Rate Of Exchange Research Articles

Grand-canonical molecular dynamics simulations powered by a hybrid 4D nonequilibrium MD/MC method: Implementation in LAMMPS and applications to electrolyte solutions.

Molecular simulations in an open environment, involving ion exchange, are necessary to study various systems, from biosystems to confined electrolytes. However, grand-canonical simulations are often computationally demanding in condensed phases. A promising method [L. Belloni, J. Chem. Phys. 151, 021101 (2019)], one of the hybrid nonequilibrium molecular dynamics/Monte Carlo algorithms, was recently developed, which enables efficient computation of fluctuating number or charge density in dense fluids or ionic solutions. This method facilitates the exchange through an auxiliary dimension, orthogonal to all physical dimensions, by reducing initial steric and electrostatic clashes in three-dimensional systems. Here, we report the implementation of the method in LAMMPS with a Python interface, allowing facile access to grand-canonical molecular dynamics simulations with massively parallelized computation. We validate our implementation with two electrolytes, including a model Lennard-Jones electrolyte similar to a restricted primitive model and aqueous solutions. We find that electrostatic interactions play a crucial role in the overall efficiency due to their long-range nature, particularly for water or ion-pair exchange in aqueous solutions. With properly screened electrostatic interactions and bias-based methods, our approach enhances the efficiency of salt-pair exchange in Lennard-Jones electrolytes by approximately four orders of magnitude, compared to conventional grand-canonical Monte Carlo. Furthermore, the acceptance rate of NaCl-pair exchange in aqueous solutions at moderate concentrations reaches about 3% at the maximum efficiency.

Making the case for an International Decade of Radiocarbon.

Radiocarbon (14C) is a critical tool for understanding the global carbon cycle. During the Anthropocene, two new processes influenced 14C in atmospheric, land and ocean carbon reservoirs. First, 14C-free carbon derived from fossil fuel burning has diluted 14C, at rates that have accelerated with time. Second, 'bomb' 14C produced by atmospheric nuclear weapon tests in the mid-twentieth century provided a global isotope tracer that is used to constrain rates of air-sea gas exchange, carbon turnover, large-scale atmospheric and ocean transport, and other key C cycle processes. As we write, the 14C/12C ratio of atmospheric CO2 is dropping below pre-industrial levels, and the rate of decline in the future will depend on global fossil fuel use and net exchange of bomb 14C between the atmosphere, ocean and land. This milestone coincides with a rapid increase in 14C measurement capacity worldwide. Leveraging future 14C measurements to understand processes and test models requires coordinated international effort-a 'decade of radiocarbon' with multiple goals: (i) filling observational gaps using archives, (ii) building and sustaining observation networks to increase measurement density across carbon reservoirs, (iii) developing databases, synthesis and modelling tools and (iv) establishing metrics for identifying and verifying changes in carbon sources and sinks. This article is part of the Theo Murphy meeting issue 'Radiocarbon in the Anthropocene'.

The Effects of Dollarization on Local Currency in Somalia

This study focused on the effects of dollarization on local currency (Somali Shilling) in Somalia. The study employed quantitative research method. The study adopted descriptive research design to assess the effects of dollarization on local currency in Somalia. The researcher collected the data through documentary review of several articles, books and journals in relation to the effects of dollarization on local currency in Somalia. The key findings the effects of dollarization on local currency in Somalia encompass: dollarization leads to local currency depreciation and shortages in Somalia, dollarization increases the rate of foreign exchange on local currency and inflation rate and dollarization weakens the local financial institutions, which creates lack of financial control in the economy by the government authority leading to financial instability. The study recommended that, the Central Bank of Somalia, and Parliament of the Federal Republic of Somalia should introduce new regulation to regulate finance in the economy, new policy on financial control, introduce financial reform and review business models in the sphere of finance in Somalia to curb the increasing devastating effects of dollarization on local currency in Somalia.

A Systematic Review of Outcomes of Total Ankle Arthroplasty with INBONE II

Category: Ankle Arthritis; Ankle Introduction/Purpose: The INBONE II is a fixed-bearing implant with a stemmed tibial component commonly used for total ankle arthroplasty (TAA). Despite its frequent use and previously reported outcomes within individual clinical studies, no study has systematically reviewed outcomes of TAA with this implant. The purpose of this study was to perform a systematic review of the literature and report on outcomes of TAA with the INBONE II. Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. Databases searched included PubMed, Google Scholar, SCOPUS and CINAHL from database date of inception through February 28th, 2023. Clinical studies of INBONE II outcomes in peer reviewed journals were included. Outcomes included were survivorship, patient reported outcome measures (PROMs), and complications. Outcome results were compiled using weighted averages when possible. This review of 26 articles included 808 patients with 667 primary TAA and 141 revision TAA. Results: Survivorship, with failure defined as metal component revision, was 97.8% at an average follow-up of 49 months (range, 14-85.4 months) and 94.2% at an average follow-up of 25.7 months (range, 9.1-47.5) months for primary and revision TAA respectively. Complication rates for primary TAA included: 3.8% intra-operative fractures, 2.5% post-operative fractures, 1.8% deep infection, 8.0% wound complications, 1.6% rate of poly exchange, and 1.6% nerve injuries. Revision TAA complication rates included: 12.3% intra-operative fractures, 6.9% wound complications, 3.3% deep infections, and a 5.5% incidence of nerve injury. Average PROMs for primary TAA included: AOFAS American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score improved 41 points, visual analog scale (VAS) scores decreased 5.9, and patient satisfaction of 92.6%. Revision TAA PROMs were not consistently reported. Conclusion: This study is the largest compilation of INBONE II outcomes and survivorship. Primary and revision TAA with the INBONE II results in satisfactory improvement in PROMs and low complication rates. The overall survivorship is 97.8% and 94.2% at an average follow-up of 49 months (range, 14-85.4 months) and 25.7 months (range, 9.1-47.5) for primary and revision total ankle arthroplasty respectively. These findings support continued use of this implant in primary and revision TAA.

Simulation and optimization of square fin concentric tube heat storage exchanger

The square fin was used to improve the heat transfer rate of the concentric tube phase change heat exchanger. The effects of fin spacing, fin arrangement, and fin length on the melting process of phase change material (PCM) were studied. The influence and mechanism of non-uniform fin arrangement were discussed in detail. The liquid phase distribution and temperature distribution of PCM with time were analyzed. The results indicated that the heat exchanger with square fins can significantly improve the heat storage rate and shortened the complete melting time of PCM. Compared with heat exchangers without fins, the melting time of PCM in a 40 mm equidistant fin heat exchanger was shortened by 15.85%, and that in a 70 mm, non-uniformly spaced fin heat exchanger was shortened by 36.79%. Due to the different distances between the square fins and the outer boundary of the concentric tube, the temperature distribution near the square fin showed anisotropy, which enhanced the melting rate of PCM. The sensitivity order was fin arrangement > fin length > fin spacing. The research results can provide a reference for the design of phase change heat exchangers.

Factors Affecting Inflation Rates in the Kingdom of Saudi Arabia: A standard study from 1980 to 2016

This study aimed at identifying the factors affecting inflation rates in the Kingdom of Saudi Arabia for the period (1980-2016). To achieve the study purpose, the researcher adopted the descriptive analytical model as it suits this phenomenon. A group of variables that are expected to affect the inflation rate in the Saudi economy is selected. These variables are: money supply growth rate, imports of GDP, oil price growth rate, rate of exchange, income growth rate interest rate on the dollar and generate price level. Besides that, a standard model was built based on a series of data of inflation determents for the Saudi economy (1980-2016). The researcher also used the EViews program to tackle the relation among the variables and to obtain the best results. The study reached the following set of results: There is a direct relation between the inflation rate and money supply growth rate, imports of GDP, and general price level. Whereas the money supply growth rate has the strongest impact on inflation followed by imports of GDP, on the other hand, there is an inverse relation with both exchange rate. Meanwhile, the rest of the variables, oil price growth rate, income growth rate, and interest rate on the dollar have no effect on the inflation rate in Saudi Arabia.

Proton vs. Photons for Breast Cancer Patients with Immediate, Implant-Based Reconstruction Receiving Postmastectomy Radiotherapy: A Multicenter Pooled Analysis

Proton therapy improves postmastectomy radiotherapy (PMRT) normal tissue sparing compared with photon techniques. However, little is understood about its effect on reconstruction outcomes. The primary objective was to evaluate complication rates in breast cancer patients treated with proton (PRO) versus photon (PHO) PMRT following immediate, implant-based breast reconstruction. Consecutive patients with breast cancer who underwent mastectomy and immediate reconstruction with a tissue expander (TE) or permanent implant (PI) and PRO or PHO PMRT between 2011 and 2022 were included from two institutions. Complication rate was defined as the sum of reconstruction failure (explantation without replacement), unplanned prosthesis exchange, and other unplanned revisional surgery. Each complication type was analyzed as an independent endpoint. Among 733 patients, median follow-up was 4.4 years; 36.5% (267) were treated with PRO and 63.5% (466) with PHO. There was no difference in age, BMI, or comorbidities between the two groups. PRO was more likely to have had, two-stage reconstruction and pre-pectoral implant placement (p<.01). Median dose was 50-50.4 Gy in 25-28 fractions, with only 50 receiving hypofractionation. Bolus was used in all PHO patients. Regional nodes were more likely to be included in PRO (99.6% v. 83.7% PHO, p<.01). Although there was no difference in the use of chest wall boost between groups, the axillary nodes were more frequently boosted in PRO (25.1% vs 2.8% PHO, p<.01). The overall rate of complications at 4 years was 26.7% (95% CI = 23.3-30.5). The 4-year rate of reconstruction failure, unplanned exchange, and other surgery was 8.2% (95% CI = 6.3-10.7), 17.4% (95% CI = 14.6-20.8), and 12.5% (95% CI = 10.1-15.5), respectively. On MVA, PRO did not confer an increased risk of reconstruction complications compared to PHO. Significant risk factors for reconstruction failure included TE-to-autologous approach [HR versus direct-to-implant reference: 4.05 (95% CI = 1.60-10.22)], TE-to-permanent implant approach [HR = 2.06 (95% CI = 1.12-3.79)], chest wall boost [HR = 2.20 (95% CI = 1.21-4.02)], and any lymph node boost [HR = 2.33 (95% CI = 1.10-4.97)]. Compared to direct-to-implant, two-stage reconstruction was also associated with a higher rate of unplanned exchange [HR for TE/PI = 1.49 (95% CI = 1.01-2.20)] and revisional surgery [HR for TE-to-autologous = 3.95 (95% CI = 1.64-9.52)]. Prepectoral implant placement was correlated with reduced risk of revisional surgery, relative to subpectoral placement [HR = 0.42 (95% CI = 0.22-0.81)]. This represents the largest combined series to date comparing PRO and PHO PMRT. Despite a higher rate of two-stage reconstruction, nodal irradiation, and nodal boost in PRO, there was no significant difference in the risk of complications between protons and photons. Differences in PRO delivery techniques between institutions and dosimetric details such as skin dose will be presented in person.

Hydrogeochemical features of groundwaters of the Ukrainian shield fractured crystalline rocks on the example of Zhytomyr and Vinnytsia regions

&#x0D; &#x0D; &#x0D; The chemical composition of groundwaters of fractured Precambrian crystalline rocks corresponding to the Ukrainian Shield aquifer system was investigated. Using the ex- ample of surveyed aquifers of the Vinnytsia and Zhytomyr regions, the similarity of the quantitative and qualitative composition of groundwater confined to the same hydrogeological structure is proven, which is due to similar natural conditions of resource formation (geological structure, the chemical composition of water-bearing rocks, rates of water exchange, amount of atmospheric precipitation, etc.). The dominant role of sulfates in the anionic composition of water samples from the aquifer in the fractured zone of crystalline rocks and their weathering crust (Vysokyi Kamin village, Zhytomyr region) was established. For the Zhytomyr region groundwaters, the dynamics of changes over time in such indica- tors of the general chemical composition as total mineralization, Ca, Mg, SO4, and Cl ions were analyzed for 2017-2019. A significant correlation was found between the concentrations of Mg, SO4, and Cl and their normalized indicators by the amount of water intake, which indicates that the content of mineral substances increases in the studied aquifer with an increase in water withdrawal. This is the evidence of the essential role of the anthropogenic factor in the formation of the general chemical composition of these waters. Using the method of mass spectrometry with inductively coupled plasma (ICP-MS), the features of the trace element composition of groundwaters of the Ukrainian Shield fractured crystalline rocks were established. The obtained concentrations of elements were com- pared with normative values of the World Health Organization and biologically significant concentrations. The lack of several essential elements was revealed. The key potential risks for the health of the population, which constantly uses the investigated groundwaters for economic and potable needs, was outlined. Moreover, the high probability of occurrence of microelementoses with regular use of the investigated groundwaters is emphasized, which are associated with a significant deficiency of such vital elements as Cr (in the Vinnytsia region), Mn, Cu, and, especially, Zn, the content of which is critically low. Subsequently, the findings of this study can serve as a basis for carrying out biogeochemical zoning with the selection of relevant taxa (provinces).&#x0D; &#x0D; &#x0D;

Exact solutions for permeable wall laminar jet with velocity slip: Momentum and thermal profiles

This study presents exact analytical solutions for the two-dimensional laminar jet flow and heat transport of Casson fluid under velocity slip condition. The laminar wall jet of classical Glauert type is extended to the Casson fluid model considering the flow to be along a flat permeable surface. The roles of velocity slip, wall temperature, and mass transfer on the fluid flow and rate of thermal exchange are investigated. The outcomes for momentum and thermal fields, skin friction and heat transfer gradient are obtained analytically with numerical solutions of the suction-far stream velocity expression. It is noted that mass transfer and velocity slip have significant effects on the flow of fluid and heat transfer. Thermal profile varies significantly for increasing Prandtl values with small suction.

Benthic sediment as stores and sources of bacteria and viruses in streams: A comparison of baseflow vs. stormflow longitudinal transport and residence times

The presence of bacteria and viruses in freshwater represents a global health risk. The substantial spatial and temporal variability of microbes leads to difficulties in quantifying the risks associated with their presence in freshwater. Fine particles, including bacteria and viruses are transported and accumulated into shallow streambed (i.e., benthic) sediment, delaying the downstream transmission during baseflow conditions but contributing to their resuspension and transport downstream during stormflow events. Direct measurements of pathogen accumulation in benthic sediments are rare. Until now, the dynamic role of benthic sediment as both a store and source of microbes, has not been quantified. In this study, we analyze microbial abundance in benthic sediment along a 1 km reach of an intermittent Mediterranean stream receiving inputs from the effluent of a wastewater treatment plant, a known point source of microbes in streams. We sampled benthic sediment during a summer drought when the wastewater effluent constituted 100 % of the stream flow, and thus, large accumulation and persistence of pathogens along the streambed was expected. We measured the abundance of total bacteria, Escherichia coli (as a fecal indicator), and presence of enteric rotavirus (RoV) and norovirus (NoV). The abundance of E. coli, based on qPCR detection, was high (4.99∙102 gc /cm2) along the first 100 m downstream of the wastewater effluent input and in general decreased with distance from the source, with presence of RoV and NoV along the study reach. A particle tracking model was applied, that uses stream water velocity as an input, and accounts for microbial exchange into, immobilization, degradation, and resuspension out of benthic sediment during baseflow and stormflow. Rates of exchange into benthic sediment were 3 orders of magnitude higher during stormflow, but residence times were proportionately lower, resulting in increased longitudinal connectivity from up to downstream during stormflow. Model simulations demonstrated mechanistically how the rates of exchange into and out of the benthic sediment resulted in benthic sediment to act as a store during baseflow and a source during stormflow.

Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging

The blood–brain barrier (BBB) undergoes functional changes with aging which may contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI technique can measure the rate of water exchange across the BBB (kw) and may thus be sensitive to age-related alterations in water exchange at the BBB. However, studies investigating relationships between kw and cognition have reported different directions of association. Here, we begin to investigate the direction of associations between kw and cognition in different brain regions, and their possible underpinnings, by evaluating links between kw, cognitive performance, and MRI markers of cerebrovascular dysfunction and/or damage. Forty-seven healthy older adults (age range 61–84) underwent neuroimaging to obtain whole-brain measures of kw, cerebrovascular reactivity (CVR), and white matter hyperintensity (WMH) volumes. Additionally, participants completed uniform data set (Version 3) neuropsychological tests of executive function (EF) and episodic memory (MEM). Voxel-wise linear regressions were conducted to test associations between kw and cognitive performance, CVR, and WMH volumes. We found that kw in the frontoparietal brain regions was positively associated with cognitive performance but not with CVR or WMH volumes. Conversely, kw in the basal ganglia was negatively associated with cognitive performance and CVR and positively associated with regional, periventricular WMH volume. These regionally dependent associations may relate to different physiological underpinnings in the relationships between kw and cognition in neocortical versus subcortical brain regions in older adults.

Analysis of a Hybrid System Solar Chimney-Air Soil Heat Exchanger for Natural Ventilation

The current study looks at a hybrid passive cooling system that combines a solar chimney with an earth-to-air heat exchanger (EAHE) usually called Canadian Well. Numerous experimental and numerical examinations with various applied radiation heat fluxes were carried out to evaluate its ability to cool a room. Glass temperature, wall temperature, air flow mean temperature, hourly rate of air exchange (ACH), outlet airflow velocity, and rate of air mass flow were determined experimentally and numerically, and validated against previously published experimental and analytical works. It was found that the chimney's operation is dependent on the radiation intensity. The EAHE has reduced the room's temperature by improving exchanges with the solar chimney. The comparison of experimental and numerical data for different radiation intensities reveals that the best diameter of the tube of the underground heat exchanger for the proper operation of our system is d = 0.04m. The efficiency of our system increases as the radiation increases, causing an increase in the temperature of the absorber, which influences the air temperature in the chimney.

Artificial intelligence based prediction of optimum operating conditions of a plate and fin heat exchanger under uncertainty: A gray-box approach

This study is based on gray-box modeling for the prediction of optimum mass flow rates of inlet streams of a Plate and Fin Heat Exchanger under uncertainty. A first principle model of the Plate and Fin Heat Exchanger was developed in Aspen Exchanger Design and Rating. Genetic algorithm was integrated with the first principle model to achieve the highest possible exit temperature of the cold process stream under uncertainty. A dataset of uncertain process conditions and their corresponding optimum inlet flow rates derived through the first principle-genetic algorithm integration was used to develop an artificial neural networks model. The artificial neural networks model was then integrated with the first principle model by replacing the genetic algorithm to form a novel gray-box framework. The proposed gray box model, i.e., artificial neural networks and first principle integration, achieved a higher effectiveness and higher outlet temperature than those derived through the straight run first principle model. The performance of the gray box framework was also comparable to the first principle integrated genetic algorithm approach and significantly minimized the computation time needed for estimating the optimum process conditions. First principle integrated genetic algorithm approach enhanced the effectiveness of the straight run model by 3.05%. Performance of the proposed gray-box model was comparable to the integrated framework of the genetic algorithm with the first principle model but was significantly faster. The developed artificial neural networks model was employed as a surrogate in Sobol and FAST sensitivity analysis framework to identify the impact of input variables on output variables. The proposed gray box based method enhanced the capability of the plate and fin heat exchanger to recover energy from the process stream and its robustness to cope with uncertainty. The proposed approach is suitable for real-time application and would contribute to laying a foundation for petroleum refinery 4.0.

Exchange Rate Fluctuation and Management of Foreign Donor-Funded Program Budget

The study was about the effect of exchange rate fluctuation on the management of foreign donor-funded program budgets. Humanitarian and development agencies receive funding from foreign donors, who require the program budgets and financial reports in their respective country currencies although the actual utilization of the budget in the host country’s local currency during the program implementation. The study explored currency conversion methods and identified the best principles for effective management of the effect of exchange rate fluctuation. The research design used was both quantitative and qualitative where relevant literature related to exchange methods, donor requirements, and average monthly exchange rate data were reviewed. The sampling year used in this study is 3 years, 2021 to 2023 and the currency sample selected was Uganda Shillings (UGX) and United States Dollars (USD). First In and First Out (FIFO), Weighted average exchange rate methods, and daily spot rate methods were the most common currency conversion methods identified during the study. The study further noted the currency conversion method chosen should be documented in the written financial manual of the grant holder for reference. The study identified budget monitoring, requests for budget amendment, effective planning, provision for contingency reserves in the budget, and constant communication with the donors among the best ways to manage the effect of exchange rate fluctuation. The Study, therefore concluded that exchange rate fluctuation has either adverse or favorable effects on foreign donor-funded program budget and needed to be closely monitored and communicated to the donor for further guidance. Keywords: Exchange rate, Fluctuation, Foreign Donor- funded, Program and Budget.

Performance of the frosting characteristics of fin-and-tube heat exchanger subject to superhydrophobic coating

The condensation and freezing processes of fin-and-tube heat exchangers with a bare surface and coated with a superhydrophobic substance were experimentally studied for various air velocities, relative humidity (RH) values, and fin spacings. The performance of the fin-and-tube heat exchangers in terms of dynamic pressure drop and heat transfer rate were reported in details. The frosting characteristics of these exchangers were visually characterized microscopically. It is found that for a superhydrophobic exchanger with 1-mm fin spacings, water bridges were likely to form, causing droplets to stick between the fins instead of slipping off the surface. At a low RH and a maximum air velocity of 1.0 m s−1, the heat transfer rate of the superhydrophobic exchanger was 12% lower than that of the surface without superhydrophobic coating. For a fin spacing of 3.0 mm, the critical droplet size was smaller than the fin spacing, hence the droplets can easily slip or jump off the fins. At a velocity of 0.6 m s−1, the steady-state pressure drop at low humidity of the superhydrophobic exchanger was 14% lower than that of the bare surface because of the differences in frosting characteristics. The results of this study indicate that the adopted superhydrophobic coating can delay frosting at high humidity and air velocity.

INE oil futures volatility prediction: Exchange rates or international oil futures volatility?

This study examines the predictive performances of volatility information from international oil futures volatility and exchange rates for Shanghai International Energy Exchange (INE) oil futures volatility. Various empirical findings show that the predictive performance of international oil futures volatility is superior to that of the exchange rate. In addition, we examine whether regime switching is efficient, and the results show that time-varying regime switching plays a satisfactory role. Moreover, these results are robust even during some special periods, including the COVID-19 pandemic, the Russia–Ukraine conflict, and different business cycles. This study provides new insights into the volatility prediction of the INE oil futures market.

Tissue Perfusion and Diffusion and Cellular Respiration: Transport and Utilization of Oxygen.

This article provides an overview of the journey of inspired oxygen after its uptake across the alveolar-capillary interface, and the interplay among tissue perfusion, diffusion, and cellular respiration in the transport and utilization of oxygen. The critical interactions between oxygen and its facilitative carriers (hemoglobin in red blood cells and myoglobin in muscle cells), and with other respiratory and vasoactive molecules (carbon dioxide, nitric oxide, and carbon monoxide), are emphasized to illustrate how this versatile system dynamically optimizes regional convective transport and diffusive gas exchange. The rates of reciprocal gas exchange in the lung and the periphery must be well-matched and sufficient for meeting the range of energy demands from rest to maximal stress but not excessive as to become toxic. The mobile red blood cells play a vital role in matching tissue perfusion and gas exchange by dynamically regulating the controlled uptake of oxygen and communicating regional metabolic signals across different organs. Intracellular oxygen diffusion and facilitation via myoglobin into the mitochondria, and utilization via electron transport chain and oxidative phosphorylation, are summarized. Physiological and pathophysiological adaptations are briefly described. Dysfunction of any component across this integrated system affects all other components and elicits corresponding structural and functional adaptation aimed at matching the capacities across the entire system and restoring equilibrium under normal and pathological conditions.

Preliminary Experimental Laboratory Methods to Analyse the Insulation Capacity of Vertical Greening on Temperature and Relative Humidity

Ground-based vertical greening is one of the well-known nature-based solutions that is widely used in city centres due to its small footprint and the large surface area of vegetation. Although the impact of vertical greening on the local microclimate has already been extensively researched, there is a poor understanding of the impact of vertical greening on historic building fabrics. The impact of vertical greening on microclimate environments has primarily been researched through in situ case-study monitoring; as such, there are currently no standard protocols for investigating this impact in laboratory studies. By performing simulations in controlled laboratory conditions, the influence of vertical greening on specific environmental conditions can be assessed as well as the significance for key mechanisms, such as the insulation capacity of a vegetation layer. Experimental results on the insulation capacity of vertical greening illustrate that the presence of vertical greening reduces the rate of heat exchange between the wall and the surrounding environment compared to the bare wall, resulting in a delayed temperature response of the wall. This delay varies across the seasons or its intensity, which is represented, for instance, by a more pronounced delay in the wall’s surface temperature response in summer than in winter. However, the magnitude of the insulation capacity is more pronounced in winter (up to +2.1 °C) compared to summertime. The insulation capacity of vertical greening is more likely to have a significant impact on façades with a lack of solar irradiation, such as façades facing north or shaded by built surroundings. This experimental investigation can help build an understanding of these processes more fundamentally and support the interpretation of in situ case-study monitoring as well as provide a standardized approach to investigate the environmental performance of vertical greening across climatic regions and seasons.

Analysis of curative effect and short-term survival rate of plasma exchange and double plasma molecular adsorption combined with half-volume plasma exchange in the treatment of liver failure

Objective: To investigate how plasma exchange (PE) and double plasma molecular adsorption combined with half-volume plasma exchange (DPMAS + half-volume PE) affect the curative effect and short-term survival rate in liver failure. Methods: Data from 181 cases of liver failure caused by different etiologies from January 1, 2017 to September 31, 2020, were selected. Patients were divided into a PE treatment alone group and a DPMAS + half-dose PE treatment group. The laboratory indicators with different models of artificial liver before and after treatment and the survival rates of 7, 14, 28, and 90 days after discharge were observed in the two groups. Measurement data were analyzed by t-tests and rank sum tests. Categorical data were analyzed by χ (2) test. Results: Non-biological artificial liver therapy with different models improved the liver and coagulation function in the two groups of patients with liver failure (P < 0.05 in PTA% intra-group). The coagulation function was significantly improved in the PE treatment alone group compared with that in the DPMAS + half-dose PE group [PT after treatment: (20.15 ± 0.88) s in the PE treatment alone group, (23.43 ± 1.02) s, t = -2.44, P = 0.016 in the DPMAS+half-dose PE group; PTA: 44.72% ± 1.75% in the PE treatment alone group, 35.62% ± 2.25%, t = 3.215 P = 0.002 in the DPMAS + half-dose PE group]. Bilirubin levels were significantly decreased in the DPMAS+half-dose PE group compared to the PE treatment alone group [total bilirubin after treatment: (255.30 ± 15.64) μmol/L in the PE treatment alone group, (205.46 ± 9.03) μmol/L, t = 2.74, P = 0.07 in the DPMAS + half-dose PE group; direct bilirubin after treatment: (114.74 ± 7.11) μmol/L in the PE treatment alone group, (55.33 ± 3.18) μmol/L, t = 7.54, P < 0.001) in the DPMAS + half-dose PE group]. However, there was no significant effect on leukocytes and neutrophils after treatment with different models of artificial liver (P > 0.05) in the two groups, and platelets decreased after treatment, with no statistically significant difference between the groups (t = -0.15, P = 0.882). The inflammatory indexes of the two groups improved after treatment with different models of artificial liver (P < 0.05], and the 28 and 90 d survival rates were higher in the DPMAS+half-dose PE group than those of the PE treatment alone group (28 d: 60.3% vs. 75.0%, χ (2) = 4.315, P = 0.038; 90 d: 56.2% vs. 72.5%. χ (2) = 10.355 P < 0.001). DPMAS + half-dose PE group plasma saving was 1385 ml compared with PE treatment alone group (Z = -7.608, P < 0.05). Conclusion: Both DPMAS+half-dose PE and PE treatment alone have a certain curative effect on patients with liver failure. In DPMAS+half-dose PE, the 28-day survival rate is superior to PE treatment alone, and it saves plasma consumption and minimizes blood use in clinic.

Spontaneous histone exchange between nucleosomes

The nucleosome is the fundamental gene-packing unit in eukaryotes. Nucleosomes comprise ∼147bp DNA wrapped around an octameric histone protein core composed of two H2A-H2B dimers and one (H3-H4)2 tetramer. The strong yet flexible DNA-histone interactions are the physical basis of the dynamic regulation of genes packaged in chromatin. The dynamic nature of DNA-histone interactions also implies thatnucleosomes dissociate DNA-histone contacts both transiently and repeatedly. This kinetic instability may lead to spontaneous nucleosome disassembly or histone exchange between nucleosomes. At high nucleosome concentrations, nucleosome-nucleosome collisions and subsequent histone exchange would be a more likely event, where nucleosomes could act as their own histone chaperone. This spontaneous histone exchange could serve as a mechanism for maintaining overall chromatin stability, although it has never been reported. Here we employed three-color single-molecule FRET (smFRET) to demonstrate that histone H2A-H2B dimers are exchanged spontaneously between nucleosomes on a time scale of a few tens of seconds at a physiological nucleosome concentration. We show that the rate of histone exchange increases at a higher monovalent salt concentration, with histone-acetylated nucleosomes, and in the presence of histone chaperone Nap1, while it remains unchanged at a higher temperature, and decreases upon DNA methylation. These results support the notion of histone exchange via transient and repetitive partial disassembly of the nucleosome and corroborate spontaneous histone diffusion in a compact chromatin context, modulating the local concentrations of histone modifications and variants.