Good Recovery Rate Research Articles

Comprehensive classification and its value of capitellar cartilage injury concomitant with radial head fracture

BackgroundThere are defects in the existing classification of capitellar cartilage injury (CCI) concomitant with radial head fracture (RHF). This study aimed to introduce a comprehensive classification of CCI and to analyze its surgical guidance value.MethodsAccording to the affected site and severity, CCI was classified into four types: Type I - partial-thickness loss of articular cartilage, Type II - full-thickness loss of articular cartilage, Type III - full-thickness loss of articular cartilage with subchondral bone loss, Type IV - full-thickness loss of articular cartilage with thin cortex loss on the border of the capitellum; Different types suggest different surgical methods. Between January 2017 and January 2023, this comprehensive CCI classification was applied in 31 operated patients with CCI concomitant with RHF. The ranges of motion (ROM), Mayo Elbow Performance Index (MEPI) score, Hospital for Special Surgery (HSS) score and visual analog scale (VAS) for pain, were used to evaluate the functional recovery of the affected limb.ResultsMason Type I-IV RHF accounted for 6.45%, 38.71%, 48.39%, and 6.45%, respectively. Type I-IV CCI accounted for 12.90%, 35.48%, 45.16% and 6.45%, respectively. There was no relationship between the CCI and RHF types (p > 0.05). At the end of the follow-up period of 11–26 months with an average of 16 months, the elbow flexion and extension ROM recovered to (147.39 ± 9.84)°, forearm rotation ROM recovered to (168.74 ± 11.70)°, MEPI score recovered to (89.19 ± 4.17), HSS score recovered to (88.74 ± 4.62), VAS score recovered to (0.50 ± 0.57), indicating significant differences compared to preoperative measurements (p < 0.05). According to the MEPI and HSS scores, the excellent and good rate of functional recovery was 100%.ConclusionDifferent types of CCI differ not only in pathology but also in treatment methods. Surgical strategy according to the comprehensive CCI classification introduced in this paper may lead to a satisfactory outcome.

Sensitive detection of Vibrio parahaemolyticus via a dual-recognition colorimetric biosensor comprising Cefe-PEG-MNPs and apt-Fe@PDA

Highly accurate and sensitive detection of Vibrio parahaemolyticus is crucial for ensuring seafood safety and preventing the transmission of foodborne diseases. Herein, a dual-recognition strategy-driven colorimetric biosensor for the detection of V. parahaemolyticus was developed. This biosensor was based on the use of PEG-mediated cefepime-functionalized magnetic nanoparticles (Cefe-PEG-MNPs) and aptamer-modified Fe-doped polydopamine (Fe@PDA) nanozymes. The magnetic platform Cefe-PEG-MNPs was introduced to enhance the enrichment efficiency of V. parahaemolyticus, achieving a capture efficiency exceeding 90%. The Fe@PDA nanozyme exhibited notable peroxidase mimetic enzyme activity. The colorimetric biosensor developed for V. parahaemolyticus detection demonstrated good sensitivity, with a detection range spanning from 2.1 × 101 to 2.1 × 106 CFU/mL, and a limit of detection of 21 CFU/mL. Moreover, the biosensor demonstrated remarkable specificity, achieving good recovery rates from 95.80% to 103.80% in Penaeus vannamei with a relative standard deviation of less than 1.38%. The newly developed colorimetric biosensor offers a remarkable opportunity for the accurate and sensitive detection of V. parahaemolyticus in seafood.

Individualized decision making in on-scene resuscitation time for out-of-hospital cardiac arrest using reinforcement learning

On-scene resuscitation time is associated with out-of-hospital cardiac arrest (OHCA) outcomes. We developed and validated reinforcement learning models for individualized on-scene resuscitation times, leveraging nationwide Korean data. Adult OHCA patients with a medical cause of arrest were included (N = 73,905). The optimal policy was derived from conservative Q-learning to maximize survival. The on-scene return of spontaneous circulation hazard rates estimated from the Random Survival Forest were used as intermediate rewards to handle sparse rewards, while patients’ historical survival was reflected in the terminal rewards. The optimal policy increased the survival to hospital discharge rate from 9.6% to 12.5% (95% CI: 12.2–12.8) and the good neurological recovery rate from 5.4% to 7.5% (95% CI: 7.3–7.7). The recommended maximum on-scene resuscitation times for patients demonstrated a bimodal distribution, varying with patient, emergency medical services, and OHCA characteristics. Our survival analysis-based approach generates explainable rewards, reducing subjectivity in reinforcement learning.

Highly fluorescent nitrogen doped carbon dots as analytical probe for sensitive detection of curcumin through smartphone integrated 3D-printed platform: A new horizon in food safety

COVID-19 pandemic has significantly influenced the dietary habits of humans, emphasizing the incorporation of natural ingredients to enhance immunity towards viral and bacterial infections. Curcumin (Cur), a widely used traditional medicine in various Asian countries and a natural coloring agent, has gained popularity, leading to surge in its usage specially in post COVID-19 era. This surge has led to increased scrutiny of the potential side effects of excessive Cur use, with recent reports suggesting it may result in inactivation of DNA and reduce adenosine triphosphate levels, leading to health risks. In this work, we synthesized highly fluorescent nitrogen-doped carbon dots with a photoluminescence quantum yield of 72.9 % for the sensitive and selective detection of Cur. The developed fluorescent probe exhibits excellent sensory response towards Cur within a concentration range of 0.081–51.45 µM, achieving an ultra-low detection limit of 15.91 nM. The sensor was successfully tested on real food samples like ginger powder, turmeric powder, and curry powder, demonstrating good recovery rates. To assess the practicality of the sensor system, we developed a 3D-printed smartphone-integrated device platform for curcumin detection through fluorescence image analysis. This developed platform exhibited promising results, achieving a limit of detection (LoD) of 132.28 nM across a curcumin concentration range of 0.13–54.00 µM. This device platform holds significant potential for the development of efficient sensors for real-time detection of Cur in food samples.

Watermelon Derived Urease Immobilized Gold Nanoparticles-Graphene Oxide Transducer for Direct Detection of Urea in Milk Samples.

Urea contamination in milk poses significant health risks, including kidney failure, urinary tract obstruction, fluid loss, shock, and gastrointestinal bleeding. This highlights the need for sensitive, rapid, and reliable methods to detect traces amount of urea in milk. In this study, we designed an electrochemical transducer for urea detection by utilizing purified watermelon urease (Urs), gold nanoparticles (AuNPs), and graphene oxide (GO). The nanomaterials and biosensor probe were characterized using UV-vis spectroscopy, XPS, TEM, XRD, FTIR, AFM, CV, EIS, and DPV. The engineered probe (GCE/AuNPs/GO/Urs) demonstrated a broad linear detection range of 5 to 90 mg/dL and a low limit of detection (LOD) of 0.037 (±0.012) mg/dL (RSD < 3.7%). The biosensor was tested for potential interferents that may be present in adulterated milk and an exceptionally low coefficient of selectivity (ksel <0.1) was obtained. Evaluation of milk samples from a local dairy farm showed good recovery rates from 93.13% to. 98.79% (RSD < 4.28%, n = 3), indicating reliable detection capabilities. Stability tests confirmed the sensor's reproducibility and consistent performance. Additionally, a comparison study of the system was carried out using the purified watermelon urease and the commercially available urease. Herein, the results obtained using the sensor probe was finally validated with the gold standard method.

Creative synthesis of pH-dependent nanoporous pectic acid grafted with acrylamide and acrylic acid copolymer as an ultrasensitive and selective riboflavin electrochemical sensor in real samples

In current research, an innovative pectic acid was grafted with poly (acrylamide-co-acrylic acid) [PA-g-poly (AAm-co-AA)] nanoporous membrane using a free radical-mediated grafting copolymerization process. The optimized parameters for the grafting copolymerization reaction such as initiator concentration, monomer concentrations, polymerization reaction time, and temperature were studied. Additionally, the solid content, graft percentage, and conversion were calculated. The unique polymeric membrane was characterized using Fourier-transform infrared spectroscopy (FT-IR), thermal gravimetry (TG), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) supported by energy dispersive X-ray spectroscopy (EDX). The formulated novel PA-g-poly (AAm-co-AA) had a nanoporous structure with a diameter of 113 nm. pH-dependent swelling and biodegradation measurements were also studied. The electrochemical characterizations of PA-g-poly (AAm-co-AA) were conducted through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Furthermore, the screen-printed electrode (SPE) was modified with pure PA and the new generation of its grafted polymeric nanoparticles to detect and quantify the concentration of riboflavin (RF) in real samples using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The modified electrode showed two linear concentration ranges from 0.01 - 2 nM and 2 – 90 nM with low detection limits (LODs) of 0.004 and 0.97 nM, respectively, demonstrating high sensitivity. Besides, the fabricated sensor exhibited more selectivity, simplicity, great reproducibility, repeatability, and good stability. Finally, the PA-g-poly (AAm-co-AA)-modified SPE based sensor was effectively used in real sample analysis of egg yolk, milk, and vitamin B2 drugs with good recovery rates.

Development of Highly Sensitive Immunochromatography Using Time-Resolved Fluorescence Microspheres for Amantadine Detection.

Amantadine (AMA), commonly used to treat viral infections in livestock and poultry, has been banned owing to its potential hazards to human well-being. To detect unauthorized AMA usage in livestock, we developed a polyclonal antibody with a high affinity for the specific recognition of AMA through a rational design based on a structure similar to AMA and revealed the availability of the hapten design by computational chemistry analysis. Using this antibody, we established a highly responsive time-resolved fluorescence immunochromatographic assay (TRFICA). The visual detection limit of the assay is 0.6 μg/kg, and the quantitative detection limit is 0.05 μg/kg. The TRFICA also showed good recovery rates ranging from 94.5 to 109.9%, with variability coefficients not exceeding 10%. The outcomes of undisclosed sample examinations aligned with those of HPLC-MS/MS analyses, indicating that this approach can function as an ideal screening and monitoring tool for detecting illegal AMA in chicken muscle.

Sensitive and selective fluorescence detection of acetamiprid using oxidized single-walled carbon nanohorns and cryonase-assisted signal amplification

To address the low accuracy of pesticide residue detection in traditional Chinese medicine, we developed a biosensor for acetamiprid detection. First, an oxidized single-walled carbon nanohorn capable of adsorbing and quenching fluorescence was prepared. Second, a novel fluorescence sensing system was constructed based on this nanomaterial. The detection performance of the sensor system was evaluated, which revealed that fluorescence quenching by the biosensor was primarily due to the adsorption of the aptamer by the nanomaterials. Optimal conditions were found to be a nanomaterial mass concentration of 800 ng/mL and an incubation time of 70 min, which resulted in the best fluorescence response. Under these optimal conditions, the system was used to detect acetamiprid residues in traditional Chinese medicine. The fluorescence intensity showed a strong linear relationship with acetamiprid concentration, with a correlation coefficient of 0.9985 and a detection limit of 6.33 ng/mL. In the sample test, the biosensor demonstrated high accuracy, with good average recovery rates and low relative standard deviation. The system showed excellent selectivity and detection performance, with no interference from other pesticides.

Comparison of Extraction Methods for the Detection of Avian Influenza Virus RNA in Cattle Milk.

Since early 2024, a multistate outbreak of highly pathogenic avian influenza H5N1 has been affecting dairy cattle in the USA. The influenza viral RNA concentrations in milk make it an ideal matrix for surveillance purposes. However, viral RNA detection in multi-component fluids such as milk can be complex, and optimization of influenza detection methods is thus required. Raw bulk tank milk and mastitis milk samples were artificially contaminated with an avian influenza strain and subjected to five extraction methods. HCoV-229E and synthetic RNA were included as exogenous internal process controls. Given the high viral load usually observed in individual raw milk samples, four out of five tested methods would enable influenza detection in milk with normal texture, over a time window of at least 2 weeks post-onset of clinical signs. Nevertheless, sample dilution 1:3 in molecular transport medium prior to RNA extraction provided the best results for dilution of inhibitory substances and a good recovery rate of influenza RNA, that reached 12.5 ± 1.2% and 10.4 ± 3.8% in two independent experiments in bulk milk and 11.2 ± 3.6% and 10.0 ± 2.9% on two cohorts of mastitis milk samples. We have also shown compatibility of an influenza RT-qPCR system with synthetic RNA detection for simultaneous validation of the RNA extraction and RT-qPCR processes.

Platinum-based fluorescent nanozyme-driven “loong frolic pearls” multifunctional nanoplatform for tri-mode ultrasensitive detection and synergistic sterilization of Burkholderia gladioli

Rapid and accurate detection of Burkholderia gladioli (B. gladioli) and effective sterilization are crucial for ensuring food safety. Hence, a novel “loong frolic pearls” platform based on platinum-based fluorescent nanozymes (Pt-OCDs) and strand exchange amplification (SEA) was reported. Magnetic nanoparticles were modified on primer SEAF, while Pt-OCDs were covalently coupled with primer SEA-R. The highly efficient amplification capability of SEA permitted the accumulation of a large number of double-labeled amplicons. After magnetic adsorption, the supernatant was detected in reverse direction to collect colorimetric-fluorescence-photothermal signal values, enabling ultra-precise detection within 1 h. Furthermore, the Pt-based multifunctional nanoplatform generated abundant •OH and 1O2, which synergistically attacked B. gladioli and its biofilm, resulting in significant bactericidal efficacy within 30 min. This “triple-detection and double-sterilization” platform has been successfully applied in the field of food analysis with good recovery rates and immediate control over B. gladioli, thus demonstrating promising prospects for broad applications.

Ultrasonically assisted fabrication of electrochemical platform for tinidazole detection

Based on sonochemistry, green synthesis methods play an important role in the development of nanomaterials. In this work, a novel chitosan modified MnMoO4/g-C3N4 (MnMoO4/g-C3N4/CHIT) was developed using ultrasonic cell disruptor (500 W, 30 kHz) for ultra-sensitive electrochemical detection of tinidazole (TNZ) in the environment. The morphology and surface properties of the synthesized MnMoO4/g-C3N4/CHIT electrode were characterized using X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and transmission electron microscope (TEM). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were utilized to assess the electrochemical performance of TNZ. The results indicate that the electrochemical detection performance of TNZ is highly efficient, with a detection limit (LOD) of 3.78 nM, sensitivity of 1.320 µA·µM−1·cm−2, and a detection range of 0.1–200 μM. Additionally, the prepared electrode exhibits excellent selectivity, desirable anti-interference capability, and decent stability. MnMoO4/g-C3N4/CHIT can be successfully employed to detect TNZ in both the Songhua River and tap water, achieving good recovery rates within the range of 93.0 % to 106.6 %. Consequently, MnMoO4/g-C3N4/CHIT’s simple synthesis might provide a new electrode for the sensitive, repeatable, and selective measurement of TNZ in real-time applications. Using the MnMoO4/g-C3N4/CHIT electrode can effectively monitor and detect the concentration of TNZ in environmental water, guiding the sewage treatment process and reducing the pollution level of antibiotics in the water environment.

Highly sensitive SERS detection of melamine based on 3D Ag@porous silicon photonic crystal

The stability, reproducibility and engineering of SERS substrate faces a great challenge in melamine SERS assay. In this work, a simple, highly sensitive, stable and cost-efficient SERS detection platform for melamine was established based on its Raman fingerprints spectrum. The Ag@ porous silicon photonic crystal (Ag@PPC) was prepared as the 3D SERS substrate by electrochemical etching and magnetron sputter technology. The main influence factors for the preparation of SERS substrate were investigated in detail. The analytical enhancement factor of the 3D SERS substrate can reach to 2.6 × 108. The 3D SERS detection platform showed a wide linear detection range of 10−4∼10 mg L−1 and a low limit of detection of 0.1 μg L−1 for melamine. Moreover, such detection platform showed good stability, high reproducibility and high recovery rates for melamine. The 3D Ag@PPC SERS substrate can be easily prepared and engineered, displaying a great potential application in food safety field.

Synthesis of green fluorescent carbon dots using cysteine and maltose as ecofriendly ligands for the detection of venlafaxine anti-depression drug in pharmaceutical and plasma samples

In this work, the green emissive carbon dots (CDs) were fabricated using cysteine and maltose as bio-precursors via refluxing process. The emission and excitation peaks of fabricated cysteine-maltose CDs (CM-CDs) are noticed at 511 and 420 nm, respectively. The as-fabricated CM-CDs displayed average mean size of 3.63 ± 1.12 nm with uniform spherical shape and good quantum yield of 32.81 %. Importantly, the as-fabricated CM-CDs act as a sensor for venlafaxine an anti-depression drug sensing via a fluorescence “turn-off” mechanism. The fluorescence lifetime of CM-CDs was 1.34 ns. The as-fabricated CM-CDs were highly sensitive towards venlafaxine, displaying good linear range from 0.1 to 180 µM with the limit of detection of 75.15 nM. The fluorescence of CM-CDs was reduced with the interaction of venlafaxine, thereby favoring to develop CM-CDs-based cellulose paper sensor for venlafaxine assay. The fabricated sensor was effectively utilized for the quantification of venlafaxine in pharmaceutical and biological samples with good recovery rates (96.01––99.65 %).

A sensitive benzothiazole fluorescent probe for the detection of γ-glutamyl transpeptidase activity and its application.

A sensitive benzothiazole fluorescent probe (PBZO) for the detection of γ-glutamyl transpeptidase (GGT) activity was developed. Based on the enzymatic hydrolysis of peptide bonds by glutamyl transpeptidase, it can be specifically recognized by PBZO. The PBZO has a good linear relationship with different gradients of GGT activity at the emission wavelength of 560 nm, the Stokes shift reached 215 nm, and the detection limit of GGT activity is 0.1644 U/ml. With the increase of GGT concentration in the probe solution, the color of the solution gradually changed from orange to dark yellow under the 365 nm UV lamp. The same color change was also observed on the probe test paper. In addition, there is a linear relationship between the GGT activity and the R-value of the probe solution. More importantly, the probe has a good recovery rate in serum. Therefore, this probe can be used as a convenient tool for detecting GGT activity.

Anterior choroidal artery aneurysms: a systematic review and meta-analysis of outcomes and ischemic complications following surgical and endovascular treatment.

Anterior choroidal artery (AChA) aneurysms account for 2%-5% of all intracranial aneurysms. Treatment considerations include microsurgical clipping, flow diversion, or coiling with or without adjunctive devices. AChA aneurysms pose challenges in treatment due to the origination of the aneurysm from the origin or proximal segment of the AChA. The AChA is particularly susceptible to vasospasm and occlusion during treatment with devastating neurological deficits, including hemiparesis, hemianesthesia, lethargy, neglect, and hemianopia. In this study, the authors performed a meta-analysis to quantify the outcomes and complication rates across treatment modalities for AChA aneurysms and to identify risk factors reported in the literature. The authors performed a systematic review of AChA aneurysms treated with surgical clipping, endovascular coiling, or flow diversion and reported in the PubMed, Embase, Scopus, and Cochrane search databases. Single-arm meta-analyses of the selected outcomes were performed in RStudio. Literature review yielded 25 studies that met the inclusion criteria. In total, 1627 patients were included in the analysis, with 554 males, 1009 females, and 64 unspecified. The rate of any complication in the full cohort was 11.6%, with a rate of ischemic complications of 5.5% and a favorable recovery rate of 90.3% of all patients treated. In total, 1064 patients underwent surgical clipping, 443 were treated with coiling, and 120 patients with flow diversion. In clipped patients, the rate of total surgical complications was 17.6%, with an ischemic complication rate of 9.4%. The rate of good functional recovery, defined on the basis of a Glasgow Outcome Scale score of 4-5 or modified Rankin Scale score of 0-2, was 88.0%, and complete obliteration was achieved in 84.5% of surgically clipped aneurysms. The complication rate in coiled patients was 10.3%, with an ischemic complication rate of 3.0%. Good functional recovery was achieved in 88.6% of coiled patients and complete aneurysm obliteration in 74.1%. Flow diversion resulted in a complication rate of 1.3%, with 0.7% rate of ischemic complications. Good functional recovery was achieved in 98.4% of patients and complete aneurysm obliteration in 79.0% in the flow diversion group. Aneurysm morphological features that impacted the complication rate were also identified to augment quantitative data and to help guide treatment selection for AChA aneurysms. Flow diversion showed significantly lower total and ischemic complications and improved outcomes compared to clipping and coiling. There may be differences in outcomes between treatment types, especially when considering the varied patient presentations that guide treatment selection.

Efficient Photocatalytic Degradation of Triclosan and Methylene Blue by Synthesized Ag-Loaded ZnO under UV Light

Industrial discharge of hazardous organic and synthetic chemicals, such as antibacterials and dyes, poses severe risks to human health and the environment. This study was conducted to address the urgent need for efficient and stable zinc-oxide-based photocatalysts to degrade such pollutants. A novel approach to synthesizing silver-loaded zinc oxide (Ag@Z) catalysts was introduced by using a simple and efficient combination of hydrothermal and precipitation methods. Comprehensive characterization of Ag@Z photocatalysts was performed using XRD, XPS, Raman, UV–vis adsorption, FTIR, and SEM, revealing an enhancement of structural, optical, and morphological properties in comparison to pure zinc oxide. Notably, the 5%Ag@Z catalyst exhibited the highest degradation efficiency among the other synthesized catalysts under UV-C light irradiation, and enhanced the degradation rate of pure zinc oxide (Z) by 1.14 and 1.64 times, for Triclosan (TCS) and Methylene Blue (MB), respectively. the effect of catalyst dose and initial concentration was studied. A mechanism of degradation was proposed after investigating the effect of major reactive species. The 5%Ag@Z catalyst increased the photostability, which is a major problem of zinc oxide due to photocorrosion after reusability. We found that 50% and 74% of energy consumption for the photocatalytic degradation of TCS and MB by 5%Ag@Z, respectively, was saved in compassion with zinc oxide. The remarkable photocatalytic performance and the good recovery rate of Ag@Z photocatalysts demonstrate their high potential for photocatalytic degradation of organic contaminants in water.

Readmissions Following Pancreaticoduodenectomy: Experience From a Tertiary Care Center in India.

Background An enhanced recovery approach in surgery helps early postoperative discharge. With the decreasing trend of morbidity and mortality in recent times in patients undergoing complex procedures such as pancreaticoduodenectomy, readmissions are the next major concern. The causes and outcomes of these readmissions should be investigated for their impact on patient care and prevention. Methodology A total of 997 patients discharged after pancreaticoduodenectomy from a tertiary care center in northern India, between 1989 and 2021, were studied retrospectively to assess the readmission rate for sequelae after pancreaticoduodenectomy. The causes, interventions, outcomes, and predictive factors were studied. Results A total of 103 (10.3%) patients required readmission for sequelae after pancreaticoduodenectomy, and 52 (50.4%) patients required interventions. The most common cause for readmission in our study was intra-abdominal collection (n = 23, 22.3%). Of these 103 patients, 63 (61.2%) had good outcomes, 36 (34.9%) had fair outcomes, and four (3.9%) had bad outcomes. Overall, 53 (51.5%) of 103 patients were readmitted within 30 days of discharge, most commonly with intra-abdominal collection (16 of 53, 30.1%). Of these 53 patients, 22 (41.5%) required interventions, 34 (64.1%) had good outcomes, and 27 (50.9%) were readmitted within seven days of discharge. Of these 27 patients, 12 (44.4%) required interventions, with 24 (88.8%) experiencing good outcomes. Of the 103 patients, 12 (11.6%) were readmitted between 31 and 90 days, mostly due to external stent, T-tube, or percutaneous transhepatic biliary drainage-related problems. Overall, 38 (36.9%) of 103 patients were readmitted after 90 days, mostly with incisional hernia and strictured hepaticojejunostomy. Of these 38 patients, 26 (68.4%) required intervention, and 23 (60.5%) had good outcomes. A previous history of cholangitis (odds ratio (OR) = 1.771, 95% confidence interval (CI) = 1.17-2.67, p = 0.007), postoperative fever (OR = 1.628, 95% CI = 1.081-2.452, p = 0.02), wound infection (OR = 2.011, 95% CI = 1.332-3.035, p = 0.001), and wound dehiscence (OR = 2.136, 95% CI = 1.333-3.423, p = 0.002) predicted readmission on univariate analysis. Multivariate analysis showed a previous history of cholangitis (OR = 1.755, CI = 1.158-2.659, p = 0.008) and wound infection (OR = 1.995, 95% CI = 1.320-2.690, p = 0.001) as factors independently predicting readmission. Conclusions Readmitted patients have high intervention rates and good recovery rates. Readmissions should not be considered a scale for poor healthcare. Patient education, proper management of postoperative complications, and a properly designed discharge care system can help tackle this problem.

An electrochemical sensor for the rapid detection of zearalenone based on the mimic peptide screened by molecular simulation

An electrochemical sensor was developed for detecting zearalenone (ZEN) based on the mimic peptide, which was screened from the library and validated by molecular simulation and electrochemical methods. The library of the mimic peptide was constructed according to the structural analysis, molecular docking, molecular dynamics and amino acid mutation. Then, the enhanced electrical signal was attributed to gold nanoparticles (AuNPs) and reduced carboxylated graphene oxide (rGO-COOH). Under the optimal conditions, the detection limit was 0.91 pg·mL−1 (S/N = 3) with a wide linear range from 0.01 ng·mL−1 to 10 ng·mL−1. In grain samples, a good recovery rate of 84% to 105.3% was achieved, while the rate ranged from 82% to 108.8% in the commercial ELISA kits. Additionally, the electrochemical sensor exhibited the remarkable specificity, excellent stability and better reproducibility (RSD = 1.94%). This sensor has great potential for rapidly detecting ZEN in food.

Pioneer electrochemical approach for the determination of Metaxalone in biomedical and environmental samples using W: TiO2/S-GCN@CPE sensor

This study focuses on developing a rapid, easy-to-use, and sensitive sensor for the electroanalytical detection of Metaxalone (MXL) for the first time. A novel sensor was created by combining sulfur-incorporated graphitic carbon nitride (S-GCN) with tungsten-doped titanium oxide nanoparticles (W: TiO2 NPs) in a carbon paste, which was then loaded into a polytetrafluoroethylene (PTFE) tube. The synthesized modifiers were characterized using SEM, XRD, and FTIR techniques to understand their structural, morphological, and functional features, contributing to the electrocatalytic activity of the modified sensor (W: TiO2/S-GCN@CPE). Comparative analysis showed that W: TiO2/S-GCN@CPE achieved higher detection currents than the unmodified carbon paste electrode (CPE). Cyclic voltammetry (CV) and square wave voltammetry (SWV) were used to detect and quantify MXL electrochemically. The electrode’s physicochemical properties were studied under optimal conditions within a potential range of 0.3 V to 1.5 V. The W: TiO2/S-GCN@CPE showed a detection limit of 0.85 x 10-8 M and demonstrated linearity over a concentration range of 0.1–100 x 10-7 M. The sensor’s selectivity against interference from metal ions was also assessed. In practical applications, the developed electrode effectively detected MXL in spiked water, tablets, and biological samples, showing significant detection capacity and good recovery rates. Additionally, the electrode demonstrated stability across multiple measurements, positioning W: TiO2/S-GCN@CPE as a promising sensor for MXL detection.

Amino‐containing α‐Diimine Nickel Complexes with Adjustable Electronic Properties and their Effective Use in Forming Highly Branched Polyethylene

AbstractA family of ten amino‐containing bis(arylimino)acenaphthene‐nickel (II) bromide complexes varied in the electronic properties of para‐substituents (R = Me, iPr, tBu, OMe, Cl, F, NO2) as well as two amino‐free comparators (R = Me, Cl) are synthesized in good yield from their corresponding unsymmetrical N,N’‐ligands. All organic compounds are well characterized by different analysis techniques. On activation with Me2AlCl, all nickel complexes exhibit moderate to high activities with a maximum activity up to 14.19 × 106 g (PE) mol−1 (Ni) h−1 and deliver narrow dispersed polyethylene (PDI: 1.85–2.65) with adjustable molecular weight values (Mw: 5.27–18.49 × 105 g mol−1). The presence of remote fluoro‐ group and (4‐amino‐3,5‐dimethylphenyl)(phenyl)methyl group has their own unique influence on activity due to their different electronic and steric properties. Nevertheless, the latter with higher steric hindrance results in better thermal stability of the current catalytic system. Moreover, all polyethylene is highly branched and exhibits typical characteristics of thermoplastic elastomers, especially good mechanical properties (εb up to 1175%) and elastic recovery rate (up to 86%).