Abstract
The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile demonstrated the presence of phenolic and flavonoid compounds. The LAECs and Cs1 prevented damage to lipids and proteins at concentrations of 50 and 10 µg/mL. They also showed a scavenging effect on 2,2-diphenyl-1-pricril-hydrazyl (DPPH) radicals in a concentration-dependent manner. Furthermore, no genotoxic effect was observed at concentrations of 10, 5 and 2 µg/mL in the Comet assay. The present study is the first evaluation regarding the characterization of C. speciosa and its safety, and the results demonstrate its antioxidant potential and suggest that its therapeutic use may be relatively safe.
Highlights
Given the importance of medicinal plants as sources of new drugs, ethnopharmacology is an important tool for the discovery of species with potential biological activity (Carlini et al, 2006), even in the absence of scientific information on the safety and efficacy of these species
This study revealed that C. speciosa extracts have promising antioxidant potential, which may be related to their high polyphenolic content
Phenolic compounds are the constituents responsible for the antioxidant potential of natural products (Krishnaveni et al, 2013; Loganayaki, Siddhuraju, Manian, 2013) from species of the genus Passiflora and Citrus, both known for being rich in flavonoids and with well-established antioxidant activity
Summary
Given the importance of medicinal plants as sources of new drugs, ethnopharmacology is an important tool for the discovery of species with potential biological activity (Carlini et al, 2006), even in the absence of scientific information on the safety and efficacy of these species. This branch of science studies traditional knowledge and use of plants as alternatives to essential resources for survival, such as food and medicine (Balick, Cox, 1996).
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