Reduce Joint Pain Research Articles

PMS54 - Lack of Association Between Beta Blocker Use and Reduction in Joint Pain and Analgesic Use Among Participants with Symptomatic Radiographic Knee Osteoarthritis

PMS54 - Lack of Association Between Beta Blocker Use and Reduction in Joint Pain and Analgesic Use Among Participants with Symptomatic Radiographic Knee Osteoarthritis

Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review.

Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review.

Optimizing Recovery After Knee Meniscal or Cartilage Injury: Guidelines Help Deliver Quality Care.

An injury to your knee meniscus or joint cartilage can happen when you move suddenly or repeatedly move the wrong way. If you have such an injury, you may feel knee pain and have limited motion. Physical therapists can ensure that you and others with these injuries receive quality care to optimize recovery. The goal of revised clinical practice guidelines published in the February 2018 issue of the JOSPT is to make recommendations based on best practices from recent published literature for the evaluation, diagnosis, treatment, and determination of patient readiness to return to activities following knee meniscus or joint cartilage injury. Based on scientific research, these guidelines summarize the treatment options currently available. J Orthop Sports Phys Ther 2018;48(2):125. doi:10.2519/jospt.2018.0504.

The Effect Range of Motion (Rom) Exercise on Lower Extremities Joint Pain Level for Elderly at Gampong Tanjung Selamat Kec. Darussalam Kab. Aceh Besar

BACKGROUND : Joint pain is a condition that often experienced for elderly and caused by a degenerative disease that causes reduced joint synovial fluid and give a pain and joint stiffness. ROM excercise is an exercise to increasing flexibility of muscles and joints.
 PURPOSE : The purpose of this research was to find out the effect of ROM excercise on lower extremities joint pain level for elderly.
 METHODS : The method of this research was a quasi experimental research design consisted of pre and postest without control. The data collected by 6 time for 2 weeks, with amount of sample counted 33 respondents. The level of the lower extremities joint pain was measured by VAS pain scale. The data were analyzed with SPSS 17 program with non parametric statistic test, to see the scale of lower extremities joint pain in elderly when there was no movement was measured by McNemar test, while moving (walk) and to see the general lower extremities pain scale before and after ROM exercise was measured by Marginal Homogenity test.
 RESULTS : The research result showed the differences of joint pain scale before and after ROM exercise when the elderly has no movement (p value = 0,05), and there is a differences for pain scale before and after ROM exercise when the elderly has movement (p value = 0,005). Generally, there is a difference joint pain level between before and after ROM exercise (p value = 0,014).
 CONCLUSIONS : After doing ROM exercise for 6 times, the reduction of joint pain in elderly was occured. When there was no any movement, the level of low joint pain in elderly before ROM exercise was about 30,3% to being 3% after ROM exercise. When moving (walk) the level of low joint pain which is being suffering by elderly from 54% before ROM exercise being 36,4% after ROM exercise. While generally before ROM exercise, the level of medium joint pain in elderly was about 15,2% before ROM exercise being null (0%), means that no body suffers joint pain after ROM exercise. Statistically, based on non-parametric test by McNemar and Marginal Homogeneity test, there was the significant difference in scale of average scores in joint pain before and after ROM exercise when there was no any movement with P-value 0,004 and when the was a movement (walk) P-value 0,005. Generally, there was the difference in avarage scores in joint pain in elderly before and after ROM exercise with P-Value 0,014. So, ROM exercise can be used as a way to decrease the scale of joint pain in erderly.

Deer Bone Extract Supplementation for Mild-to-Moderate Knee Osteoarthritis Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial.

In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy of deer bone extract (DBE) in participants with knee osteoarthritis (OA). We enrolled 50 participants aged 50-70 years, having knee OA with a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score ≥5.0. The participants were assigned to the placebo or DBE group (550 mg/day) for 12 weeks. The outcome measures were as follows: pain score on the visual analog scale (VAS); WOMAC score; and blood and urine biomarkers. In the DBE group, VAS scores, WOMAC total scores, and WOMAC subscores (for pain, stiffness, and physical function) improved significantly compared with the baseline values. However, there was no significant difference in outcomes between the DBE and placebo groups. The present findings suggest that DBE may mildly reduce joint pain and stiffness and improve joint function in patients with painful knee OA.

Adult Stem Cell Treatment for Rheumatoid Arthritis

Since methotrexate began to be used in the treatment of rheumatoid arthritis (RA) 30 years ago, RA treatments have advanced rapidly from only reducing joint pain and inflammation to suppressing disease progression and joint destruction. In particular, the development of biologics and targeted anti-rheumatic drugs has almost made it possible to induce remission in patients with RA. On the other hand, the current RA treatments are still limited by adverse effects and treatment failure. Stem cell therapy has been suggested as an alternative treatment of RA, and preclinical studies and clinical trials using representative adult stem cells (ASCs), hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), are currently underway. HSC therapy in RA has mostly progressed based on the concept of ‘immune reset’, in which the existing immune cells are replaced with healthy ones. HSC transplantation was completed relatively safely, and the patients showed a positive treatment response. Nevertheless, the treatment response of HSCs in RA depends on the conditioning regimen, and the efficacy did not persist for a long time. The MSCs possessed a hypo-immunogenicity, immune modulation effect and tissue regeneration capability, making them another promising candidate for the RA treatment. MSC transplantation in RA was found to be safe with few adverse effects, such as immune rejection or embolism, but it showed a partial and transient response. This review addresses the characteristics of ASCs, focusing specifically on HSCs and MSCs, and summarizes the results of preclinical studies and clinical trials of ASC therapy in RA. (J Rheum Dis 2018;25:158-168)

Extraction, Isolation and Analysis of Chondroitin Sulphate from Chicken Shank by Spectrophotometric Method

This study evaluated Chondroitin sulphate isolated from chicken shank cartilage in aspects such as sufficient quantities and requisite quality for feasible source of Chondroitin sulphate. Chondroitin sulphate has been widely used in treatment of osteoarthritis. Chondroitin sulphate not only reduces joint pain, but also inhibiting the disease progression. Chondroitin sulphate was obtained from cartilage of chicken shank, using enzyme (papain), acid (acetic acid), and heat. The cartilage obtained from chicken shank was hydrolysed using papain for 24h. Extraction was carried out using acetic acid and incubated at pH 4.5 and 37°C for 6h and 8h. The supernatan was treated with cetylpyridinium chloride (CPC), NaCl, methanol and ethanol. The precipitate obtained from extraction was dried in oven at 55°C.Chondroitin sulphate yield from 6h incubation was 16.30% and from 8h incubation was 36.35 % (dry weight). The FT-IR spectra of extracted Chondroitin sulphate was identical with Chondroitin sulphate standard (Fenchem Biotek Ltd). Overlay of the spectras showed characteristic absorption at the wave number 854.64 cm-1 for sample and 856.54 cm-1 for standard chondroitin sulphate. Quantitative analysis was performed using spectrophotometry. The precision was good with RSD <7.3% and the accuration was good with recovery of 82.48-108.88%.The detection limit and quantification limit were 0.15 ppm and 0.46 ppm. This study shows that chicken shank cartilage produces a source for isolation of chondroitin sulphate of 36.35% (dry weight) and purity of 87.87%.

Traditional Knowledge of Gucchi, Morchella esculenta (Ascomycetes), in Doda District, Jammu and Kashmir, India.

The gucchi mushroom, Morchella esculenta, commonly known as the morel, is called thunthoo in the Bhaderwahi dialect spoken in District Doda of Jammu and Kashmir, India, and is an expensive food item that grows wild and is collected manually. Its nutritive and medicinal values are acknowledged. The farming community in the district traditionally collects the mushroom from forested areas through a well-managed community approach. Elders of families and communities have taught farmers how to identify the mushroom, recognize distribution patterns, and collect it. The knowledge and ability to differentiate M. esculenta from other poisonous wild mushrooms has also been inherited from the elders and community members. Women and children collect it from the outskirts of the forested areas and villages; men penetrate deeper into the dense forests in groups. It is either sold fresh to local shopkeepers or dried at home; the majority of gucchi collectors do the latter. Traditionally, the mushrooms are most commonly dried in the sun or the kitchen. The mushroom fetches a remunerative price and supplements the household incomes of the rural folk who collect it. Marketing gucchi has not been reported as a constraint. It has traditionally been used to overcome gastric problems and indigestion, as a tonic, to help heal wounds, and to reduce joint pain. Its medicinal uses are, however, restricted to only the hills and far-flung areas.

A therapeutic role for potassium (K) to reduce pain and complications related to the cardiovascular system and bone in rheumatoid arthritis (RA): A clinical research perspective

Rheumatoid arthritis is a painful inflammatory disorder. Patients seek relief mostly with analgesics and anti-inflammatory drugs which are rife with life-threatening side effects. Alterations in the body’s potassium (K) status may be one such factor. K along with sodium is critical to cellular homeostasis and the electrophysiology of nerve impulses. This review is based on the premise that K can be used therapeutically to reduce joint pain and inflammation in RA and co-morbidity. K ion channel inhibition was shown to cause persistent nerve stimulation (a prelude to pain sensation) and altered immunity (T cells) in experimental studies. Diets rich in K (with normal/reduced salt intake) have to reduce hypertension in several large population studies. Premature atherosclerosis-related cardiovascular disorders and osteoporosis are important complications of RA. The third National Health and Nutrition Examination Survey (1994) carried out in the USA also reported hypokalemia in several RA patients. A diet deficient in K in RA patients was recently reported by an Indian study. In a controlled clinical trial (Iran), K supplementation (diet-based) led to a significant reduction in pain and arthritis in women suffering from seropositive RA. Some of the benefits of K in RA were postulated to be due to an improved cortisol status. K is not a known therapeutic agent in the treatment of RA. Vegetables and fruits are rich sources of K and provide a safe option for intervention. The existing data on the potential therapeutic role of K in RA is encouraging and merits further research.

Aflapin®: A novel and selective 5-lipoxygenase inhibitor for arthritis management

Osteoarthritis (OA) is the most common form of arthritis characterized by progressive destruction of joint cartilage tissue, pain and inflammation, stiffness, and impaired physical activity. It is the most prevalent and leading cause of pain and disability across the globe. During the pain and inflammatory process, 5-lipoxygenase (5-LOX) pathway is also involved, which generates leukotrienes (LTs), namely LTB4 and cysteinyl LTs. Osteoblasts also synthesize LTs, which stimulate and enhance the production of interleukin 1, tumor necrosis factor α, and various other cytokines that are potent inflammatory mediators. LT formation leads to cartilage degradation and compensates chondrocyte-mediated cartilage repair mechanism. Current therapies include nonsteroidal anti-inflammatory drugs, analgesics, and disease-modifying agents, but do not affect 5-LOX pathway. Boswellia serrata extract–derived boswellic acids are specific, non-redox inhibitors of 5-LOX, and 3-O-acetyl-11-keto-β-boswellic acid (AKBA) possesses the most potent 5-LOX inhibitory activity. B. serrata extracts have shown significant efficacy and safety in the treatment of various inflammatory disorders such as OA, rheumatoid arthritis, asthma, and inflammatory bowel diseases. Aflapin® is a novel synergistic composition containing B. serrata extract selectively enriched with 20% AKBA and B. serrata nonvolatile oil. Aflapin® is a patented, selective, and most potent 5-LOX inhibitor, which significantly reduces joint pain, inflammation, stiffness, and improves physical function compared to placebo and other B. serrata extract. Aflapin® also significantly reduces matrix metalloproteinase levels, enhances chondrocytes proliferation, and increases glycosaminoglycans levels, thereby providing cartilage protection in arthritis. Numerous in vitro studies, preclinical studies, and clinical studies suggest the potential of Aflapin® as a useful therapeutic intervention for the management of arthritis.

Autoinflammatory Diseases and Physical Therapy.

Autoinflammatory diseases (AIDs) constitute a group of clinical conditions, characterized by recurrent episodes of systemic inflammation, due to dysregulation of the innate immune system, without involving autoantibodies or antigen-specific T-cells. The patients exhibit recurrent episodes of fever with potentially serious complications and may have classic rheumatologic symptoms, including joint, skin, eye and muscle inflammation. Therefore, musculoskeletal problems and impaired quality of life can be anticipated as unavoidable consequences. In this regards any approach to ease the burden of symptoms and compensate the functional deficits are the main objectives of rehabilitation approach. For patients with inflammatory arthritis, physical therapy and rehabilitation methods have an important role in reducing joint pain and stiffness, preventing deformity, reconstructing muscle tissue and improving function. In order to justify the integration of rehabilitation approach in the management of AIDs and to determine the optimal protocols to use in this group of patients, well-designed, comprehensive, longitudinal, clinical trials using physical therapy centred outcomes are greatly needed.

A study of the role of platelet rich plasma in the treatment of knee osteoarthritis

A study of the role of platelet rich plasma in the treatment of knee osteoarthritis

Randomized double-blind placebo-controlled study of the efficacy of Litsea japonica fruit extract in subjects with mild to moderate knee osteoarthritis

In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy of Litsea japonica fruit extract (LJF) in subjects with knee osteoarthritis (OA). Eighty-seven 50- to 70-year-old subjects with knee OA were assigned to a placebo group, a low-dose LJF group (LJF-L, 100mg/d) or a high-dose LJF group (LJF-H, 200mg/d) for 12weeks. The outcome measures were pain score assessed using a visual analog scale (VAS); Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores; and blood and urine biomarkers. In response to LJF consumption, VAS scores; WOMAC total scores; WOMAC scores on the pain, stiffness and function subscales; and blood MMP-9 levels significantly improved over the course of the examined 12-week period (P=0.0001, 0.0102, 0.0293, 0.002, 0.0152 and 0.026, respectively). This study suggests that LJF may reduce joint pain and stiffness and improve joint function in subjects with painful knee OA.Study identifier: KCT0001029 (www.who.int/ictrp/en/).

Improving access to better care for people with knee and/or hip pain: service evaluation of allied health professional-led primary care.

Chronic knee and hip pain is prevalent, impairing mobility, function and quality of life. Allied health professions (AHPs) are better trained and have more time than general practitioners in primary care to advise and support people to adopt healthier lifestyles (maintain healthy weight, increase physical activity) that reduce joint pain. We evaluated whether AHP-led primary care delivering person-centred, practical lifestyle coaching was a feasible, effective way to manage chronic knee and/or hip pain. At initial assessment the 'Joint Pain Advisor' assessed pain, function, quality of life, physical activity, waist circumference and body mass, taught simple self-management strategies and used behaviour change techniques (motivational interviewing, goal setting, action/coping planning) to alter participants' lifestyles. Participants were invited for 6-week and 6-month reviews, when the Advisor reassessed clinical outcomes, fed back progress and reinforced health messages. Feasibility and effectiveness of the service was evaluated using quantitative and qualitative methods. Uptake of the service was good: 498 people used the service. Between initial assessment and reviews, participants' pain, function, quality of life, weight, waist circumference and physical activity improved (p<0.005). Service user satisfaction was high; they reported easier access to advice and support tailored to their needs that translated into clinical benefits and a more efficient pathway reducing unnecessary consultations and investigations. Relatively few people returned for a 6-month review as they considered they had received sufficient advice. AHP-led care is a popular, effective, efficient and sustainable way to manage joint pain, without compromising safety or quality of care.

The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint

BackgroundRecently, intra-articular botulinum toxin A (IA BoNT A) has been shown to reduce joint pain in osteoarthritic dogs. Similar results have been reported in human patients with arthritis. However, the mechanism of the antinociceptive action of IA BoNT A is currently not known. The aim of this study was to explore this mechanism of action by investigating the effect of IA BoNT A on synovial fluid (SF) and serum substance P (SP), prostaglandin E2 (PGE2), and tumor necrosis factor alpha (TNF-α) in osteoarthritic dogs. Additionally, the aim was to compare SF SP and PGE2 between osteoarthritic and non-osteoarthritic joints, and investigate associations between SP, PGE2, osteoarthritic pain, and the signalment of dogs. Thirty-five dogs with chronic naturally occurring osteoarthritis and 13 non-osteoarthritic control dogs were included in the study. Osteoarthritic dogs received either IA BoNT A (n = 19) or IA placebo (n = 16). Serum and SF samples were collected and osteoarthritic pain was evaluated before (baseline) and 2 and 8 weeks after treatment. Osteoarthritic pain was assessed with force platform, Helsinki Chronic Pain Index, and joint palpation. Synovial fluid samples were obtained from control dogs after euthanasia. The change from baseline in SP and PGE2 concentration was compared between the IA BoNT A and placebo groups. The synovial fluid SP and PGE2 concentration was compared between osteoarthritic and control joints. Associations between SP, PGE2, osteoarthritic pain, and the signalment of dogs were evaluated.ResultsThere was no significant change from baseline in SP or PGE2 after IA BoNT A. Synovial fluid PGE2 was significantly higher in osteoarthritic compared to control joints. Synovial fluid PGE2 correlated with osteoarthritic pain. No associations were found between SP or PGE2 and the signalment of dogs. The concentration of TNF-α remained under the detection limit of the assay in all samples.ConclusionsThe results suggest that the antinociceptive effect of IA BoNT A in the joint might not be related to the inhibition of SP nor PGE2. Synovial fluid PGE2, but not SP, could be a marker for chronic osteoarthritis and pain in dogs.

Whole-body vibration of mice induces progressive degeneration of intervertebral discs associated with increased expression of Il-1β and multiple matrix degrading enzymes.

Whole-body vibration (WBV) is a popular fitness trend based on claims of increased muscle mass, weight loss and reduced joint pain. Following its original implementation as a treatment to increase bone mass in patients with osteoporosis, WBV has been incorporated into clinical practice for musculoskeletal disorders, including back pain. However, our recent studies revealed damaging effects of WBV on joint health in a murine model. In this report, we examined potential mechanisms underlying disc degeneration following exposure of mice to WBV. Ten-week-old male mice were exposed to WBV (45Hz, 0.3g peak acceleration, 30min/day, 5 days/week) for 4 weeks, 8 weeks, or 4 weeks WBV followed by 4 weeks recovery. Micro-computed tomography (micro-CT), histological, and gene expression analyses were used to assess the effects of WBV on spinal tissues. Exposure of mice to 4 or 8 weeks of WBV did not alter total body composition or induce significant changes in vertebral bone density. On the other hand, WBV-induced intervertebral disc (IVD) degeneration, associated with decreased disc height and degenerative changes in the annulus fibrosus (AF) that did not recover within 4 weeks after cessation of WBV. Gene expression analysis showed that WBV for 8 weeks induced expression of Mmp3, Mmp13, and Adamts5 in IVD tissues, changes preceded by increased expression of Il-1β. Progressive IVD degeneration induced by WBV was associated with increased expression of Il-1β within the IVD that preceded Mmp and Adamts gene induction. Moreover, WBV-induced IVD degeneration is not reversed following cessation of vibration.

The effect of mad honey on testosterone levels of male rats.

We aimed to investigate the effect of mad honey on sexual performance. In traditional medicine in Turkey, mad honey is used to improve appetite, to heighten mental alertness, to reduce joint pain, to eliminate gastrointestinal system pains and to increase sexual performance. In this experimental animal study eighteen Sprague Dawley male rats were randomized into three groups, a control group, a normal honey group and a mad honey group. Rats in the treatment groups were given a daily dose of 80 mg/kg normal honey or mad honey throughout the 30-day study period. Total testosterone, free testosterone, FSH, LH, estradiol, and progesterone levels were subsequently investigated from blood sera on day 30. Comparison of blood total testosterone levels among the groups revealed significantly higher levels in the mad honey group compared to the normal honey and control groups (p = 0.006, p = 0.00). Free testosterone levels were also significantly higher in the mad honey group than in the normal honey and control groups (p = 0.023, p = 0.01). No statistically significant differences were determined for other hormonal measurements. This study revealed a significant increase in both total and free testosterone levels in mad-honey group (Tab. 1, Fig. 2, Ref. 16).

Pengaruh yoga terhadap Nyeri Sendi pada Lansia di PSLU Blitar

The aging process is a process of gradual disappearance of the network’s ability to repair itself and maintain its normal functions. Some physical changes will occur on all systems, for example in the musculoskeletal system decreased fluid in the bone resulting in joint stiffness and joint pain. The management of joint pain with some nonpharmacological therapy one of them is yoga. The purpose of this study was to identify the effectiveness of yoga to the joint pain of elderly. Method; This study design used pre and post test without control, with the number of sample 10 elderly people by purposive sampling. This research was conducted in elderly social services Blitar 11 to 14 December 2016. The data collected by using the Visual Analog Scale (VAS). The results of this study before the elderly did yoga was 80% felt joint pain scale was after attending a yoga 50% of elderly felt mild pain, the results of statistical analysis with Paired T Test was p = 0.001 means that there was an effect on joint pain by yoga exercises. Therefore, health employee could facilitate the elderly to follow yoga by bringing yoga instructors since yoga is considering not only reduces joint pain but also reduce stress and improve the energy balance.

Senam Rematik Meningkatkan Jarak Tempuh Berjalan Lansia dengan Nyeri Sendi di Panti Wreda Dharma Bhakti Pajang Surakarta

Joint pain experienced by the elderly may limit walking ability like mileage. Mileage can be improved by reducing joint pain through exercise. The purpose of this study was to clarify the effect of rheumatic gymnastics to mileage in older adults with joint pain. This type of research is “True Experimental” with The Randomized Pre Test and Post Test Control Group Design. Population is elderly inelderly house of Dharma Bhakti Pajang Surakarta who suffer joint pain and not in a state of total dependency. Sample was elderly who meet the inclusion and exclusion criteria are 40 people (20 people per group). Normality test data used the Kolmogorov-Smirnov test. Analysis of data (pre and post test) with a paired t test (for normal data) and Wilcoxon Signed Ranks Test test (for not normal data) with significance level of 95%. Changes in mileage differences between groups were tested with unpaired t test with significance level of 95%. The results showed mileage in the treatment group experienced an increase, in which the prices are p &lt;0,05. The results of the study data analysis between groups showed that the mileage have p &lt;0,05 (p = 0,022), which means that there are significant differences between groups. It needs a longer time for the adoption and application of the distance so exercise movement performed by the elderly is closer to the direction of movement so that the effect of exercise on mileage is higher.

Research progress of bisphosphonates in the treatment of osteoarthritis

Osteoarthritis is clinical common disease,radiography shows articular cartilage damaging, joint space narrowing, sclerosis of subchondral bone. The main pathological changes includes cartilage degeneration, joint edge and subchondral bone hyperplasia of reactivity. Osteoarthritis tends to slow development, generally treated by conservative management. However there is no cure about conservative treatment. The conservative treatment of osteoarthritis mainly includes physical healing, anti-inflammatory analgesic therapy, cartilage protective treatment. Recently, there are a few new ideas about the pathogenesis of OA, mainly considered OA occurred not only with the cartilage degenerative lesion caused the subchondral bone changes, but also subchondral bone metabolic abnormalities leading to cartilage injury biomechanics structural abnormalities (cartilage attached). In addition,studies have found that the subchondral bone changed osteoclasts in patients with OA, therefore bisphosphonates were used in the treatment of OA. Bishosphonates is a effective inhibitors of bone resorption, inhibiting osteoclast activity and subchondral bone bone metabolic abnormalities, delay cartilage degeneration of articular cartilage; In addition bishosphonates can inhibit articular cartilage bone mass loss, maintain the subchondral bone microstructure and joint function, reduce joint pain. Bishosphonates show positive results in the animal OA model, accompanied with clinical practice.In this paper, we discuss bishosphonates for the treatment of knee osteoarthritis and improvement of clinical symptoms.