The skills that were considered necessary for success in the 21st century included the ability to improve social and intellectual abilities such as communication, cooperation, critical thinking, and problem-solving, as well as creativity and innovation. It also contains methods of working, interacting, cooperating, and working in teams so that they can encourage and support skills relevant to the 21st century, such as literacy, information technology, and digital networks. Thus, this study aims to know the reality of middle school (intermediate) pupils in the Kingdom of Saudi Arabia about putting the skills of the 21st century into practice. The researcher employed the descriptive survey approach in her work, and the study tool (questionnaire) was used on a random sample composed of middle school (intermediate) teachers (female) in the Al-Qassim region. The following are some of the major results of the study: The use of technology by the middle school (intermediate) female students efficiently and effectively garnered a high response rate from the study participants. However, the intermediate students’ skills in information, media and technology culture, health and safety skills, and self-leadership put into practice earned an average response rate from the study participants. There were statistically significant differences in the study, which favored higher education qualifications and the attendance of training courses relevant to the “skills of the 21st century,” with no statistically significant differences for the more years of experience. The study advised that material and moral motivation tactics should be utilized as it is of essential relevance and required for the leaders of schools to urge them on new leadership practices.