effect on reduction of raptor fatalities; no white‐tailed eagle carcasses were recorded after painting. Applying contrast painting to the rotor blades significantly reduced the collision risk for a range of birds. Painting the rotor blades at operational turbines was, however, resource demanding given that they had to be painted while in‐place. However, if implemented before construction, this cost will be minimized. It is recommended to repeat this experiment at other sites to ensure that the outcomes are generic at various settings.

Black boxes, not green: Mythologizing artificial intelligence and omitting the environment

We are repeatedly told that AI will help us to solve some of the world's biggest challenges, from treating chronic diseases and reducing fatality rates in traffic accidents to fighting climate change and anticipating cybersecurity threats. However, the article contends that public discourse on AI systematically avoids considering AI’s environmental costs. Artificial Intelligence- Brevini argues- runs on technology, machines, and infrastructures that deplete scarce resources in their production, consumption, and disposal, thus increasing the amounts of energy in their use, and exacerbate problems of waste and pollution. It also relies on data centers, that demands impressive amounts of energy to compute, analyse, categorize. If we want to stand a chance at tackling the Climate Emergency, then we have to stop avoiding addressing the environmental problems generated by AI.

Dysfunctional Coagulation in COVID-19: From Cell to Bedside.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which can induce multisystem disease. Human angiotensin-converting enzyme 2 (ACE2) widely expressing in arterial and venous endothelial cells and arterial smooth muscle cells has been identified as a functional receptor for SARS-CoV-2. Dysfunction of ACE2 leads to abnormal activation of the renin-angiotensin system and a systemic endotheliitis that may relate to abnormal coagulation and sepsis. Meanwhile, innate immune response and inflammation activation participate in dysfunctional coagulation. Previous research indicated that dysfunctional coagulation was one of the important risk factors accountable for a high risk of severe disease and death in patients with COVID-19. Understanding the possible mechanisms of dysfunctional coagulation and appropriate anticoagulation therapeutic strategies are important to prevent disease deterioration and reduce fatality rates during the ongoing COVID-19 pandemic.

Wildlife and infrastructure: impact of wind turbines on bats in the Black Sea coast region

In Eastern Europe, wind energy production is currently promoted as an important source of renewable energy, yet in most cases without appropriate consideration of the negative impacts wind turbines (WT) may have on protected species such as bats. Here, we present first data on fatality rates, fatality factors and the likely origin of bats killed by WT in the Dobrogea region (Romania), located in a major migratory corridor for wildlife in Eastern Europe. Over a 4-year period, we found a total of 166 bat carcasses from 10 species, mostly representing migratory species such as Pipistrellus nathusii and Nyctalus noctula. Most fatalities at WT occurred in July and August. We documented 15 cases of barotrauma and 34 cases of blunt-force trauma in carcasses found below WT. After adjusting for carcass removals and variations in searcher efficiency, we estimated for the 4-year study period a total of 2394 bat casualties at the studied WT facility consisting of 20 units, resulting in a mean fatality rate of 30 bats/WT/year, or 14.2 bats/MW/year. By implementing a curtailment measure at wind speeds below 6.5 m/s, we reduced fatality rates by 78%. Isoscape origin models based on hydrogen stable isotope ratios in fur keratin revealed that the majority of N. noctula that were killed by WT or captured nearby in mist nets originated from distant areas in the North (Ukraine, Belarus, Russia). The estimated high fatalitjegangy rates of bats at WT in this area have far-reaching consequences, particularly for populations of migratory bats, if no appropriate mitigation schemes are practised.

Importance of timely management of patients in reducing fatality rate of coronavirus disease 2019

The outbreak of coronavirus disease 2019 (COVID-19) characterized with pneumonia, firstly occurred in Wuhan city, China, in December 2019 has so far spread in over 200 countries and territories in the world. One of the important goals in facing outbreaks of COVID-19 is to reduce the case fatality rate. We reported here that the fatality rate of COVID-19 in other provinces of mainland China was 0.82% (121/14,708), significantly lower than 6.62% (4512/68,128) in Hubei province (p<0.0001). The main reason for the lower fatality rate was likely due to the timely management of the patients in other provinces, highlighting the importance of timely management of patients in reducing the fatality rate of COVID-19.

COMPARATIVE ANALYSIS OF COVID-19 EPIDEMIC IN HUBEI PROVINCE AND REST PARTS OF MAINLAND CHINA

Background: China 's national-level anti-COVID-19 campaign has been going on for a month. With the development of the epidemic, it is found that COVID-19 severity in Hubei province (Hubei) is different from the rest of mainland China (Rest of China). It is necessary to compare the two areas, summarize experiences and lessons, analyze the epidemic trend and further point out the direction for the campaign. Methods: Prevent, quarantine and treat the disease according to The Novel Coronavirus Infected Pneumonia Diagnosis and Treatment Standards. Collect the numbers of total close contacts, daily observation cases, daily suspected cases, total conrmed cases, daily severe cases, total deaths from January 20 to February 19, input them into SPSS 25 and Microsoft ofce 2019 excel for data processing, statistical analysis and drawing. Findings: Total conrmed cases in Hubei account for 83.2% of the country. Daily suspected cases growth rates for both areas have become negative since February 9. Daily observation cases in Rest of China reached highest point on February 5 as opposed to February 13 in Hubei, and total close contacts growth rates for the last three days are declining steadily to 1.9% and 3.8% respectively. Total conrmed cases growth rate has hit the lowest levels in Rest of China at 0.34% by comparison with 0.57% in Hubei. Mean fatality rate and mean percentage of severe cases for the last three days in Rest of China are 0.67% and 5.83% in contrast to 3.12% and 18.2% in Hubei. There have been very signicant differences in fatality rate and percentage of severe cases existing in the two areas since January 23 and 24 respectively (P&lt;0.01). Interpretation: Hubei is the main epidemic area. COVID-19 has low fatality rate and high transmissibility. Cutting off the source of infection is pivotal in containing COVID-19 outbreak and has a guiding effect on prevention and control of pandemic worldwide. The Novel Coronavirus Infected Pneumonia Diagnosis and Treatment Standards has played an important role in helping medical staff across the country to ght the epidemic. Coordinating national medical resources to support disaster areas, making full use of the existing facilities to isolate and quarantine, providing timely and accurate treatment can reduce fatality rate. Further efforts are needed to develop highly effective Chinese medicines, western drugs and vaccines in order to eradicate the virus or prevent the epidemic from continuing.

The Impact of Employers’ Liability on English Coalmining Fatalities, 1863-1966

This paper examines the economic basis of nineteenth century common law of employers’ liability, and the impact of statutory reforms such as the Employers’ Liability Act 1880, Workmen’s Compensation Act 1897 and no-fault liability under the Industrial Injuries Scheme that accompanied the nationalisation of the UK coal mining industry on English regional and British coalmining fatality rates over the period 1863 to 1966. The empirical and econometric analysis indicates that the 1880 had little impact but there is some indication that nationalisation of the coalmining industry may have reduced fatality rates.

A comparative analysis of road safety across the provinces of Iran from 2005 to 2015

During the most recent decade, Iran has invested in road safety improvement programs and has experienced a reduction in road fatalities, with rates of improvement differing across provinces. Knowing which road safety investments are performing well across provinces is essential for wisely investing in future road safety improvements. This firstly requires identification of successful provinces. Accordingly, the aim of this study is to evaluate the relative performance of Iranian provinces in improving their safety, while accounting for a variety of factors that influence road safety outcomes. To achieve this aim, traffic fatality rates recorded in each province during 2005–2015 were analyzed. The analysis framework involved first estimating a panel data model to control for random variations as well as exogenous factors—in effect providing a safety performance function for provinces. Then, the “expected provincial safety performance” was compared to actual provincial safety performance, to identify “outlying” provinces with respect to safety performance. The results reveal that the fatality rates are positively associated with exposure as captured by per capita fuel consumption, and percentage of undivided two-lane, two-way rural roads, and negatively related to urban to rural population ratio, population density, and hospital beds per 100,000 residents. Moreover, the number of speed cameras per 100 km rural roads is associated with reduced fatality rates. A comparative assessment of provinces over the 11 year period revealed significant differences among the provinces in terms of safety performance in each year as well as safety improvement rates over time.

Dealing with existing theory: national fatality rates, vehicle standards and personal safety

In this paper we discuss some of the weaknesses in exiting theories and understandings behind road safety interventions and policy making. The paper deals with four main issues: road traffic fatality rates and per capita income of countries, vehicle crashworthiness standards, role of pedestrian and powered two-wheeler share in traffic on fatalities, and safety standards for vehicles other than cars. Recent data indicate that there may not be a strong relationship between income and road safety performance and it is possible for low and middle-income countries (LMIC) to decrease death rates at present income levels. Safer cars have had a major role in reducing fatality rates, but, gains in traffic safety in high income countries may be partly due to reducing exposure of vulnerable road users. Small lightweight vehicles (like tuk-tuks, three-wheeled scooter taxis) operating in many LMIC appear to have low fatality rates though they do not follow any crashworthiness standards. Very different crashworthiness standards need to be developed for low mass vehicles incapable of operating speeds greater than 50 km/h. LMIC may not be able to reduce fatality rates below about 7 per 100,000 population unless there are innovative developments in road design and all vehicle safety standards.