This study is focused on evaluating ground motion durations of Vrancea intermediate-depth earthquakes in Romania, in the context of future updates to the Romanian seismic design code P100-1/2013. The ground motion database compiled for this study consists of about 200 ground motions recorded during five moderate and large Vrancea intermediate-depth earthquakes that occurred in the period of 1977–2004 and had moment magnitudes of MW ≥ 6.0. Two empirical models were derived in this study for the significant ground motion duration considering two time intervals (5–75% and 5–95%) for the accumulation of the Arias Intensity IA. An analysis of the data shows that the mean ratio between D5-95 and D5-75 is about 2.8. Moreover, the regression also shows that the largest share of variability is due to the within-event component (site term). Among the regression coefficients, the hypocentral distance and the soil conditions appear to have a larger impact on the ground motion duration compared to the earthquake magnitude. It was also observed that the median ground motion durations predicted using the empirical model proposed in this study were much smaller than the ones from the proposed Eurocode 8 draft for the same magnitude range. Finally, geographic trends related to the distribution of residuals were also evaluated using the data from the three earthquakes with the largest number of available ground motion recordings.