Rate Of Exchange Research Articles

Currency Conversions Considerations in Estate Planning: How to Protect Your Estate From Losing Its Value

Currency Conversions Considerations in Estate Planning: How to Protect Your Estate From Losing Its Value

Plant physiological indicators for optimizing conservation outcomes.

Plant species of concern often occupy narrow habitat ranges, making climate change an outsized potential threat to their conservation and restoration. Understanding the physiological status of a species during stress has the potential to elucidate current risk and provide an outlook on population maintenance. However, the physiological status of a plant can be difficult to interpret without a reference point, such as the capacity to tolerate stress before loss of function, or mortality. We address the application of plant physiology to conservation biology by distinguishing between two physiological approaches that together determine plant status in relation to environmental conditions and evaluate the capacity to avoid stress-induced loss of function. Plant physiological status indices, such as instantaneous rates of photosynthetic gas exchange, describe the level of physiological activity in the plant and are indicative of physiological health. When such measurements are combined with a reference point that reflects the maximum value or environmental limits of a parameter, such as the temperature at which photosynthesis begins to decline due to high temperature stress, we can better diagnose the proximity to potentially damaging thresholds. Here, we review a collection of useful plant status and reference point measurements related to photosynthesis, water relations and mineral nutrition, which can contribute to plant conservation physiology. We propose that these measurements can serve as important additional information to more commonly used phenological and morphological parameters, as the proposed parameters will reveal early warning signals before they are visible. We discuss their implications in the context of changing temperature, water and nutrient supply.

Non-Newtonian natural-convection cooling of a heat source of variable length and position placed at the bottom of a square cavity

Natural-convection cooling of a heat source placed at the bottom wall of a square cavity filled with non-Newtonian fluid was investigated numerically. Two thermal conditions were assumed at the source (imposed temperature or flux density). The effects of Rayleigh number, rheological index, n, source length, SL, its position, D, and Prandtl number, were analyzed. For a centered source. The three first parameters were varied. The results show an increase in dynamic and thermal fields? perturbations when Rayleigh number increases and/or source length increases and/or n decreases. These observations are clearer in the first heating type compared to the second. Mean Nusselt number increase is recorded when Rayleigh number increases and/or n decreases, while it decreases with source length increase until SL = 1.0 where a new increase is recorded. For a non-centered source, the previous observations still valid, noting the loss of symmetry. The highest mean rate of heat exchange is recorded when D = 0.0 with decreasing amounts when moving towards the center. Finally, Prandtl number effect is analyzed. Results show a better diffusion of heat when increases for low n. Consequently, a marked increase in the mean Nusselt number for n < 1.0, weak for n = 1.0 and almost absent for n > 1.0 are recorded with a clearer effect for the first type of heating.

Photochemical processes in surface water bodies and their potential impacts on the chemical composition of water: A review

AbstractThe present study is a review of photochemical processes that occur in surface water bodies and which can affect the chemical composition of water. It is expected that water bodies with a slow rate of water exchange, including lakes, reservoirs, estuaries and ponds with significant areas of shallow water will be most vulnerable to the impacts of these processes. It involves natural organic compounds and xenobiotics of organic origin that enter water bodies from anthropogenic sources or are formed in water bodies because of the development of cyanobacteria and other algae species. Photodegradation of dissolved organic matter (DOM) occurs as a result of both direct photolysis and photosensitized cleavage involving inorganic and organic compounds, which are characterized by chromophore properties, such as humic substances. Photolysis is accompanied by the transformation of high molecular weight organic compounds into lower molecular weight compounds that can become bioavailable to, and promote the development of, microorganisms. Photodegradation results in bioavailable forms of nitrogen and phosphorus being released into the water column. Accordingly, the present study presents the results of analysis of the photochemical destruction of humic substances, such as the most widespread group of the surface water body DOM under the influence of artificial UV irradiation and solar radiation. The results provide data on the products of humic substances photolysis, as well as the influence of the latter on the destruction of a number of organic substances, including xenobiotics (herbicides, pesticides, etc.). Photolysis of algotoxins, which are mainly concentrated in the water of highly trophic reservoirs and lakes during the period of water “blooming,” is among the main concerns being addressed, noting photochemical destruction of these dangerous toxicants can be considered an important means of removing them from drinking water. Also emphasized is that photochemical processes in surface water will likely intensify in the future amid the recent climate changes, also affecting the chemical composition of water.

Світовий досвід дослідження і впровадження цифрової валюти центрального банку: інституційний аспект

The purpose of the article is to disclose the influence of institutional factors on the formation of the effects of the introduction of a central bank digital currency and to substantiate the prerequisites for the possible introduction of a central bank digital currency (CBDC) in the Ukrainian system of financial and institutional coordinates. The carried out study concludes that the global regulatory community has no final certainty about the very fact of creating such a revolutionary payment mechanism. At the same time, approaches to the design, goals, and possible results of putting the CBDC into circulation are focused on functional areas of analysis, while the issue of the influence of the institutional environment on the formation of the effects of the digital transformation of the monetary space requires a more thorough research. The search for answers to the question of how to use the CBDC to form a controlled, inclusive, transparent, and efficient financial and institutional space should include, as an essential constituent, an analysis of trust in the actions of the government and the central bank at each stage of the CBDC development. The poor and complex experience of introducing the CBDC demonstrates that in the absence of a sufficient level of trust, the financial, economic, and social situation becomes destabilized. The experience of introducing digital currency in an unstable economic environment shows that a central bank’s digital currency can be introduced only if there is a high level of trust in the national currency, the monetary policy pursued by the central bank, and a low level of inflation; the conversion of the national currency into digital form should be preceded by an effective monetary policy aimed at increasing the reliability of the national currency. The author concludes that, given the revolutionary nature of the reform, the introduction of digital currency cannot be used as an element of stabilization measures and cannot be considered a monetary experiment; its prospects should be conditioned by general economic and monetary stabilization.

Effect of phase change material tubes inclination angel on the performance of indirect hybrid thermal energy storage system: An experimental approach

• A modular indirect hybrid thermal energy storage tank is designed and investigated. • Temperature evolution of the PCM and the water in the tank are studied. • Thermal performance of the water tanks with and without PCM tubes are compared. • Effect of the PCM tubes inclination angel on the thermal performance is discussed. For an efficient use of indirect hybrid thermal energy storage, it is necessary to investigate the heat transfer characteristics of its charging and discharging processes. However, in previous studies, the inclination angel of phase change material (PCM) units is fixed. The influence of PCM units inclination angel on the thermal performance of the indirect hybrid thermal energy storage has not attracted much attention. To address this research gap, this study proposes a modular indirect hybrid thermal energy storage tank in which the PCM tubes inclination angel can be changed freely. The heat transfer characteristics of the tanks with horizontal, inclined, vertical PCM tubes, and without PCM tubes are studied by experiments. The experimental results show that the melting time of horizontal PCM tube is the shortest, which is 25% less than that of vertical PCM tube. However, the solidification time for all the three different inclination angel tubes is the same at 96 min. Compared to the tank without PCM tubes, the average overall heat transfer coefficient of the heat exchanger during charging/discharging processes for the tanks with PCM tubes are increased by 7.18%/7.58% (horizontal), 1.37%/10.05% (inclined), and 4.43%/8.96% (vertical), respectively. The maximum average thermal storage rate of 1.31 kW is observed in the tank with horizontal PCM tubes, which is an increase of 5.65% compared with the tank without PCM tubes. For the discharging process, the difference of the average thermal release rate among the four tanks is not noticeable. The results indicate that the PCM tubes inclination angel has significant impacts on the melting time of PCM, the heat transfer coefficient of the heat exchanger and average thermal storage rate of the tank. Optimizing the PCM tubes inclination angel is an effective way to improve the thermal storage rate of the indirect hybrid thermal energy storage system.

Translation of transfer pricing adjustments in South Africa: A seemingly insignificant detail

The South African rand is one of the most volatile currencies in the world — at times the most volatile. To this is added a further area of uncertainty, namely the tax implications relating to transfer pricing. Section 31 of the South African Income Tax Act does not have any specific foreign currency translation rules. The general rule in s 25D of the Income Tax Act is therefore applicable, which provides for the translation of foreign currency to rand using the spot rate. However, given the nature of transfer pricing transactions, it raises the question whether the spot rate is indeed appropriate. The purpose of the study was to investigate South Africa’s translation rules and to seek guidance from an international perspective. The research design was non-empirical, adopting an interpretative paradigm, together with a doctrinal research methodology. The conclusion of this study is that the translation rules concerning transfer pricing adjustments have seemingly been overlooked. The study recommends a legislative amendment of s 31 and proposes that transfer pricing adjustments are converted using the average rate of exchange for the year of assessment to which the adjustments relate, as such an amendment will lead to certainty, equity and convenience.

РАЗВИТИЕ ЦИФРОВЫХ ФИНАНСОВЫХ АКТИВОВ В МИРОВОЙ ЭКОНОМИКЕ

In the article, the author defines the concept of “digital financial assets”, “cryptocurrency”, “tokens” and their relationship and the need for application, noting the advantages of introduction in the countries of the world. The significance of the introduction of these assets is as follows: in the potential for democratizing access to financial services, in increased transparency and efficiency compared to traditional financial assets, in the possibility of introducing new business models and financial products, in the possibility of accelerating and reducing the cost of cross-border payments, in reducing the cost of currency conversion. The paper examines the practices and features of regulation of digital financial assets in different countries and in Russia.

Selected Factors Influencing China's Palm Oil Import Demand from Malaysia

The export of palm oil from Malaysia to China has declined since 2013, although the Malaysian Ringgit has depreciated. The Malaysian palm oil market has also struggled against the Indonesian palm oil and soy oil in China. Hence, this study aimed to identify the significant factors influencing China's demand for Malaysian palm oil by adopting the Auto-Regressive Distributed Lag (ARDL) analysis. The finding revealed that the currency rate of exchange, the foreign trade price of Malaysian palm oil to China, and the international soy oil price significantly influence Malaysian palm oil demand in China. Nevertheless, China's real GDP per capita showed a positive and significant influence only in the long run. The demand for Malaysian palm oil in China was not significantly impacted by the palm oil price offered by Indonesia, neither in the long run nor short run. Thus, the authorities related to this industry need to strategize the stock management system to control the price and currency stabilization to maintain its competitive power.

Conventional versus hybrid knife endoscopic submucosal dissection in large colorectal laterally spreading tumors: A propensity score analysis.

Colorectal endoscopic submucosal dissection (CR-ESD) has become a promising treatment for laterally spreading tumors (LSTs), but is accompanied by great challenges. This study aimed to evaluate the efficacy and safety of CR-ESD with a hybrid knife, versus the conventional technique for LSTs ≥30 mm in diameter, and analyze the risk factors for piecemeal resection and perforation. Patients eligible for CR-ESD were divided into two groups according to the use of the hybrid knife (HK group) or the use of the conventional technique, with an interchange of injection and hook knife (C-group). We performed propensity score matching (PSM) to compare the HK group and the C-group. Risk predictors for perforation and piecemeal resection were identified. PSM identified 61 (132 patients) and 61 (129 patients) patients in the C-group and the HK group, respectively. Resection speed was significantly faster in the HK group than in the C-group (18.86 vs. 13.33 mm2/min, P < 0.001). The rate of knife exchange was significantly lower in the HK group than in the C-group (1.6% vs. 49.2%, P < 0.001). Multivariate analysis revealed that unfavorable locations, including the splenic flexure, hepatic flexure, or cecum, were predictive of piecemeal resection. The presence of severe fibrosis and a semilunar fold were independent risk factors for perforation. : The use of a hybrid knife appears to increase CR-ESD resection speed. The indicators for piecemeal resection or perforation in CR-ESD identified herein might help to assess the technical difficulties of CR-ESD.

S. A. OŜga. The Rate of Exchange and the Terms of Trade. New Brunswick, New Jersey / London: Aldine Transaction, 2008. 116 pages. Paperback. Price not given.

S. A. OŜga aims to provide a concise outline of the theory behind the rate of exchange and the terms of trade, in textbook fashion at an elementary level. The terms of trade are defined as the ratio of the money prices of imports and exports, while the balance of trade is the ratio of the value of exports to imports. The analysis in the book, as pointed out by the author, is limited in several ways. First, it does not go beyond defining and exploring relations between limited concepts, and does not touch upon ways of testing or proving any concepts. Secondly, the book deals with only the theory of ratios of exchange as they pertain to international trade. Yet, the discussion in the book is quite focused, which makes it easy to follow.

Food security under compound shocks: Can Lebanon produce its own Mediterranean food basket?

As Lebanon faces compound challenges, a looming food security crisis is rapidly approaching, much of which could be attributed to the lack of long-term planning for sustainability in its agricultural sector. The disconnect between decision-makers within the agricultural sector, and other interconnected sectors is exacerbated by the lack of integrative national platforms and methodologies for quantifying the trade-offs associated with possible interventions. This study aims to: (1) identify and quantify the critical interconnections between water, energy, nutrition, and food systems in Lebanon; (2) develop a framework to quantify the trade-offs associated with adopting interventions within current water, energy, and agriculture portfolios and practices; (3) evaluate producers' perceptions toward their willingness to implement proposed changes in crop production, renewable energy, and water reuse. Findings show that investing in locally producing Lebanon's needs of broad beans, lentils, chickpeas, and peas, results in cost savings, increased nutritional value in the locally produced basket, and reduced reliance on foreign markets. In turn, this comes at additional water, energy, land and carbon footprints which needs to be accounted for. Given the uncertainty of future currency conversion rates, it becomes more critical to identify a strategic food basket that could be produced locally to reduce reliance on imports. Conclusions from this study can play a role in informing policymaking and planning in Lebanon, which could be adapted and replicated in other countries in the MENA Region.

The protein dynamics of bovine and caprine β-lactoglobulin differ as a function of pH

The properties of milk proteins differ between mammalian species. β-Lactoglobulin (βlg) proteins from caprine and bovine milk are sequentially and structurally highly similar, yet their physicochemical properties differ, particularly in response to pH. To resolve this conundrum, we compared the dynamics of both the monomeric and dimeric states for each homologue at pH 6.9 and 7.5 using hydrogen/deuterium exchange experiments. At pH 7.5, the rate of exchange is similar across both homologues, but at pH 6.9 the dimeric states of the bovine βlg B variant homologue have significantly more conformational flexibility compared with caprine βlg. Molecular dynamics simulations provide a mechanistic rationale for the experimental observations, revealing that variant-specific substitutions encode different conformational ensembles with different dynamic properties consistent with the hydrogen/deuterium exchange experiments. Understanding the dynamic differences across βlg homologues is essential to understand the different responses of these milks to processing, human digestion, and differences in immunogenicity.

Information currency converter based on Telegram messenger

The work is dedicated to the development of a mobile chatbot containing an information currency converter, designed for use by a wide range of people. A chatbot is a subject-oriented text-based dialog interface that allows a user to perform a limited set of tasks: getting information about the current rate of currencies (USD or EUR) relative to the national currency and finding out the current rate of cryptocurrencies (Bitcoin, Ethereum, Litecoin) in dollars or euros. To achieve this goal, the selected subject area was analyzed and appropriate conclusions were made. A corresponding study of analogs who perform tasks similar in complexity was carried out, only a few chatbots were identified, as a certain number of bots posted in Telegram no longer provide their services or work incorrectly. The algorithm of the service for currency conversion based on the Telegram messenger is described. The chatbot is implemented in the Python programming language and uses the Pycharm development environment, as it is best suited for programming the intended project and is easy to use. There are two options available to the user: the cryptocurrency rate from the CoinGecko site or the exchange rate from PrivatBank. The article examines the development and improvement of chatbots. Similar Telegram bots, which function similarly to the created one, are reviewed. The author’s bot has been developed, and the architecture and algorithm of the CurrencyBot currency conversion service are presented.

Toward Understanding of the Li-Ion Migration Pathways in the Lithium Aluminum Sulfides Li3AlS3 and Li4.3AlS3.3Cl0.7 via 6,7Li Solid-State Nuclear Magnetic Resonance Spectroscopy.

Li-containing materials providing fast ion transport pathways are fundamental in Li solid electrolytes and the future of all-solid-state batteries. Understanding these pathways, which usually benefit from structural disorder and cation/anion substitution, is paramount for further developments in next-generation Li solid electrolytes. Here, we exploit a range of variable temperature 6Li and 7Li nuclear magnetic resonance approaches to determine Li-ion mobility pathways, quantify Li-ion jump rates, and subsequently identify the limiting factors for Li-ion diffusion in Li3AlS3 and chlorine-doped analogue Li4.3AlS3.3Cl0.7. Static 7Li NMR line narrowing spectra of Li3AlS3 show the existence of both mobile and immobile Li ions, with the latter limiting long-range translational ion diffusion, while in Li4.3AlS3.3Cl0.7, a single type of fast-moving ion is present and responsible for the higher conductivity of this phase. 6Li-6Li exchange spectroscopy spectra of Li3AlS3 reveal that the slower moving ions hop between non-equivalent Li positions in different structural layers. The absence of the immobile ions in Li4.3AlS3.3Cl0.7, as revealed from 7Li line narrowing experiments, suggests an increased rate of ion exchange between the layers in this phase compared with Li3AlS3. Detailed analysis of spin-lattice relaxation data allows extraction of Li-ion jump rates that are significantly increased for the doped material and identify Li mobility pathways in both materials to be three-dimensional. The identification of factors limiting long-range translational Li diffusion and understanding the effects of structural modification (such as anion substitution) on Li-ion mobility provide a framework for the further development of more highly conductive Li solid electrolytes.

Ligand Exchange on MoS2 Nanosheets: Applications in Array-Based Sensing and Drug Delivery.

Two-dimensional MoS2 nanosheets (2D-MoS2) have been widely used in many biological applications due to their distinctive physicochemical properties. Further, the development of surface modification using thiolated ligands allows us to use them for many specific applications. But the effect of possible ligand exchange on 2D-MoS2 has never been explored, which can play an important role in diverse biological applications. In this study, we have observed the ligand-exchange phenomenon on 2D-MoS2 in the presence of different thiolated ligands. The initial study proceeded with boron-dipyrromethene (BODIPY) functionalized MoS2 with different concentrations of glutathione (GSH), which is the most abundant thiol species in the cytoplasm of various cancer cells. It was found that in the presence of GSH the fluorescence of BODIPY can be regenerated, which is time and concentration dependent. We have also examined this phenomenon with different thiol ligands and transition-metal dichalcogenides (TMDs). We observed a variable rate of ligand exchange in different solvents, surface functionality, and receptor environments that helped us to construct sensor arrays. Interestingly, a ligand-exchange process was not observed in the presence of dithiols. Further, this concept was applied to a cancerous cell line for in vitro delivery. We found that BODIPY-functionalized 2D-MoS2 undergoes thiol exchange by intracellular GSH and subsequently enhanced the fluorescence in the cytoplasm of cancer cells. This strategy can be applied to the development of 2D-TMD-based materials for various biological applications related to ligand exchange.

Isolated Liner Exchange in Total Hip Arthroplasty at a Mean of 13 Years of Follow-up: Does Fixation Technique Matter?

BackgroundIsolated liner exchange is an option to address polyethylene wear after total hip arthroplasty (THA). The liner can be fixed with either the original locking mechanism or cemented into the acetabular cup. Whether the method used for liner fixation has any bearing on the outcomes in the first and second decade after surgery is still unclear. MethodsData for all patients who had undergone isolated liner exchange surgery in our institution between April 1995 and January 2015 were retrieved. Patients were classified according to the type of polyethylene liner (conventional or highly crosslinked polyethylene) and the locking mechanism used (original locking mechanism or cemented). Survivorship and revision rates were compared among different subgroups. A total of 118 isolated liner exchanges were performed and patients had a mean duration of follow-up of 13 years (range, 5 to 25). ResultsOverall estimated mean survivorship was 17 years. Use of highly crosslinked polyethylene (HXLPE) had a lower re-revision rate compared to conventional liners (10.5 versus 46.9%) (P < .001). The re-revision rate of exchanges using HXLPE was not affected by the type of fixation (original locking mechanism 11.1 versus cement 10.0%, P = .868). Conversely, using the original locking mechanism with a conventional liner had a higher re-revision rate compared to cemented conventional liners (58.3 versus 12.5%) (P = .024). ConclusionHXLPE liners should be used in insert exchange surgery whenever possible. Re-revision rate of exchanges using HXLPE was not affected by the fixation technique used. Cementing an insert into an acetabular component is associated with good survivorship at a mean of 13 years follow-up.

NUMERICAL INVESTIGATION OF THE NANOFLUID NATURAL CONVECTION FLOW IN A CPU HEAT SINK USING BUONGIORNO TOW-PHASE MODEL

In this paper, a numerical investigation using the finite element method on the cooling capacity of an electronic heat sink has been presented. This heat sink is intended for cooling applications of micro-computer CPUs. It deals with a parallelepipedal block with rectangular fins, filled with a nanofluid and crossed by four cylindrical pipes in which a cooling gas flows and dissipates the heat generated by the processor. Indeed, the cooling occurs by three transfers: the first one evacuates the heat from the processor towards the gas, the second one transfers this heat towards the nanofluid and the last one is cooled from the ambient air by means of the fins laterally arranged on the block. From this work, it has been planned to contribute to the study of the behavior of a nanofluid in the heat sink in the presence of a uniform magnetic field in order to enhance the operating and cooling performances. The effects of some control parameters have been highlighted on the hydrodynamic, thermal, and mass behavior of the nanofluid, namely: the Rayleigh number (103 ≤ Ra ≤ 105), the Hartmann number (0 ≤ Ha ≤ 100), the angle of inclination of the magnetic field (0 ≤ γ ≤ 90°) and the nanoparticles diameter (1 nm ≤ dp ≤ 10 nm). On the other hand, a new fin design has been proposed in this study allowing the enhancement of the heat exchange rate with ambient medium. The studied phenomenon is governed by the equations of the two-phase nanofluid model proposed by Buongiorno and which describe the following balances: mass, momentum, energy and nanoparticles. The system of partial differential equations with initial-boundary conditions has been solved by the finite element method. After performing a mesh independence check and validating with previous papers, the results of the investigation were presented. They showed that the application of a magnetic field significantly reduces the rate of heat exchange. However, increasing the angle of inclination of this field promotes convective heat transfer. Moreover, the use of zigzag fins improves the cooling rate by about 4% for amplitude of 0.05 compared to the standard configuration.

Net Ecosystem Exchange of Carbon Dioxide in Rice Summer – Autumn crop of the lower Mekong delta, Vietnam

This study describes the net ecosystem exchange of CO2 in a rice summer-autumn growth season in the lower Mekong Delta, Vietnam. Eddy Covariance and bio-meteorological systems were used to continually record the net CO2 exchange between the paddy field and the atmosphere, together with environmental variables affecting the exchange rate. Rice plant growth (height, above-, and belowground biomass) was measured every 15 days during the entire crop. Our study paddy field emitted CO2 at the mean rate of 5.06 ± 2.49 µmol m-2 s-1, while the rate of CO2 capturing was 18.65 ± 11.76 µmol m-2 s-1 throughout the entire crop. The paddy field acted as a CO2 sink almost during the crop. The quick increase of leaf area from the 15th to the 60th day led to the rise in CO2 influx. The decrease in influx rate after the 60th day resulted from the senescence and death of the aboveground biomass. The drainage in the last ten days of the crop probably contributed to the increase in CO2 effluxes and hence, turned the paddy field into a CO2 source. Ambient temperature was an important factor affecting the rate of CO2 exchange affects the photosynthesis, plant respiration, photorespiration, and organic matter decomposition.

Insights into the Dynamics and Binding of Two Polyprotein Substrate Cleavage Points in the Context of the SARS-CoV-2 Main and Papain-like Proteases.

It is well known that vital enzymes in the replication process of the coronavirus are the SARS-CoV-2 PLpro and SARS-CoV-2 3CLpro, both of which are important targets in the search for anti-coronavirus agents. These two enzymes are responsible for cleavage at various polyprotein sites in the SARS-CoV-2 lifecycle. Herein, the dynamics of the polyprotein cleavage sequences for the boundary between non-structural proteins Nsp1 and Nsp2 (CS1) and between Nsp2 and Nsp3 (CS2) in complex with both the papain-like protein PLpro and the main protease 3CLpro were explored using computational methods. The post dynamics analysis reveals that CS1 and CS2 both have greater stability when complexed with PLpro. Of these two, greater stability is observed for the CS1-PLpro complex, while destabilization resulting in loss of CS2 from the PLpro active site is observed for CS2-PLpro, suggesting the rate of exchange by the papain-like protease is faster for CS2 compared to CS1. On the other hand, the 3CLpro main protease also reveals stability for CS1 suggesting that the main protease could also play a potential role in the cleavage at point CS1. However, destabilization occurs early in the simulation for the complex CLpro-CS2 suggesting a poor interaction and non-plausible protease cleavage of the polyprotein at CS2 by the main protease. These findings could be used as a guide in the development and design of potent COVID-19 antiviral inhibitors that mimic the CS1 cleavage site.