DYNAMICS OF CHANGES IN THE SERUM MINERAL METABOLISM OF YOUNG PEOPLE WITH GENERALIZED PERIODONTITIS ON THE BACKGROUND OF PRIMARY HYPOTHYROIDISM

Abstract

At present, there is no definitive opinion on the effect of thyroid hormones on bone metabolism, as the dualism of their effects has been proven. Various studies show mixed data on metabolic changes in periodontal tissues on the background of thyroid dysfunction. Bone tissue plays a key role in the complex system of mechanisms of regulation of calcium and phosphorus homeostasis in the body. The processes of modeling and remodeling of bone and its mineralization are closely related to calcium metabolism. The biochemical manifestation of osteoporotic processes in the cell bone in generalized periodontitis is a violation of calcium-phosphorus homeostasis on the background of altered markers of bone metabolism. According to the literature, it is known that the main indicator of calcium-phosphorus metabolism is the content of calcium in the serum. However, for the metabolic characteristics of the inflammatory-dystrophic process in the cell bone, it is necessary to study the level of inorganic phosphorus and calculate the molar ratio of calcium / phosphorus. The calcium / phosphorus ratio in the blood is important for the study of calcium deposits in bone tissue. Maintenance of normal bone structure depends on the exchange of phosphates between blood and bone tissue. Magnesium along with calcium is needed to achieve optimal bone mineral density. Magnesium helps maintain normal levels of calcium in bone tissue, its constant renewal in bone, prevents calcium loss. With limited intake of magnesium, the formation of calcium phosphate is inhibited. In order to establish indicators that would reflect the peculiarities of metabolic disorders in the organic matrix of the cell process, which is the main component of the periodontium, we conducted biochemical studies, which included the study of calcium-phosphorus metabolism and serum magnesium in patients with primary hypothyroidism and persons without endocrine pathology. According to the results of studies, in young people with generalized periodontitis on the background of reduced thyroid function, there were violations of calcium-phosphorus metabolism in the serum, which consisted of hypocalcemia and decreased calcium-phosphorus ratio. This may indicate abnormalities in calcium intake and absorption in patients with hypothyroidism. We attribute this fact to the fact that for the normal absorption and metabolism of calcium, thyroid hormones are needed, the production of which is reduced in this endocrine pathology. Data on the negative changes of calcium-phosphorus homeostasis, and especially the violation of calcium absorption by patients with generalized periodontitis in young people with primary hypothyroidism, should be considered when developing schemes for the treatment and prevention of periodontal disease in this category of patients.