Reduced Thyroid Function Research Articles

Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective.

Background: The management of primary hypothyroidism demands a comprehensive approach that encompasses both the implications of autoimmune thyroid disease and the distinct effects posed by obesity and metabolic irregularities. Despite its clinical importance, the interplay between obesity and hypothyroidism, especially in the context of metabolic perspectives, is insufficiently explored in existing research. This study endeavors to classify hypothyroidism by considering the presence of autoimmune thyroid disease and to examine its correlation with various metabolic obesity phenotypes. Method: This research was conducted by analyzing data from 1,170 individuals enrolled in the Thyroid Disease Database of Shandong Provincial Hospital. We assessed four distinct metabolic health statuses among the participants: Metabolically Healthy No Obese Metabolically Healthy Obese Metabolically Unhealthy No Obese and Metabolically Unhealthy Obese Utilizing logistic regression, we investigated the association between various metabolic obesity phenotypes and hypothyroidism. Results: The study revealed a significant correlation between the Metabolically Unhealthy Obese (MUO) phenotype and hypothyroidism, particularly among women who do not have thyroid autoimmunity. Notably, the Metabolically Unhealthy No Obese (MUNO) phenotype showed a significant association with hypothyroidism in individuals with thyroid autoimmunity, with a pronounced prevalence in women. Furthermore, elevated levels of triglycerides and blood glucose were found to be significantly associated with hypothyroidism in men with thyroid autoimmunity and in women without thyroid autoimmunity. Conclusion: Effective treatment of hypothyroidism requires a thorough understanding of the process of thyroid autoimmune development. In patients without concurrent thyroid autoimmunity, there is a notable correlation between obesity and metabolic issues with reduced thyroid function. Conversely, for patients with thyroid autoimmunity, a focused approach on managing metabolic abnormalities, especially triglyceride levels, is crucial.

Topical application of vitamin D cream in particiants with inflammatory acne due to vitamin D deficiency

Acne vulgaris (AV) represents a chronic inflammatory condition affecting pilosebaceous units, characterized by a multifactorial etiology. AV can manifest as both inflammatory and non-inflammatory skin lesions. Non-inflammatory acne is termed a comedone, which can be either closed (whiteheads) or open (blackheads). Inflammatory acne encompasses papules, pustules, nodules, and pseudocysts. The most common regions for acne occurrence are the facial region (90%), thoracic area (14%), and dorsal region (60%). In the study involving transdermal application of vitamin D cream (applied twice daily; morning and evening) in subjects with inflammatory acne due to vitamin D deficiency, 33 participants took part, comprising 8 males and 25 females. The age group most affected was 18-25 years (adolescent age), followed by a lesser impact in the 26-30 age group, and the lowest incidence observed in the late 36-45 age group. Among males, facial and thoracic regions were most affected by inflammatory acne (37.5%), while among females, the facial region showed a higher percentage of 54%, and the thoracic area was at 40%, with a minimal impact on the dorsal region (M=25%; F=8%). Reductions in inflammatory acne ranged from 100% to 10%, with substantial improvements noted in the male population, achieving 100% and 80% reduction (100% reduction: facial region 25%, thoracic area 12.5%, 80% reduction: dorsal region 25%). Similarly, the female group, with a larger sample size (25 participants), demonstrated significant reductions (100% reduction: facial region 36%, thoracic area 24%, 80% reduction: dorsal area 4%). Overall, improvements were evident in all participants, with none falling below a 30% reduction, indicating remarkable outcomes after one month of vitamin D cream use. Numerous factors contribute to the onset of inflammatory acne, with this study specifically highlighting vitamin D deficiency in the blood. Other indications include the occurrence of polycystic ovaries and reduced thyroid function in women, heightened stress, and prostate issues in men. Reduced or deficient vitamin D levels may be associated with further immune system suppression, activating the aforementioned factors. This research marks a significant stride in uncovering the manifold health benefits of vitamin D. Keywords: acne, vitamin D, participants

Assessment Of The Effect Of Menopause On Thyroid Function In South East,Nigeria

Menopause marks the end of a woman’s reproductive life and is associated with significant physiological changes. The thyroid gland plays an important role in regulating overall body metabolism including sexual development and reproductive function. Worldwide, thyroid gland diseases are among the most common endocrine disorders in females, especially those in menopause. This study evaluated the effect of menopause on thyroid function. Methodology: It was a case-control study among post-menopausal women in Nnewi, Anambra, Nigeria with pre-menopausal women serving as controls. Sampling was by simple random method and comprised 45 post-menopausal women matched with 45 premenopausal women in a ratio of 1:1. Data was obtained with the use of a semi-structured questionnaire. The subjects’ blood samples were taken and assayed for thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) by ELISA technique. Their body mass index (BMI) and blood pressure were obtained using standard procedures. Result: The mean serum levels of free T4 and TSH in the menopausal individuals were significantly higher compared to the premenopausal group. Following linear regression analyses with adjustment for age and BMI, the the average level of TSH and free T4 were higher in the study group, while free T3 level was lower. Also, systolic and diastolic blood pressure was significantly higher in the study group than in the control group. Conclusion: The findings suggest that menopause is associated with reduced thyroid function and could as a result play a role in cardiovascular disease play a role in cardiovascular dysfunction among women

Databases for Gastrointestinal Clinical and Public Health Research: Have Database, Will Research

Databases for Gastrointestinal Clinical and Public Health Research: Have Database, Will Research

Гіпотиреоз і нетиреоїдні соматичні захворювання у підлітків

Проаналізовано структуру та взаємозв’язок порушення функції щитоподібної залози та нетиреоїдної патології у підлітків. Проведення адекватної замісної терапії гіпотиреозу, що має на меті компенсувати його прояви, сприятиме не тільки покращенню соматичного стану пацієнта, а й слугуватиме профілактикою численних органних порушень, що виникають на тлі зниженої тиреоїдної функції.

Синдром гіпотиреозу як фактор розвитку патології серцево-судинної системи (огляд літератури)

У статті наведені дані про патогенетичні аспекти розвитку патології серцево-судинної системи при зниженні функції щитоподібної залози. Гіпотиреоз асоціюється з підвищенням ризику розвитку ішемічної хвороби серця, інфаркту міокарда, хронічної серцевої недостатності й смертності від серцево-судинних захворювань незалежно від статі, віку й попередніх серцево-судинних захворювань. Це спонукає до пошуку додаткового впливу на патогенетичні механізми гіпотиреозу з метою ефективної терапії вказаних загрозливих проявів та наслідків хвороби.

ВЛИЯНИЕ ГИПОФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ НА ПРОГНОЗ СТОМАТОЛОГИЧЕСКОГО ОРТОПЕДИЧЕСКОГО ЛЕЧЕНИЯ

Background. The problem of preventing complications of complex dental treatment is one of the main problems in modern dentistry, the solution of which is impossible without a systematic approach, including, among other things, the relationship of these complications with the general somatic status of a particular patient. The aim of the study. Identification of the features and terms of use of dentures in patients with reduced thyroid function. Methodology. The data of 304 patients who applied to a dental clinic for re-prosthetics of the dentition were studied. The distribution of patients into groups was carried out in accordance with the type of denture and the presence or absence of thyroid diseases established by the endocrinologist, leading to hypothyroidism. Standard clinical (survey, examination, etc.) and paraclinical (radiological, functional) methods of examination were used for such diagnoses. Edema of the oral mucosa was determined by palpation, and their frequency and severity were recorded. Results. Statistically significant differences in the reasons for replacement of dentures between patients of different groups were revealed. The difference in the terms of use of dentures in patients of different groups was determined. Clinical differences in the state of the tissues of the prosthetic bed and the supporting teeth of the bridge prostheses in patients, depending on the presence of hypofunction of the thyroid gland, were revealed. Conclusions. The presence of hypothyroidism in the anamnesis of patients worsens the long-term prognosis of dental orthopedic treatment. The dispensary observation of patients with hypothyroidism should differ from the observation of healthy individuals, in the direction of reducing the inter-examination intervals in order to identify early complications of dental treatment.

DYNAMICS OF CHANGES IN THE SERUM MINERAL METABOLISM OF YOUNG PEOPLE WITH GENERALIZED PERIODONTITIS ON THE BACKGROUND OF PRIMARY HYPOTHYROIDISM

At present, there is no definitive opinion on the effect of thyroid hormones on bone metabolism, as the dualism of their effects has been proven. Various studies show mixed data on metabolic changes in periodontal tissues on the background of thyroid dysfunction. Bone tissue plays a key role in the complex system of mechanisms of regulation of calcium and phosphorus homeostasis in the body. The processes of modeling and remodeling of bone and its mineralization are closely related to calcium metabolism. The biochemical manifestation of osteoporotic processes in the cell bone in generalized periodontitis is a violation of calcium-phosphorus homeostasis on the background of altered markers of bone metabolism. According to the literature, it is known that the main indicator of calcium-phosphorus metabolism is the content of calcium in the serum. However, for the metabolic characteristics of the inflammatory-dystrophic process in the cell bone, it is necessary to study the level of inorganic phosphorus and calculate the molar ratio of calcium / phosphorus. The calcium / phosphorus ratio in the blood is important for the study of calcium deposits in bone tissue. Maintenance of normal bone structure depends on the exchange of phosphates between blood and bone tissue. Magnesium along with calcium is needed to achieve optimal bone mineral density. Magnesium helps maintain normal levels of calcium in bone tissue, its constant renewal in bone, prevents calcium loss. With limited intake of magnesium, the formation of calcium phosphate is inhibited. In order to establish indicators that would reflect the peculiarities of metabolic disorders in the organic matrix of the cell process, which is the main component of the periodontium, we conducted biochemical studies, which included the study of calcium-phosphorus metabolism and serum magnesium in patients with primary hypothyroidism and persons without endocrine pathology. According to the results of studies, in young people with generalized periodontitis on the background of reduced thyroid function, there were violations of calcium-phosphorus metabolism in the serum, which consisted of hypocalcemia and decreased calcium-phosphorus ratio. This may indicate abnormalities in calcium intake and absorption in patients with hypothyroidism. We attribute this fact to the fact that for the normal absorption and metabolism of calcium, thyroid hormones are needed, the production of which is reduced in this endocrine pathology. Data on the negative changes of calcium-phosphorus homeostasis, and especially the violation of calcium absorption by patients with generalized periodontitis in young people with primary hypothyroidism, should be considered when developing schemes for the treatment and prevention of periodontal disease in this category of patients.

Особливості перебігу патології шлунково-кишкового тракту у хворих на гастроезофагеальну рефлюксну хворобу на тлі гіпотиреозу

The article identifies the features of the pathology of the gastrointestinal tract in patients with gastroesophageal reflux disease on the background of hypothyroidism. The frequency of gastroesophageal reflux disease and the severity of this disease increase with age and the presence of comorbid pathology. In the elderly, the frequency of the typical esophageal manifestations decreases, and the erosive esophagitis with atypical symptoms is more common. The growing number of cases of combined thyroid dysfunction with gastropathology requires in-depth study of the reasons for the relationship between these processes. Pathological changes in the gastrointestinal tract in these patients make their condition severer, contributing to the development and progression of metabolic disorders. An important aggravating effect on the regulatory mechanisms of esophageal kinetics has a pathological functioning of the thyroid gland on the background of iodine deficiency. Results and discussion. In patients with gastroesophageal reflux disease with hypothyroidism, all changes in gastric and duodenal function are associated with a decrease in the acid-forming function of the gastric mucosa, due to its atrophy, decreased tone and contractility of the stomach. This in turn leads to a slowing of gastric and duodenal evacuation, dysfunction of the closing capacity of the cardia and, as a consequence, the development of duodenogastroesophageal reflux. The esophageal contents are not so pronounced, so patients with non-erosive forms of esophagitis predominate (46.2%) against 16% of patients in the second group (patients with gastroesophageal reflux disease). At the same time, erosive forms predominate among patients in the control group with predominant acid reflux. It should be noted that there is a clear relationship between the frequency of erosive changes in the esophageal mucosa and the duration of the disease. Thus, among patients of the main group with a 5-year history of the disease, the number of erosive forms of gastroesophageal reflux disease was minimal. The number of erosive changes in the esophageal mucosa increased sharply in patients with a 10-year history and reached its maximum after 15 years from the onset of the disease. Conclusion. The delay in gastric evacuation is more pronounced in patients with gastroesophageal reflux disease on the background of hypothyroidism. It can be explained by a decrease in gastric motility and the presence of duodenostasis. The slowing of gastric evacuation was more pronounced in patients with gastroesophageal reflux disease on the background of reduced thyroid function. In patients with gastroesophageal reflux disease on the background of hypothyroidism there is an alkaline duodenogastroesophageal reflux as a consequence of reduced acid-forming function of the gastric mucosa and reduced contractility of the stomach and duodenum

INDICATORS OFTHYROID FUNCTIONOF WOMEN OF REPRODUCTIVE AGE, LIVING ON THE ECOLOGICALLY UNFAVORABLE TERRITORIES OF ARAL SEA REGION OF KAZAKHSTAN.

Background:The Aral crisis consider as one of the largest ecological catastrophes on the planet. TheKazakhstan part of the Aral Sea regiondeclared an environmental disaster zone. The constantly changing unfavorable environmental situation contributed to higher number of thyroid pathology and initiates the study of this problem in women of reproductive age in the AralSea area.Aims:To study thyroid function in women of reproductive age living in ecologically unfavorable territories of Kazakhstan part of the Aral Sea region.Materials and methods:The survey was conducted within scientific and technical program: “Integrated approaches in managing the health status of the population of the Aral Sea region” 2014–2016 years, performed by Ministry of Health and Social Development of the Republic of Kazakhstan. The study was cross-sectional, observational, uncontrolled and multicenter.Study included the representative sample of 2205 women of reproductive age from 18 to 49 years old living in the Aral Sea region.The levels ofTSH,FT4and AntiTPOweredetermined by the laboratory of collective use of KSMU on the Evolis Robotized System using“Tiroid-ELISA-TTG,0.23-3.4µIU/ml”, “Thyroid–ELISAfreeT4,10-23.2pmol/l”,“Tiroid ELISA – atTPO,<30EDU/ml”testsystems.Results:A huge number of women from environmental disadvantaged areas of the Kazakhstan part of the Aral Sea region have TSH values exceeding reference of 3.4 μI/ml.The frequency of SH was 0.2%;0.9%,0.2% in the different study areas at TTG values≥10.0 μIU/ml and freeT4 from 10to23.2 pmol/l. The frequency of MH was 2.4%;2.7%,2.5% in the studied areas at TSH values ≥10.0μIU/ml and FreeT4<10.0 pmol/l, Thus, the data obtained on the prevalence of reduced thyroid function in women living in the studied areas of the Aral Sea ecological disaster can be considered as comparative. About3%of women of reproductive age neededon replacement therapy for hypothyroidism. Thelargest number of women with elevated AT-TPO identified in the zone of the ecological crisis. Almost same number of women with hypothyroidism was revealed among AT-TPO hosts in all studied zones.Conclusions:Women of reproductive age living in ecologically unfavorable territories havea high, comparable frequency of manifest hypothyroidism in the three studied zones of the Kazakhstan part of the Aral Sea region of the Republic of Kazakhstan.

Adherence to a Mediterranean Diet and Thyroid Function in Obesity: A Cross-Sectional Apulian Survey.

: BackgroundMuch research suggests that Mediterranean eating habits and lifestyle contribute to counteract the risk of chronic diseases while promoting longevity, but little information is available on the effects of the Mediterranean diet (Med-Diet) on thyroid function, particularly among overweight/obese subjects. Nevertheless, consistent data reported a slight increase in serum levels of the thyroid-stimulating hormone (TSH) and a higher rate of conversion of thyroxine (T4) to triiodothyronine (T3) in obesity. This cross-sectional study was aimed at investigating the relationship between adherence to the Med-Diet and circulating thyroid hormones in a cohort of overweight/obese subjects from Apulia (Southern Italy). Methods: We studied 324 consecutive outpatient subjects (228 women and 96 men, age range 14–72 years) taking no drug therapy and showing normal levels of thyroid hormones, but complicated by overweight and obesity (body mass index (BMI) ≥ 25 Kg/m2). The PREDIMED (PREvención con DIeta MEDiterránea) questionnaire was cross-sectionally administered to assess the adherence to the Med-Diet, and hormonal, metabolic, and routine laboratory parameters were collected. Results: Higher adherence to Med-Diet was found to be inversely related to free T3 (p < 0.01) and T4 (p < 0.01) serum levels. Considering each item in the PREDIMED questionnaire, people consuming at least four spoonfuls of extra-virgin olive oil (EVOO) per day, as well as those consuming at least two servings of vegetables per day, had lower free T3 levels (p 0.033 and p 0.021, respectively). Furthermore, consuming at least four spoonfuls of EVOO per day was found to be associated to lower free T4 serum concentrations (p 0.011). Multinomial logistic regression models, performed on tertiles of thyroid hormones to further investigate the relationship with Med-Diet, corroborated the significance only for free T4. Conclusion: Increased adherence to the Med-Diet was independently associated to a slightly reduced thyroid function, but still within the reference range for free T3 and T4 serum levels. This first finding in this field opens up a research line on any underlying biological interplay.

Морфологические изменения щитовидной железы крыс после интервального голодания

Литературные данные относительно влияния интервального голодания на функциональную активность и, особенно, на морфологические изменения в щитовидной железе единичны. А имеющиеся сведения об его эффекте на морфо-функциональное состояние щитовидной железы часто противоречивы. Цель работы — исследовать морфологические изменения щитовидной железы взрослых крыс после воздействия интервального голодания. Материал и методы. Исследование проведено на 24 крысах-самцах линии Wistar в возрасте 15 месяцев. Подопытные крысы подвергались интервальному голоданию (1 день полное голодание / 2 дня стандартный рацион). Доступ к воде был свободным. Продолжительность эксперимента составляла 28 суток. Крыс декапитировали под легким эфирным наркозом. Работу с животными проводили в соответствии с принципами Хельсинкской декларации. Из ткани щитовидной железы изготавливали гистологические препараты по стандартной методике. С использованием цифровой камеры микропрепараты фотографировали на микроскопе «Nicon» (Япония). Морфометрию железы осуществляли на цифровых изо-бражениях с помощью компьютерной программы «Image J». Результаты. Щитовидная железа крыс после влияния интервального голодания сохраняла физиологическую структуру с четким делением на центральную и периферическую зоны. Фолликулы в ней были разной величины и имели овальную и удлиненную форму. Коллоид фолликулов щитовидной железы подопытных животных был умеренной плотности, часто имел«пенистый» характер из-за наличия многочисленных резорбцированных вакуолей. Тиреоциты подопытных крыс имели кубическую и призматическую форму. Выявлено, что в щитовидной железе крыс, находившихся на интервальном голодании, уменьшаются размеры фолликулов и коллоида, снижается внутренний диаметр фолликулов, увеличивается высота тиреоцитов, возрастает фолликулярно-коллоидный индекс, снижается индекс накопления коллоида, возрастает количество резорбцированных вакуолей в коллоиде фолликулов и количество интерфолликулярных островков. В железе этих животных выявлено уменьшение относительной площади стромы и стромально-паренхиматозного индекса, а также снижение ширины прослоек междолевой, междольковой и межфолликулярной соединительной ткани. Вывод. Влияние интервального голодания сопровождается появлением морфологических признаков активации синтетической активности щитовидной железы у взрослых крыс. Полученные данные могут представлять интерес для практической медицины при решении вопроса о назначении интервального голодания людям с пониженной функцией щитовидной железы.

High Thyroid-stimulating Hormone Level in Down's Syndrome: A Mere Resetting of Hypothalamopituitary Axis in Subclinical Hypothyroidism?

Objective:Hyperthyrotropinemia (HT) or reduced thyroid function in Down syndrome (DS) is not uncommon, causes range from glandular dysgenesis to altered hypothalamopituitary axis. In the present study, we have compared hypothyroid Indian children with and without DS (NDS), especially focusing on family history, goiter, and biochemical features.Methods:We conducted this retrospective observational study from previous medical records of children with DS (1-17 years) having an elevated TSH (≥5 mIU/L) who were consecutively referred for with HT to Endocrinology OPD of a tertiary care hospital in India. Records from hypothyroid children (1-17 years) without Down Syndrome (NDS) were evaluated as controls. Free thyroxine (FT4), anti-thyroid peroxidase (TPO) antibody were measured and congenital hypothyroidism was excluded in all subjects.Results:Thirty-four DS cases [median age 8 years (IQR: 2-14), M: F = 13:21] and 34 controls [median age 10.5 years (IQR: 7-13.25), M: F = 13:21] were comparable in terms of age and sex, Median age of presentation was significantly earlier in case of DS vs NDS [7 years vs. 10 years]. DS children had significantly less family history of thyroid disorders compared to NDS [14.7% vs 64.7%]. Goiter was significantly less common in patients with DS [DS - 32.25% vs. NDS - 73.5%, P = 0.001]. Anti-TPO antibody positivity was significantly less common in patients with DS [DS- 41% vs. NDS- 73.5%, P = 0.014].Conclusion:There is a significant difference in presentation in hypothyroid children with DS compared to NDS. DS children with hypothyroidism compared to NDS, had earlier presentation, lower incidence of traceable family history, goiter, and anti-TPO-antibody positivity.

About the possible role of the hypocaloric diet in the pathogenesis of hypothyroidism

Many researchers of the thyroid pathology consider that the investigation of the epidemiology of thyroid disease in conjunction with the study of the diet are relevant. The question is if the unbalanced diet may worsen the course of hypothyroidism. The purpose of this study was to establish the relationship between the peculiarities of the diet of patients with hypothyroidism and the functional state of the thyroid gland. Methods and materials. It was observed 400 women of Polish nationality aged 19–28 years living in Biala Podlaska district of the Lublin Voivodeship of Poland which consider themselves healthy. The blood levels of free (FT3) and total (T3) triiodothyronine, free (FT4) and total (T4) thyroxin, thyrotropic hormone (TSH) were determined. With the help of questionnaires and food tables, the approximate average amount of proteins, fats and carbohydrates in the daily ration was determined, as well as the average amount consumed daily with iodine. The prevalence of hypothyroidism among surveyed women was 3.5 % and was not significantly different from the values ​​observed in the European Union. Women with reduced thyroid function consumed with food significantly 3.78 times less iodine, 2.97 times (P &lt; 0.001) less salt and 1.47 times (P &lt; 0.001) less protein compared to women with normal thyroid function. In addition, women with hypothyroidism consumed with food 2.25 times (P &lt; 0.001) more products with properties of strumogens. The development of hypothyroidism in the examined women was combined with a reduced intake of iodine and proteins with food products and an increased use of products with the properties of strumogens.

Fizjologiczne aspekty postępowania dietetycznego w chorobie Hashimoto

Zapalenie tarczycy typu Hashimoto, nazywane popularnie chorobą Hashimoto, to przewlekłe schorzenie autoimmunologiczne charakteryzujące się podwyższonym mianem przeciwciał anty-tarczycowych we krwi i zmianami w miąższu tarczycy stwierdzanymi w badaniu ultrasonograficznym. Ponadto jest ono najczęstszą przyczyną pierwotnej niedoczynności tarczycy. Z roku na rok istotnie wzrasta liczba osób z chorobą Hashimoto i w związku z tym zainteresowanie metodami wspomagania leczenia, w tym również możliwościami dietoterapii. Niestety jak dotąd brak jest standardów postępowania dietetycznego w chorobie Hashimoto. Wiadomo natomiast, że działanie tarczycy i wydzielanych przez nią hormonów oraz mechanizmy regulujące procesy zapalne w gruczole tarczowym zależą istotnie od wielkości podaży energii oraz od ilości w diecie i składu białka i tłuszczów, a także spożycia składników mineralnych tj. jod, selen, żelazo i cynk oraz witamin D, E, A i C. Znajomość efektów i mechanizmów działania czynników żywieniowych w tym obszarze może być pomocna w formułowaniu zaleceń żywieniowych dla osób z chorobą Hashimoto.&#x0D; Słowa kluczowe: autoimmunologiczne zapalenie tarczycy typu Hashimoto, makroskładniki, mikroskładniki, oś tarczycowa

The effect of intrathyroidal versus intraperitoneal bevacizumab on thyroid volume and vasculature flow in a rat model.

Several clinical conditions increase thyroid gland vascularity, impacting surgical blood loss. Bevacizumab has been observed to reduce thyroid function, possibly through its effect on gland angiogenesis. This study aimed to determine if bevacizumab has any effect on thyroid vascularity as measured by gland volume and superior thyroid artery (STA) flow velocity in the normal rat thyroid. Sixteen adult female Sprague-Dawley rats were placed under general anesthesia to measure baseline thyroid gland characteristics. A Vevo 2100 high-frequency ultrasound with 40 mHz transducer was used to obtain STA flow measurements and thyroid gland dimensions. Four rats served as controls. Six rats received intrathyroidal (IT) injections and 6 received intraperitoneal (IP) injections of bevacizumab (4-5 mg/kg). After two weeks ultrasound measurements were repeated. Pretreatment animals displayed similar thyroid volume and vascularity. Thyroid volume decreased (62.583 vs. 42.161, P=0.004) after IP administration of bevacizumab, and blood flow measurements did not change [peak velocity 75.896 vs. 76.7, P=0.96, average velocity 45.748 vs. 43.867, P=0.88, or resistivity index (RI) 30.345 vs. 25.32, P=0.60]. IT bevacizumab did not change thyroid volume (55.229 vs. 58.16, P=0.64). The average peak (73.191 vs. 100.589 cm/s, P=0.03) and mean (45.047 vs. 62.843 m/s, P=0.03) velocities were increased, but did not differ in the RI (0.619 vs. 0.632, P=0.82). No differences were noted on VEGF or CD 31 immunohistochemical analysis. Single systemic administration of bevacizumab appears to decrease thyroid volume without an effect on STA flow, VEGF or CD31 staining. These preliminary findings support further study of pharmacologic intervention in thyroid conditions characterized by increased angiogenesis and vascularity, such as iodine deficiency, Graves disease, and hypothyroidism.

Association of endemic goitre and exceptional longevity in Sardinia: evidence from an ecological study.

This study aims to test the hypothesis that a high prevalence of endemic goitre, considered as a proxy measure for subclinically reduced thyroid function in the population, is geographically associated with exceptional longevity. Using historical data available for 377 Sardinian municipalities in the first half of the twentieth century, we performed an ecological study to investigate the geographic distribution of goitre and its spatial association with demographic indicators of population longevity. This analysis was conducted by using both conventional ordinary least square and geographically weighted regression models to take into account spatial autocorrelation and included other longevity-associated factors previously identified in Sardinia. The spatial analysis revealed that the goitre rate (p < 0.0001), the proportion of inhabitants involved in pastoralism (p = 0.016), the terrain inclination (p = 0.008), and the distance from the workplace as a proxy for physical activity (p = 0.023) were consistently associated with population longevity at an aggregated level in the 377 municipalities. Within the limits of an ecological study design, our findings support the existence of a significant association between high goitre prevalence and increased probability to survive into old age. The present study confirms previous results and is consistent with animal studies and epidemiological surveys in other long-lived areas known as Blue Zones. Potential mechanisms underlying this association need to be further investigated.

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.

Anemia and thyroid dysfunction often co-occur, and both increase with age. Human data on relationships between thyroid disease and anemia are scarce. To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia. Individual participant data meta-analysis. Sixteen cohorts participating in the Thyroid Studies Collaboration (n = 42,162). Primary outcome measure was anemia (hemoglobin <130 g/L in men and <120 g/L in women). Cross-sectionally, participants with abnormal thyroid status had an increased risk of having anemia compared with euthyroid participants [overt hypothyroidism, pooled OR 1.84 (95% CI 1.35 to 2.50), subclinical hypothyroidism 1.21 (1.02 to 1.43), subclinical hyperthyroidism 1.27 (1.03 to 1.57), and overt hyperthyroidism 1.69 (1.00 to 2.87)]. Hemoglobin levels were lower in all groups compared with participants with euthyroidism. In the longitudinal analyses (n = 25,466 from 14 cohorts), the pooled hazard ratio for the risk of development of anemia was 1.38 (95% CI 0.86 to 2.20) for overt hypothyroidism, 1.18 (1.00 to 1.38) for subclinical hypothyroidism, 1.15 (0.94 to 1.42) for subclinical hyperthyroidism, and 1.47 (0.91 to 2.38) for overt hyperthyroidism. Sensitivity analyses excluding thyroid medication or high levels of C-reactive protein yielded similar results. No differences in mean annual change in hemoglobin levels were observed between the thyroid hormone status groups. Higher odds of having anemia were observed in participants with both hypothyroid function and hyperthyroid function. In addition, reduced thyroid function at baseline showed a trend of increased risk of developing anemia during follow-up. It remains to be assessed in a randomized controlled trial whether treatment is effective in reducing anemia.

Diffuse Nontoxic Goiter in Children and Its Impact on Dental Pathology

The objective of the research was to assess the thyroid status of children with diffuse nontoxic goiter and its effect on dental pathology depending on age.Materials and methods. Clinical observation of 226 children at the age of 12-15 years was conducted. To analyze their thyroid status, serum levels of total thyroxine, free thyroxine, total triiodothyronine, and thyroid stimulating hormone were determined using enzyme immunoassay. The following thyroid indices were calculated for the integral estimation of the functional state of the pituitary-thyroid system: the peripheral inversion index (total triiodothyronine/total thyroxine), the integral index (total triiodothyronine + total thyroxine/thyroid stimulating hormone) and the indices of thyroid stimulating hormone/total triiodothyronine and thyroid stimulating hormone/total thyroxine. Their dental status was determined by means of standard indices recommended by the World Health Organization.Conclusions. In children with euthyroid enlargement of the thyroid gland, there were detected changes in the thyroid status within the reference range. According to the direction of changes in the most indices, dysthyroidism is characterized by the reduced thyroid function that can affect metabolic processes in the body, including the dentofacial system, as evidenced by significantly worse indices of the intensity of damage to hard dental tissues and periodontal tissues in children with diffuse nontoxic goiter.

Soy isoflavones inducing overt hypothyroidism in a patient with chronic lymphocytic thyroiditis: a case report

BackgroundMany people have thyroid conditions that make them susceptible to hypothyroidism. If the foods they eat may interfere with the production of thyroid hormone, which can lead to development of serious hypothyroidism. The danger of health drinks should always be noted.Case presentationA 72-year-old Japanese woman was previously diagnosed with chronic lymphocytic thyroiditis caused by a goiter and had an elevated thyroid-stimulating hormone level (6.56 μIU/ml), a high anti-thyroid peroxidase antibody level (>600 IU/ml), and a high antithyroglobulin level (> 4000 IU/ml) but normal levels of free triiodothyronine (3.08 pg/ml) and thyroxine (1.18 ng/ml). She presented to our hospital with sudden-onset general malaise, edema, and hoarseness with an elevated thyroid-stimulating hormone (373.3 μIU/ml) level and very low triiodothyronine (< 0.26 pg/ml) and thyroxine (0.10 ng/ml) levels. It was determined that for 6 months she had been consuming a processed, solved health drink (“barley young leaf”) in amounts of 9 g/day, which included soybean and kale powder extract. Hypothyroidism might be affected by ingredients of health drinks. She discontinued consumption of the health drink immediately and began taking 12.5 μg of levothyroxine. The amount of levothyroxine was gradually increased every 3 days up to 100 μg. At day 61, her thyroid-stimulating hormone level had decreased (6.12 μIU/ml), her free triiodothyronine (2.69 pg/ml) and thyroxine (1.56 ng/ml) levels had increased, and her general condition was improved. Among risky foods lowering thyroid function, some experimental studies have revealed that isoflavones reduce thyroid function. Therefore, we measured the presence of isoflavones in the patient’s frozen serum with thin-layer chromatography. After she discontinued consumption of the health drink, two components quickly disappeared, and the other three components gradually decreased. On the basis of developing solvent composition and a positive ferric chloride reaction in thin-layer chromatography experiment, the five ingredients that disappeared or decreased were highly suspected to be soy isoflavones.ConclusionsThis case emphasizes that consuming health drinks that include soy isoflavone powder extracts can lead to severe hypothyroidism.