Human groundwater extraction alters hydrological processes, thereby influencing climate through land–atmosphere interactions. As socioeconomic development progresses, the escalating water demand exacerbates conflicts with limited water resources. Nevertheless, potential response of the global terrestrial water cycle to the combined impact of climate change and groundwater extraction under various future scenarios remain vaguely understood. Therefore, this study developed human water regulation projection schemes based on Shared Socio-economic Pathways (SSPs) and Representative Concentration Pathways (RCPs) integrated into a global climate model (CAS-FGOALS-g3). The results show that global water demand in 2100 under the SSP370 scenario almost doubled relative to 2010. The proportion of surface soil drying due to warming is 3%-11% more in the medium- and high-emission scenarios than in the low one. In major irrigated areas, excessive groundwater extraction changed the groundwater storage trend, especially in the Southern Plains of the United States, where the increasing groundwater storage trend became negative compared to scenarios without groundwater extraction. This study underscores the complex interplay between human water use and hydroclimate within an evolving environment, emphasizing the critical need for effective water resource management to mitigate future water stress.