Abstract
The world is desperately seeking for a sustainable solution to combat the coronavirus strain SARS-CoV-2 (COVID-19). Recent research indicated that optimizing Vitamin D blood levels could offer a solution approach that promises a heavily reduced fatality rate as well as solving the public health problem of counteracting the general vitamin D deficiency. This paper dived into the immunoregulatory effects of supplementing Vitamin D3 by elaborating a causal loop diagram. Together with D3, vitamin K2 and magnesium should be supplemented to prevent long-term health risks. Follow up clinical randomized trials are required to verify the current circumstantial evidence.
Highlights
The COVID-19 pandemic is a current pandemic of high international interest, caused by the coronavirus strain SARS‐CoV‐2
One retrospective cohort study that investigated the correlation between the mean D3 serum levels of different European countries and the COVID-19 mortality rate was not considered significant (Ali, 2020)
The majority of the previtamin D3 is both acquired in the human skin from the conversion of 7-dehydrocholesterol through cutaneous solar ultraviolet radiation
Summary
The COVID-19 pandemic is a current pandemic of high international interest, caused by the coronavirus strain SARS‐CoV‐2. One retrospective cohort study that investigated the correlation between the mean D3 serum levels of different European countries and the COVID-19 mortality rate was not considered significant (Ali, 2020). An explanation for this could be that testing conditions differ in each European country, making it difficult to reach a conclusion in such a retrospective study. The mean D3 serum levels do not necessarily apply to people who are especially vulnerable to that virus (e.g. aged and bedridden people) This assumption is supported by De Smet et al (2020) who documented a significantly lower median D3 value in patients with COVID-19 compared to control subjects
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