Background: In this study we highlight the difference between two recent single file endodontic systems XP-endo Shaper by FKG and WaveOne Gold by Dentsply by measuring their efficiency through assessing the centering ability, canal transportations, preparation time and changes in canal curvature on resin endodontic blocks using Cone Beam Computed Tomography. Material and Methods: Fourteen resin endodontic blocks are used for each system. The assessment was done by comparing and measuring the data collected of pre-instrumentation and post-instrumentation CBCT axial and sagittal images to assess the centering ability, canal transportation, preparation time and changes in canal curvature. These measurements were taken in 3mm ,5mm and 7 mm from the apical exit of the endodontic block used. Results: The mean Canal Transportation of XP System (Group A) in 3mm, 5mm and 7mm sections measured with values (-.5214, -.2714 and -.02140) respectively. The mean transportation of WaveOne Gold system (Group B) in 3mm, 5mm and 7mm in sections with values (-.3214, -.2571 and -.1143.) respectively, whereas the mean centering ability of XP System (Group A) in 3mm, 5mm and 7mm sections measured with values (.0714, -.6131 and -.9881) respectively. The mean transportation of WaveOne Gold system (Group B) in 3mm, 5mm and 7mm sections is given as (-.3255, -.6310 and -.6429) and there was no significant difference noted in centering ability and canal transportation between the two systems. The mean root canal preparation time showed no statistical difference between the two systems employed. There was statistical difference noted in the changes in pre- and post-curvatures of the canal between two systems studied. Conclusion: With our limitation in sample size, it was concluded that reciprocation motion in WaveOne Gold system gave better results in canal transportation and centering ability in the simulated apical part in endo-blocks than continues motion rotary preparation in XP endo shaper system. WaveOne Gold produced lesser canal transportation in the apical 3rd while XP endo shaper produced less canal transportation and centering ability in the middle 3rd simulated endo-blocks.