Based on the Rayleigh-Ritz method, the transverse vibration characteristics of a rectangular plate with an arbitrarily shaped inner opening are investigated. A modified two-dimensional Fourier series was chosen as the trial function and springs of different stiffnesses were used to equate the arbitrary boundary conditions of the rectangular plate. The Lagrange generalization of the transverse vibration of the open rectangular plate is obtained by equating the open area to a special film with physical properties of zero according to the energy superposition principle. The variational method is used to derive the characteristic equations of the thin plate and to find the intrinsic frequencies and corresponding vibration modes. The convergence of this theoretical method is analyzed by means of an example, and the accuracy of the method is verified by comparison with the results of finite element software calculations, which provides a reference for practical engineering problems.