The critical thinking is an important part of education supported by the Czech curriculum documents, and its importance is now being discussed in the context of the development of artificial intelligence. In the teaching of (not only) chemistry, the critical thinking can be purposefully developed through appropriate activities. The article presents three comprehensive teaching tasks for chemistry education that have the potential to develop critical thinking: Genetically Modified Crops (a task using the problem-based learning and analysis of information sources), Nuclear Energy and Spent Nuclear Fuel Management (a task focused on critical reading of text, reasoning and working with artificial intelligence) and Reaction Kinetics (research-oriented laboratory work enhanced with elements of graph and data interpretation and reasoning). Building critical thinking skills in chemistry is essential for understanding abstract concepts and acquiring skills that enable students to approach chemistry topics responsibly and knowledgeably in everyday life. Full text English translation is available in the on-line version.