Red Rash Research Articles

Cefpodoxime Proxetil associated bloody diarrhoea, itching and red rashes in child: A case report

Case Report: A case report of a five-year-old paediatric patient was presented here, who received Cefpodoxime proxetil for the treatment of Dengue fever and experienced bloody diarrhoea, itching and red rashes on hands. His laboratory data includes haemoglobin level 10.9 gm % (13-17 gm %), total leucocyte count 4100 /cmm (4000-1000 /cmm), neutrophils 73 % (40-75 %), lymphocytes 20 % (20-45 %), eosinophils 03 % (1-6 %), monocytes 04 % (2-10 %), platelet count 2.42 Lac /cµmm (1.5-4.5 Lac /cµmm), Lymph% 19.9 % (20-45), Gran% 72.5 % (40-75), HGB 10.9/103 /µL (11.0-16.0), HCT 34.9 % (37-54), MCV 68.1 fL (80-100), MCH 21.2 pg, MCHC 31.0 g /dL, RDW-CV 16.2 %, anti-Dengue-IgG and IgM tests are non-reactive and Dengue NS1 antigen test is weakly reactive. The patient recovered from red rashes and bloody diarrhoea after treatment discontinuation.
 Conclusions: Events bloody diarrhea and red rashes are probably due to Cefpodoxime Proxetil treatment as per WHO causality assessment.

Ofloxacin/ tinidazole induced fixed drug eruption- a case report

Introduction: An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp borders, erythematous lesions with or without blisters developing within an hour or in a few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection.
 Case report: This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

An Improved Machine Learning Technique with Effective Heart Disease Prediction System

Heart disease is the leading cause of death worldwide. Predicting heart disease is challenging because it requires substantial experience and knowledge. Several research studies have found that the diagnostic accuracy of heart disease is low. The coronary heart disorder determines the state that influences the heart valves, causing heart disease. Two indications of coronary heart disorder are strep throat with a red persistent skin rash, and a sore throat covered by tonsils or strep throat. This work focuses on a hybrid machine learning algorithm that helps predict heart attacks and arterial stiffness. At first, we achieved the component perception measured by using a hybrid cuckoo search particle swarm optimization (CSPSO) algorithm. With this perception measure, characterization and accuracy were improved, while the execution time of the proposed model was decreased. The CSPSO-deep recurrent neural network algorithm resolved issues that state-of-the-art methods face. Our proposed method offers an illustrative framework that helps predict heart attacks with high accuracy. The proposed technique demonstrates the model accuracy, which reached 0.97 with the applied dataset.

Recurring Facial Rash after Eating in a 12-month-old Girl.

1. Farhan Ullah, MD* 2. Matthew Tien, MD*,† 1. *MetroHealth Medical Center, Cleveland, OH 2. †Case Western Reserve University School of Medicine, Cleveland, OH 1. Address correspondence to Matthew Tien, MD, Department of Pediatrics, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109. E-mail: mtien{at}metrohealth.org A previously healthy 12-month-old girl presents to the office for a well-child visit. Her mother mentions a recurring red blotchy facial rash that appears during or right after mealtimes. This was initially noticed around 6 months of age, shortly after introducing solid foods. At first, the blotchy rash seemed to come on several times when trying applesauce, and her mother wondered whether this might be an allergic reaction. As a result, the mother had avoided applesauce for a while. Since then, the mother has noticed the rash at mealtimes with other foods also, and it has been happening on a more frequent, daily basis. The rash is nonraised, red and blotchy—on further probing, the mother reported that it …

Fifth Disease

Patient Education| 2021 Fifth Disease Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Facebook Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Fifth Disease. Pediatric Patient Education 2021; 10.1542/peo_document555 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All AAP SitesAll PublicationsPediatric Patient Education Search Advanced Search Topics: erythema infectiosum, exanthema, sickle cell anemia Fifth disease, also called erythema infectiosum, is usually not a serious infection. Its most notable symptom is a bright red patch or rash on your child's cheeks. It is caused by a virus called parvovirus B19 and can be spread from one person to another through droplets or secretions (eg, saliva, sputum). It can also be passed from a pregnant woman to her fetus. The virus can cause serious illness in a fetus or in any child who has a certain type of anemia (low red blood cell count) such as sickle cell anemia. Outbreaks of parvovirus B19 infections occur from time to time in elementary and middle schools during the late winter and early spring months. In the initial stages of fifth disease, your child may develop mild cold-like symptoms including a stuffy or runny nose, sore throat, mild fever, muscle... Copyright © 20122012American Academy of Pediatrics You do not currently have access to this content.

Managing Chronic Health Needs in Child Care and Schools—Anaphylaxis

Patient Education| 2021 Managing Chronic Health Needs in Child Care and Schools—Anaphylaxis Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Facebook Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Managing Chronic Health Needs in Child Care and Schools—Anaphylaxis. Pediatric Patient Education 2021; 10.1542/ppe_document006 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All AAP SitesAll PublicationsPediatric Patient Education Search Advanced Search Subjects: Managing Chronic Health Needs in Child Care Anaphylaxis is a life-threatening allergic reaction that affects the whole body. It happens when the body intensely responds to an allergen. Symptoms can includeDrop in blood pressureFlushing, sweating, or paleness of the skinSwelling of the skin, lips, mouth, or throatRaised red rash (hives) and itchingNausea, stomach cramps, or sudden vomiting or diarrheaDifficulty breathing, including wheezingFainting, light-headedness, or convulsionsCardiopulmonary arrestThese symptoms usually occur within minutes of contact with the allergen or allergy-causing substance; however, sometimes symptoms can be delayed a few hours.Anaphylaxis can be caused by many things, but insect stings, food, medications, and latex are some of the more common allergens.Anaphylaxis is the most frequently occurring and most immediately life-threatening event that teachers and caregivers are likely to encounter daily. Preparation and quick action are crucial. Anaphylaxis usually occurs with... © 2019 American Academy of Pediatrics. All rights reserved. You do not currently have access to this content.

Childhood Immunoglobulin A Vasculitis Associated with COVID-19: A Case Report

AbstractPrimary immunoglobulin A vasculitis (IgAV) is one the most common childhood vasculitis. A 5-year and 10-month-old girl child patient presented with confluent palpable purple red rash, mainly over both ankles. This was associated with edematous, tender ankles, limited range of movement, and inability to walk. A concomitant coronavirus disease 2019 (COVID-19) was documented by nasopharyngeal swab. This case suggested that COVID-19 can trigger IgAV in children. Hence, awareness of COVID-19 infection in IgAV should be present, and it may be useful to investigate COVID-19 as one of the causes of IgAV, especially in the presence of an epidemic.

13. Uncommon rash and neurological symptoms related to Shingrix

BackgroundShingrix is a non-live recombinant vaccine approved by the Food and Drug Administration (FDA) in 2017 to prevent shingles and postherpetic neuralgia in immunocompetent adults age 50 years and older. A myriads of local and systemic reactions due to the vaccine have been reported, but diffuse erythematous maculopapular rash and neurological symptoms have not yet been reported in English literature.MethodsUsing Google and PubMed, we searched for relevant case reports and journal articles describing adverse effects related to shingrix vaccination.ResultsA 54-year female without significant past medical history presented with diffuse erythematous maculopapular rash, itching and a feeling of weakness in both legs. Her symptoms started with itching and erythematous macular rash at the site of shingles shot followed by headache, myalgia, and malaise which did not improved much with Benadryl. Next day, she felt numbness and weakness in both legs. On the third day, she awoke with diffuse red rash on the face, trunk, lower extremities, fewer lesions on upper extremities. Her review of systems was negative except as mentioned. on examination, she was found to have diffuse erythematous maculopapular itchy rash as shown in Fig 1, but no sensory, motor, cranial never or cerebellar signs. Infectious disease was consulted who recommended IV acyclovir considering early varicella with given morphology. The morphology of lesions did not change over a period of times and VZV PCR of lesions came negative hence acyclovir was discontinued after three days. Her symptoms and rash improved over the hospital stay with supportive treatment and was discharged home on day fifth of admission.Fig. 1A, Rash over face Fig. 1B, Rash over right thigh ConclusionThe safety of shingrix was evaluated by the pool data from eight clinical trials of more than 10,000 participants. Among the study population, 9.4% had local injection-site reactions including pain, redness, and swelling and 10.8% had systemic events including myalgia, fatigue, headache, shivering, fever, and gastrointestinal symptoms. The nature and duration of rash described in our patient has not been reported in english literature including these clinical trials. Noticing new reactions with broad use of new vaccine is conceivable.Disclosures All Authors: No reported disclosures

PSY15 Utilizing Administrative DATA to Determine the Healthcare Burden for Atopic Dermatitis Patients

Previous studies that have assessed atopic dermatitis (AD) burden have been conducted on surveys targeted to the general population. A major limitation is that the survey item that queries ‘recurrent red itchy rash’ lacks diagnostic validation for ascertaining AD cases. Furthermore, the burden on the healthcare system of these patients has not yet been adequately assessed. We use previous validated algorithms and universal administrative health data to determine the healthcare burden of AD. Population Data BC was utilized to ascertain AD cases, which encompasses provincial healthcare data for over 4.5 million residents in British Columbia. The following were calculated: i) incident and prevalence cases, ii) topicals and systemic agents used, iii) number of medical visits per year. In addition, the age distribution for accessing physician care and systemic treatments administered were analyzed. From 2004-2014, incident and prevalent AD cases ranged from 1.28-1.35% and 16.35-18.67%, respectively. The majority of cases were mild (90.41%). The highest frequency for cases accessing the healthcare system was for those aged 0-4 years (4.36%), incident cases per 5 year intervals ranged between 1-2%. The treatments given were as follows: low potency topical steroids-35.93%, moderate to high potency topical steroids-46.84%, high potency topical steroids-16.45%, ultra-high potency steroids-5.34%, topical immunomodulators-4.20%, systemic prednisone-8.41%, systemic immunosuppressants (except prednisone)-1.29%. Out of an average 49,861 AD patients presenting yearly, there were 65,794 general practitioner visits and 12,769 dermatology clinical visits, while other specialties were involved in less than 10% of visits. Although the prevalence of AD cases ranges from 15-20%, the proportion of cases accessing the healthcare system on a yearly basis is only 1-2% of the general population. General practitioners and dermatologists manage majority of cases within the BC healthcare system, and only a minority of patients require systemic immunosuppressant agents.

Scented lotions may cause scaring and premature fading of tattoos

Although tattoo artists provide tattoo aftercare instructions to their clients, recommendations are often not cost-effective or supported by evidence. A 22-year-old man developed a pruritic red rash over his healing tattoo one week after receiving the tattoo. Although multiple queries were negative, the patient did note use of a scented lotion before the eruption. We determined that allergic contact dermatitis from the scented lotion caused scarring and premature fading of the new tattoo. Tattoo artists should recommend avoidance of scented lotions and instruct clients to care for their new tattoo like a wound in their aftercare instructions.

Acquisition Rate of Scabies in Employees After Care of an Undiagnosed Crusted Scabies Patient

Background: Scabies is a contagious dermatosis caused by human mites, (Sarcoptes scabei, variant hominis). In crusted (Norwegian) scabies, the burden of mite infestation is higher and up to 2 million per person, facilitating easy skin-to-skin transmission and nosocomial transmission. We describe a case of undiagnosed crusted scabies and subsequent transmission to employees in our hospital. Methods: A 90-year-old female was admitted to our 636-bed, nonprofit, academic hospital for 22 days prior to diagnosis of crusted scabies by skin scraping. The patient was admitted to 2 different medical-surgical wards and the medical intensive care unit. We collected healthcare worker (HCW) demographics, including department of service, age, sex, pregnancy, and breastfeeding status in those who were at risk of exposure. We interviewed HCWs at 2 time points and collected information related to infestation, allergies to treatment, acceptance of empiric treatment, and whether employee was furloughed. Results: On initial screening, 20 of 124 at-risk HCWs had symptoms (Fig.). Most had a “new onset raised red rash or new pimple like rash (not on face), or linear rash” and 4 had “new onset uncontrollable itching.” All 124 HCWs were contacted 28 days later. One HCW that had not been compliant with prophylaxis became symptomatic and was diagnosed with scabies by dermatology. Of the remaining 20 HCWs, 3 were still having symptoms (2 had itching and 1 had a rash and a scrape performed by dermatology with confirmation of mites). All 3 were retreated with ivermectin. Overall, 21 of 124 exposed HCWs were ultimately symptomatic. Conclusions: During a 22-day admission of an undiagnosed and unisolated elderly patient with crusted scabies, the scabies mite was transmitted to 21 HCWs for an acquisition rate of 17%. Persistence of symptoms after treatment with permethrin occurred in 14%. The infectivity of this disease necessitates early recognition and infection control measures.Funding: NoneDisclosures: None

Dr. Bodilly. Puerperal Erythema simulating scarlat Fewer. (British med. Journ., 1894, 17 / w). Postpartum erythematous rash that appeared to be scarlet fever

A woman who resolved from the 2nd pregnancy, on the 4th day after normal labor, developed a fever and a red rash on the legs and abdomen, similar to scarlet fever. The next morning, the rash spread all over the body. But the excellent state of health of the patient, the decrease in temperature to normal, the correctness of the postnatal separations, indicated that it was not scarlet fever. The rash quickly faded, the postpartum woman, who got out of bed on the 10th day, remained healthy. Anamnesis revealed that this lady had a similar spillage before her marriage; but during her first childbirth, nothing of the kind happened.

SELF CARE TRADITIONAL HERBAL THERAPY FOR PSORIASIS

Background: Psoriasis a skin ailment leading to frustration, stress and social isolation is a vital health problem to be addressed. Research in the area of herbal medicine and rejuvenation practice is based on the number of Random trials in the prevalence of a disease and a survey on the number of published in the journals indexed in the subject area.
 Objective: To document successful casestudies and suggest the progressive herbal treatment plan carried out in Rajendra Herbal Research and training centre.
 Methodology:In a survey of 1000 patients with reported skin problems undergoing traditional herbal and Ayurvedic treatment, 554 had scratchy itch related skin problems, 215 bite based blisters, 32 Hair related Allopecia, 47 White patch, 36 Black patch, 49 psoriasis and 67 patients had red rashes. The group had 518 males and 482 females. Five sets of skin patients were chosen for a cohort study with 0 to 70 years of age having151, 149, 149,154 &175nos.An experiment was designed to carryout a randomized double blind placebo controlled study in 140 psoriatic patients.
 Results: Random survey of 1000 skin patients and cohort study of five sets of herbal respondents of agegroup 0-70 were tabulated.Out of the 140 treated Psoriatics, sixcase studies presented with the treatment plan followed at the Rajendra Herbal Research centresshowedsuccesstowards positive health.
 Conclusion:In all the sets females out-numbered males with the prevalence of skin problems in 11 to 40 years of age. More females of the age group 41 to 50 ended up in Psoriatic arthritis and males with Diabetes. Rajendra supportive herbal therapy for Psoriasis promises social freedom and psychological harmony.

Screening of Chemical Modifications in Human Skin Keratins by Mass Spectrometry-Based Proteomic Analysis via Noninvasive Sampling and On-Tape Digestion.

Proteins are continuously exposed to diverse chemical stresses, and the resulting chemical modifications can provide significant information on biological events. Keratins are the main constituent of human skin and are the major target proteins of various chemical modifications. We have previously developed a mass spectrometry-based noninvasive proteomic methodology to screen oxidative modifications in human skin keratins. We have improved this methodology in terms of sample preparation time and amino acid sequence coverage using an on-tape digestion method. After sampling by tape stripping, skin proteins on the tape were subjected to reduction/alkylation, followed by trypsin digestion without a presolubilization step using detergents. To screen chemical modifications in keratins, target modifications and tryptic target peptides carrying the modification sites were determined from in vitro experiments with major reactive chemical species (4-hydroxy-2(E)-nonenal (HNE), 4-oxo-2(E)-nonenal, glucose, methylglyoxal, peroxynitrite, and hydrogen peroxide). The developed method was used to screen target modifications in controls and patients with a swollen red rash. Basal levels of lipid-derived modification, oxidation, nitration, and glycation in keratins were detected in controls. Principal component analysis based on the relative chemical modification resulted in a clear classification of both groups within a 95% confidence interval. Lipid-derived HNE modification increased most significantly in the patient group. This methodology can be easily applied to patients with other diseases, and the target modifications can be used as biomarkers of certain physiological conditions.

The importance of skin biopsies: Sweet syndrome as a differential for 'acute painful red rash’ in a patient with normal neutrophils and polymyalgia rheumatica on glucocorticoids

Cutaneous lesions and skin rashes are commonly encountered on the acute take in acute medical units. Sweet syndrome (SS) is an uncommon inflammatory disorder, originally described as ‘acute febrile neutrophilic dermatosis’ by Sweet.[1][1] There are numerous aetiological associations reported and

Perancangan Aplikasi Sistem Pakar Penyakit Roseola Dengan Menggunakan Metode Certainty Factor

Measles Roseola usually attacks infants with transmission from a sprinkling of sufferers' saliva. Roseola must be treated quickly because it can cause liver and brain inflammation. Roseola's disease for people whose economy is low is not given much attention because it is often diagnosed in severe or acute illness. This is because the red rash in infants is a common measles. Early diagnosis of Roseola's disease is a good way to avoid adverse consequences for the baby's health. The Roseola disease expert system is able to help low-income people to self-diagnose the disease. Roseola's disease expert system is applied knowledge gained from experts, namely specialist dermatologists in children. Processing of symptoms based on facts with the value and calculation of the Certainty Factor method. Certainty Factor determines good results by combining expert values and user values.

Online, Anytime.

When Pediatrics in Review was first published 40 years ago, I was in diapers, and Visual Diagnosis was still 2 decades from conception. At its 20-year mark, I was unaware that Pediatrics in Review was beginning to publish content online. I was keenly aware of the shifting tides from traditional media to online information; after all, I was starting a career in multimedia production. However, I was still several years from discovering my second calling in pediatric medicine, so I was not yet a Pediatrics in Review reader.When I finally discovered Pediatrics in Review, it was the online version that worked best for my learning style. It has always been difficult for me to focus on reading textbooks, and the Pediatrics in Review search box solved that problem. I found that I could quickly access content relevant to my practice on demand, which made the topics come alive and allowed me to apply the knowledge to real patients.For Pediatrics in Review, the birth of online publishing opened opportunities to create additional material, and Visual Diagnosis was born in March of 2000. It was initially printed, but the format of a presenting image followed by the diagnosis and discussion allowed for a smooth transition to online-only publication. Dr Joe Zenel was the inaugural editor of this section and wrote the first article, titled “An Infant Who Has Fever and Rash.” Dr Zenel built the foundations of Visual Diagnosis and eventually became editor-in-chief. It is an honor for me to learn from him and to continue his legacy with the Visual Diagnosis feature.Dr Zenel concluded the first Visual Diagnosis article with this question: “…will the clinician-in-training recognize measles in the patient presenting with fever, cough, coryza, conjunctivitis, and a red maculopapular rash?” Given the fact that measles was eradicated from the United States in that same year, it was a valid question.Today, pocket-sized computers and excessive media hype can induce irrational fears in anxious parents. I suspect that many of you have received photographs via text message from parents asking if something looks like measles, a spider bite, or fungus. Luckily, for today’s clinicians and clinicians-in-training, there is a vast library of Visual Diagnosis cases available to access when you find yourself confronted with an unusual fever and rash. Pediatrics in Review will continue to move forward, adding to this library and offering expert content to pediatricians for many generations to come.

Diagnosis Penyakit Rubella Menggunakan Metode Fuzzy Tsukamoto

Rubella or better known as German measles is a viral infection characterized by a red rash on the skin. Lack of general public understanding of this disease makes the number of patients with Rubella increasing. So Fuzzy Tsukamoto's method is used to detect Rubella disease. The purpose of this study is to facilitate the public in understanding about Rubella disease so as to reduce the number of sufferers of this disease. The first step to detecting Rubella disease is to determine the fuzzy set and the domain which includes 3 variables: red rash, swollen lymph nodes, and fever. The output of fuzzy calculations is someone experiencing Rubella or normal symptoms. The value obtained from the calculation process usig the Tsukamoto method is 6.00.

Diagnosa Penyakit Rubella Menggunakan Metode Fuzzy Tsukamoto

Rubella or better known as German measles is a viral infection characterized by a red rash on the skin. Lack of general public understanding of this disease makes the number of patients with Rubella increasing. So Fuzzy Tsukamoto's method is used to detect Rubella disease. The purpose of this study is to facilitate the public in understanding about Rubella disease so as to reduce the number of sufferers of this disease. The first step to detecting Rubella disease is to determine the fuzzy set and the domain which includes 3 variables: red rash, swollen lymph nodes, and fever. The output of fuzzy calculations is someone experiencing Rubella or normal symptoms. The value obtained from the calculation process usig the Tsukamoto method is 6.00.

Hepatic Langerhans Cell Histiocytosis (LCH) Mimicking Antimitochondrial Antibody (AMA)–Negative Primary Biliary Cholangitis (PBC), Presenting as a Harbinger of Multisystem LCH

Abstract Objectives LCH is a rare systemic disorder characterized by an infiltration of CD1a+/Langerin+ histiocytes. LCH commonly involves bone, skin, and lymph nodes in children. Hepatic involvement is rarely observed in multisystem LCH. We describe an exceptional case of hepatic LCH in an adult, mimicking AMA-negative PBC, preceding the diagnosis of multisystem LCH. Methods A 65-year-old man presented with intermittent pruritus, weakness, dyspnea, fever, and chills that have been progressive for 4 years. Physical examination was unremarkable. Laboratory work revealed elevated alkaline phosphatase (471 U/L; ref 40-120 U/L), GGT (271 U/L; ref 0-41 U/L), total bilirubin (2.0 mg/dL; ref 0.0-1.2 mg/dL), and direct bilirubin (1.1 mg/dL; ref 0.0-0.3 mg/dL). Indirect bilirubin, AST, and ALT were within normal limits. Liver biopsy was performed. Results Liver biopsy showed lobular and portal nonnecrotizing granulomas with one “florid duct lesion” with duct injury, suggestive of PBC. Tests for autoimmune diseases including AMA were negative. ERCP was negative for biliary obstruction. One month after the liver biopsy, he developed flaking, red, and burning rash on the right scalp, forehead, and epigastric skin. A skin biopsy at an outside institution revealed dermal and epidermal infiltration of CD1a-positive histiocytes with indented nuclei and pale eosinophilic cytoplasm, consistent with LCH. Subsequent reexamination of the liver biopsy showed that the histiocytes within the florid duct lesion were positive for CD1a and S-100, while the remaining granulomas were negative. The following day, a small focus of LCH was noted in his gastric biopsy performed for gastritis symptoms. Conclusion Hepatic LCH may mimic AMA-negative PBC histologically and clinically, and may present as a harbinger of multisystem LCH. While rendering the diagnosis would be challenging without prior history of LCH and with focal involvement, awareness of such presentation and communication with clinical colleagues may be helpful.