Rational Therapy Research Articles

Impact of Baduanjin exercise combined with rational emotive behavior therapy on sleep and mood in patients with poststroke depression: A randomized controlled trial.

Poststroke depression (PSD) is one of the most common stroke complications. It not only leads to a decline in patients' quality of life but also increases the mortality of patients. In this study, the method of combining Chinese traditional exercise Baduanjin with psychotherapy was used to intervene in patients with PSD and to explore the improvement of sleep, mood, and serum levels of brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT), and interleukin-6 (IL-6) levels in patients with PSD by combined treatment. A total of 100 patients with PSD who met the inclusion criteria were randomly assigned to Baduanjin group (n = 50) or control group (n = 50). The control group received treatment with escitalopram oxalate and rational emotive behavior therapy, while the experimental group received Baduanjin training in addition to the treatment given to the control group. Changes in sleep efficiency, sleep total time, sleep latency, arousal index, Hamilton Anxiety Rating Scale, Hamilton Depression Scale score, serum BDNF, 5-HT, IL-6 levels, and Modified Barthel Index were measured at baseline, 4 weeks and 8 weeks after intervention, and the results were compared between the 2 groups. Significantly improvements in the sleep efficiency, sleep total time, serum 5-HT, BDNF levels, and Modified Barthel Index score were detected at week 4 in the Baduanjin group than in the control group (P < .05). Additionally, the sleep latency, arousal index, Hamilton Anxiety Rating Scale, Hamilton Depression Scale scores and IL-6 levels in the Baduanjin group were lower than those in the control group (P < .05). After 8 weeks of treatment, the above indexes in the Baduanjin group were further improved compared with the control group (P < .05), and the above indexes of the 2 groups were significantly improved compared with the baseline (P < .001). Baduanjin exercise combined with rational emotive behavior therapy effectively improves the mood and sleep status of patients with PSD; It increases the serum levels of 5-HT and BDNF while reducing the level of serum proinflammatory factor IL-6; additionally, the intervention alleviates the degree of neurological impairment, upgrades the ability of daily living, and improves the quality of life.

Fundamentals of rational antibiotic therapy in outpatient pediatrics

Antibiotics are one of the most prescribed groups of drugs in outpatient pediatric practice. To date, there are still disagreements about the need for the use of antibiotics and the optimal dosage regimen for many infections that pediatricians face daily. The authors conducted a search for publications in the PubMed, Google Scholar and eLibrary by the following keywords: «pediatric,» «antibiotics,» «antibiotic resistance,» «outpatient pediatrics» in English, and «педиатрия,» «антибиотики,» «антибиотикорезистентность,» «амбулаторная педиатрия» in Russian. Recent studies show that uncomplicated childhood infectious diseases in vaccinated children can be treated with shorter courses of antibiotics. The rational use of antibiotics in outpatient pediatric practice is of great importance for reducing resistance to them. Since the first step in choosing treatment tactics is to establish the etiology of the disease, future research should focus more on identifying potential biomarkers and diagnostic tests that allow rapid diagnosis of the etiology of an infectious disease, as well as optimizing the dosage and duration of antibiotic therapy courses.

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years, but the limited efficiency of their infiltration into solid tumors makes it difficult to achieve desired antitumor effects when used alone. In this study, an oncolytic virus (rVSV-LCMVG) that is not prone to induce virus-neutralizing antibodies was designed and combined with adoptively transferred T cells. By transforming the immunosuppressive tumor microenvironment into an immunosensitive one, in B16 tumor-bearing mice, combination therapy showed superior antitumor effects than monotherapy. This occurred whether the OV was administered intratumorally or intravenously. Combination therapy significantly increased cytokine and chemokine levels within tumors and recruited CD8+ T cells to the TME to trigger antitumor immune responses. Pretreatment with adoptively transferred T cells and subsequent oncolytic virotherapy sensitizes refractory tumors by boosting T-cell recruitment, down-regulating the expression of PD-1, and restoring effector T-cell function. To offer a combination therapy with greater translational value, mRNA vaccines were introduced to induce tumor-specific T cells instead of adoptively transferred T cells. The combination of OVs and mRNA vaccine also displays a significant reduction in tumor burden and prolonged survival. This study proposed a rational combination therapy of OVs with adoptive T-cell transfer or mRNA vaccines encoding tumor-associated antigens, in terms of synergistic efficacy and mechanism.

The Organization of Irrational Beliefs in Academic Burnout

From the Rational-Emotive Behavior Therapy (REBT) perspective, irrational beliefs are posited as the primary catalysts for a myriad of problems, including academic burnout. This study aims to examine the theoretical model of irrational beliefs organization in academic burnout. The hypothesized model delineates the following pathways: (1) from demandingness (DEM) to academic burnout (BURN) via catastrophizing (CAT); (2) from demandingness (DEM) to academic burnout (BURN) via low frustration tolerance (LFT); and (3) from demandingness (DEM) to academic burnout (BURN) via self-depreciation (DEP). To achieve the aim, the study employed a causal relationship design. 424 subjects obtained by stratified random sampling participated in the study. The Indonesian version of the Attitude Belief Scale II and the School Burnout Inventory were used to collect data. Data analysis was carried out using path analysis with SPSS 16. The results show that the hypothesized model has received adequate empirical support after eliminating a path from LFT to BURN. In conclusion, two alternative paths of irrational beliefs contribute to academic burnout: (1) the path from DEM to BURN via CAT; and (2) the path from DEM to BURN via DEP. These results underscore demandingness as a primary irrational belief that affects academic burnout via two other secondary irrational beliefs: catastrophizing and self-depreciation. Conversely, low frustration tolerance does not emerge as a significant contributor to academic burnout within this framework.

Development and validation of risk prediction model for bacterial infections in acute liver failure patients.

Infections significantly increase mortality in acute liver failure (ALF) patients, and there are no risk prediction models for early diagnosis and treatment of infections in ALF patients. This study aims to develop a risk prediction model for bacterial infections in ALF patients to guide rational antibiotic therapy. The data of ALF patients admitted to the Second Hospital of Hebei Medical University in China from January 2017 to January 2022 were retrospectively analyzed for training and internal validation. Patients were selected according to the updated 2011 American Association for the Study of Liver Diseases position paper on ALF. Serological indicators and model scores were collected within 24 h of admission. New models were developed using the multivariate logistic regression analysis. An optimal model was selected by receiver operating characteristic (ROC) analysis, Hosmer-Lemeshow test, the calibration curve, the Brier score, the bootstrap resampling, and the decision curve analysis. A nomogram was plotted to visualize the results. A total of 125 ALF patients were evaluated and 79 were included in the training set. The neutrophil-to-lymphocyte ratio and sequential organ failure assessment (SOFA) were integrated into the new model as independent predictive factors. The new SOFA-based model outperformed other models with an area under the ROC curve of 0.799 [95% confidence interval (CI): 0.652-0.926], the superior calibration and predictive performance in internal validation. High-risk individuals with a nomogram score ≥26 are recommended for antibiotic therapy. The new SOFA-based model demonstrates high accuracy and clinical utility in guiding antibiotic therapy in ALF patients.

LAYANAN BIMBINGAN KARIR DALAM UPAYA MENGURANGI KECEMASAN SISWA SMA DALAM PEMILIHAN KARIR

This research aims to determine the results of services in an effort to reduce students' anxiety in choosing a career using the SLR (Systrmatic literature review) method. Literature sources were obtained from the crossref metadata database in the Indonesian Bebrahasa journal for 2016-2023. In this research there are several results from career guidance services in an effort to reduce students' anxiety in choosing a career, including; (1) career guidance services; (2) career anxiety; and (3) the role of guidance and counseling teachers. There are several strategies from guidance services that have provided positive results in the success of career guidance services, including; (1) career guidance services, (2) trait factors, (3) Rational Emotive Therapy (TRE), (4) cognitive information processing career counseling, and (5) Client Centered Therapy.

Reperfusion therapy for ischemic stroke without prior neuroimaging

Clinical guidelines and the order of providing care in acute cerebrovascular accidents (CVA) have been developed for standard clinical situations, primarily for patients admitted to medical institutions in an emergency state. However, there are clinical situations when a generally accepted order of therapeutic and diagnostic measures concerning patients with stroke is unjustified and, on the contrary, its implementation threatens life and health of a patient. These situations include ischemic strokes developing intraoperatively during such endovascular interventions as diagnostic cerebral and coronary angiography and transcutaneous neuro- and cardiovascular surgery. Ischemic cerebral events after diagnostic endovascular procedures are relatively rare complications, but their development can lead to unfavorable consequences. Thus, the rates of transient cerebral circulatory disorders after cerebral angiography, a stroke with a reversible neurological deficit, and an ischemic stroke with a persistent neurological deficit are 2.45 %, 0.3 %, and 1.0 % respectively, while total mortality due to acute cerebrovascular pathology is 0.14 %. The rate of cerebral stroke after coronary angiography and percutaneous coronary interventions is up to 0.4 %. Prevention of neurologic complications in diagnostic and surgical transcutaneous interventions is strongly dependant on their correct technique, rational perioperative antithrombotic therapy, and lesser duration of endovascular operations.

Effect of group rational emotive behaviour therapy on mathematics anxiety on secondary school students

Effect of group rational emotive behaviour therapy on mathematics anxiety on secondary school students

Is REBT Useful for Reducing Adolescents’ Career Decision Difficulties and Distress? A Randomized Trial

The present study examined the efficacy of a 6-session Rational Emotive Behavior Therapy (REBT) career intervention program for high school students in reducing career decision-making difficulties and emotional distress. Nine classes of 11th graders in two Romanian public high schools ( N = 233) were randomly assigned to a REBT career intervention and a Regular career course. The data were collected in three waves: before and after the interventions and at a 6-month follow-up. Career decision-making difficulties decreased in both intervention groups post-intervention and at the 6-month follow-up. Worry and irrational beliefs decreased more in the REBT group at the 6-month follow-up. Emotional distress and negative dysfunctional emotions decreased in the REBT group both post-intervention and at the 6-month follow-up, but they increased in the Regular group. The Discussion explores factors that may contribute to the decreased career decision-making difficulties in both groups and the benefits of the REBT career intervention.

A scoping review of the literature on interventions to reduce stress and burnout among teachers.

IntroductionExperience of chronic stress among professionals is a risk factor for poor mental and physical well-being. There is limited knowledge regarding the kinds of interventions, and outcomes achieved using different modalities to address stress and burnout among teachers.ObjectivesTo undertake a scoping review of recent literature to determine psychological interventions and reported outcomes related to stress and burnout among teachers.MethodsThe PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was followed. Relevant search terms were used to determine different interventions adopted to reduce teachers’ stress and burnout. Articles published between 2018 and 2022 were identified using five bibliographic databases. Relevant articles were extracted, reviewed, collated, and thematically analyzed, and findings s were summarized.Results Forty studies conducted in Asia, North America, Oceania, Europe, and Africa, met the inclusion criteria. Sixteen kinds of burnout and stress-reduction interventions were identified. The most popularly studied intervention were Mindfulness-Based Interventions alone or in combination with yoga or Cognitive Behavioural Therapy (CBT), followed by Rational Emotive Behavioral Therapy (REBT). Mindfulness-Based Interventions led to decreased overall Teacher Stress Inventory (TSI) and emotional exhaustion subscale scores. REBT, primarily used with special education teachers, especially in Africa, has also shown positive results. Other interventions reporting positive outcomes include Inquiry-Based Stress Reduction (IBSR), the Stress Management and Resiliency Training Program (SMART), Cyclic Meditation, Group Sandplay, Progressive Muscle Relaxation, Autogenic Training, Sport-Based Physical Activity, Emotional Intelligence Ability Models and Christian Prayer and Prayer-ReflectionImage:ConclusionsStress and burnout can have a negative impact on teachers and, very often, on the students they teach. Implementing suitable school-based interventions are necessary to improve teachers’ stress-coping ability, reduce the likelihood of burnout and improve general well-being. Policymakers, governments, school boards and administrators should prioritize the implementation of school-based awareness and intervention programs to mitigate teacher stress and burnout.Disclosure of InterestNone Declared

Pendekatan Rational Emotive Behavior Therapy dalam Konseling Kelompok

Every individuals, especially students, certainly has problems in their life. Various problems are also caused by various factors, one of which is problems related to the individual’s own thingking errors which result in irrational belief (illogical). This has been researched by the character Ellis the REBT (Rational Emotive Behavior Therapy) approach which that the consequences/impact of problems faced by individuals are due to their irrational beliefs which distrub the individual themselves. Therefore, counseling is needes to help with these problems, one of which is group counseling which utilizes group dynamics. The purpose of this writing is to learn together about group counseling using the REBT approach. The method used is a literature study which examine exisiting literature. So the result can be seen that you can use group counseling with the REBT approach to help overcome problems related to irrational belief that are changed to more rational (logical). Thus, it can be concluded that overcoming the problems of irrational belief becoming rational belief from the REBT approach can be done through group counseling by utilizing group dynamics to work together to overcome these problems Keywords: REBT; Group counseling

Study of the sensitivity of methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt; to antibiotics and bacteriophage preparations

Objective. To evaluate the sensitivity of methicillin-resistant Staphylococcus aureus strains to antibiotics and therapeutic and prophylactic preparations of bacteriophages. Materials and methods. The antibiotic sensitivity of strains of methicillin-resistant S.aureus was studied by the disco-diffusion method, the determination of the minimum inhibitory concentrations of vancomycin and linezolid by broth microdilution method, and ceftaroline by E-tests. The sensitivity of methicillin-resistant S.aureus to bacteriophage preparations was studied. Results. It has been established that linezolid and vancomycin are quite active drugs against methicillin-resistant S.aureus (MRSA), however, resistance to them begins to develop. MRSA resistance to fluoroquinolones and cefoxitin was the highest of all antibiotics tested; the results obtained with cefoxitin can be interpreted for other cephalosporins (except ceftaroline) and all penicillins. Only 67.9% of MRSA strains retained sensitivity to ceftaroline, but ceftaroline-resistant strains had low levels of minimal inhibitory concentration. The preparations of the bacteriophages “Sextaphage” and “Piobacteriophage Phagio” showed their lytic activity only in relation to 35.8% and 18.9% of MRSA isolates, respectively. Conclusion. Monitoring the development of antibiotic resistance in methicillin-resistant S.aureus is an important part of the strategy of rational antibiotic therapy for staphylococcal infections. Only taking into account the preliminary step-by-step determination of the phage sensitivity of the causative agent of the disease, bacteriophage preparations can be considered as a completely possible alternative to antibiotics for the treatment of purulent inflammatory diseases caused by MRSA.

The Effectiveness of "Kancani": An REBT-Based Web Application on Junior High Students' Subjective Well-Being

Abstract. The high prevalence of mental health issues among Indonesian adolescent students signifies persistently low levels of subjective well-being. Junior high school students tend to engage in negative thinking and experience a decline in positive feelings, contributing to mental health issues, as well as low life satisfaction. To address this, enhancing socio-emotional abilities such as emotion regulation, especially in dealing with irrational thoughts as the root of the problem, becomes crucial. This research aims to evaluate the effectiveness of the "Kancani" web app, which implements Rational-Emotive Behavior Therapy (REBT)-based interventions on the subjective well-being of junior high school adolescents. A quasi-experimental one-group pretest-posttest design was employed with 22 junior high school participants aged 12-15 who received the intervention for 2 weeks. The research instruments used were a 25-item Subjective Well-Being scale measuring positive affect (a = 0.861), negative affect (a = 0.861), and life satisfaction (a = 0.828). Data were tested using the paired samples t-test technique. Data were analyzed using paired samples t-test showed that the Kancani web app, with REBT-based interventions, effectively increased the subjective well-being of junior high school students, particularly in the aspects of positive affect and life satisfaction (p = 0.004 &lt; 0.05), although not significantly in reducing negative affect (p = 0.104 &gt; 0.05). Nevertheless, the improvement in the subjective well-being of students after the intervention is still reflected in the descriptive analysis of the mean differences, indicating an increase in positive affect and life satisfaction, as well as a decrease in negative affect.

Fixed combination of non-steroidal anti-inflammatory drug and muscle relaxant as the basis for rational therapy of pain syndromes: A review

The incidence of pain in the lower back ranges from 10% to 25% of all cases of algia. 37–64.7% of the world's population have muscle spasms of varying severity during an exacerbation of pain. The problem of pain therapy is far from being solved. Achieving greater or equal pain relief can be achieved through combination drug therapy, where drugs have different mechanisms of action or combine pharmacokinetic properties to produce a synergistic effect. Fixed combinations of non-steroidal anti-inflammatory drugs and a muscle relaxant (chlorzoxazone 500 mg and ibuprofen 400 mg) are the basis of rational therapy, allowing them to achieve a number of clinical and pharmacological advantages.

Death Anxiety in the COVID-19 Pandemic: Testing REBT Models of Psychopathology and Psychological Health of Death Anxiety.

Objective: This paper aimed to examine the validity of the death anxiety psychopathological and psychological health models of Rational-Emotive Behavior Therapy (REBT). We investigated whether irrational and rational beliefs were associated with death anxiety and if there are possible significant positive correlations between death anxiety and depression, anxiety, and stress. Method: A sample of 200 individuals completed online self-report measures and Structural Equation Modelling (SEM) was chosen to assess the validity of the REBT psychopathological model and the REBT psychological health model. Pearson's correlation analysis was utilized to confirm the relationships between death anxiety and depression, anxiety, and stress. Results: REBT's model of psychopathology provide acceptable fit of the data. Results suggest that LFT beliefs mediate the relationship between DEM and death anxiety, while no mediation effect was found for the psychological health model. Additionally, high correlations were obtained between death anxiety and depression, anxiety, and stress. Conclusions: Results provided empirical support for the REBT models of death anxiety and underline the critical importance of cognitive constructs in the prediction of death anxiety. Results are discussed within the framework of REBT theory, which can serve as a foundation for new research directions regarding death anxiety, both theoretical and clinical.

I Will Meet You There, and We Can Be Anxious Together: The Lived Experiences of College Students with Anxiety Disorders

&lt;i&gt;The purpose of this qualitative transcendental phenomenological study was to understand the essence of the shared lived experiences of undergraduate college students with anxiety disorders at two universities in the Southeastern United States. Ellis’s cognitive theory, rational emotive behavior therapy, guided the study which took place at a mid-sized, public nonsectarian university and a small, private liberal arts college. The central research question elicited rich data regarding the shared lived experiences of the study participants. The four research sub-questions address participants’ perceptions regarding the impact of their disorders on their lifestyles and academic performance. A purposeful criterion sample was used to select the participants who completed a questionnaire, open-ended individual interviews, a single focus group interview, and participant journals. Phenomenological reduction was used to create a composite integration of meaning and the essence of the lived experience of the participants. Data results identified five themes: (a) social fears, (b) stressor issues, (c) generational issues, (d) academic performance barriers, and (e) institutional education and accommodation preferences.&lt;/i&gt;

Erratum for the Research Article "Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers," by C. Sun et al.

Erratum for the Research Article "Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers," by C. Sun et al.

MICROBIOTA ANALYSIS OF PAROTID GLAND SECRETIONS IN CHILDREN WITH EXACERBATION OF CHRONIC PARANCHYMAL MUMPS

In the structure of chronic nosological forms of sialoadenitis, chronic parenchymal mumps accounts for 80%, and is characterized by a recurrent course. To date, the issue of its etiologic origin remains controversial, and data on the pathogenetic influence of external and internal factors on the occurrence of another exacerbation are constantly being supplemented. In particular, the role of the duktogenic pathway of microbial penetration into the glandular duct system is often discussed. Objective: to study the microbiota of parotid secretion in children with exacerbation of chronic parenchymal mumps.&#x0D; Materials and methods. To investigate the qualitative characteristics and quantitative parameters of microbial flora in the secretion of the parotid salivary glands during disease exacerbation, we enrolled 41 children aged 3 to 15 years, with 18 cases classified as having an active course and 23 as inactive. The study was conducted following the guidelines outlined by CLSI, EUCAST, and relevant State Regulatory Orders and Supplements.&#x0D; Results. It was found that at the time of the exacerbation in the active course, plasma-coagulating staphylococci and hemolytic streptococci strains in the amount of 106-107 CFU/ml prevailed in the glandular secretion, which were mainly sensitive to beta-lactam antibiotics of all generations, macroliths, natural and semi-synthetic aminoglycosides. An association of microorganisms was isolated from the secretion of 4 glands (11.1%), consisting of coccal cultures, gram-negative bacilli, and yeast cells. In the inactive course, Staphylococcus aureus and hemolytic streptococci slightly prevailed in the glandular secretion, but the proportion of non-pathogenic coccal microorganisms increased, and their number was 105-106 CFU/ml. Their antibiotic patterns did not differ significantly from those in the active course. The isolation of microbial associations concerned 8 glands, which amounted to 17.5%.&#x0D; Conclusion. Taking into account the presence of microorganisms in the secretion from the parotid glands in the acute exacerbation of chronic parenchymal mumps with pathogenicity factors and an increase in their number depending on the activity of the disease, it is necessary to take a differentiated approach to rational antibiotic therapy by instillation of antimicrobial drugs into the ductal system.

Effectiveness of Rational Emotive Behavior Therapy (REBT) on Self-Control and Impulsivity in Male Prisoners.

Objective: Consequences of imprisonment include negative psychological effects, social stigma, and challenges for reintegrating into society. In this regard, this study aimed to investigate the effectiveness of Rational Emotive Behavior Therapy (REBT) on self-control and impulsivity among male prisoners. Method : A randomized controlled clinical trial (RCT) utilizing a design the included pretest, post-test, and follow-up assessment as well as a waiting-list control group was conducted. A total of 30 male prisoners were selected using convenience sampling and randomly assigned to experimental and waiting list control groups (the intervention group (n = 15) and the control group (n = 15)). The participants in the experimental group underwent the 12-session REBT intervention over a period of six weeks. (For six weeks). All participants responded to the Self- Control Scale (SCS) and Dysfunctional Impulsivity Questionnaire (DFIQ) as dependent variables at three time points (pretest, post-test, and one-month follow-up). A repeated measures analysis of variance was used to analyze the data. Results: The results revealed that after the implementation of the REBT intervention, the mean scores of self-control increased (P < 0.05), while the mean scores of impulsivity diminished significantly (P < 0.05). Furthermore, these changes remained relatively stable during the follow-up period (P < 0.05). Conclusion: Based on the findings of this study, it can be inferred that REBT intervention plays a significant role in diminishing self-control deficits and mitigating impulsivity among incarcerated individuals. These results present promising implications for the utilization of REBT in lowering recidivism rates.

Preliminary efficacy of a transdiagnostic parent-led internet-delivered intervention for children with anxiety and depressive symptoms: a pilot randomized controlled trial

BackgroundThere is extensive research indicating that transdiagnostic interventions are effective for adults and children with anxiety and depressive disorders; however, limited research has been conducted on the efficacy of such programs targeting parents of children with anxiety and depressive symptoms delivered via the Internet. This study aims to investigate the preliminary efficacy of a transdiagnostic Internet-delivered intervention for Romanian parents of children with elevated anxiety and depressive symptoms.MethodsWe conducted a single-blinded pilot randomized controlled trial. Forty-two parents of children with anxiety and depressive symptoms (Mage = 39.79, 78.6% women) from Romania were randomly assigned to one of the two groups, to ParentKIT, an Internet-delivered intervention based on Rational Emotive and Behavioral Therapy (n = 21), or to a delayed treatment condition (waitlist group) (n = 21). ParentKIT consisted of a brief transdiagnostic intervention delivered through nine modules with therapist guidance.ResultsA significant Group by Time effect was found for child emotional problems as reported by parents (Cohen’s d = − 0.85) and for parental self-efficacy (Cohen’s d = 0.71).ConclusionA transdiagnostic Internet-delivered intervention addressed to parents of children with elevated anxiety and depressive symptoms is a promising approach. Future research should include blind assessments as well as multiple outcome assessors and investigate the long-term efficacy of the intervention.Trial registrationNCT05341297.