The main problem in the operation of nuclear power plants (NPPs) is the scale formation of mineral impurities in an open recirculating system (ORS). The discharge of water from an ORS into natural water bodies can alter the chemical equilibrium of wastewater components, necessitating continuous monitoring. The purpose of this study was to analyse the behaviour of dissolved inorganic salts (DIS) in water within an ORS during water treatment, using the Rivne Nuclear Power Plant (RNPP) as a case study. Moreover, the analysis impact of their discharge with return water in the Styr River. The DIS concentration has a significant impact on the efficiency of the system and the environmental of an ORS power plant. Altogether, each of the DIS components was analysed separately using the standard measurement methods, statistical methods of data processing and correlation analysis. In addition, the annual discharge of the DIS components was calculated, and the amount of discharge was assessed for compliance with the maximum discharge limit. Thus, the impact of the formation of DIS and the variations in their concentration levels upon the discharge of wastewater into a natural water body were examined.