Reduce Blood Cholesterol Research Articles

Efektivitas Penambahan Sari Kurma Dalam Pemenuhan Gizi Ibu Hamil Anemia Di Puskesmas Wedi, Kabupaten Klaten

Abstract: Sarikurma, Pregnancy, Anemia, Hemoglobin. Dates also have many benefits including increasing the number of platelets, preventing blood clots, prevent strokes and heart attacks, prevent uterine bleeding, thin brain during fasting, increase energy, hindering the process of aging, prevent constipation and smooth bowel movement, reduce blood cholesterol, keeping eye health and good for the nervous system. Aim. To determine the effectiveness of the addition of palm juice against anemia in pregnant women at health centers Wedi Klaten district. This type of research is experimental, quasi-experimental approach, using a pretest-posttest control group design. population (N) = 303 people, found the number of samples (S) as many as 50 people. Of the 50 people, will be dividedinto two equal groups, 25 people will be used as the treatment group (giving palm juice) and 25 will be used as the control group (without a date palm juice). In the group without extract dates, respondents consumed MMN. Data were analyzed using t-test. Results.Anemia hemoglobin levels of pregnant women who were given MMN average was 10.4 mmHg. Hemoglobin levels of pregnant women are anemic before given Sarikurma average of 10.38 and after Sarikurma by an average of 10.84. Conclusion. Sarikurma more effective compared to MMN with p = 0.045 (p <0.05).

Terapi Hiperkolesterol pada Mencit (Mus musculus) strain Balb/C Betina Umur 2 Bulan Menggunakan Sari Bawang Putih

Cholesterol is a waxy substance which is mainly made in the body. Cholesterol can provide benefits. However, having too much cholesterol in the blood can increase risk of cardiovascular disease. Prevention and treatment of cardiovascular disease can be done by taking synthetic drugs such as statin. Due to side effects of synthetic drugs, it is necessary to substitute synthetic drugs with herbal plant and some natural component in these plants. The important ones is garlic. Garlic contain organosulphur compounds such as diallyldisulphide (DADS), dipropyldisulphide (DPDS), diallytrisulphide (DATS) and dipropyltrisulphide (DPTS) which have anti artherogenic effects. Garlic also have active agent allicin, can reduce the levels of cholesterol. This research was conducted at the Experimental Animal Enclosure Installation, Center for Veterinary Farma Surabaya with 3 experimental groups. Animals used in this research were female mice 2 months old were feeding with high cholesterol feed such as fried offal of chicken twice a day as much 0,5 cc/ day every 3 days. On the 3rd day, the levels of cholesterol in each group was examined. On the 4th day, mice in group 3 were given 1cc of garlic juice. 1 hour later mice was examined blood cholesterol using Strip Test Easy Touch GCU. The results through T-paired test on SPSS stated that (p < 0,05), it means there is influence between the 3 treatment of mice. This results it can be concluded that the provision of garlic juice can reduced blood cholesterol levels in mice after fed with high cholesterol.

BIOLOGICAL PROPERTIES OF Eugenia uniflora L. ESSENTIAL OIL: CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY

Various pathologies that compromise public health are of bacterial origin. Among the species of importance to human health is Salmonella Typhimurium gastroenteritis agent, Enterobacter aerogenes and Pseudomonas aeruginosa, pathogens causing nosocomial infections in various organs. The Eugenia uniflora L., popularly known as Brazilian cherry, belonging to the Myrtaceae family is a tree native to the Brazilian Atlantic Forest found from Minas Gerais to Rio Grande do Sul. According to the popular medicine the infusion of its leaves has antimicrobial activity, astringent, antidiarrheal, carminative, diuretic, antireumatic, antipyretic, hypotensive, reducing blood cholesterol and uric acid in the urine controller. Based on the above, the study aimed to obtain the essential oil of Surinam cherry sheets, perform chemical characterization of the compounds present in the oil and evaluate the in vitro antibacterial activity on strains of Enterobacter aerogenes, Pseudomonas aeruginosa and Salmonella Typhimurium. To evaluate the antibacterial activity, we used the disk diffusion test, determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Oil yield obtained in the extraction process was 0.65% and bactericidal action was found facing the strains of Enterobacter aerogenes and Salmonella Typhimurium with 3.125% MIC. It has been no biological action of the essential oil on Pseudomonas aeruginosa. Thus, it can be concluded that the essential oil of cherry is an alternative medical means with antibacterial action on Enterobacter aerogenes and Salmonella Typhimurium is considered possible natural source for the development of new drugs.

Sericin improves heart and liver mitochondrial architecture in hypercholesterolaemic rats and maintains pancreatic and adrenal cell biosynthesis

Hypercholesterolaemia is well known to be associated with mitochondrial dysfunction, subsequently leading to multiple organ failure. Similar to other natural products, sericin is a candidate for adjunctive therapy in hyperlipidaemic conditions. However, the cholesterol-lowering mechanisms of sericin are multifactorial and controversial. Here, a high-cholesterol-fed rat model with or without sericin treatment was established using a dosage of 1000mg/kg/day for 30 days. Blood lipid profiles, oxidative stress markers (superoxide dismutase, SOD; malondialdehyde, MDA; nuclear factor erythroid 2-related factor, Nrf-2), dysmorphic mitochondria in relation to fission (dynamin-related protein-1; Drp-1) and fusion (guanosine triphosphatase mutated in dominant optic atrophy; OPA-1) markers and biosynthetic markers (aquaporin, AQP-1; tubulin-4β, Tb4B) in the pancreas and adrenal gland were evaluated. The results showed that sericin reduced blood cholesterol and increased high-density lipoprotein (HDL) by acting against oxidative stress. Hypocholesterolaemic and antioxidant conditions further preserved heart and liver mitochondrial architecture; however, this protection was not exhibited in the kidney, where a high level of renal mitophagy, indicating by LC-3 up-regulation, was presented. The steps of ultrastructural alteration of mitochondria from degenerative changes to necrosis were also demonstrated. Sericin also conserved AQP-1 and Tb4B levels in the exocrine pancreatic acinar cells and zona glomerulosa cells, which were positively correlated with serum lipase, HDL, antioxidative markers and mitochondrial integrity. The present study revealed that sericin not only has antioxidant capacity but also balances pancreatic and adrenal cell biosynthesis, especially lipase activity, which may have played an important role in improving lipid dysregulation in the hypercholesterolaemic rat model, leading to the reduction of dysmorphic mitochondria, particularly in the heart and liver.

Effect of n-3 polyunsaturated fatty acid rich fish oil supplementation on serum biochemical profile in goat

The present study was designed to determine the effect of different levels of n-3 PUFA rich fish oil supplementation on serum biochemical profiles in goat. Goats (20) were divided into 4 equal groups (n,5) and supplemented with one of the 4 levels of EPA and DHA enriched fish oil to provide 0 mg (Control; CG); 78 mg/kg BW (T1); 156 mg/kg BW (T2); and 312 mg/kg BW (T3) doses. The diets in all the groups were made isocaloric by adding palm oil. There was a treatment and day interaction for serum cholesterol concentration. Serum cholesterol in fish oil supplemented groups decreased with the increase in dose and indicated potential effect of n-3 PUFA rich fish oil on reducing the circulatory cholesterol concentration. There was a treatment and day interaction for serum triglycerides concentration at probability of 10%. The mean triglycerides concentration was lower in T2 and T3 on day 20 of supplementation than T1. Further, no effect of supplementation could be observed on serum NEFA concentration on different days of sampling. However, serum BHBA concentration had a treatment and day interaction. The mean concentration was lower in T3 than CG on day 38 of supplementation. The finding suggested that n-3 PUFA supplementation influenced serum biochemical profiles and dose-dependent effect was observed on reducing blood cholesterol concentration.

ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Joint Consensus Document on cholesterol and cardiovascular risk: diagnostic-therapeutic pathway in Italy.

Atherosclerotic cardiovascular disease still represents the leading cause of death in Western countries. A wealth of scientific evidence demonstrates that increased blood cholesterol levels have a major impact on the outbreak and progression of atherosclerotic plaques. Moreover, several cholesterol-lowering pharmacological agents, including statins and ezetimibe, have proved effective in improving clinical outcomes. This document focuses on the clinical management of hypercholesterolaemia and has been conceived by 16 Italian medical associations with the support of the Italian National Institute of Health. The authors discuss in detail the role of hypercholesterolaemia in the genesis of atherosclerotic cardiovascular disease. In addition, the implications for high cholesterol levels in the definition of the individual cardiovascular risk profile have been carefully analysed, while all available therapeutic options for blood cholesterol reduction and cardiovascular risk mitigation have been explored. Finally, this document outlines the diagnostic and therapeutic pathways for the clinical management of patients with hypercholesterolaemia.

Physicochemical Characteristics of Mung Bean Kefir with Variation Levels of Skim Milk and Fermentation Time

Kefir is fermentation milk drink as yoghurt which is classified to functional drink. Kefir has a benefit for health that could reduce blood cholesterol levels. Kefir is usually made of fresh milk as cow and goat milk. Kefir is also made of vegetable milk as mung bean milk. Mung bean consists of complete nutrition that are protein, fat, vitamin as phosphoric acid, B1, riboflavin, B6, pantothenic acid, niacin, and mineral. Mung bean also contains bioactive component that is oleanolic acid which is functioning to inhibit cardiovascular diseases and increase immune system. The purpose of this study is to find the effect of skim milk concentration and fermentation time to chemical natures (pH, total acid number, alcohol level) of kefir cider mung bean and its formulation that is favored by the panel. The research method is Factorial RAL (Stands for Rancangan Acak Lengkap) method. The first factor is skim milk concentration treatment (0%, 3%, 5%, and 7%) which is added to cider mung been and second factor is fermentation time (21 hours, 24 hours and 27 hours). The result of study is analyzed by One-Way Analysis of Variances (ANOVA). The result showed that pH range of 3.8-4.4, total acid number range of 1-3%, alcohol level is 0.39%, viscosity range of 3.20-3.25 dPaS. Based on organoleptic test, kefir favoured by panel is kefir with skim milk concentration 7%, fermentation time 27 hours, pH 3.94, lactate acid 2.6%, alcohol level 0.39% and viscosity 3.25 dPaS.

Production of statins by fungal fermentation

Fungi are used industrially to obtain a variety of products, from low value bulk chemicals to high value drugs like, immunosuppressants, antibiotics, alkaloids and statins. Lovastatin and compactin are natural statins produced as secondary metabolites by predominantly Aspergillus and Penicillium species, following a polyketide pathway. Lovastatin was one of the first cholesterol-lowering drugs. Many statins are now chemically synthesised but lovastatin is still required to produce simvastatin. Apart from reducing blood cholesterol levels simvastatin causes pleotropic effects and has potential to treat various kinds of disorders including neurodegenerative disease and cancer.

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile demonstrated the presence of phenolic and flavonoid compounds. The LAECs and Cs1 prevented damage to lipids and proteins at concentrations of 50 and 10 µg/mL. They also showed a scavenging effect on 2,2-diphenyl-1-pricril-hydrazyl (DPPH) radicals in a concentration-dependent manner. Furthermore, no genotoxic effect was observed at concentrations of 10, 5 and 2 µg/mL in the Comet assay. The present study is the first evaluation regarding the characterization of C. speciosa and its safety, and the results demonstrate its antioxidant potential and suggest that its therapeutic use may be relatively safe.

The Effects of Exercise Training on the Traditional Lipid Profile and Beyond

ABSTRACT The purpose of this review is to provide up-to-date information regarding the effects of aerobic and resistance exercise training on the traditional blood lipid and lipoprotein profile. In addition, emerging coronary artery disease (CAD) risk factors, such as postprandial lipemia (PPL) and metabolic syndrome (MetS), are reviewed. Numerous studies report that aerobic exercise combined with weight loss significantly reduces blood cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TG) while improving high-density lipoprotein cholesterol (HDL-C). Both aerobic and resistance training demonstrated a reduction in non-HDL-C independent of changes in body weight. Transient beneficial effects of a single session of aerobic exercise are observed for PPL. Nonetheless further research is needed to provide a better understanding of the potential mechanisms for reducing PPL. Exercise as an intervention for patients with MetS leads to improved CAD risk factors including atherogenic dyslipidemia, blood pressure, body composition, insulin sensitivity, and fat metabolism.

Sericin ameliorated dysmorphic mitochondria in high-cholesterol diet/streptozotocin rat by antioxidative property.

Sericin has been implicated in lower cholesterolemic effect due to its properties with several mechanisms. Mitochondria are one of the most important targets to be affected in high blood cholesterol and glucose conditions. The protective role of sericin on mitochondria remains doubtful. To examine this role, electron microscopic, histopathologic, immunohistochemical, and biochemical studies were performed in a high-cholesterol diet/streptozotocin rat model. The results demonstrated that sericin reduced blood cholesterol without hypoglycemic effect. Sericin alleviated dysmorphic mitochondria in heart and liver but not in kidney and also decreased peculiar endoplasmic reticulum in the exocrine pancreas. In addition, sericin decreased hepatic steatosis and preserved zymogen granule referable to the decline of reactive oxygen species production in hepatic mitochondrial extraction and down-regulation of malondialdehyde expression in the liver and exocrine pancreas however irrelevant to lipase activity. This study suggests that sericin has antioxidative property to reduce blood cholesterol by means of diminishing fat deposit in hepatocyte and improves mitochondria and endoplasmic reticulum integrities. [Box: see text].

Physico-Chemical Evaluation for <em>Allium hookeri</em> Thw. Enum Leaves

<p>Awareness and general acceptability of the natural products is increasing day by day because of its lesser side effect and cost factor. Above 80% of the world population is depending upon herbal medicines. Use of plants as medicine is the oldest practice that has been used in all countries from ancient time. Based on those old practices medicines of modern days are derived either directly or indirectly from the natural products. Manipur is one of the north eastern states of India and one of the hot spot areas of biodiversity, blessed with the amazing variety of flora and fauna.</p><p><em>Allium hookeri</em> belongs to Alliaceae family and is a perennial herb growing in dampy soil in every kitchen garden in Manipur. It is locally known as Maroi Napakpi and used as spice and condiment in almost all Manipuri dishes. Its taste is preferred over onion in Manipur.Fresh leaves and fibrous roots are used as medicine in reducing temperature, in swelling as an antimicrobial and antioxidant and reducing blood cholesterol etc. It is reported that its root has antioxidant, free radical scavenging, antimicrobial and anti-inflammatory action. In Manipur people are taking fresh green leaves for many ailments like reducing temperature, reducing blood cholesterol, etc.. So the present study has been carried out to evaluate pharmacognostic and physicochemical analysis of shade dried leaves of <em>Allium hookeri</em>.. The reported information will provide data which will be useful in proper identification and authentification of this plant for future research work.</p>

Диагноз и лечение хронического цереброваскулярного заболевания, применение пентоксифиллина

Chronic cerebrovascular disease (CCVD) is one of the most common iagnoses in Russian neurology, by which is meant vascular cognitive impairment (VCI) in modern foreign literature. There are data available in the literature on the diagnosis and treatment of CCVD (VCI). Theresults of the author’s studies show that CCVD often masks other diseases (anxiety and depressive disorders, primary headache, peripheral vestibulopathy, and Alzheimer's disease) that are unfortunately poorly diagnosed in our country, so patients do not receive effective treatment. To modify risk factors for stroke (smoking and alcohol cessation, sufficient exercise), to normalize blood pressure (the use of antihypertensivemedications), to reduce blood cholesterol levels (statins), to perform antithrombotic therapy (antiplatelet agents and anticoagulants), and to use cognitive enhancers are of key importance when treating patients with CCVD (VCI). There are data on the use of pentoxifylline in patients with CCVD, vascular dementia.

Pengolahan Biji Kakao Menjadi Pasta Cokelat Sebagai Makanan Kesehatan Penurun Bobot Badan dan Kolesterol Darah

This research is aimed to process non fermented cocoa beans into chocolate paste as functional food for body weight and blood cholesterol reduction benefits. The research was undergone as followed: preparing paste/dark chocolate from unfermented cacao bean; analysis of chocolate paste’s water, fat, polyphenol, flavanoid, catechin, amino acid, magnesium, calium, and theobromin content;test on mouse weight reduction consisting of diuretic effect, motoric activity, and weight level monitoring and analysis of blood cholesterolreduction effect. Result showed that water content is 3.21%; fat content is 53.14%; potassium content is 1366.74 mg per 100 grams chocolate paste; magnesium content is 257,20 mg per 100 grams chocolate paste; theobromin content is 1.13%; amino acid is 11.92%; catechin is 3.28%; flavanoid 0.16% counting as quercetin and poliphenol 10.03% equal with tanic acid. Diuretic monitoring activity indicated that chocolate paste contributes in raising motoric activity. Observation on weight reduction showed that 0,2ml/mouse chocolate paste decreased mouse body mass from 200 grams to 140 grams in 8 days. 0,2 ml/mouse chocolate paste treatment for 6 days decreased blood cholesterol level, equal to treatment with Simvastatin 0.18mg/200g .

Integration of genomic and proteomic data to identify candidate genes in HT-29 cells after incubation with Bifidobacterium bifidum ATCC 29521

As the predominant group inhabiting the human gastrointestinal tract, bifidobacteria play a vital role in human nutrition, therapeutics, and health by shaping and maintaining the gut ecosystem, reducing blood cholesterol, and promoting the supply of nutrients. The interaction between bacterial cells and human intestinal epithelial cell lines has been studied for decades in an attempt to understand the mechanisms of action. These studies, however, have been limited by lack of genomic and proteomic database to aid in achieving comprehensive understanding of these mechanisms at molecular levels. Microarray data (GSE: 74119) coupled with isobaric tags for relative and absolute quantitation (iTRAQ) were performed to detect differentially expressed genes and proteins in HT-29 cells after incubation with Bifidobacterium bifidum. Real-time quantitative PCR, gene ontology, and Kyoto Encyclopedia of Genes and Genomes analyses were further conducted for mRNA validation, functional annotation, and pathway identification, respectively. According to the results of microarray, 1,717 differentially expressed genes, including 1,693 upregulated and 24 downregulated genes, were selected and classified by the gene ontology database. The iTRAQ analysis identified 43 differentially expressed proteins, where 29 proteins were upregulated and 14 proteins were downregulated. Eighty-two candidate genes showing consistent differences with microarray and iTRAQ were further validated in HT-29 and Caco-2 cells by real-time quantitative PCR. Nine of the top genes showing interesting results with high confidence were further investigated in vivo in mice intestine samples. Integration of genomic and proteomic data provides an approach to identify candidate genes that are more likely to function in ubiquitin-mediated proteolysis, positive regulation of apoptosis, membrane proteins, and transferase catalysis. These findings might contribute to our understanding of molecular mechanisms regulating the interaction between probiotics and intestinal epithelial cell lines.

ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Consensus document. Hypercholesterolemia and cardiovascular risk: diagnostic and therapeutic pathways in Italy

Atherosclerotic cardiovascular disease still represents the leading cause of death in western countries. A wealth of scientific evidence demonstrates that increased blood cholesterol levels have a major impact on the outbreak and progression of atherosclerotic plaques. Moreover, several cholesterol-lowering pharmacological agents, including statins and ezetimibe, have proven effective in improving clinical outcomes. This document is focused on the clinical management of hypercholesterolemia and has been conceived by 16 Italian medical associations with the support of the Italian National Institute of Health. The authors have considered with particular attention the role of hypercholesterolemia in the genesis of atherosclerotic cardiovascular disease. Besides, the implications of high cholesterol levels in the definition of the individual cardiovascular risk profile have been carefully analyzed, while all available therapeutic options for blood cholesterol reduction and cardiovascular risk mitigation have been considered. Finally, this document outlines the diagnostic and therapeutic pathways for the clinical management of patients with hypercholesterolemia.

PCSK9 inhibitors : New treatment option in clinical practice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptors leading to their degradation in the liver. Inhibition of PCSK9 leads to an increase in LDL receptors and as a result to a reduction of LDL cholesterol in blood. Currently, two antibodies against PCSK9 are available for clinical treatment in Germany, evolocumab (Repatha®) and alirocumab (Praluent®). Clinical studies have shown that treatment with these antibodies, which must be subcutaneously injected by patients every 2 or 4 weeks, in addition to an already existing lipid therapy can lower the LDL cholesterol level in blood by an average of 50-60 %. Data from previous study programs show that this treatment is safe although long-term data are still lacking. The results of currently running cardiovascular endpoint studies are not yet available, whereby a beneficial effect is to be expected after the preliminary analyses. These novel effective therapy approaches open up new perspectives for the treatment of patients whose LDL cholesterol values are still in excess of the corresponding target values despite previous maximum lipid-reducing therapy and suffer from a preexisting cardiovascular disease, statin intolerance, genetic forms of familiar hypercholesterolemia and patients on LDL apheresis.

PCSK9: estructura y función. PCSK9 y receptor de lipoproteínas de baja densidad. Mutaciones y cambios derivados de estas

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor (LDLr) and then targets it for lysosomal degradation in cells, thus preventing LDLr from recycling back to the hepatocyte surface, with a consequent decrease in LDLr density and clearance of LDL-cholesterol (LDLc). There have been reports of both gain-of-function mutations in the PCSK9 gene that cause a marked increase in LDLc conentrations and loss-of-function mutations, which lead to modest reductions in LDLc and low rates of coronary heart disease. The PCSK9 gene has become a promising therapeutic target to reduce blood cholesterol levels. This review discusses the most interesting recent data on PCSK9 regulation and its molecular function in cholesterol homeostasis.

Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia.

Prospective studies have demonstrated that the risk of death due to ischaemic heart disease is strongly correlated with blood cholesterol (TC) levels. Diet is the basic treatment for all dyslipidaemia. If diet alone proves inadequate, supplements can be used to try to reduce cholesterol levels. These substances are indicated in moderate dyslipidaemia, as they are able to induce a moderate reduction in blood cholesterol. The objective of our study was to investigate the effects of a dietary supplement containing Omega-3, Policosanol, Resveratrol, L-carnitine, Monascus purpureus, Coenzyme Q10, Vitamin B6 and Vitamin B12 on TC (primary end point) and LDL, triglycerides and HDL (secondary endpoints). The study involved 40 men and 40 women recruited from the outpatient section of our Department randomly assigned to the treatment group (A) or the control group (B). There was a statistically significant reduction in TC 6 months after the end of treatment in both groups. In Group A, there was also a statistically significant change in HDL, LDL and TG, while in group B, there was no statistically significant change in HDL, LDL or TG. The dietary supplement used in our study, in combination with a balanced diet and physical exercise, was found to induce a significant reduction in TC and LDL-C and an improvement in HDL-C. In contrast, while a balanced diet together with physical exercise but without the dietary supplement produced a significant reduction in TC, it had no significant effect on the other lipid parameters tested.

Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate

Fucosylated chondroitin sulfates (fCSs) are glycosaminoglycans extracted from sea cucumbers, consisting of chondroitin sulfate E (CSE) backbones and sulfated fucose branches. The biological properties of fCSs could be affected by the sulfation pattern of their fucose branches. In the present study, two fCSs were isolated from sea cucumbers Isostichopus badionotus (fCS-Ib) and Pearsonothuria graeffei (fCS-Pg). Their monosaccharide compositions of glucuronic acid (GlcA), N-acetylgalactosamine (GalNAc), fucose (Fuc) and sulfate were at similar molar ratio with 1.0/0.7/0.9/3.1 for fCS-Ib and 1.0/0.8/1.5/2.6 for fCS-Pg. The two fCSs have different sulfation patterns on their fucose branches, fCS-Pg with 3,4-O-disulfation while fCS-Ib with 2,4-O-disulfation. Their antihyperlipidemic effects were compared using a high-fat high-fructose diet (HFFD)-fed C57BL/6J mice model. Both fCS-Ib and fCS-Pg had significant effects on lipid profile improvement, liver protection, blood glucose diminution and hepatic glycogen synthesis. Specifically, fCS-Pg with 3,4-O-disulfation fucose branches was more effective in reduction of blood cholesterol (TC), low density lipoprotein (LDL) and atherogenic index (AI). Our results indicate that both fCSs, especially fCS-Pg, could be used as a potential anti-hyperlipidemic drug.