The analysis of the current state and prospects for implementation of the integrated land reclamation program in Krasnodar Territory is one of the main tasks in the development of the agro-industrial complex to reduce the risks of industrial safety in the region. The article pays special attention to the crucial importance of the agro-industrial complex of the region in supporting and ensuring food security of the country on the example of Krasnodar Territory, since the Southern region makes a great contribution to the formation and development of the agro-industrial complex of the country. In accordance with the documents of the Program, Krasnodar Territory is a key element in the creation of the “main food base of the country” on the territory of the Southern Federal District on the basis of the formation of a national mega cluster of the agro-industrial complex. The article also pays special attention to the problematic aspects and difficulties in the practice of creating and operating a reclamation complex in the regions of Southern Russia. Taking into account the accumulated experience, the key components of the integrated land reclamation of Krasnodar Territory are identified, providing for improvement of physical and physical-chemical properties of soils through the use of modern irrigation technologies, introduction of new methods for removing excess water during the growing season and expansion of the use of progressive methods of anti-erosion land reclamation. Forecasting the effectiveness of the use of complex land reclamation in the conditions of Krasnodar Territory should show its feasibility and necessity. Thanks to the implementation of comprehensive measures, it is possible to reduce soil degradation, increase the effectiveness of drainage systems, as well as irrigation in general, and ultimately get a positive economic effect. An example of such an economic approach to agricultural lands of Kuban can be the improvement of the overall organic and chemical state of soils, which is mainly reflected in an increase in the gross harvest of agricultural crops.