Reduced Wall Thickness Research Articles

Abstract 4137339: Application of PLGA-PEG-PLGA Thermosensitive Hydrogel Loaded with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Ginsenoside Rb3 in the Treatment of Acute Myocardial Infarction

Background: Ginsenoside Rb3 (GSRb3) is a traditional Chinese medicine monomer. We aim to investigate the effects of GSRb3 on the proliferation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and the reparative effects of PLGA-PEG-PLGA thermosensitive hydrogel loaded with hiPSC-CMs and GSRb3 (NP GSRb3 @Gel+iCM) on myocardial infarction (MI). Methods: 1. Western Blot, RT-qPCR, cell immunofluorescence staining, and CCK-8 assays were employed to assess the proliferative effects of different concentrations of GSRb3 on neonatal mouse primary cardiomyocytes (NCMs) and hiPSC-CMs. 2. Transcriptomic gene sequencing technology was utilized to investigate the mRNA expression changes of hiPSC-CMs induced by GSRb3; The NP GSRb3 @Gel+iCM was injected into the left ventricular myocardium of the MI mice; the same volume injections of hiPSC-CMs (iCM group) and PLGA-PEG-PLGA thermosensitive hydrogel loaded with GSRb3 (NP GSRb3 @Gel group) served as control; Additionally, MI model group without additional treatment and sham group were established. 3. At 4 weeks post-MI, echocardiography, Sirius Red/Fast Green staining and immunofluorescence staining were utilized to evaluate the heart function, infarction size and survival rate of transplanted hiPSC-CMs. Results: GSRb3 inhibit the apoptosis of NCMs while promote proliferation of NCMs and hiPSC-CMs significantly. After 4 weeks of treatment, the engraftment rate of hiPSC-CMs in NP GSRb3 @Gel+iCM group (36.7%) was 4.8 times that of iCM group (7.7%); Compared to the MI group, NP GSRb3 @Gel group and iCM group, NP GSRb3 @Gel+iCM group showed significant improvement in cardiac function; The myocardial repair effect in NP GSRb3 @Gel+iCM group was significantly superior to NP GSRb3 @Gel group and iCM group, with a 47% reduction in infarct size compared to MI group, and further reduction in left ventricular anterior wall thickness compared to NP GSRb3 @Gel group and iCM group. Conclusion: GSRb3 promotes the proliferation of hiPSC-CMs both in vitro and in vivo. NP GSRb3 @Gel+iCM significantly increase the engraftment of hiPSC-CMs, promote angiogenesis, reduce infarction size, inhibit left ventricular remodeling and improve cardiac function.

Abstract 4135531: The Ubiquitin-Specific Protease 30 Inhibitor, MTX652, Attenuates Cardiac Dysfunction And Remodelling In a Murine Model Of Transverse Aortic Constriction

Introduction: Mitochondrial abnormalities are a characteristic of heart failure leading to energy deprivation and disease worsening. The mitochondrial deubiquitinating enzyme USP30, removes ubiquitin and represses PINK1/PARKIN-mediated mitophagy leading to accumulation of dysfunctional mitochondria. In this study we investigated the role of MTX652, a clinical stage USP30 inhibitor, in a mouse model of cardiac hypertrophy using transverse aortic constriction (TAC). Hypothesis: Inhibition of USP30 will promote mitophagy resulting in clearance of dysfunctional mitochondria and improved cellular health leading to cardioprotective effects. Aims: To determine if MTX652 can protect from TAC induced cardiac hypertrophy and remodelling. Methods: Male C57BL/6 mice, 8 weeks old, were subjected to sham surgeries or TAC using a 26G needle to induce cardiac pressure overload. MTX652 (1.5 or 5 mg/kg, n =12-13) or vehicle ( n =11) was administered orally, twice daily, starting 2 days post-surgery. Captopril (30 mg/kg/d, n =13) was also included as a positive control. After 4 weeks, echocardiography assessed left ventricle (LV) function and morphology. Cell based assays assessed MTX652 target engagement and TOM20 ubiquitination in vitro. Results: LV hypertrophy and wall thickening was observed in TAC animals. Treatment with MTX652 decreased systolic LV volume (1.5 mg/kg p<0.05 and 5 mg/kg p<0.01) and diameter (1.5 mg/kg p<0.01 and 5 mg/kg p<0.05,) demonstrating comparable effects to Captopril. A reduction in anterior wall thickness in diastole was also observed with MTX652 (5 mg/kg, p<0.01). Cardiac dysfunction was also evident in TAC animals with MTX652 showing improvements in both ejection fraction (1.5 mg/kg and 5 mg/kg, p<0.0001) and fractional shortening (1.5 mg/kg and 5 mg/kg, p<0.0001). Cellular target engagement for MTX652 was confirmed in HeLa-YFP-Parkin cells with an EC 50 of 2.7 nM ( n =2). Furthermore, the USP30 substrate TOM20 was ubiquitinated following MTX652 treatment in vitro (EC 50 =6.1 nM, n =4) providing evidence of mitophagy activation, a finding also confirmed in mouse heart tissue (MTX652, 5mg/kg). Conclusions: The USP30 inhibitor, MTX652 significantly protected mice from TAC induced cardiac hypertrophy and LV dysfunction. Furthermore, MTX652 potentiates ubiquitylation of TOM20 as a mechanism to promote mitophagy. These data suggest our clinical stage molecule could provide a novel therapeutic approach for the treatment of cardiac hypertrophy and heart failure.

CapD deletion in the Elizabethkingia miricola capsular locus leads to capsule production deficiency and reduced virulence.

Elizabethkingia miricola is a multidrug-resistant pathogen that can cause life-threatening infections in immunocompromised humans and outbreaks in amphibians. However, the specific virulence factors of this microorganism have not been described. In this study, we identified the polysaccharide biosynthesis protein-encoding gene capD, which is located in the conserved region of the Wzy-dependent capsule synthesis gene cluster in the E. miricola strain FL160902, and investigated its role in the pathogenesis of E. miricola. Our results revealed that the capD deletion strain (ΔcapD) lost its typical encapsulated structure, with a 45% reduction in cell wall thickness. CapD affects wza expression in the capsule polysaccharide synthesis pathway. Furthermore, the survival rates were significantly reduced in ΔcapD in response to complement-mediated killing, desiccation stress, and macrophage phagocytosis, whereas biofilm formation, surface hydrophobicity, and adherence to both endothelial and epithelial cells were increased. Additionally, the deletion of capD sharply attenuated the virulence of E. miricola in a frog infection model. Complementation of the capD gene restored the biological properties and virulence to wild-type levels. Overall, these findings suggest that CapD contributes to polysaccharide synthesis and plays a crucial role in the pathogenesis of E. miricola.

Rupture energy coupling of alkali washing tower cylinder

The energy generated by the container during the explosion induces destructive effects on the surrounding objects and itself, such as deformation, compression, rupture, etc. The explosive energy is one of the richest pieces of evidence in the analysis of the accident cause, and therefore a comprehensive analysis of the accident explosive energy is essential for determining accident properties. Considering the rupture accident of an alkali washing tower in an aromatic hydrocarbon plant as an example, the destructive energy and the rupture internal pressure are estimated to ascertain the explosive properties of the accident by analyzing the field damage characteristics. This study aims to conduct a comprehensive analysis and calculation of the energy associated with an alkali washing tower rupture accident. The objective is to determine the cause of the accident, which can be attributed to the combined effect of wall thickness reduction and fluctuations of production process parameters. The findings of this analysis will serve as a scientific basis for the examination of similar accidents and the formulation of safety protection measures.

Morphological, electrophysiological, and molecular alterations in foetal noncompacted cardiomyopathy induced by disruption of ROCK signalling.

Left ventricular noncompaction cardiomyopathy is associated with heart failure, arrhythmia, and sudden cardiac death. The developmental mechanism underpinning noncompaction in the adult heart is still not fully understood, with lack of trabeculae compaction, hypertrabeculation, and loss of proliferation cited as possible causes. To study this, we utilised a mouse model of aberrant Rho kinase (ROCK) signalling in cardiomyocytes, which led to a noncompaction phenotype during embryogenesis, and monitored how this progressed after birth and into adulthood. The cause of the early noncompaction at E15.5 was attributed to a decrease in proliferation in the developing ventricular wall. By E18.5, the phenotype became patchy, with regions of noncompaction interspersed with thick compacted areas of ventricular wall. To study how this altered myoarchitecture of the heart influenced impulse propagation in the developing and adult heart, we used histology with immunohistochemistry for gap junction protein expression, optical mapping, and electrocardiography. At the prenatal stages, a clear reduction in left ventricular wall thickness, accompanied by abnormal conduction of the ectopically paced beat in that area, was observed in mutant hearts. This correlated with increased expression of connexin-40 and connexin-43 in noncompacted trabeculae. In postnatal stages, left ventricular noncompaction was resolved, but the right ventricular wall remained structurally abnormal through to adulthood with cardiomyocyte hypertrophy and retention of myocardial crypts. Thus, this is a novel model of self-correcting embryonic hypertrabeculation cardiomyopathy, but it highlights that remodelling potential differs between the left and right ventricles. We conclude that disruption of ROCK signalling induces both morphological and electrophysiological changes that evolve over time, highlighting the link between myocyte proliferation and noncompaction phenotypes and electrophysiological differentiation.

The fracture and perforation failure analysis of downhole tubes

：The downhole tubes were fractured and perforated after 5 years of shut-in due to high water cuts. This study employs a comprehensive array of analytical techniques to investigate the mechanisms behind fractures and perforations. Utilizing non-destructive testing (NDT), direct reading spectrometer, tensile strength testing machine, impact testing machine, optical microscope (OM), macroscopic fracture morphology observation, scanning electron microscope (SEM) and energy spectrum analysis (EDS), and sulfide stress corrosion cracking (SSCC) was studied. The reason for the fracture of the tubing is that under the condition of low pH value, high hydrogen sulfide environment, the tubing is fractured due to stress concentration caused by cracks in the outer thread relief groove. The perforation of the inner tube wall was caused by gradual wall thickness reduction under the influence of H2S, CO2, and Cl−, resulting in fouling and eventual perforation. To prevent tube corrosion during long-term shut-in, it is recommended to inject crude oil or diesel into the well.

Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease.

Arteriovenous fistulae (AVFs) are the preferred vascular access for hemodialysis in patients with end-stage kidney disease. Chronic kidney disease (CKD) is associated with endothelial injury, impaired AVF maturation, and reduced patency, as well as utilization. Because CKD is characterized by multiple pathophysiological processes that induce endothelial-to-mesenchymal transition (EndMT), we hypothesized that CKD promotes EndMT during venous remodeling and that disruption of endothelial TGF (transforming growth factor)-β signaling inhibits EndMT to prevent AVF failure even in the end-stage kidney disease environment. The mouse 5/6 nephrectomy and aortocaval fistula models were used. CKD was created via 5/6 nephrectomy, with controls of no (0/6) or partial (3/6) nephrectomy in C57BL/6J mice. AVFs were created in mice with knockdown of TGF-βR1/R2 (TGF-β receptors type 1/2) in either smooth muscle cells or endothelial cells. AVF diameters and patency were measured and confirmed by serial ultrasound examination. AVF, both murine and human, were examined using Western blot, histology, and immunofluorescence. Human and mouse endothelial cells were used for in vitro experiments. CKD accelerates TGF-β activation and promotes EndMT that is associated with increased AVF wall thickness and reduced patency in mice. Inhibition of TGF-β signaling in both endothelial cells and smooth muscle cells decreased smooth muscle cell proliferation in the AVF wall, attenuated EndMT, and was associated with reduced wall thickness, increased outward remodeling, and improved AVF patency. Human AVF also showed increased TGF-β signaling and EndMT. CKD promotes EndMT and reduces AVF patency. Inhibition of TGF-β signaling, especially disruption of endothelial cell-specific TGF-β signaling, attenuates EndMT and improves AVF patency in mouse AVF. Inhibition of EndMT may be a therapeutic approach of translational significance to improve AVF patency in human patients with CKD.

Effects of plasma electrolytic polishing on the surface and mechanical properties of Ti-6.5Al-3.5Mo-1.5Zr-0.3Si specimen fabricated by laser powder bed fusion

The high roughness of titanium alloy specimen fabricated by laser powder bed fusion (LPBF) may limit the application of LPBF technology. Plasma electrolytic polishing (PEP) can effectively reduce the surface roughness of metal samples. In this study, an orthogonal test was designed to investigate the effects of polishing time, voltage and electrolyte temperature on the reduction of roughness and wall thickness of Ti-6.5Al-3.5Mo-1.5Zr-0.3Si specimens fabricated by LPBF. The surface roughness of the specimen decreased from Ra = 49.1 μm to Ra = 9.1 μm and the thickness decreased from 1.72 mm to 1.38 mm after the PEP. Due to the recoil pressure induced by rupture of vapor-gaseous envelope (VGE) and the annealing effect caused by electron impact, the width of α/α' grains on the surface of TC11 specimen decreased from 0.51 μm to 0.46 μm; the mean value of geometrically necessary dislocations (GND) increased by 9.8 %; the proportion of high angle grain boundaries (HAGBs) increased from 75.2 % to 80.8 %; the proportion of twin grain boundary length increased from 2.9 % to 11.9 %, and the activated twin variant type increased from 2 to 4. The number of pores in the samples reduced from 85 to 2 after PEP, which resulted in the improvement of tensile and fatigue properties. The ultimate strength and elongation of the tensile specimens increased by 6.2 % and 53.5 % respectively. The infinite fatigue life maximum stress of the high cycle fatigue specimen increased by 62.5 %. Another reason for the improvement of mechanical properties may be the self-healing of microcracks and the electroplasticity in the specimens.

Significance of changes in cavity after treatment in Mycobacterium avium complex pulmonary disease

Cavities are characteristic radiological features related to increased mycobacterial burden and poor prognosis in Mycobacterium avium complex pulmonary disease (MAC-PD). However, cavity changes following treatment and their clinical implications remain unknown. We aimed to elucidate whether cavity obliteration or reduction in cavity size or wall thickness correlates with microbiological cure. In total, 136 adult patients with cavitary MAC-PD treated for ≥ 6 months between January 1st, 2009, and December 31st, 2021, in a tertiary referral centre in South Korea were enrolled. The cavity with the largest diameter at treatment initiation was tracked for size and thickness changes. Following median treatment of 20.0 months, 74 (54.4%) patients achieved microbiological cure. Cavity obliteration, achieved in 58 (42.6%) patients at treatment completion, was independently associated with microbiological cure. In patients with persistent cavities, size reduction of ≥ 10% was significantly associated with microbiological cure, whereas thickness reduction was not. Five-year mortality rates in patients with cavity obliteration, persistent but reduced cavity, and persistent cavity without shrinkage were 95.6%, 72.1%, and 65.3%, respectively (P < 0.001). In conclusion, cavity obliteration or shrinkage at treatment completion is associated with microbiological cure and reduced mortality in MAC-PD, suggesting that cavity changes could serve as a proxy indicator for treatment response.

The roles of cell wall polysaccharides in response to waterlogging stress in Brassica napus L. root

BackgroundBrassica napus L. (B. napus) is susceptible to waterlogging stress during different cultivation periods. Therefore, it is crucial to enhance the resistance to waterlogging stress to achieve a high and stable yield of B. napus.ResultsHere we observed significant differences in the responses of two B. napus varieties in root under waterlogging stress. The sensitive variety (23651) exhibited a more pronounced and rapid reduction in cell wall thickness and root integrity compared with the tolerant variety (Santana) under waterlogging stress. By module clustering analysis based on transcriptome data, we identified that cell wall polysaccharide metabolism responded to waterlogging stress in root. It was found that pectin content was significantly reduced in the sensitive variety compared with the tolerant variety. Furthermore, transcriptome analysis revealed that the expression of two homologous genes encoding polygalacturonase-inhibiting protein 2 (PGIP2), involved in polysaccharide metabolic pathways, was highly upregulated in root of the tolerant variety under waterlogging stress. BnaPGIP2s probably confer waterlogging resistance by inhibiting the activity of polygalacturonases (PGs), which in turn reduces the degradation of the pectin backbone polygalacturonic acid.ConclusionsOur findings demonstrate that cell wall polysaccharides in root plays a vital role in response to the waterlogging stress and provide a theoretical foundation for breeding waterlogging resistance in B. napus varieties.

Maximizing strength and durability in wood concrete (arbolite) via innovative additive control and consumption

AbstractA new approach for assessing the effectiveness and determining the consumption of additives to regulate the structural and mechanical characteristics of wood concrete is proposed, which allows rapid assessment in a short time and reduces the consumption of materials. The period is reduced from 28 to 1 day, and the sample sizes are reduced from 150 × 150 × 150 to 20 × 20 × 20 mm compared to those of the standard method. The results obtained are comparable using both methods within an error of up to 7%. The thermal conductivity of wood concrete with the addition of potassium sulfate was 20.8% less than that with the addition of calcium chloride. This reduction will reduce wall thickness, material consumption, and cost by 20.8%. In this regard, potassium sulfate, which does not form crystalline hydrates and makes it possible to obtain a material with lower thermal conductivity than other additives, all other things being equal, has a new advantage for wood concrete. In addition, potassium sulfate reduces the risk of corrosion of cement stone because one of the main causes of corrosion is crystalline hydrates. Reducing the risk of corrosion will increase the durability of the material.

Numerical Simulation Study of Wall Thickness Change Rule of Single Point Progressive Molding of Al5083

With the development and progress of science and technology, the application of single-point progressive molding is more and more extensive, but single-point progressive molding still exists the problem of excessive thinning of wall thickness of molded parts, which seriously affects the quality of molded parts. The article takes Al5083 plate forming cone as the research object, uses Abaqus finite element simulation software, according to the principle of single variable, respectively explores the influence of process parameters such as tool head diameter, layer spacing, feed rate and residual height on the average wall thickness reduction rate and the maximum wall thickness reduction rate of the molded parts. The results show that: increasing the tool head diameter, the average wall thickness reduction rate increases and the maximum wall thickness reduction rate decreases; the average wall thickness reduction rate and the maximum wall thickness reduction rate increase with the increase of ply spacing; the average wall thickness reduction rate and the maximum wall thickness reduction rate increase with the increase of the tool feed rate; the average wall thickness reduction rate decreases and the maximum wall thickness reduction rate increases with the increase of the residual height.

METHOD FOR PREDICTING THE TECHNICAL CONDITION OF GAS WELL TUBING WITH CORRECTION BASED ON IN-LINE DIAGNOSTICS INFORMATION

The article presents a methodology for monitoring and predicting the technical condition of the suspension of pump-compressor pipes (tubing) of gas wells exposed to carbon dioxide corrosion. The tubing suspension as an object of control and diagnostics is considered, the main loads acting on the object in question are determined, as well as the expression for the equivalent value of the loads. An expression has been obtained for determining the permissible reduction in the tubing wall thickness, provided that the facility remains operational, as well as an expression for determining the total and residual life of the tubing hanger.A comparative analysis of the main methods for determining the corrosion rate of a diagnostic object was carried out, and the optimal method was selected. A method for correcting the results of calculating the corrosion rate using tubing wall thickness values obtained during in-line diagnostics is described.

Impact of conventional and biological disease-modifying anti-rheumatic drugs on arterial lesions in Takayasu arteritis.

The definition of Takayasu arteritis (TAK) remission and disease activity is still unclear. Vascular imaging is an essential tool for following-up patients. Herein, we aimed to compare the evolution of vascular lesions (ie vessel wall thickening and stenosis) under conventional disease-modifying anti-rheumatic drugs (cDMARDs) relatively to biological DMARDs (bDMARDs) in TAK patients followed with the same CT angiography modalities. We compared 75 lines of therapy in TAK patients who received cDMARDs (n = 40 lines) and bDMARDs (n = 35 lines) using CT angiography. We established 1-3 main target vessels with vessel wall thickening and/or stenosis. Every targeted vessel had its thickness and its lumen diameter measured at the initiation of immunosuppressive treatment and at 12 months. We observed an overall reduction of arterial wall thickness in 73% of cases and 31% had >25% of wall thickness relative decrease. Using a linear mixed effects model, first line immunosuppressive therapy (p= 0.012) and bDMARDs relatively to cDMARDs (p= 0.026) were independently associated with vessel wall thickness reduction in TAK. Thirty-eight percent of the stenotic vessels had a > 25% relative increase in lumen diameter under immunosuppressive therapy. The relative increase >25% in lumen diameter was noted in 56% vs 17% with bDMARDs compared with cDMARDs. Immunosuppressive treatments can reduce arterial wall thickness and widen lumen diameter in TAK. bDMARDs seems to be more effective than cDMARDs to improve arterial lesions in TAK.

Non-destructive testing technology for corrosion wall thickness reduction defects in pipelines based on electromagnetic ultrasound

Non-destructive testing technology for corrosion wall thickness reduction defects in pipelines based on electromagnetic ultrasound

Effects of sacubitril-valsartan on aging-related cardiac dysfunction

Heart failure (HF) remains a huge medical burden worldwide, with aging representing a major risk factor. Here, we report the effects of sacubitril/valsartan, an approved drug for HF with reduced EF, in an experimental model of aging-related HF with preserved ejection fraction (HFpEF).Eighteen-month-old female Fisher 344 rats were treated for 12 weeks with sacubitril/valsartan (60 mg/kg/day) or with valsartan (30 mg/kg/day). Three-month-old rats were used as control.No differential action of sacubitril/valsartan versus valsartan alone, either positive or negative, was observed. The positive effects of both sacubitril/valsartan and valsartan on cardiac hypertrophy was evidenced by a significant reduction of wall thickness and myocyte cross-sectional area. Contrarily, myocardial fibrosis in aging heart was not reduced by any treatment. Doppler echocardiography and left ventricular catheterization evidenced diastolic dysfunction in untreated and treated old rats. In aging rats, both classical and non-classical renin-angiotensin-aldosterone system (RAAS) were modulated. In particular, with respect to untreated animals, both sacubitril/valsartan and valsartan showed a partial restoration of cardioprotective non-classical RAAS.In conclusion, this study evidenced the favorable effects, by both treatments, on age-related cardiac hypertrophy. The attenuation of cardiomyocyte size and hypertrophic response may be linked to a shift towards cardioprotective RAAS signaling. However, diastolic dysfunction and cardiac fibrosis persisted despite of treatment and were accompanied by myocardial inflammation, endothelial activation, and oxidative stress.

Multi-pass deep-drawing process and mould design for thin-walled hollow cylindrical parts

Thin-walled hollow cylindrical parts are widely employed in various industries, including automobiles, ships, and aviation, due to their increased demand and the escalating quality requirements for their formation. The production of these parts primarily relies on a multi-stage deep drawing process. However, during the deep drawing process, the gradual reduction in the side wall thickness creates a susceptible area at the bottom rounded transition, where local over-thinning may occur, thereby increasing the risk of cracking. Furthermore, the deep-drawing process becomes more intricate for thin-walled hollow cylindrical parts with a large height-to-diameter ratio, amplifying the likelihood of defects during actual production. This paper combines CAE simulation and empirical design to comprehensively investigate and analyze the multi-stage deep drawing process and mold design for thin-walled hollow cylindrical parts. The aim is to optimize the deep-drawing process and mold parameters, enhance the products qualification rate, and provide valuable guidance for the practical production of relevant enterprises.

Influence of polishing process on surface morphology and thermo-hydraulic performance of additively manufactured Gyroid-structured heat exchanger

As additive manufacturing technology overcomes fabricating obstacles, the Gyroid structure, characterized by its intricate topology, emerges as a promising heat exchanger configuration. Nonetheless, the substantial surface roughness intrinsic to additive manufacturing considerably constrains the practical deployment of Gyroid-structured heat exchangers. This study focuses on the post-treatment of a Gyroid-structured heat exchanger, manufactured by selective laser melting, employing abrasive jet polishing. It further investigates the influence of this process on surface morphology and thermo-hydraulic performance, utilizing characterization, experimental, and numerical methodologies. Surface characterization indicates that the polishing process markedly diminishes the distribution density of protrusion microstructures on the internal surface. Pre-polishing surface roughness results in an area expansion of 106–123%, which is reduced to 20–45% after polishing. Moreover, the coupling effect of concurrent reduction in wall thickness and surface roughness enables the polished prototype to attain a 40% decrease in differential pressure, while maintaining nearly identical heat transfer capacity. The overall performance evaluation criterion of the post-polishing prototype consistently surpasses the offset strip fin heat exchanger by 12.94–26.09%, within a Reynolds number range of 300–3000. This study introduces a validated technology for modifying the internal surface of additively manufactured heat exchangers, especially Gyroid-structured heat exchangers, thereby facilitating its practical utilization in cutting-edge fields.

Error analysis of self-compensated ultrasound measurements of the thickness loss due to corrosion in pipe walls

The ultrasonic pulse-echo technique is widely employed to measure the wall thickness reduction due to corrosion in pipelines. Ultrasonic monitoring is noninvasive and can be performed online to evaluate the structural health of pipelines. Although ultrasound is a robust technique, it presents two main difficulties arising from the temperature variation in the medium being monitored: the mechanical assembly must have high stability and the ultrasonic propagation velocity must take into account the temperature variation. In this paper, a detailed strategy is presented to compensate for changes in the propagation velocity whenever the temperature changes. The method is considered self-compensated because the calibration data is obtained from the ultrasonic signals captured using the pipe under evaluation. The analysis of systematic errors in the temperature compensation is presented, first considering that a reference initial pipe thickness is given, and second when a reference sound velocity is given. The technique was evaluated under laboratory conditions using a closed loop with accelerated corrosion through the use of continuous flow saline water containing sand. In this test, the ultrasonic results were compared with the traditional coupon method used to determine corrosion loss. The results show that the self-compensated method was able to compensate for temperature fluctuations, and the total thickness loss measured by the ultrasound technique was close to the value measured by the coupons. Finally, the measurement system was tested in a production pipeline exposed to sunlight. The results show that the self-compensated method can reduce the oscillations in the thickness loss readings, caused by temperature swings, but large temperature variations cannot be completely compensated for. This experiment also shows the effects of low mechanical stability, which caused completely invalid results.

Stress corrosion phenomenon of casing in CO2 medium and magnetic memory detection

Due to being in an acidic CO2 environment and high-pressure underground, the stress corrosion phenomenon on the inner wall of the CCUS wellbore is more pronounced, with the possibility of wall thickness reduction and crack propagation, which affects the integrity and storage reliability of the wellbore. This article conducted indoor experiments on stress corrosion of oil casing, and characterized the stress corrosion through magnetic memory detection technology. Through experiments, the stress corrosion morphology of specimens under different concentrations, stresses, and defects was obtained. The microstructure of the stress corrosion site was observed using SEM electron microscopy, and the stress corrosion situation of the material in CO2 was observed, laying a foundation for magnetic memory detection; A stress corrosion detection method under CO2 environment was proposed, and the magnetic memory detection method was used to measure that the more severe the stress corrosion, the more obvious the magnetic signal mutation; The shape and morphology of different defects vary, but the main factors affecting magnetic memory signals are concentration and loading force. This article verifies the feasibility of magnetic memory in stress corrosion detection through experiments, and characterizes the stress corrosion situation using magnetic memory signals, which is of great significance for non-destructive testing of wellbore stress corrosion in CO2 storage.