In this paper, we propose an ambiguousness-aware state evolution (AASE) method which represents the uncertainty of the input sequence and evolves the subsequent skeletons to generate a reasonable full-length sequence for action prediction. Unlike most existing methods that enforce partial sequences with the labels of full-length videos and ignore the semantic information of the subsequent action, we develop an evolution method by predicting the instructional actions and generating the reasonable candidate subsequent actions, so that the ambiguity of the full sequence’s label supervising for the partial actions can be effectively alleviated. Our method generates the rational subsequent actions under the instructional action class to complement the partially observed action sequence. We design two criteria for a rational generation: 1) the instruction of subsequent action keeps the semantic consistency with the observed sequence; 2) the generation sequence is satisfied with the distribution of the sequence of real data. Moreover, we design an uncertainty module to decide the instructional action class for the generation network. AASE predicts instructional actions with uncertainty learning and evolves different instructional actions by generating the subsequent skeletons, which find the most probable action to represent the partially observed action by learning the way of perceiving the tendency of the ongoing action. We conduct experiments on seven widely used action datasets: NTU-60, NTU-120, UCF101, UT-Interaction, BIT, PKU-MMD and HMDB51, and our experimental results clearly demonstrate that our method achieves very competitive performance with state-of-the-art.