Monomer Ratio Research Articles

Computational Investigation of the Monomer Ratio and Solvent Environment for the Complex Formed between Sulfamethoxazole and Functional Monomer Methacrylic Acid.

In this study, the molecularly imprinted polymers (MIPs) that will be formed by the sulfamethoxazole (SMX) molecule and methacrylic acid (MAA) molecule were examined theoretically. The most stable interaction region between the two molecules was determined in solvent environments (ethanol, acetonitrile, and dimethylsulfoxide), and monomer ratios (SMX/MAA; 1:1, 1:2, and 1:3) were examined to form the most stable geometry. The number and length of the hydrogen bonds formed between the template molecule and the functional monomer and the interaction between the atoms were determined. Geometry optimizations of the molecules were calculated by the DFT method at the M06-2X/ccpVTZ level, and single-point energy calculations were carried out at the B2PLYP-D3/ccpVDZ level. In addition to the theoretical studies, the experimental Fourier-transform infrared spectroscopy (FTIR) spectrum of the complex formed between SMX and MAA was compared with the theoretical FTIR spectrum. As a result of the studies, the monomer ratio and solvent environment in which the stable complex was formed were determined in the MIP studies carried out with the SMX template molecule and MAA monomer. The most stable template molecule–monomer ratio of the complex between SMX and MAA was determined to be 1:3, and the solvent medium in which the most stable geometry was formed was acetonitrile.

Molecularly Imprinting Microfiltration Membranes Able to Absorb Diethyl Phthalate from Water.

In this study, polypropylene porous membranes with an average pore size of 1.25 µm were modified by barrier discharge plasma. Next, molecularly imprinted layers with an imprint of diethyl phthalate (DEP) ware grafted of their surface. In order to optimize the composition of the modifying mixture various solvents, the ratios of functional monomers and the cross-linking monomer as well as various amounts of phthalate were verified. It was shown that the most effective membranes were obtained during polymerization in n-octane with the participation of functional monomers in the ratio 3:7 and the amount of phthalate 7 wt.%. The membranes were tested in the filtration process as well as static and dynamic sorption. In all of these processes, the imprinted membranes showed better properties than those without the imprint. The diethyl phthalate retention coefficient was 36.12% for membranes with a grafting yield of 1.916 mg/cm2. On the other hand, DEP static sorption for the imprinted membranes was 3.87 µmol/g higher than for non-imprinted membranes. Also, in the process of dynamic sorption higher values were observed for membranes with the imprint (DSMIM, 4.12 µmol/g; DSNIM, 1.18 µmol/g). The membranes were also tested under real conditions. In the process of filtration of tap water contaminated with phthalate, the presence of imprints in the membrane structure resulted in more than three times higher sorption values (3.09 µmol/g) than in the case of non-imprinted membranes (1.12 µmol/g).

Defining the Collapse Point in Colloidal Unimolecular Polymer (CUP) Formation.

Colloidal unimolecular polymer (CUP) particles were made using polymers with different ratios of hydrophobic and hydrophilic monomers via a self-organization process known as water reduction. The water-reduction process and the collapse of the polymer chain to form a CUP were tracked using viscosity measurements as a function of composition. A vibration viscometer, which allowed for viscosity measurement as the water was being added during the water-reduction process, was utilized. The protocol was optimized and tested for factors such as temperature control, loss of material, measurement stability while stirring, and changes in the solution volume with the addition of water. The resulting viscosity curve provided the composition of Tetrahydrofuran (THF)/water mixture that triggers the collapse of a polymer chain into a particle. Hansen as well as dielectric parameters were related to the polymer composition and percentage v/v of THF/water mixture at the collapse point. It was observed that the collapse of the polymer chain occurred when the water/THF composition was at a water volume of between 53.8 to 59.3% in the solvent mixture.

Characterization of proton T2 relaxation time of bovine lactoferrin powder before and after high-temperature storage

Proton T2 relaxation is a useful parameter for investigating the motion of and interaction between dried proteins and water molecules. This study aimed to investigate the relationship of proton T2 relaxation with aggregation and water hydration or dehydration in five bovine lactoferrin powders (LFs) before and after storage at 40 °C or 50 °C. Using time-domain nuclear magnetic resonance (TD-NMR), we detected T2short and T2long with different relaxation times. The two fractions and their average T2 relaxation time (T2) were used for analysis. Average T2 was positively correlated with the pre-storage water content. For the 40°C-storage test, T2 increased in all LFs; this increase can be explained by the monomer loss rate and change in water content. Conversely, for the 50°C-storage test, the change in T2 was correlated with the change in water content. Furthermore, the tendency for change in T2 showed variation with the monomer ratio and water content before storage. Thus, this study provides a novel insight that the factors contributing to the change in T2 during storage vary with storage temperature. In addition, we suggested that the T2 relaxation time was not sufficient as a predictor of susceptibility to aggregation.

Effective production of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) by engineered Halomonas bluephagenesis grown on glucose and 1,4-Butanediol

Halomonas bluephagenesis has been engineered to produce flexible copolymers P34HB or poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose and petrol-chemical precursor, γ-butyrolactone. Herein, gene cluster aldD-dhaT was constructed in recombinant H. bluephagenesis for catalyzing 1,4-butanediol (BDO) into 4-hydroxybutyrate, which could grow to 86 g L−1 dry cell mass (DCM) containing 77 wt% P(3HB-co-14 mol% 4HB) in 7-L bioreactor fed with glucose and bio-based BDO. Furthermore, 4HB monomer ratio could be increased to 16 mol% by engineered H. bluephagenesis TDH4-WZY254 with defected outer-membrane. Upon deletion of 4HB degradation pathway, followed by aldD-dhaT integration, the resulted H. bluephagenesis TDB141ΔAC was grown to 95 g L−1 DCM containing 79 wt% P(3HB-co-14 mol% 4HB) with a BDO conversion efficiency of 86% under fed-batch fermentation. Notably, 4HB molar ratio can be significantly improved to 21 mol% with negligible effects on cell growth and P34HB synthesis by adding 50% more BDO. This study successfully demonstrated a fully bio-based P34HB effectively produced by H. bluephagenesis.

Zwitterionic Amino Acid-Derived Polyacrylates as Smart Materials Exhibiting Cellular Specificity and Therapeutic Activity.

The synthesis of new amino acid-containing, cell-specific, therapeutically active polymers is presented. Amino acids served as starting material for the preparation of tailored polymers with different amino acids in the side chain. The reversible addition-fragmentation chain-transfer (RAFT) polymerization of acrylate monomers yielded polymers of narrow size distribution (Đ ≤ 1.3). In particular, glutamate (Glu)-functionalized, zwitterionic polymers revealed a high degree of cytocompatibility and cellular specificity, i.e., showing association to different cancer cell lines, but not with nontumor fibroblasts. Energy-dependent uptake mechanisms were confirmed by means of temperature-dependent cellular uptake experiments as well as localization of the polymers in cellular lysosomes determined by confocal laser scanning microscopy (CLSM). The amino acid receptor antagonist O-benzyl-l-serine (BzlSer) was chosen as an active ingredient for the design of therapeutic copolymers. RAFT copolymerization of Glu acrylate and BzlSer acrylate resulted in tailored macromolecules with distinct monomer ratios. The targeted, cytotoxic activity of copolymers was demonstrated by means of multiday in vitro cell viability assays. To this end, polymers with 25 mol % BzlSer content showed cytotoxicity against cancer cells, while leaving fibroblasts unaffected over a period of 3 days. Our results emphasize the importance of biologically derived materials to be included in synthetic polymers and the potential of zwitterionic, amino acid-derived materials for cellular targeting. Furthermore, it highlights that the fine balance between cellular specificity and unspecific cytotoxicity can be tailored by monomer ratios within a copolymer.

Tuning PEDOT:PSS low-impedance thin films with high charge injection for microelectrodes applications

The use of conductive polymers as thin films has become increasingly popular for a vast array of applications, such as biomedical in the form of microelectrodes, energy harvesting, thermal and electrical solutions. In this work, we studied the effects of different concentrations ratios of monomer 3,4-ethylenedioxythiophene (EDOT) to poly(4-styrenesulfonate) (PSS) and two distinct modes of electrochemical deposition (Potentiodynamic and Potentiostatic) to polymerize and deposit PEDOT:PSS (Poly-(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)). The produced thin films were morphologically and electrochemically characterised. The 1:5 ratio of EDOT to PSS from the Potentiostatic mode showed the highest charge storage capacity, better phase response which translated into larger charge injection capabilities without deformation of the original current input and a lower impedance. The comparison with a gold (Au) thin film highlights both the increased capacity to store charge and deploy it safely, within the water catalysis window. Furthermore, the impedance magnitude for the PEDOT:PSS sample was vastly reduced, with the impedance phase revealing an ohmic behaviour for the PEDOT:PSS sample contrasting with a capacitive behaviour for the Au sample. These results demonstrate that PEDOT:PSS is highly promising for 2D and 3D microelectrode applications and, most importantly, show the advantage of tuning the polymerization of PEDOT:PSS instead of using pre-made solutions in conjunction with a facile method of electrodeposition.

Synthesis of Poly(Hexamethylene Succinate-Co-Ethylene Succinate) Copolymers With Different Physical Properties and Enzymatic Hydrolyzability by Regulating the Ratio of Monomer.

Poly(hexylene succinate) (PHS), poly(ethylene succinate) (PES), and their random copolyesters, poly(hexylene succinate-co-ethylene succinate) ((P(HS-co-ES)), were synthesized by melting polycondensation. Simply varying the ratios of HS/ES afforded control over the copolymer crystallinity, thermal and mechanical properties, wettability, and enzymatic hydrolyzability as shown by X-ray diffraction (XRD), differential scanning calorimetry (DSC), tensile tests, and water contact angle (WCA) measurements. The enzymatic hydrolysis rates of all prepared copolyesters were higher than those of the corresponding homopolyesters. The hydrolysis rates were affected by crystallinity, melting temperature, and hydrophobicity of the copolyesters, and therefore, the degradation rates could be tuned along with the ES content. The library of copolymers prepared here with tunable degradation rates, ranging from HS-enriched to ES-enriched copolyesters, is promising for a variety of different applications. The P(HS-co-ES51) copolyester that did not fully degrade is particularly promising for use in long-term storage applications, whereas P(HS-co-ES13) and P(HS-co-ES76) that rapidly degrade are good for use in very short-term applications.

Greatly Enhanced Electromagnetic Interference Shielding Effectiveness and Mechanical Properties of Polyaniline-Grafted Ti3C2Tx MXene–PVDF Composites

Nowadays, evolutions in wireless telecommunication industries, such as the emergence of complex 5G technology, occur together with massive development in portable electronics and wireless systems. This positive progress has come at the expense of significant electromagnetic interference (EMI) pollution, which requires the development of highly efficient shielding materials with low EM reflection. The manipulation of MXene surface functional groups and, subsequently, incorporation into engineered polymer matrices provide mechanisms to improve the electromechanical performance of conductive polymer composites (CPCs) and create a safe EM environment. Herein, Ti3C2Tx MXene nanoflakes were first synthesized and then, taking advantage of their abundant surface functional groups, polyaniline (PA) nanofibers were grafted onto the MXene surface via oxidant-free oxidative polymerization at two different MXene to monomer ratios. The electrical conductivity, EMI shielding effectiveness (SE), and mechanical properties of poly (vinylidene fluoride) (PVDF)-based CPCs at different nanomaterial loadings were then thoroughly investigated. A very low percolation threshold of 1.8 vol % and outstanding electrical conductivities of 0.23, 0.195, and 0.17 S/cm were obtained at 6.9 vol % loading for PVDF-MXene, PVDF-MX2AN1, and PVDF-MX1AN1, respectively. Compared to the pristine MXene composite, surface modification significantly enhanced the EMI SE of the PVDF-MX2AN1 and PVDF-MX1AN1 composites by 19.6 and 32.7%, respectively. The remarkable EMI SE enhancement of the modified nanoflakes was attributed to (i) the intercalation of PA nanofibers between MXene layers, resulting in better nanoflake exfoliation, (ii) a large amount of dipole and interfacial polarization dissipation by constructing capacitor-like structures between nanoflakes and polymer chains, and (iii) augmented EMI attenuation via conducting PA nanofibers. The surface modification of the MXene nanoflakes also enhanced the interfacial interactions between PVDF chains and nanoflakes, which resulted in an improved Young's modulus of the PVDF matrix by about 67 and 46% at 6.9 vol % loading for PVDF-MX2AN1 and PVDF-MX1AN1 composites, respectively.

Helix-Sense-Selective Polymerization of Achiral Monomers for the Preparation of Chiral Helical Polyacetylenes Showing Intense CPL in Solid Film State.

Polymer-based circularly polarized luminescent (CPL) materials have attracted ever-increasing interest. However, to construct CPL materials from achiral monomers is still a big challenge. Here, a series of chiral helical substituted polyacetylenes are prepared by helix-sense-selective polymerization (HSSP) of achiral acetylenic monomers (achiral monomer + fluorescent monomer). HSSPs are accomplished in a bi-solvent mixture consisting of chloroform and chiral α-pinene (chiral component). Chirality transfers from the chiral component to the helical copolymers during polymerization, thereby endowing the copolymers with helical chirality. The resulting copolymers are then fabricated into blend films which exhibit intense optical activity and CPL. The monomer ratio and the physical state of the copolymers have significant impacts on their chiroptical and CPL properties. The maximum luminescence dissymmetry factor of the blend films can be up to 1.3 × 10-2 . The universality of the established strategy for exploring polymer-based CPL materials is demonstrated by using different achiral fluorescent monomers. The present work opens a novel alternative for developing CPL-active polymeric materials starting from achiral monomers.

Preparation and properties of ZnMoO4 anode materials with polymer network gel method

Polymer network gel method combines the advantages of solid-phase method and liquid phase method, triggering acrylamide (AM) radical polymerization in aqueous solution and N, N′- methylene bis acrylamide (MBAM) active double bond cross-linking reaction, forming polymer chains to form a three-dimensional network. The polymer network space formed by the gel is bound and evenly distributed to the ions in the solution, thereby reducing the contact and aggregation of molecules and achieving the purpose of uniform particle size and small particle size. The principle diagram of network gel is shown in Figure. Using cubic zinc acetate and ammonium molybdate tetrahydrate as raw materials, cubic ZnMoO4 negative electrode materials were prepared with polymer network gel method. The polymer network gel method has various effects on the structure, morphology and electrochemical properties of materials. Besides, the calcination temperature and calcination time were also the key factors to the electrochemical properties of the materials. In this paper, the effects of the ratio of monomer and crosslinker, calcination temperature and calcination time on ZnMoO4 materials were studied by single variable method, the preparation process was optimized, and its characterization and electrochemical tests were carried out. After 100 cycles, the optimized ZnMoO4 electrode has a discharge capacity of 374.0 mAh· g−1, 332.5, 263.5 and 177.1 mAh · g−1 at current densities of 0.1, 0.5, 1.0 and 2.0 A g−1, respectively. The electrochemical results show that the optimized ZnMoO4 has high capacity, large rate capability and excellent cycle stability.

STUDY OF PHYSICAL AND MECHANICAL PROPERTIES OF POLYMER-IMPREGNATED COMPOSITION IN CLINICAL PURULENT OSTEOLOGY

Bone cement, or PMMA (polymethyl methacrylate) is often used in purulent surgery. Scientific literature contains very contradictory data on the physical and mechanical properties of polymer-impregnated compositions, in particular, on the temperature of the PMMA polymerization process and the ways to reduce it, such as introduction of antimicrobial drugs for prevention and treatment of infectious complications in patients after injuries and musculoskeletal surgery.
 The aim of the study is to conduct an in vitro experiment and to evaluate the temperature of the exothermic polymerization reaction of bone cement (PMMA) and possible ways to reduce it.
 Materials and Methods. The authors conducted 8 series of experiments in vitro. In each series, a disk (45–50 mm in diameter, 5–7 mm thick) was made by hand after mixing the components of the polymer composition. The temperature of the ongoing exothermic reaction was measured on the disk surface using a non-contact infrared thermometer ADA TemPro 300 in a continuous scanning mode.
 Results. The temperature of the exothermic polymerization reaction of PMMA Synicem 1-based bone cement was 92.8±1.6 °C (min 91.2 °C, max 94.9 °C), and Palacos®MV+G-based bone cement 92.7±1.2 °С (min 91.1 °C, max 93.8 °C). Reducing the monomer amount by 50 % (polymer / monomer ratio was equal to 4:1) and simultaneously introducing “Sextaphage” (10 ml) led to a sharp temperature decrease of the exothermic reaction by more than 30 °C.
 Conclusions. One of the ways to reduce the temperature of the exothermic reaction in vitro is to change the ratio of polymer powder and liquid monomer, reducing the amount of monomer introduced into the polymer composition.

Bottom-up synthesis of few-layered graphene powders and their applications as efficient lubricating and electromagnetic shielding additives

The unique properties of graphene powders strongly depend on their morphologies and synthetic routes. Herein, a general bottom-up approach of synthesizing graphene powders was developed via pyrolysis of self-polymerized compounds of small aromatic molecules with bis-amino groups onto NaCl microcrystals. The key properties of graphene powders including the thickness of graphene layers, surface area and electronic conductivity can be effectively modulated by adjusting mass ratios of monomer and NaCl, and pyrolysis temperature. Typical graphene powders prepared using m-phenylenediamine as precursor with various mass ratios of NaCl at 1500 ℃ process a high specific surface area up to 545 m2 g−1, high powder conductivity (up to 1351 S m−1 at 20 MPa) and the thickness <3.0 nm. Attributed to these specific properties, the graphene powders exhibit outstanding performance as lubrication enhancing and electromagnetic shielding additives, demonstrating their practical application prospect wherein graphene powders can significantly enhance the friction-reduction and anti-wear capacities of the base oil with significant wear volume loss of 47.0% and friction coefficient reduction of 15.5% respectively at few amount addition of graphene (0.3 wt%), while only 20 wt% incorporation also demonstrates high average electromagnetic shielding effect of up to 86.4 dB in the electromagnetic waves range of 8–18 GHz.

Optimized step‐growth polymerization of water‐insoluble, highly sulfonated poly(phenylene sulfone)

AbstractDue to its potential for fuel cell applications, the synthesis of sulfonated poly(phenylene sulfone) with an ion‐exchange capacity (IEC) of 2.78 mequiv g−1 (sPPS‐360) is optimized and the effect of increased molecular weight on mechanical properties studied. The synthesis comprises the step‐growth polymerization of sulfonated difluorodiphenylsulfone (sDFDPS) with thiobisbenzenethiol (TBBT), followed by an oxidation (via hydrogen peroxide). In the past, this procedure was marked by very low reproducibility and often limited achievable molecular weight. Sodium sulfate—a by‐product in the preparation of sDFDPS—is found to be retained throughout the monomer's established purification procedure via recrystallization from alcohol/water mixtures. The contamination is quantified by atomic absorption spectroscopy (AAS) and combustion analysis. At corrected monomer ratios, the preparation of sPPS‐360 is highly reproducible and a subsequent optimization of synthetic parameters yields a significant increase in number average molecular weight (typical Mn 15–30 kDa up to 154 kDa). Improved viscoelastic properties of optimized sPPS‐360s are evident in tensile tests at 30 %RH, better membrane‐forming properties and reduced water uptake (when submerged in water).

Preparation and characterization of polymer retarder for plugging cement slurry

The cement slurry is an important lost circulation material. However, as oil and gas exploration continues toward deeper stratum, the majority of conventional cement retarders are insufficient at these depths. This research identified a synthetic high-temperature copolymer retarder as a potential replacement product, containing sodium styrene sulfonate (SSS)/itaconic acid (IA)/N-vinylcaprolactam (NVCL). By analyzing the effects of monomer mass ratios, initiator concentration, reaction temperature, and pH value of the solution on the thickening time, the ideal reaction conditions of the copolymer retarder were confirmed to be the mass ratio of monomers SSS/IA/NVCL (SNI) = 13/4/1, initiator concentration = 1.0 wt%, reaction temperature = 55 °C, and pH value = 4. Nuclear magnetic resonance proton spectroscopy (1HNMR), thermal gravimetric analysis (TGA) and Fourier transform infrared (FTIR) were used to characterize the resulting copolymer, and its morphology was studied. The results demonstrate that SNI possesses excellent thermal resistance and that the microstructure is conducive to producing good retarding properties under high temperature (150 °C). SNI has temperature-sensitive associative characteristics, making the cement achieve good sedimentation stability due to the high-temperature retarder. SNI-based slurry has excellent overall performance, is simple to control and regulate, and can meet leakage-stopping requirements.

Tandem ROMP/Hydrogenation Approach to Hydroxy-Telechelic Linear Polyethylene.

Hydroxy-telechelic polyalkenamers have long been synthesized using ring-opening metathesis polymerization (ROMP) in the presence of an acyclic olefin chain-transfer agent (CTA); however, this route typically requires protected diols in the CTA due to the challenge of alcohol-mediated degradation of ruthenium metathesis catalysts that can not only deactivate the catalysts, but also compromise the CTA. We demonstrate the synthesis and implementation of a new hydroxyl-containing CTA in which extended methylene spacers isolate the olefin and alcohol moieties to mitigate decomposition pathways. This CTA enabled the direct ROMP synthesis of hydroxy-telechelic polycyclooctene with controlled chain lengths dictated by the initial ratio of monomer to CTA. The elimination of protection/deprotection steps resulted in improved atom economy. Subsequent hydrogenation of the backbone olefins was performed by a one-pot, catalytic approach employing the ruthenium complex used for the initial ROMP. The resultant approach is a streamlined, atom-economic, and low-waste route to hydroxy-telechelic linear polyethylene that uses a green solvent, succeeds with miniscule quantities of catalyst (0.005 mol %), and requires no additional purification steps.

Synthesis and evaluation of a multi-block polycarboxylic acid for improving low-rank coal to make the slurry

To increase the solid concentration and optimize the rheological properties and of low-rank coal water slurry (CWS), a series of multi-block polycarboxylic acid (PCRaf) dispersants wearing hybrid-length side chains by the reversible addition-fragmentation chain transfer (RAFT) polymerization in aqueous solution. Meantime, the random polycarboxylic acid (PCRan) dispersants with same monomers were prepared by random polymerization. The PCRaf dispersant used in making low-rank CWS shows better viscosity reduction and stabilizing effect on CWS than that of the PCRan dispersants with the same mole ratio of monomers. The rational reason supported by the results of the zeta potential and adsorption test is that the multi-block conformation of PCRaf is beneficial to molecule expansion which is more effective in the dispersion of coal particles. The multi-block PCRaf with hybrid-length side chains is well worth being popularized as a new high-effective dispersant for low-rank coal to make a slurry.

Effect of non-repetitive linker on in vitro and in vivo properties of an anti-VEGF scFv

Single chain antibody fragments (scFvs) are favored in diagnostic and therapeutic fields thanks to their small size and the availability of various engineering approaches. Linker between variable heavy (VH) and light (VL) chains of scFv covalently links these domains and it can affect scFv’s bio-physical/chemical properties and in vivo activity. Thus, scFv linker design is important for a successful scFv construction, and flexible linkers are preferred for a proper pairing of VH–VL. The flexibility of the linker is determined by length and sequence content and glycine-serine (GS) linkers are commonly preferred for scFvs based on their highly flexible profiles. Despite the advantage of this provided flexibility, GS linkers carry repeated sequences which can cause problems for PCR-based engineering approaches and immunogenicity. Here, two different linkers, a repetitive GS linker and an alternative non-repetitive linker with similar flexibility but lower immunogenicity are employed to generate anti-Vascular Endothelial Growth Factor scFvs derived from bevacizumab. Our findings highlight a better in vitro profile of the non-repetitive linker such as a higher monomer ratio, higher thermal stability while there was no significant difference in in vivo efficacy in a zebrafish embryonic angiogenesis model. This is the first study to compare in vivo efficacy of scFvs with different linkers in a zebrafish model.

High Mannose-Specific Aptamers for Broad-Spectrum Virus Inhibition and Cancer Targeting

High Mannose-Specific Aptamers for Broad-Spectrum Virus Inhibition and Cancer Targeting

A transformable and biocompatible polymer series using ring-opening polymerization of cyclic silane for more effective transdermal drug delivery

Transdermal drug delivery system (TDDS) has drawn attention in clinical and translational medicine for its advantages such as painless and facile drug administration and the first-pass metabolism avoidance. We disclosed a new siloxane-based polymer series (named PDDS) prepared using the ring-opening polymerization of cyclic silane (2,2,5,5-tetramethyl-2,5-disila-1-oxacyclopentane) using acidic initiators (acetic acid, citric acid, trifluoroacetic acid, and hydrochloric acid). The properties of the PDDS polymer series including molecular weight, viscosity, and the surface wettability were controlled by (i) acidity of the initiators, (ii) molar ratio of monomer and initiator, and (iii) polymerization temperature. Hydrophobic-/hydrophilic-substrates were successfully encapsulated into the polymers when the polymerization was initiated, and the polymerization condition readily controlled their encapsulation efficiency and release profile. Among the series, the C2 polymer (initiator: citric acid) showed the lowest toxicity and excellent biocompatibility in vivo among the others. In addition, the C2 polymer showed significantly enhanced drug permeation efficacy through the skin and improved considerably therapeutic efficacy relative to the free drug in melanoma xenograft model mice. This study presents a new series of biocompatible polymers that can be used in TDDS as a promising carrier with skin permeation and therapeutic ability.