Recent disruptive events, such as COVID-19 and Russia–Ukraine conflict, had a significant impact of global supply chains. Digital supply chain twins have been proposed in order to provide decision makers with an effective and efficient tool to mitigate disruption impact. This paper introduces a hybrid deep learning approach for disruption detection within a cognitive digital supply chain twin framework to enhance supply chain resilience. The proposed disruption detection module utilises a deep autoencoder neural network combined with a one-class support vector machine algorithm. In addition, long-short term memory neural network models are developed to identify the disrupted echelon and predict time-to-recovery from the disruption effect. The obtained information from the proposed approach will help decision-makers and supply chain practitioners make appropriate decisions aiming at minimizing negative impact of disruptive events based on real-time disruption detection data. The results demonstrate the trade-off between disruption detection model sensitivity, encountered delay in disruption detection, and false alarms. This approach has seldom been used in recent literature addressing this issue.