Abstract. Elimination of HBV can not be achieved without an effective antiviral immune response. One of the achievements in the field of immunology was the discovery of the interaction between resident macrophages - Kupffer cells (KC) and macrophages that are transformed from monocytes. Monocytes play crucial role in the innate and adaptive immune system, carry out phagocytosis, represent an antigen and produce cytokines. The timely response of mononuclear cells to HBV guarantees the development of the subsequent adequate immune processes. The aim of the work – studying the dynamics of indicators of phagocytic activity of monocytes in the blood of patients with HBV-infection. Material and methods. 108 patients with acute hepatitis B were under observation. 56 men and 52 women with an average 34±1,88 (from 18 to 69 years old). 17 healthy persons were included into a control group. In order to estimate phagocytic activity of neutrophils (PAN) phagocytic index of neutrophils (PIN) and phagocytic number of neutrophils (PNN) with incubation period of 30, 60 and 180 minutes have been detected. Results. Indicators of PIM in acute hepatitis B have been reduced by 1.1-3.2 times compared with the control group, perhaps due to a decrease in the number of phagocytic monocytes in the blood of patients with HBV infection. The intensity of reduction of phagocytic reactions of monocytes correlates with the degree of GV severity. It can be suggested that a significant reduction in the number of phagocytes in the peripheral blood of infected patients is connected with the redistribution of phenotypes of monocytes and the recruitment of these immune cells in the inflammatory site. The increase in the level of PNM up to 1.8 times among patients with acute hepatitis B may indicate significant compensatory possibilities of monocytes by increasing their absorption capacity. The use of symbiotic in the complex therapy for patients with acute hepatitis B increases the intensity of phagocytosis, which shows an increase in the number of monocytes entering phagocytosis, however, their level does not reach the values of the control group.