Reasonable Nutrition Support Research Articles

Analysis of quality of life and risk factors in 122 patients with persistent hemodialysis.

Objectives:To summarize existing evidence on the quality of life and influencing factors in maintenance hemodialysis (MHD) patients.Methods:Total 122 MHD patients treated in the department of hemodialysis, Liyang branch of Jiangsu Provincial People’s Hospital from January 2018 to June 2020 were selected as the patient group. and 98 healthy persons in the same period were selected as the control group. The quality of life of the two groups was investigated by SF-36 score scale. At the same time, the clinical data of the patient group were investigated. Influencing factors of patients’ quality of life were analyzed by univariate test, and independent risk factors were analyzed by logistic multiple regression.Results:Univariate analysis showed that age, education, marital status, dialysis time, urea clearance index (Kt/V), income level, diabetic nephropathy, nutritional status, medical insurance type, depression and anxiety were single factors influencing the quality of life of MHD patients (P<0.05). Logistic multiple regression analysis showed that age ≥ 60 years, dialysis time ≥ one year, income less than 3000 yuan/month, primary disease is diabetic nephropathy., low medical insurance reimbursement, depression and anxiety were independent risk factors affecting the quality of life of MHD patients (P < 0.05).Conclusions:There was a relatively high proportion of patients with age ≥ 60 years, dialysis time ≥ one year, income less than 3000 yuan/month, primary disease is diabetic nephropathy, low medical insurance reimbursement, depression and anxiety. Timely nursing interventions such as reasonable nutritional support, comprehensive monitoring and psychological counseling for patients with the above situation may be helpful in improving quality of life of MHD patients.

Nutritional support therapy during treatment of chronic critical illness

Chronic critical illness (CCI) refers to a group of critically ill patients who survive the acute phase of intensive care, but with persistent organ dysfunction, thus entering a chronic period of continuous dependence on life support system, and still need to stay in intensive care unit (ICU) for a long time. Persistent inflammatory response-immunosuppression-catabolic syndrome (PICS) is the main pathophysiological feature of CCI. Three factors interact to form a vicious circle, leading to poor prognosis. Nutritional support therapy is a key link in the comprehensive treatment of CCI. Enteral nutrition (EN) should be started as soon as possible if conditions permit. If EN can not be implemented, temporary or transitional parenteral nutrition (PN) should be used, and EN should be added gradually in time. At the same time, the amount of PN should be gradually reduced. When EN meets more than 60% of patients' energy and protein requirements, PN can be considered to be discontinued. The main strategies and functions of CCI nutritional support therapy are as follows: strengthening high protein supply to correct negative nitrogen balance and inhibit catabolism, selecting branched chain amino acids (BCAA) to promote anabolism, using immunomodulators (arginine, ω3 polyunsaturated fatty acids) to improve immune suppression and inflammatory response, supplementing micronutrients (vitamins and trace elements) to counteract the decrease in intake and the increase in consumption, and adding probiotics to maintain the intestinal microecological balance, and so on. Reasonable nutritional support therapy not only improve malnutrition of CCI patients, but also help to reduce complications, thus speeding up rehabilitation, improving prognosis, shortening ICU hospitalization time, and even reducing mortality.

Intestinal flora as the potential target for nutritional support treatment in abdominal infection and its clinical significance

Intra-abdominal infections (IAIs) are common in the clinical practice, which include a variety of patholo-gical conditions. Severe IAIs can lead to sepsis, secondary organ dysfunction, and threaten the lives of patients. Patients with IAIs are under a high metabolic reaction, and often have gastrointestinal dysfunction, manifesting as impaired intestinal mucosal barrier function, out of control in intestinal flora regulation, and continuous loss of nutrients. The body is in a malnutrition condition, and body resistance severely declines, which further aggravates disease progression. Intestinal micro-ecology is the largest and most complex ecosystem in the human body. In the case of coexistence of many bacteria, the synergy and antagonism between different strains maintain the balance of digestive tract microecology. Intestinal flora and nutritional status under IAIs have their particularity. Understanding the mechanism of intestinal flora abnormalities under IAIs, reasonable and effective nutritional support treatment and management is essential for improving the prognosis of patients with IAIs. Key words: Critical illnes; Infection; Intra-abdominal infections; Intestinal flora; Nutritional support

Effects of early enteral nutrition on gastrointestinal function recovery and nutritional status after gastrointestinal surgery in children

Background: Young children are at a developmental stage, and any change in their body growth/development and nutritional status during this period has a direct impact on the prognosis of a specific disease. Clinically, most of the pediatric patients receiving an abdominal surgery are children with congenital malformations of the digestive system. They often have compromised nutritional status after the surgery due to factors including surgical trauma and stress reaction. Therefore, reasonable nutrition support has become a required intervention. In this prospective study, we investigated the influence of early enteral nutrition (EEN) on gastrointestinal (GI) function recovery and nutritional status after GI surgery in children. Methods: A total of 60 children with GI diseases undergoing surgical treatment in our center from January 2017 to December 2018 were enrolled in this study. They were randomly divided into the control group and the EEN group according to the order of admission. No EEN was applied in the control group; in contrast, the EEN group received EEN via percutaneous endoscopic jejunostomy (PEJ) tube and postoperative jejunostomy tube. The recovery of GI function, changes in biochemical indicators within 7 days after surgery, postoperative nutritional status, and complications were compared between these two groups. Results: After the surgery, the time to eating solid food and the time to first flatus/defecation were significantly shorter in the EEN group than in the control group (all P Conclusions: Proper EEN after a GI surgery can increase the survival rate, accelerate the recovery of GI function, and improve the nutritional status in pediatric patients. This intervention can be further applied in clinical settings.

Sequential nutrition support with the combination of parenteral and enteral nutrition in the management of severe acute pancreatitis

Background: Severe acute pancreatitis (SAP) patients are in a highly catabolic state, and reasonable nutritional support is important in improving prognosis. This retrospective study was designed to assess the efficacy of combined sequential therapy of total parenteral nutrition with enteral nutrition (TPN-EN) in the management of SAP patients. Methods: The clinical data (including recovery time, APACHE II score, and hematological indicators) of 39 SAP patients who had received TPN-EN in our center in the past 6 years were retrospectively analyzed. Furthermore, the results were compared with those in 39 patients treated with total parenteral nutrition (TPN) alone (control group). Results: One week after the nutritional therapy (week 1), the APACHE II score, serum calcium, and arterial blood lactate and albumin levels were not significantly different between the TPN-EN group and the control group, and the control group had better blood glucose control. However, the APACHE II score, serum calcium, and arterial blood lactate and albumin levels in the TPN-EN group were significantly improved compared with the control group at weeks 2 and 3, and blood glucose control showed no significant difference between these two groups. Serum creatinine levels were not significantly different between these two groups throughout the treatment. Conclusions: TPN-EN can improve the prognosis of SAP patients and shorten hospital stay without increasing the visceral burdens.

Experience of management of 21 cases enteric fistula after surgery

Objective To review the causes of 21 cases of exteric fistula after surgery, treatment and prognosis, and to explore the clinical treatment of exteric fistula after surgery. Methods To collection the Xinjiang Uygur Autonomous Region People′s Hospital of Gastrointestinal Surgery from Aug 2013 to Aug. 2016 admitted during the period of parenteral fistula patients after abdominal surgery, 21 patients with intestinal fistula outside, 12 cases were male, 9 were female cases. According to the case records of descriptive statistics, the treatment methods was summarized and analyzed retrospectively. Results Au patients with intestinal fistula outside, 12 cases were male, female 9 cases. Conservative treatment of 11 cases, healing in 2 cases, 5 cases, 4 cases died and the sigmoid colon perforation repair 1 case, postoperative ileus postoperative renal function failure in 1 case, gastric cancer by intraperitoneal hemorrhage after early postoperative restrictive ploration in 2 cases; Early surgical treatment of 10 cases, of which the deterministic operation in 1 case, late deterministic surgery in 9, were cured. Conclusions The early diagnosis of parenteral fistula and rapid processing, taken on the basis of the condition of the patients with timely complete drainage, infection control, reasonable nutrition support and correct homeostasis imbalance as the main content of a comprehensive individualized treatment, most patients can improve the self-healing, cannot heal patients to choose the appropriate surgical timing and proper operation method, can improve the cure rate and reduce the case fatality rate. Key words: Enteric fistula; Therapeutic uses; Surgical procedures, operative; Prognosis

Application progress of perioperative nutritional support for general surgical patients with nutritional risk

Most of general surgical patients in perioperative period have nutritional risk. An appropriate nutritional risk screening may contribute to developing a nutritional support plan. Reasonable perioperative nutritional support can improve nutritional status, reduce complications, shorten hospitalization time and promote recovery of patients, and so that patients can be benefitted from this treatment. This paper will review the present situation of nutritional risk, and the methods and effects of nutritional support for patients in perioperative period, and so as to provide reference and guide for nutritional support. Key words: Review; Nutritional support; General surgery; Perioperative nursing; Nutritional risk

Analysis of the effect of preoperative nutritional risk screening on clinical outcomes, immune function and nutritional index in patients with colorectal cancer

Objective To analyze the effect of preoperative nutritional risk screening on clinical outcomes, immune function and nutritional index in patients with colorectal cancer. Methods 140 cases with colorectal cancer between September 2015 and March 2016 were selected, according to the score of NSR 2002 screening scale, they were divided into A group (87 cases), which was less than 3 points, and B group (53 cases), which was more than 3 points.A group was divided into non nutrition support group (50 cases) and nutrition support group (37 cases), while B group was divided into non nutrition support group (21 cases) and nutrition support group (32 cases). The clinical outcomes, immune function, nutritional index and complication were compared. Results The clinical outcomes[(1.9±0.5)d vs.(1.3±0.4)d], immune function[(31.93±5.27)pg/mL vs.(31.46±4.68)pg/mL], nutritional index[(2.09±0.36)g/L vs.(2.01±0.32)g/L]of the non nutrition support group and nutrition support group of A group had no significant differences (t=0.992, 0.981, 0.991, all P>0.05). The clinical outcomes[(3.5±0.7)d vs.(2.2±0.6)d], immune function[(25.49±5.49)pg/mL vs.(56.41±9.52)pg/mL], nutritional index[(1.71±0.40)g/L vs.(1.94±0.35)g/L]of one week after operation of the non nutrition support group in B group were worse than nutrition support group (t=4.033, 7.335, 4.997, all P 0.05). The complication rate of non nutrition support group of A group was 21.7%, which was higher than that in nutrition support group (9.3%)(χ2=7.299, P<0.05). Conclusion For newly admitted patients with colorectal cancer, nutritional risk screening in early admission, according to the physiological index test results such as nutritional index and screening results, get the nutritional status of patients, choose reasonable nutrition drug dosage and the infusion way on the need of nutritional support of patients in a timely and reasonable nutrition support, improve the postoperative nutritional status, and accelerate the postoperative recovery. Key words: Nutritional risk screening; Colorectal neoplasms; Immune function; Nutritional index

Persistent inflammation immunosuppression catabolism syndrome: a special type of chronic critical illness

After the concept of "chronic critical illness (CCI)" was proposed, the new concept persistent inflammation immunosuppression catabolism syndrome (PICS) is present recently. Patients with PICS are manifested by fast decreasing body weight, poor nutritional status, long-term immunosuppression and repeated nosocomial infections. These patients are faced with great challenges of persistent inflammation, acquired immunosuppression and high catabolism, which finally results in repeated nosocomial infections, prolonged hospital stay and increased mortality. At present, main problems of PICS diagnosis standard include varying length of ICU stay, difference in normal C reactive protein value, poor value of nutrition indexes, absence of clinical verification. Though associated pathophysiology mechanism is not clear, PICS is preventable and magageable with certain therapy, including early comprehensive prevention and treatment focused on infection control for CCI patients to stop the progression of PICS, application of immune modulator to improve immune function and prognosis of patients, and reasonable nutritional support and treatment. Besides, through the analysis of the association between PICS and CCI, authors draw a conclusion that PICS is a new phenotype of CCI, and immune paralysis is its main feature.

Perioperative nutritional support in patients with digestive tract cancer

Tumor patients are high-risk group of malnutrition, and the characteristics of pathophysiology of digestive tract tumor can aggravate the malnutrition, so the perioperative nutritional support should be planed and implemented for these patients. However, the understanding of nutritional support is still insufficient. Reducing preoperative fasting time, reasonable preoperative nutritional support, early postoperative enteral nutrition and multiple forms in combination are the optimal strategy of the perioperative nutritional treatment and management. As the condition of cancer patients is always complicated, in the practice of clinical implementation, medical guidelines, patients condition and clinical experience of the medical practitioners should be combined to accelerate the effect of nutritional support and to improve the outcome of the patients.

Factors associated with anastomotic leak following anterior resection for rectal cancer

To explore the related factors of anastomotic leakfollowing anterior resection for the rectal cancer and the association of the preoperative nutritional risk screening 2002(NRS2002) score. Clinical data of 396 rectal cancer patients who underwent elective anterior resection from January 2010 to July 2015 at Affiliated Lu'an Hospital of Anhui Medical University were collected. Patient's nutritional risk score on admission was calculated by NRS2002 scoring system according to original medical records. NRS2002 score less than 3 was defined as nutritious risk. Chi-squared test, or Fisher exact test and multivariate logistic regression wereused to analyze the association of the clinical pathological factors and NRS2002 risk factor with anastomotic leak. Of the 396 patients, NRS2002 score≥3, and anastomotic leak occurred in 157(39.6%) and 13(3.3%), respectively. In univariate analysis, different ages, NRS2002 score, preoperative intestinal obstruction, distance from anastomosis to anal vergeand tumor TNM stage were significantly associated with postoperative anastomotic leak(all P<0.05). The incidence of postoperative anastomotic leak among patients with NRS2002 score≥3 was significantly higher than those with NRS2002 score<3[6.4%(10/157) vs. 1.3%(3/239), χ(2)=7.806, P=0.005]. Multivariate analysis showed that NRS2002 score≥3(OR=3.988, 95% CI:1.004-15.837, P=0.049), existence of preoperative intestinal obstruction(OR=5.780, 95% CI:1.320 ~ 25.311, P=0.020),distance from anastomosis to anal verge≤5 cm(OR=0.236, 95% CI: 0.071 ~ 0.785, P=0.019) were the independent risk factors of anastomotic leak following anterior resection for the rectal cancer. Rectal cancer patients undergoing anterior resection with preoperative NRS2002 score≥3 should receive reasonable perioperative nutritional support to prevent anastomotic leak.

Comprehensive evaluation of nutritional status before and after hematopoietic stem cell transplantation in 170 patients with hematological diseases.

ObjectiveTo investigate the nutritional status of patients before and after hematopoietic stem cell transplantation (HSCT), and explore optimal methods for assessing nutritional status in patients with hematological diseases.MethodsThis cohort study enrolled 170 patients who were diagnosed with hematological diseases and underwent allogeneic HSCT in the Department of Hematology, Peking University People’s Hospital between May 2011 and April 2013. We used fixed-point continuous sampling and four nutritional screening tools, Nutritional Risk Screening 2002 (NRS-2002), Mini Nutritional Assessment (MNA), Subjective Global Assessment (SGA) and Malnutrition Universal Screening Tools (MUST), in combination with body measurements, to extensively screen and evaluate nutritional risks and status in patients receiving HSCT before entering and after leaving laminar air flow rooms.ResultsAfter HSCT, patients had significant reduction in weight, hip circumference, waist-hip ratio, calf circumference, mid-upper arm circumference, and suprailiac skinfold thickness compared with pre-HSCT measurements. Before HSCT, NRS-2002 identified that 21.2% of patients were at nutritional risks, compared with 100% after HSCT. MUST indicated that before HSCT, 11.77% of patients were at high nutritional risk, compared with 59.63% after HSCT. MNA assessed that 0.06% of patients were malnourished before HSCT, compared with 19.27% after HSCT. SGA identified that before HSCT, 1.76% of patients had mild to severe malnutrition, which increased to 83.3% after HSCT. There is a significant increase in the nutritional risk and malnutrition in patients who received HSCT.ConclusionsBefore HSCT, some patients already had nutritional risk or nutritional deficiencies, and prompt and close nutritional screening or assessment should be performed. The nutritional status of patients after HSCT was generally deteriorated compared with that before transplantation. Body measurements should be taken more frequently during the subsequent treatment window in the laminar air flow rooms. After HSCT, it is recommended to combine MNA and SGA to fully evaluate the nutritional status, and thus provide timely and reasonable nutritional support.

Clinical significance of measuring resting energy expenditure for guiding an accurate nutritional support in elderly bedridden patients with nasal feeding

Objective To investigate the clinical significance of measuring resting energy expenditure (REE) for guiding an accurate nutritional support in elderly bedridden patients with nasal feeding. Methods The REE of 32 elderly bedridden patients with nasal feeding was assessed by using the Cosmed K4b2 portable telemetric gas analysis system. The waist-hip ratio, serum levels of albumin, transferrin, prealbumin and retinol-binding protein were determined to assess comprehensive nutrition status. The energy intakes were calculated, and the correlation of REE and the difference between the energy intakes and consumption with nutritional index were analyzed. Results The resting energy expendture was lower in the patients with waist-hip ratio≥0.95 than in patients with waist-hip ratio <0.95 (t=3.622, P<0.01). The waist-hip ratio was reduced and serum albumin and transferrin levels were decreased along with the increase of REE in elderly patients (r=-0.55, -0.36 and -0.593, respectively, P=0.001, 0.043, <0.001). The difference between the energy intake and expenditure was higher in patients with waist-hip ratio≥0.95 than those with waist-hip ratio<0.95 (t=5.643, P<0.001). Serum albumin, prealbumin, transferrin and retinol-binding protein levels were increased along with the increase of the difference between the energy intake and expenditure, which showed the positive correlations (r=0.525, 0.409, 0.624, 0.414, respectively, P=0.002, 0.02, <0.001, 0.019). Conclusions Precise determination of REE and energy intake guided by REE are the important guarantees for the reasonable nutrition support in the elderly. Key words: Energy metabolism; Intubation, nasogastric; Nutrition therapy

Hot topics in the perioperative nutritional support therapy in abdominal surgery

Malnutrition is common in the abdominal surgery and affects the recovery of patients. Reasonable nutritional support therapy can improve the prognosis of patients. The nutritional risk screening should be applied to patients within 24 hours of admission. Patients with the nutritional risk and malnutrition should receive the nutritional support by selecting a good timing and way based on the nutritional support planning. Preoperative fasting all night for the majority of patients is not necessary, patients should be allowed to intake low-concentration liquid diet at hour 2 before anesthesia. Patients with preoperative severe malnutrition should be given 7- 10 days of nutritional support therapy. The enteral nutritional therapy was preferred to patients needing postoperative nutritional support therapy, while parenteral nutrition therapy should be supplied to patients with infeasible enteral nutrition or expected target of 60% for enteral nutrition. Individual nutritional support therapy is not necessary for patients without severe concomitant disease. Pharmacological nutrients such as ω-3 polyunsaturated fatty acids and glutamine are beneficial for abdominal surgery and critical patients, which should be used reasonably. Key words: Abdominal surgery; Nutritional support therapy; Perioperative period

Nutritional status and its related factors in patients undergoing allogenetic hematopoietic stem cell transplantation

Objective We tried to investigate the nutritional status and related factors in patients undergoing allogenetic hematopoietic stem cell transplantation. Methods A total of 75 patients were re-cruited from a class-three hospital in Suzhou. They were investigated with a basic information questionnaire and the Patient-Generated-Subjective Global Assessment (PG-SGA). The related factors influencing nutri-tional status were analyzed. Results The PAB level began to rise since conditioning regimen, and it rose to the highest level in the second week, then began to decline. The weight and the BMI had been declining in the four weeks since conditioning regimen. 29.33% of the patients were malnourished, the scored PG-SGA was (5.60±4.96), the percentage of patients with dietary problems was 33.3% before conditioning regi-men; 85.33% of the patients were malnourished, the scored PG-SGA was (19.26±7.18), the percentage of patients with dietary problems was 93.2% in the second week since conditioning regimen; 85.33% of the patients were malnourished, the scored PG-SGA was (12.95±6.19), the percentage of patients with dietary problems was 75.8% in the fourth week; Age is the main factor affecting the patients' albumin level in the second week. Conclusions The nutritional status of patients deteriorated and the percentage of patients with malnutrition increased during allogeneic hematopoietic stem cell transplantation. Clinical staff should pay atten-tion to the assessment of nutritional status, and give a reasonable nutritional support when necessary. Key words: Allogeneic hematopoietic stem cell transplantation; Nutritional status; Nutritional as-sessment

Nutrition risk screening and nutrition assessment of hospitalized children

Disease is closely related to nutrition,and disease state of hospitalized children with nutrient consumption and malnutrition is worrying. Malnutrition affects not only children′s growth,reduce the body func-tion,but also can increase the nutrition related complications and mortality. However currently the decision crite-ria of nutrition risk screening and evaluation method are not identical, there is no systemic, standard, unified plan,which cause a lot of malnutrition cases misdiagnosis and miss the timing of the early intervention. There-fore,it is necessary to do nutritional risk screening,nutrition assessment and nutritional surveillance for hospital-ized children,so that we can timely find the nutritional problems and take reasonable nutrition support and inter-vention measures. In this paper,the hospitalized children with nutritional risk screening and nutrition evaluation research progress are reviewed briefiy. Key words: Hospitalized children; Nutrition; Risk screening; Assessment

Nursing care of conservative treatment for children with sagittal fracture of the mandibular condyle

Objective To explore the nursing intervention of conservative treatment for children with sagittai fracture of the mandibular condyle (SFMC).Methods Eight patients with SFMC who received the conservative treatment were given psychological intervention,reasonable nutrition support,oral care and functional training.Results Clinical satisfactory results were obtained in all the patients with good occlusion,no joint murmurs and ankylosis.Mandible movement and function was normal.Conclusions Conservative treatment with appropriate nursing care for patients with SFMC can promote their fracture healing and improve clinical rehabilitation effect. Key words: Child; Nursing; Sagittal fracture of the mandibular condyle; Conservative treatment

Application of different nutritional support modes in early stage for severe mechanical ventilation patients

Objective To explore three nutritional support mode in early stage on curative effect and outcome in the severe patients with mechanical ventilation and provide references for the clinic.Methods A total of 90 patients with mechanical ventilation from February 2009 to December 2011 were randomly divided into group A,B and C with 30 cases in every group,and were recevied parenteral nutrition(PN),enteral nutrition(EN)and combined enteral and parenteral nutrition(CEPN),respectively.The nutrition indexes,the immune indexes and the level of plasma endotoxin were mensurated in the 1st day and the 7th day after mechanical ventilation.The complications and the condition changes were carefully observed.Results Among 90 cases,57 cases were successfully detached from the respirator,at early stage,25 cases died,32 cases had complicatinns.All the observation indexes including nitrogen balance,albumin,IgA,IgG,the level of plasma endotoxi,the cases with complication,and the cases detached from respirator were recorded in the 7th day after mechanical ventilation,group A(PN):(2.3±1.2)g/d,(30.6±2.7),(1.4±0.5),(7.8±2.1) g/L,(37.1 ±6.3) pg/ml,17 cases,13 cases; group B(EN):(4.2 ±0.5) g/d,(33.5 ±1.8),(2.5 ±0.3),(13.6 ±1.5) g/L,(49.7 ±7.3) pg/ml,9 cases,21 cases,group C(CEPN):(5.8 ±0.8) g/d,(35.8 ±1.7),(2.5 ± 0.2),(13.9±1.7) g/L,(50.3 ±7.1) pg/ml,23 cases,6 cases.The differences between all the observation indexes in group B and C were superior to group A,which showed statistically significant difference(P ＜0.05).The difference of nutrition indexes and the incidence of complication was statistically significant between group C and group B (P ＜ 0.05 ).Conclusions EN combined with PN is an reasonable and effective nutrition support mode for patients with mechanical ventilation. It can improve the curative effects,and reduce the incidence of complication. Key words: Nutritional support; Parenteral nutrition; Enteral Nutrition; Combined enteral and parenteral nutrition; Mechanical ventilation

Therapeutic effects of reasonable nutrition support on severe acute pancreatitis

目的 探讨合理营养支持对重症急性胰腺炎治疗的作用.方法将96例重症急性胰腺炎病人随机分为全胃肠外营养组和肠内与肠外营养结合组.分别检测血清内毒素、尿L/M值、CD4/CD8比值和IgG水平以监测肠黏膜通透性和免疫状态的改变,同时观察TNF-α和IL-6血清病人感染率和死亡率.结果肠内与肠外结合营养组病人血清IgG和CD4/CD8明显高于全胃肠外营养组(P<0.05), 而内毒素、尿L/M值以及TNF-α、IL-6水平则明显低于全胃肠外营养组(P<0.05),病人感染率和死亡率亦明显降低(P<0.05).结论合理应用肠外与肠内营养相结合的营养支持方式可缓解炎性细胞因子及炎性介质的释放,从而对重症急性胰腺炎具有积极的治疗作用。