Reactive Adaptation Research Articles

Resources don't grow on trees: A framework for resource-driven adaptation

Software systems execute tasks that depend on different types of resources. However, the variability of resources may interfere with the ability of software systems to execute important tasks. In this paper, we present a proactive and reactive resource-driven adaptation framework that supports different types of resources and is based on the prioritisation of tasks. In our previous work, we defined a task modelling notation called SERIES. This paper builds on that notation and focuses on the adaptation process to improve resource utilisation by substituting tasks with their variants, substituting resources with alternative ones, executing tasks in a different order, or cancelling the execution of low-priority tasks. The framework was evaluated in terms of the percentage of executed critical task requests, average criticality of the executed task requests in comparison to the non-executed ones, overhead, and scalability. The evaluation was executed using two datasets related to a medicine consumption system and a manufacturing system. The evaluation results showed that the proposed framework increased the number of executed critical task requests and the average criticality of the executed task requests under resource variability with marginal overhead.

Adaptation in Edge Computing: A Review on Design Principles and Research Challenges

Edge computing places the computational services and resources closer to the user proximity, to reduce latency, and ensure the quality of service and experience. Low latency, context awareness and mobility support are the major contributors to edge-enabled smart systems. Such systems require handling new situations and change on the fly and ensuring the quality of service while only having access to constrained computation and communication resources and operating in mobile, dynamic and ever-changing environments. Hence, adaptation and self-organisation are crucial for such systems to maintain their performance, and operability while accommodating new changes in their environment. This article reviews the current literature in the field of adaptive edge computing systems. We use a widely accepted taxonomy, which describes the important aspects of adaptive behaviour implementation in computing systems. This taxonomy discusses aspects such as adaptation reasons, the various levels an adaptation strategy can be implemented, the time of reaction to a change, categories of adaptation technique and control of the adaptive behaviour. In this article, we discuss how these aspects are addressed in the literature and identify the open research challenges and future direction in adaptive edge computing systems. The results of our analysis show that most of the identified approaches target adaptation at the application level, and only a few focus on middleware, communication infrastructure and context. Adaptations that are required to address the changes in the context, changes caused by users or in the system itself are also less explored. Furthermore, most of the literature has opted for reactive adaptation, although proactive adaptation is essential to maintain the edge computing systems’ performance and interoperability by anticipating the required adaptations on the fly. Additionally, most approaches apply a centralised adaptation control, which does not perfectly fit the mostly decentralised/distributed edge computing settings.

The Current use of Adaptive Strategies for External Beam Radiotherapy in Cervical Cancer: A Systematic Review

AimsVariability in the target and organs at risk (OARs) in cervical cancer treatment presents challenges for precise radiotherapy. Adaptive radiotherapy (ART) offers the potential to enhance treatment precision and outcomes. However, the increased workload and a lack of consensus on the most suitable ART approach hinder its clinical adoption. This systematic review aims to assess the current use of adaptive strategies for cervical cancer and define the optimal approach. Materials and methodsA systematic review of current literature published between January 2012 and May 2023 was conducted. Searches used PubMed/Medline, Cochrane Library, and Web of Science databases, supplemented with the University of Manchester, Google Scholar, and papers retrieved from reference lists. The review assessed workflows, compared dosimetric benefits, and examined resources for each identified strategy. Excluded were abstracts, conference abstracts, reviews, articles unrelated to ART management, proton therapy, brachytherapy, or qualitative studies. A narrative synthesis involved data tabulation, summarizing selected studies detailing workflow for cervical cancer and dosimetric outcomes for targets and OARs. ResultsSixteen articles met the inclusion criteria; these were mostly retrospective simulation planning studies, except four studies that had been clinically implemented. We identified five approaches for ART radiotherapy for cervical cancer: reactive and scheduled adaptation, internal target volume (ITV)-based approach using library of plans (LOP), fixed-margin approach using LOP, and real-time adaptation, with each approach reducing irradiated volumes without compromising target coverage compared to the non-ART approach. The LOP-based ITV approach is the most used and clinically assessed. ConclusionIdentifying the optimal strategy is challenging due to dosimetric assessment limitations. Implementing cervical cancer ART necessitates strategic optimization of clinical benefits and resources through research, including studies to identify the optimal frequency, and prospective evaluations of toxicity.

Advanced myocardial deformation echocardiography for evaluation of the athlete's heart: Functional and mechanistic analysis

BackgroundAssessment of the athlete's heart is challenging because of a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The potential value of myocardial deformation remains controversial in identifying early cardiomyopathy. AimTo identify the echocardiographic phenotype of athletes using advanced two-dimensional speckle tracking imaging, and to define predictive factors of subtle left ventricular systolic dysfunction. MethodsIn total, 191 healthy male athletes who underwent a preparticipation medical evaluation at Nancy University Hospital between 2013 and 2020 were included. Clinical and echocardiographic data were compared with 161 healthy male subjects from the STANISLAS cohort. Borderline global longitudinal strain value was defined as<17.5%. ResultsAthletes demonstrated lower left ventricular ejection fraction (57.9±5.3% vs. 62.6±6.4%; P<0.01) and lower global longitudinal strain (17.5±2.2% vs. 21.1±2.1%; P<0.01). No significant differences were found between athletes with and without a borderline global longitudinal strain value regarding clinical characteristics, structural echocardiographic features and exercise capacity. A borderline global longitudinal strain value was associated with a lower endocardial global longitudinal strain (18.8±1.2% vs. 22.7±1.9%; P=0.02), a lower epicardial global longitudinal strain (14.0±1.1% vs. 16.6±1.2%; P<0.01) and a higher endocardial/epicardial global longitudinal strain ratio (1.36±0.07 vs. 1.32±0.06; P<0.01). No significant difference was found regarding mechanical dispersion (P=0.46). ConclusionsBorderline global longitudinal strain value in athletes does not appear to be related to structural remodelling, mechanical dispersion or exercise capacity. The athlete's heart is characterized by a specific myocardial deformation pattern with a more pronounced epicardial layer strain impairment.

Adaptations to a patient navigation program for follow-up colonoscopy in rural primary care practices.

Patient navigation is a recommended practice to improve cancer screenings among underserved populations including those residing in rural areas with care access barriers. We report on patient navigation programme adaptations to increase follow-up colonoscopy rates after abnormal fecal testing in rural primary care practices. Participating clinics delivered a patient navigation programme to eligible patients from 28 affiliated clinics serving rural communities in Oregon clustered within 3 Medicaid health plans. Patient navigation adaptations were tracked using data sources including patient navigation training programme reflections, qualitative interviews, clinic meetings, and periodic reflections with practice facilitators. Initial, planned (proactive) adaptations were made to address the rural context; later, unplanned (reactive) adaptations were implemented to address the impact of the COVID-19 global pandemic. Initial planned adaptations to the patient navigation programme were made before the main trial to address the needs of the rural context, including provider shortages and geographic dispersion limiting both patient access to care and training opportunities for providers. Later unplanned adaptations were made primarily in response to COVID-19 care suspension and staff redeployments and shortages that occurred during implementation. While unplanned adaptations were implemented to address the contextual impact of the COVID-19 pandemic on care access patterns and staffing, the changes to training content and context were beneficial to the rural setting overall and should be sustained. Our findings can guide future efforts to optimise the success of such programmes in other rural settings and highlight the important role of adaptations in implementation projects.

Effects of three prophylactic interventions on French middle-schoolers’ mental health: protocol for a randomized controlled trial

Adolescence is a strategic developmental stage in terms of preventing later difficulties and ensuring good mental health. Prophylactic interventions, which are conducted before the onset, prolongation, or worsening of difficulties, and aim to prevent or reduce symptoms or to promote wellbeing, therefore appear particularly appropriate for adolescents. However, existing prophylactic interventions conducted with adolescents have several weaknesses, including sparse theoretical frameworks, ambivalent evidence of their efficacy, and implementation and dissemination difficulties. In addition, no data are currently available on the effectiveness of such interventions in France. To fill this gap, a four-arm randomized controlled trial will be performed to assess the effectiveness of three prophylactic interventions targeting reactive, proactive and interpersonal adaptation in fourth-grade middle-school students, together with participants’ experience and perception of the interventions. Based on existing knowledge about adolescents, their learning mechanisms, and field constraints, these three interventions have been designed to promote their learning and receptiveness to interventions. Compared with baseline (i.e., before the intervention), we expect to observe a significant decrease in the level of distress (anxiety and depressive symptoms, functional impairment, and psychosocial difficulties) and a significant increase in the level of wellbeing after the intervention, across the three intervention groups, but not in the control group. In addition, we expect to observe post-intervention improvements in the processes targeted by the reactive adaptation intervention (operationalized as coping strategy use and flexibility), those targeted by the proactive adaptation intervention (operationalized as the tendency to engage in committed actions and general self-efficacy), and those targeted by the interpersonal adaptation intervention (operationalized as assertiveness in interactions), but only in the corresponding groups, with no change in any of these processes in the control group. The results of this research will not only enrich our knowledge of the processes involved in adolescents’ distress and wellbeing, but also provide clues as to the best targets for intervention. Moreover, the material for these interventions will be freely available in French on request to the corresponding author, providing access to innovative and fully assessed interventions aimed at promoting adolescents’ mental health in France.This clinical trial is currently being registered under no. 2023-A01973-42 on https://ansm.sante.fr/. This is the first version of the protocol.

The effect of plant protein high levels in feed on biometric and histopathological parameters of rainbow trout

Comparative studies of the effect of replacing animal protein in the structure of the diet with vegetable protein on biometric parameters and histopathological parameters of the liver of rainbow trout have been carried out on biological models of rainbow trout. Changes in trout carcass structure were revealed, indicating a change in live weight in the 1st control and 2nd experimental groups with a result of 3.7%, changes occurred in the 3rd group - 7.4%. Moreover, the changes in muscle mass in group 2 were expressed better than in the control group by 1.5%, similarly in group 3 – 12.8%. The weight gain of edible parts in group 2 was expressed better by 4.1% than in the control group, and in the experimental group 3 – 7.3%. The mass of in-edible parts in the study groups was also higher than in the control group. The yield of edible parts was higher in the 2 experimental group by 0.21%, in the experimental group 3 – 0.2%. When examining the liver tissue of the experimental group 3, some degenerative changes were revealed. Vacuolization of liver cells in the experimental group 3, which were fed a diet with vegetable protein high content in its structure, was significantly lower, and accordingly, in this group there were the smallest hepatocytes. Defects in cellular contacts in the liver, destruction, and proliferation of lymphohistiocyte cells into sinusoids were observed. Thus, a decrease of animal feed in the structure of predatory fish diets to the level of 25% leads to liver degeneration. This reactive adaptation of the liver to a new vegetable protein ingredient is of a short-term nature.

Effects of protective step training on proactive and reactive motor adaptations in Parkinson's disease patients.

The aim of this study was to investigate to what extent PD affects the ability to walk, respond to balance perturbations in a single training session, and produce acute short-term effects to improve compensatory reactions and control of unperturbed walking stability. Understanding the mechanism of compensation and neuroplasticity to unexpected step perturbation training during walking and static stance can inform treatment of PD by helping to design effective training regimens that remediate fall risk. Current rehabilitation therapies are inadequate at reducing falls in people with Parkinson's disease (PD). While pharmacologic and surgical treatments have proved largely ineffective in treating postural instability and gait dysfunction in people with PD, studies have demonstrated that therapy specifically focusing on posture, gait, and balance may significantly improve these factors and reduce falls. The primary goal of this study was to assess the effectiveness of a novel and promising intervention therapy (protective step training - i.e., PST) to improve balance and reduce falls in people with PD. A secondary goal was to understand the effects of PST on proactive and reactive feedback responses during stance and gait tasks. Multiple-baseline, repeated measures analyses were performed on the multitude of proactive and reactive performance measures to assess the effects of PST on gait and postural stability parameters. In general, the results indicate that participants with PD were able to use experiences with perturbation training to integrate and adapt feedforward and feedback behaviors to reduce falls. The ability of the participants with PD to adapt to changes in task demands suggests that individuals with PD could benefit from the protective step training to facilitate balance control during rehabilitation.

Transhumanism: the friendly face of the overhuman and the comic book Superman

Abstract The core of the study is a critical comparison of Nietzsche’s notion of Übermensch, and its transhumanist rewriting into different variants of the posthuman. The first part contextualizes transhumanist thought, primarily in relation to certain evolutionary ideas that, in their totality, exhibit a fundamental anthropological deficit: they speak of the evolutionary overcoming of human, but the limit of sensibility that attempts to imagine a future human being is only the mere negation of what human has been so far. In this way, the posthuman is not removed from the somewhat vague context of the technological “extension” of previous humanity. In this respect, the whole concept is grossly unaesthetic. The second part shows that Nietzsche’s rethinking of the overhuman was intertwined with other anthropological structures, for example, the idea of Mitfreude (‘shared joy’), which is supposed to creatively (in the manner of art) replace the morally misleading notion of compassion. The Übermensch therefore enabled Nietzsche to propose a different conception of intersubjectivity; one that would no longer be reduced to contempt for the human being. The third section traces the causes of the transhumanist failure in productive imagination. It is based on the hypothesis that this failure is driven by an unconscious preference for the figure of the comic book Superman. It postulates, through a Kantian conception of the sublime, that an adequate elaboration of the image of the posthuman cannot do without an affective component that would allow for Bejahung (‘affirmation’). Only the artificial will always appear, to some degree, as alien, and therefore will never transcend the limits of reactive adaptation. A living posthuman could only emerge if he offered anthropological techniques of the art of living. Therefore, transhumanism continuously raises anthropological questions, especially regarding the problem of the extent to which the artificiality of art can be identified with technology. Without proper answers, it will not achieve the complexity of Nietzsche’s overhuman, and will always only dilute him into technological supplements. The posthuman will come into being when he is conceived as a grandiose work of art.

Motor adaptation and immediate retention to overground gait-slip perturbation training in people with chronic stroke: an experimental trial with a comparison group.

Perturbation-based training has shown to be effective in reducing fall-risk in people with chronic stroke (PwCS). However, most evidence comes from treadmill-based stance studies, with a lack of research focusing on training overground perturbed walking and exploring the relative contributions of the paretic and non-paretic limbs. This study thus examined whether PwCS could acquire motor adaptation and demonstrate immediate retention of fall-resisting skills following bilateral overground gait-slip perturbation training. 65 PwCS were randomly assigned to either (i) a training group, that received blocks of eight non-paretic (NP-S1 to NP-S8) and paretic (P-S1 to P-S8) overground slips during walking followed by a mixed block (seven non-paretic and paretic slips each interspersed with unperturbed walking trials) (NP-S9/P-S9 to NP-S15/P-S15) or (ii) a control group, that received a single non-paretic and paretic slip in random order. The assessor and training personnel were not blinded. Immediate retention was tested for the training group after a 30-minute rest break. Primary outcomes included laboratory-induced slip outcomes (falls and balance loss) and center of mass (CoM) state stability. Secondary outcomes to understand kinematic contributors to stability included recovery strategies, limb kinematics, slipping kinematics, and recovery stride length. PwCS within the training group showed reduced falls (p < 0.01) and improved post-slip stability (p < 0.01) from the first trial to the last trial of both paretic and non-paretic slip blocks (S1 vs. S8). During the mixed block training, there was no further improvement in stability and slipping kinematics (S9 vs. S15) (p > 0.01). On comparing the first and last training trial (S1 vs. S15), post-slip stability improved on both non-paretic and paretic slips, however, pre-slip stability improved only on the non-paretic slip (p < 0.01). On the retention trials, the training group had fewer falls and greater post-slip stability than the control group on both non-paretic and paretic slips (p < 0.01). Post-slip stability on the paretic slip was lower than that on the non-paretic slip for both groups on retention trials (p < 0.01). PwCS can reduce laboratory-induced slip falls and backward balance loss outcomes by adapting their post-slip CoM state stability after bilateral overground gait-slip perturbation training. Such reactive adaptations were better acquired and retained post-training in PwCS especially on the non-paretic slips than paretic slips, suggesting a need for higher dosage for paretic slips. NCT03205527.

Interpretable Machine Learning Reveals Potential to Overcome Reactive Flood Adaptation in the Continental US

AbstractFloods cause average annual losses of more than US$30 billion in the US and are estimated to significantly increase due to global change. Flood resilience, which currently differs strongly between socio‐economic groups, needs to be substantially improved by proactive adaptive measures, such as timely purchase of flood insurance. Yet, knowledge about the state and uptake of private adaptation and its drivers is so far scarce and fragmented. Based on interpretable machine learning and large insurance and socio‐economic open data sets covering the whole continental US we reveal that flood insurance purchase is characterized by reactive behavior after severe flood events. However, we observe that the Community Rating System helps overcome this behavior by effectively fostering proactive insurance purchase, irrespective of socio‐economic backgrounds in the communities. Thus, we recommend developing additional targeted measures to help overcome existing inequalities, for example, by providing special incentives to the most vulnerable and exposed communities.

Indigenous knowledge in climate change adaptation: Choice of indigenous adaptation responses to coastal erosion in Ghanaian communities

Coastal erosion as a threat to Ghana’s coastline is being exacerbated by natural and anthropogenic processes. Adaptation to coastal erosion helps in managing the impacts and the levels of destruction to livelihoods, properties and investments along the coastline. Government intervention in adaptation to coastal erosion has always focused on the development of coastal sea defences without the integration of Indigenous knowledge and initiatives of coastal dwellers. This paper contributes to this gap by examining the Indigenous adaptation responses to coastal erosion in selected coastal communities of Ghana, factors influencing the choice of adaptation responses and the extent to which these Indigenous adaptation responses are addressing coastal erosion. Findings from the explorative qualitative study revealed that coastal dwellers are engaged in different forms of planned and reactive adaptation responses to coastal erosion. It was also found out that most of the Indigenous adaptation responses to coastal erosion were unsustainable in addressing coastal erosion and the choice of Indigenous adaptation response to coastal erosion was shaped by socio-economic and ecological factors or perception. Maladaptation responses by coastal dwellers were contributing to the phenomenon of coastal erosion. Coastal dwellers have survived the impacts of coastal erosion in the absence of support from central and local governments and their unsustainable adaptation responses have become a cyclical ritual over a period of time. The paper contributes to the debates on adaptation to climate change and the consideration of Indigenous knowledge into climate change mitigation and adaptation strategies in coastal zone planning and management.

Proactive Adaptation Responses by Vulnerable Communities to Climate Change Impacts

We explored the proactive responses of local communities against locally experienced climate change impacts and anticipated threats. This study interviewed 124 rural households from three community forestry user groups representing three ecological regions of Nepal using a semi-structured questionnaire. The study used eight criteria to distinguish the proactive nature of adaptation. Both qualitative and quantitative methods were used to analyze data, including the use of a chi-square (χ2) test to determine the proactive measures and their association with livelihood options and the ordered logistic regression model to explain determining factors of choosing proactive adaptations. The results indicate that 83.9% of households adapted both proactive and reactive measures, while 10.5% applied solely reactive adaptation and 5.6% were earmarked only for proactive adaptation measures. Over 50 different proactive adaptation measures were implemented by the households. The measures were significantly associated with agricultural diversification, cash crop cultivation, livestock raising, small-scale enterprise development, and disaster control. Socio-economic and spatial factors such as a household’s wellbeing, land holding size, geographical location, livelihood options, and the number of adaptation measures implemented by households were found to be decisive factors in choosing proactive adaptation. The study concludes that local people in Nepal are not only aware of escalating climate risks but also engage their cognition and knowledge proactively to adapt locally. The results suggest that even small proactive initiatives by households can offer multiple benefits against climate risks as an architect of individuals. Therefore, adopting a trans-disciplinary approach and nurturing local proactive actions in strategic connectivity between environmental, political, and societal functions is pivotal, which primarily takes a step to drive expediently successful climate change policy and strategy implementation. The findings of this study offer valuable insights into policy and strategy planning for the unsolicited consequences of climate change and highlight the importance of understanding the perspective of local communities in adaptation planning and implementation.

Scenario Approach to Adaptation of Forest Ecosystems in the Russian Federation under Climate Change

Correlations between the quantitative values of abiotic factors associated with climate change and the criteria for the vulnerability of forest ecosystems for 24 model subjects of the Russian Federation have been established. A high degree of closeness of the relationship between climatic parameters and forest fires was revealed for forest ecosystems in the Center and the South of Russia, as well as Eastern Siberia. Using a matrix model for positioning the adaptive potential of a single regional forest ecosystem, clusters with the most vulnerable to climate change groups of regional forest ecosystems were identified. The application of the developed methodology for the analysis of regional complexes of forest ecosystems made it possible to establish that there is a shift in the indicators of their adaptive potential to the lower limit of their sustainability (Arkhangelsk, Leningrad, Voronezh, Tyumen, Irkutsk oblasts, Khanty-Mansi Autonomous Okrug, Khabarovsk krai). Based on the study and clustering of model federal subjects according to the level of adaptive potential, differentiation of management decisions and forestry measures for enlarged territorial objects, including various federal subjects, was carried out in order to maintain and strengthen the adaptive potential of forest ecosystems. Measures for adapting forest ecosystems to climate change can be implemented in the context of three scenarios: forest management with elements of reactive adaptation to climate change for stable forest ecosystems, implementation of the forestry adaptation strategy to climate change for unstable forest ecosystems and restoration and maintenance of ecosystem functions of forests for degrading forest ecosystems.

Fear of falling is associated with gait parameters during obstacle avoidance with different physical characteristics in older adults

BACKGROUND: Fear of falling (FOF) is related to worse locomotor performance, is a predictor of decline in functionality, and predisposes falls in older adults. It is necessary to investigate how FOF influences locomotor parameters during walking and in obstacle avoidance in older adults. AIM: To investigate the relationship between FOF and the locomotor variables during walking through and obstacle avoidance with different physical characteristics. METHOD: 22 older adults participated in this study and were invited to perform three tasks: 1) Walking Through; 2) Walking with a solid obstacle and 3) Walking with a fragile obstacle. RESULTS: Correlations were found between FOF and following variables: 1) Walking Through: step velocity (r=-0.640, p=0.003), width (r=0.641, p=0.003), double support time (r=0.523, p=0.022); 2) Solid obstacle: step velocity (r=-0.666, p=0.002), length (r=-0.758, p&lt;0.001), foot-obstacle horizontal distance (r=-0.479, p=0.038), right stride velocity (r=-0.534, p=0.019), length (r=-0.522, p=0.022), left stride velocity (r=-0.551, p=0.014), left stride duration (r=0.561, p=0.012); 3) Fragilid obstacle: step velocity (r=-0.629, p=0.004), length (r=-0.556, p=0.014), foot-obstacle distance (r=-0.540, p=0.017), obstacle-foot distance (r=-0.492, p=0.032), right stride velocity (r=-0.583, p=0.009), length (r=-0.498, p=0.030), left stride velocity (r=-0.574, p=0.010), length (r=-0.462, p=0.047), width (r=-0.514, p=0.024), right stride duration (r=0.479, p=0.038), left stride duration (r=0.646, p=0.003). CONCLUSION: The characteristics of the obstacle did not influence the older adults FOF during walking through and obstacle avoidance. Although they adopt predictive and reactive compensatory adaptations in an attempt to make the task safer, these adaptations actually make the task more dangerous and increase the risk of stumbling and falling.

Advanced myocardial deformation echocardiography for the athlete's heart evaluation: Functional and mechanistic analysis

Echocardiographic assessment of the athlete's heart remains challenging because of a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of left ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy. This study sought to identify echocardiographic phenotype of endurance athletes using 2D speckle tracking imaging with a multi-layer approach and to define predictive factors of subtle LV systolic dysfunction. Healthy male athletes who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020 were included. Clinical and echocardiographic data were compared with healthy men from the STANISLAS cohort. Subtle LV dysfunction was defined as a GLS < 17.5%. A total of 191 athletes and 161 control subjects were studied. Athletes demonstrated lower LVEF (57.9% vs. 62.6%; P < 0.01) and lower GLS (17.8% vs. 21.1%; P < 0.01). No significant differences were found between athletes with and without subtle LV dysfunction regarding clinical characteristics, structural echocardiographic features, and exercise capacity. Athletes with subtle LV dysfunction exhibited a lower endocardial GLS (18.8% vs. 22.7%; P < 0.02), a lower epicardial GLS (14.0% vs. 16.6%; P < 0.01) and a greater endocardial/epicardial GLS ratio (1.36 vs. 1.32; P < 0.01). No significant difference was found regarding mechanical dispersion (P = 0.46). The endurance athlete's heart is characterized by a specific myocardial deformation pattern with a greater endocardial/epicardial GLS ratio. Subtle LV dysfunction seems mainly driven by a decreased epicardial GLS and not related to exercise capacity, structural remodelling or mechanical dispersion (Fig. 1).

THE ESSENCE AND EVOLUTION OF STRATEGIC BUSINESS MANAGEMENT

The article examines the theoretical foundations of strategic enterprise management, the evolution of strategic management, the essence, critical approaches, and principles of strategic enterprise management. It is noted that the term «strategy» was first used by A. Chandler in 1962 and the term «strategic management» by I. Ansoff in 1965. The evolution of strategic planning was studied. I. Ansoff identified four stages of strategic management development, in particular: Stage I – reactive (Chandlerian) adaptation, Stage II – strategic planning, Stage III – management of strategic opportunities, and Stage IV – management of problems on a real-time scale. Namely: Stage I – budgeting and control, Stage II – long-term planning, Stage III – strategic planning, and Stage IV – strategic market management. The strategies of the school were analyzed, which were analyzed in detail in the work of H. Mintzberg, B. Ahlstrand, and J. Lempel. These schools can be grouped according to the nature of research into three groups in the following group: Group I – includes three schools: design, planning, and positioning; II group – consists of six schools: entrepreneurial, cognitive (cognitive), school of education, power (force), culture and external environment; III group – includes one school: configurations. The article analyzes the existing definitions of the essence of the concept of «strategic management», which means the processes of making managerial decisions or sets of decisions; management process; action model; management of the organization based on human potential, etc. The author’s definition of strategic management has been formulated, which should be understood as the specific processes of making and implementing management decisions regarding the formation and implementation of a strategy with the targeted achievement of established goals, which are based on an objective assessment of the external and internal conditions of the enterprise’s functioning.

Climate change adaptation responses among riparian settlements: A case study from Bangladesh.

As transition areas between aquatic ecosystems and the adjacent terrestrial ones, riparian regions are highly exposed to coastal climate hazards. This article describes how climate change and extreme weather impact vulnerable riparian communities and settlements. The analysis is done by reviewing past research and empirical case studies from riparian rural communities of the impact zone of the Sundarbans in Bangladesh, the world's most extensive mangrove forest. The article discusses the climate-related impacts on households through a Severity Index of Vulnerability and assesses the adaptation responses they may pursue. The principal climate-related vulnerabilities and impacts due to increases in temperature, storm surges, sea flooding, and sea-level rise are seawater intrusion and riverbank erosion. Many households have adopted several autonomous reactive adaptation strategies rather than planned ones, to cope with these impacts. However, government organisations and NGOs provide less than optimal technical and financial support to households for planned and anticipatory adaptive responses. The main barriers to adaptation were the high cost of improved crop varieties, inadequate agricultural extension services, and a lack of knowledge on effective climate adaptation. The restoration of the mangrove ecosystem may increase its resilience and, among other things, make local communities less exposed. The article also presents some adaptation measures proper to reduce the climate-related vulnerability of riparian settlements.

Turning digital technology to immersive marketing strategy: a strategic perspective on flexibility, agility and adaptability for businesses

PurposeThe purpose of this study is to conduct a systematic literature review of the adoption of immersive marketing technology (IMT) in terms of strategic planning of its adoption, resource requirements and its implications and challenges.Design/methodology/approachThis study categorizes and contextualizes qualitative approaches to evaluate the literature, with Scopus databases serving as the primary source of 90 selected articles in the areas of information technology, business and marketing strands. Theme analysis was carried out using thematic techniques and grounded approach principles to facilitate thematic coding and generate theme analysis.FindingsThe analysis was supported by the three concepts of business flexibility, agility and adaptability, which were drawn as a strategy for IMT adoption. The findings presented three main themes: proactive flexibility, responsive agility and reactive adaptability that enable business owner–managers to craft a strategy for IMT adoption.Originality/valueThe novel contribution of this study is the inclusion of key implications related to IMT as a starting point of the next level of innovative marketing for all academics, practitioners and business owner–managers.

Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy.

Upregulation of NADPH oxidases (NOXs) in cancer cells leads to chronic increase in intracellular reactive oxygen species (ROS) and adaptation to a high ROS level for cell survival and, thereby, low sensitivity to radiotherapy. To overcome resistance to radiotherapy, we have developed a bioactive and CD44 targeted hyaluronic acid nanoparticle encapsulated with an NOX inhibitor, GKT831 (HANP/GKT831). We found that HANP/GKT831 had stronger inhibitory effects on ROS generation and cell proliferation than that of GKT831 alone in cancer cells. Systemic delivery of HANP/GKT831 led to the targeted accumulation in breast cancer patient derived xenograft (PDX) tumors in nude mice. Importantly, the combination of systemic delivery of HANP/GKT831 with a low dose of local radiotherapy significantly enhanced tumor growth inhibition in breast cancer PDX models. Our results showed that HANP/GKT831 primed tumor cells to radiation-induced DNA damage and cell death by downregulation of DNA repair function and oncogenic signal pathways.