Molecules with pyranobenzophenone moiety are widely distributed in nature. They have a range of biological and pharmacological properties. Among these, clusiacitran A (1) with a citran nucleus was isolated as an optically inactive racemate along with clusiacitran B (2) from an extract of the fruits of Clusia multiflora (Figure 1). Recently, clusiacitran A (1) was also isolated from Gaucinia schombrugkiana Pierre, which was collected from Songkla area in southern Thailand along with clusiacitran B (2) and fluorinated clusiacitrans A (3) and B (4). This plant is used in the treatment of coughs and diabetes as well as for improving the menstrual blood quality. The crude hexane extract of the stems of this plant has also shown antimalarial activity with an EC50 value of 2.2 μg mL−1.4 Although the structures of these materials 1-4 have been determined by spectral and Xray analysis, there are no synthetic approaches to these compounds. Both vismiaphenone B (5) and isovismiaphenone B (6) with prenylated benzophenone moiety were isolated from the fruits of either Vismia decipiens or Clusia ellipticifolia. Although one synthetic approach to vismiaphenone B (5) and isovismiaphenone B (6) has been reported, this synthetic route is limited by its many reaction steps, harsh reaction conditions, and low yield involving many side reactions. Myrtiaphenone B (7) was isolated from both Garcinia myrtifolia and Garcinia pseudoguttifera. The biosynthetic approaches to myrtiaphenone B (7) have been described, but there are no reports on the synthesis of compound 7. Recently, we reported a new methodology for preparing citrans and cyclols with polycycles by ethylenediamine diacetate (EDDA)-catalyzed reactions of substituted trihydroxybenzenes to citral or trans,trans-farnesal. We also reported a new methodology for synthesizing benzopyrans via ethylenediamine diacetate (EDDA)-catalyzed reactions of resorcinols to α,β-unsaturated aldehydes. As a part of an ongoing study into the synthetic efficacy of these two methodologies, this study examined the synthesis of naturally occurring molecules with the pyranobenzophenone moiety. This paper reports an efficient and concise synthesis of clusiacitran A (1), vismiaphenone B (5), isovismiaphenone B (6), and myrtiaphenone B (7).