Red Cell Mass Volume Research Articles

Clinical and quality evaluation of red blood cell units collected via apheresis versus those obtained manually.

To evaluate the impact of collection procedure on the in vitro quality of red blood cells (RBC), we studied 30 units of apheresis-prepared RBC (ARBC) and 30 units of manually collected RBC (MRBC). We performed assays on day 1 and day 21 of the study, evaluating red cell mass volume (RCM); rate of hemolysis; pH, and levels of sodium, potassium, adenosine triphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG) and glucose. Eight patients with aplastic anemia received RBC transfusions of both components and their post-transfusion hematocrit (HCT) levels were compared. On day 21, we observed a significant drop of sodium and glucose levels in the ARBC group, compared with the MRBC group (P <.05). ARBC group demonstrated higher RCM that provided significantly higher HCT values to our group of anemic patients (P <.05). Hemolysis was significantly lower in the ARBC group, compared with the MRBC group (P <.05). At day 21, both groups had no detectable 2,3-DPG. Specimens from both groups retained ATP in sufficiently healthy amounts. The ARBC group demonstrated higher RCM and lower hemolysis levels compared with the MRBC group.

Stimulation of Erythropoiesis by Androgenic Hormones.

s1 April 1962Stimulation of Erythropoiesis by Androgenic Hormones.B. J. Kennedy, M.D., F.A.C.P.B. J. Kennedy, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-685_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAndrogenic hormones have been proven to have specific stimulatory effect on erythropoiesis. In patients with advanced breast cancer, the administration of large doses of hormone resulted in an increase in hemoglobin, increase in hematocrit, reticulocytosis, and clinical signs of polycythemia. Extended studies have been performed to define this phenomenon more clearly. Radioactive chromium studies of blood volume and red cell mass have recorded an increase in the red cell mass volume. Bone marrow examinations revealed a hyperplasia of the erythroid elements without alteration of the white cell elements or megakaryocytes. The elevation of the hemoglobin and hematocrit was noted in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minn. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 685-685KeywordsBlood cellsBone marrow cellsBreast cancerChromiumErythropoiesisHematocritHemoglobinHormonesMegakaryocytesPolycythemia Issue Published: 1 April 1962 PDF downloadLoading ...