Rate Of Change Research Articles

The Strategy of Continuous Commutation Failure Suppression by Combining Turn-off Angle Compensation and Dynamic Nonlinear VDCOL

In recent years, with the continuous growth in China’s economy, the continuous advancement of urbanization and industrialization, the contradiction between rapid economic development and the continuous reduction in traditional fossil energy reserves such as coal, oil, and natural gas, the continuous aggravation of environmental pollution has become increasingly prominent. In this era, clean energy power generation technologies such as hydropower, wind power, and solar power generation, which have the advantages of renewability, environmental protection, and economy, have developed rapidly. However, wind and photovoltaic power plants are often located in remote areas, which means significant losses in the transmission process. High-voltage direct current (HVDC) transmission technology becomes the best choice to solve this problem. The HVDC transmission system based on a grid commutator is widely used in China’s AC-DC hybrid power grid. When an AC fault occurs on the inverter side, the line-commutated converter high-voltage direct current (LCC-HVDC) system is more prone to continuous commutation failure, which brings serious harm to system operation. To better suppress the problem of continuous commutation failure on the contravariant side, this paper analyzes the mechanism of continuous commutation failure from multiple angles. The DC current command sensitivity of a voltage-dependent current order limiter (VDCOL) in the LCC-HVDC system is low, which will lead to different degrees of continuous commutation failure. In addition, the rapid rise in DC current and the drop in commutation voltage during the fault will cause the turn-off angle to drop, and the probability of continuous commutation failure of the system will increase significantly. Based on the above theoretical analysis, a new control strategy combining the dynamic compensation of the turn-off angle of a virtual inductor and the suppression of continuous commutation failure by dynamic nonlinear VDCOL is proposed. A dynamic nonlinear VDCOL control strategy is proposed for the low sensitivity of current command adjustment under conventional VDCOL control. Secondly, two concepts of virtual inductance and DC current change rate are introduced, and a control strategy based on virtual inductance is proposed to comprehensively ensure that the switching angle has sufficient commutation margin during fault recovery. Finally, based on the CIGRE standard test model in PSCAD/EMTDC, the accuracy of the correlation mechanism analysis and the effectiveness of the suppression method are verified.

Image security using steganography and cryptography with sweeping computational ghost imaging

A sweeping computational ghost imaging (SCGI)-based encryption system is intended for increased data security and speedier data transport. SCGI is combined with steganography and cryptography processes in this system. SCGI requires fewer shots, resulting in faster image capture, transmission, encryption, and decryption. This strategy also results in smaller, more compact data packages and higher bitrates. Least significant bit (LSB) uses steganography to conceal the hidden picture. In the case of Rivest–Shamir–Adleman (RSA) encryption, public and private keys are generated via a one-way function based on bucket values. Encryption is performed on two levels, with an asymmetric approach divided into three sub-items that significantly increase encryption. Surprisingly, the method uses fewer pictures for image reconstruction, resulting in faster image reconstruction. SCGI promises applications in an extensive number of data encryption sectors since this technology leads to smaller data packages and higher bitrates. The presented approach is examined using the number of pixel change rate (NPCR), normalized root mean square (NRMS), peak signal-to-noise ratio (PSNR), and correlation coefficient (CC), which indicates constant encryption improvement. We experimentally and situationally demonstrate our findings under eavesdropping, which prove the resistance and robustness of our methods. In optimal settings, this innovation enhances encryption by up to 90% when compared to traditional encryption methods.

Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease.

Microscopic nephrocalcinosis is a common pathological feature of chronic kidney disease (CKD) in cats. Detection of macroscopic nephrocalcinosis using ultrasonography and its implications remain unexplored. Identify risk factors associated with ultrasound-diagnosed nephrocalcinosis and evaluate the influence of nephrocalcinosis on CKD progression. Thirty-six euthyroid client-owned cats with CKD. Prospective cohort study. Cats with CKD with and without ionized hypercalcemia were enrolled for renal ultrasonography. Cats were categorized according to the presence or absence of ultrasound-diagnosed nephrocalcinosis. Binary logistic regression was performed to identify nephrocalcinosis risk factors. The influence of nephrocalcinosis on CKD progression was assessed using linear mixed models. Ultrasound-diagnosed nephrocalcinosis was evident in 61% of CKD cats overall, with increased prevalence (81%) in those with hypercalcemia. At enrollment, higher blood ionized calcium concentration (odds ratio [OR], 1.27 per 0.1 mg/dL; P = .01), plasma phosphate concentration (OR, 1.16 per 0.1 mg/dL; P = .05), plasma creatinine concentration (OR, 1.29 per 0.1 mg/dL; P = .02) and alanine aminotransferase activity (OR, 2.08 per 10 U/L; P = .04) were independent nephrocalcinosis risk factors. The rate of change in log-transformed fibroblast growth factor-23 differed significantly between groups (P = .04). Cats with CKD and nephrocalcinosis had increasing plasma creatinine concentrations (.03 ± .01 mg/dL/month; P = .04) and phosphate concentrations (.06 ± .02 mg/dL/month; P < .001) and decreasing body weight (.02 ± .01 kg/month; P < .001) over time. Nephrocalcinosis is prevalent in cats with CKD, especially in those with hypercalcemia. This pathological feature appears to be associated with CKD progression in cats.

Identifying constraints and limits to climate change adaptation in Austria under deep uncertainty

Although humanity has always been adapting to a changing environment, the accelerated rate of climate change in combination with continued socioeconomic development and the delay in climate action result in deep uncertainties, further challenging policy, and decision making. A main are of concern, triggered by the increasing frequency and intensity of climatic hazards are growing uncertainties regarding the effectiveness of prevailing adaptation strategies, as well as constraints and eventually limits to adaptation. The existing literature is largely conceptual and focusses on the Global South, where evidence for reaching adaptation limits already exists. In this study, we aim to uncover whether Austria, a Global North country, faces intolerable risks from climate change and experiences adaptation constraints that may trigger limits to adaptation. As there are still considerable uncertainties involved in quantifying potential adaptation limits, we use a social science approach to collect first empirical evidence on this crucial issue. We identify and discuss sources of concern based on semi-structured interviews (n = 26) with climate change adaptation and disaster risk management experts. Our results indicate that although Austria may currently not face physical constraints, which could lead to “hard” adaptation limits, it is nevertheless essential to upgrade existing adaptation strategies for more severe climatic events that may impose “soft” adaptation limits at the local and individual level. Many of these perceived soft adaptation limits are linked to constraints in imagination, awareness, and knowledge, but also to confining decision-making processes and the locked-in focus on technical adaptation measures, which cannot be scaled up indefinitely. To overcome these constraints and avoid adaptation limits, we suggest more inclusive stakeholder involvement in adaptive planning and the design of climate strategies by fostering bottom-up or participatory processes and integrating disaster risk management and climate change adaptation more strongly within polycentric risk governance approaches. Our insights can be seen as a precursory scoping study for the establishment of comprehensive decision making under deep uncertainty approaches in Austria and beyond, since at least many Global North countries share similar constraints and uncertainties regarding technological, economic, and political trends.

The genomic signatures of evolutionary stasis.

Evolutionary stasis characterizes lineages that seldom speciate and show little phenotypic change over long stretches of geological time. Although lineages that appear to exhibit evolutionary stasis are often called living fossils, no single mechanism is thought to be responsible for their slow rates of morphological evolution and low species diversity. Some analyses of molecular evolutionary rates in a handful of living fossil lineages have indicated that these clades exhibit slow rates of genomic change. Here, we investigate mechanisms of evolutionary stasis using a dataset of 1,105 exons for 481 vertebrate species. We demonstrate that two ancient clades of ray-finned fishes classically called living fossils, gars and sturgeons, exhibit the lowest rates of molecular substitution in protein-coding genes among all jawed vertebrates. Comparably low rates of evolution are observed at fourfold degenerate sites in gars and sturgeons, implying a mechanism of stasis decoupled from selection that we speculate is linked to a highly effective DNA repair apparatus. We show that two gar species last sharing common ancestry over 100 million years ago produce morphologically intermediate and fertile hybrids in the wild. This makes gars the oldest naturally hybridizing divergence among eukaryotes and supports a theoretical prediction that slow rates of nucleotide substitution across the genome slow the accumulation of genetic incompatibilities, enabling hybridization across deeply divergent lineages and slowing the rate of speciation over geological timescales. Our results help establish molecular stasis as a barrier to speciation and phenotypic innovation and provide a mechanism to explain the low species diversity in living fossil lineages.

A simple estimation method of grid‐forming inverter inertia based on rate of change of frequency

AbstractInertia is the core index of the estimation of power system frequency stability; a simple estimation method of grid‐forming inverter inertia based on the rate of change of frequency (RoCoF) is proposed in this paper. The method records and fits the active power curve by applying RoCoF to obtain the value of the grid‐forming inverter inertia, and it is simpler and higher accuracy compared to existing methods. In addition, the inertia and damping are analysed to support the system, and the relationship equation between the grid frequency slope change and the output active power is derived. Considering the theoretical analyses and influencing factors, the inertia and damping are obtained by using the method of function fitting. The test steps show the simplicity of the proposed test method. Finally, the effectiveness of the proposed method is verified in MATLAB/Simulation and two 1.575‐MW parallel grid‐forming electrochemical energy storage power plants.

Highly stable and antifungal properties on the oilseed rape of Cu3(MoO4)2(OH)2 nanoflakes prepared by simple aqueous precipitation

In the last few decades, nanoparticles have been a prominent topic in various fields, particularly in agriculture, due to their unique physicochemical properties. Herein, molybdenum copper lindgrenite Cu3(MoO4)2(OH)2 (CM) nanoflakes (NFs) are synthesized by a one-step reaction involving α-MoO3 and CuCO3⋅Cu(OH)2⋅xH2O solution at low temperature for large scale industrial production and developed as an effective antifungal agent for the oilseed rape. This synthetic method demonstrates great potential for industrial applications. Infrared spectroscopy and X-ray diffraction (XRD) results reveal that CM samples exhibit a pure monoclinic structure. TG and DSC results show the thermal stable properties. It can undergo a phase transition form copper molybdate (Cu3Mo2O9) at about 300 °C. Then Cu3Mo2O9 nanoparticles decompose into at CuO and MoO3 at 791 °C. The morphology of CM powder is mainly composed of uniformly distributed parallelogram-shaped nanoflakes with an average thickness of about 30 nm. Moreover, the binding energy of CM NFs is measured to be 2.8 eV. To assess the antifungal properties of these materials, both laboratory and outdoor experiments are conducted. In the pour plate test, the minimum inhibitory concentration (MIC) of CM NFs against Sclerotinia sclerotiorum (S. sclerotiorum) is determined to be 100 ppm, and the zone of inhibiting S. sclerotiorum is 14 mm. When the concentration is above 100 nm, the change rate of the hyphae circle slows down a little and begins to decrease until to 200 ppm. According to the aforementioned findings, the antifungal effects of a nano CM NFs solution are assessed at different concentrations (0 ppm (clear water), 40 ppm, and 80 ppm) on the growth of oilseed rape in an outdoor setting. The results indicate that the application of CM NFs led to significant inhibition of S. sclerotiorum. Specifically, when the nano CM solution was sprayed once at the initial flowering stage at a concentration of 80 ppm, S. sclerotiorum growth was inhibited by approximately 34%. Similarly, when the solution was sprayed once at the initial flowering stage and once at the rape pod stage, using a concentration of 40 ppm, a similar level of inhibition was achieved. These outcomes show that CM NFs possess the ability to bind with more metal ions due to their larger specific surface area. Additionally, their semiconductor physical properties enable the generation of reactive oxygen species (ROS). Therefore, CM NFs hold great potential for widespread application in antifungal products.

Chiral Assembly of Perovskite Nanocrystals: Sensitive Discrimination of Amino Acid Enantiomers.

Chirality is a widespread phenomenon in nature and in living organisms and plays an important role in living systems. The sensitive discrimination of chiral molecular enantiomers remains a challenge in the fields of chemistry and biology. Establishing a simple, fast, and efficient strategy to discriminate the spatial configuration of chiral molecular enantiomers is of great significance. Chiral perovskite nanocrystals (PNCs) have attracted much attention because of their excellent optical activity. However, it is a challenge to prepare perovskites with both chiral and fluorescence properties for chiral sensing. In this work, we synthesized two chiral fluorescent perovskite nanocrystal assembly (PNA) enantiomers by using l- or d-phenylalanine (Phe) as chiral ligands. PNA exhibited good fluorescence recognition for l- and d-proline (Pro). Homochiral interaction led to fluorescence enhancement, while heterochiral interaction led to fluorescence quenching, and there is a good linear relationship between the fluorescence changing rate and l- or d-Pro concentration. Mechanism studies show that homochiral interaction-induced fluorescence enhancement is attributed to the disassembly of chiral PNA, while no disassembly of chiral PNA was found in heterochiral interaction-induced fluorescence quenching, which is attributed to the substitution of Phe on the surface of chiral PNA by heterochiral Pro. This work suggests that chiral perovskite can be used for chiral fluorescence sensing; it will inspire the development of chiral nanomaterials and chiral optical sensors.

Length and saturation of choline plasmalogens alter the aggregation rate of α-synuclein but not the toxicity of amyloid fibrils

Plasmalogens comprise a large fraction of the total phospholipids in plasma membranes. These molecules modulate membrane fluidity, produce inflammatory mediators mitigating effects of metabolic stresses. A growing body of evidence suggests that an onset of Parkinson's disease (PD), a severe neurodegenerative pathology, can be triggered by metabolic changes in plasma membranes. However, the role of plasmalogens in the aggregation of α-synuclein (α-syn), an expected molecular cause of PD, remains unclear. In this study we examine the effect of choline plasmalogens (CPs), unique phospholipids that have a vinyl ether linkage at the sn-1 position of glycerol, on the aggregation rate of α-syn. We found that the length and saturation of fatty acids (FAs) in CPs change rates of protein aggregation. We also found drastic changes in the morphology of α-syn fibrils formed in the presence of different CPs compared to α-syn fibrils grown in the lipid-free environment. At the same time, we did not observe substantial changes in the secondary structure and toxicity of α-syn fibrils formed in the presence of different CPs. These results indicate that the length and saturation of FAs in CPs present in the plasma membrane can alter α-syn stability and modulate its aggregation properties, which, in turn can accelerate or delay the onset of PD.

A Study of Acreage Dynamics and Crop Variability in the Horticultural Sector of ODOP Scheme of Madhya Pradesh, India

The objective of the present study was to analyse the dynamics of acreage of major horticultural crops included under the ODOP scheme in Madhya Pradesh. The research methodology used for the purpose of analysing the data includes absolute change, relative change, compound annual growth rate and coefficient of Variation. For analysis secondary data on area under various horticultural crops was collected from the official website of Directorate of Economics and Statistics, India for a period of 21 years (2000-01 to 2020-21). Nine major horticultural crops were selected in the study which were divided under spices (Chillies, Coriander, Ginger, Garlic, and Turmeric), vegetables (Potato, and Onion) and fruits (Mango and Banana). The change and growth rate of area under major crops were analysed by using absolute and relative change and compound annual growth rate and coefficient of variation. The analysis and research findings showed that area share under most of spices declined except for chillies in Khargone district. Highest growth rate in area under spices was for garlic in Mandsaur district. For vegetables onion showed increase in area in Shajapur and potato in Dewas and Ujjain, and positive growth rate was recorded for all districts in both crops except potato in Gwalior district. While in fruits banana showed considerable increase in share as well as growth rate in Burhanpur district. Mango showed positive growth rate in Anuppur district. The theoretical implications of the study was a decline in area share but a positive growth rate in majority of spices in Guna, Tikamgarh and Rewa. While the majority of vegetables showed positive growth in the state. The contribution of study is in bringing the attention of spice, vegetable and fruit growers towards the real potential of various districts for the growth of spices, fruit or vegetable in that region. This will ultimately contribute in profiting the farmers and increasing their production efficiency.

Ratcheting Effect of 304 Stainless Steel Manufactured by Laser Metal Deposition Under Uniaxial Cyclic Stress

Laser metal deposition (LMD) is an advanced manufacturing technology which has become increasingly popular in recent years. The cyclic tests of 304 austenitic stainless steel (SS304) manufactured by LMD are conducted under symmetrical and asymmetrical cyclic stress. In the results, it is shown that SS304 manufactured by LMD exhibits cyclic softening/hardening and ratcheting effect under symmetrical cyclic stress. The ratcheting strain and ratcheting strain rate of the smooth specimen both increase as the cyclic stress amplitude under the asymmetric cyclic stress. The ratcheting strain and ratcheting strain rate of the smooth specimen change non‐monotonously as the mean stress increases. As the stress amplitude increases, the area of fatigue fracture becomes smaller until no fatigue crack initiation zone can be observed. In this case, only the characteristic of plastic fracture is significant. Park et al.'s model has the worst predicted accuracy. Modified Goodman equation and Smith–Watson–Topper model have the similar predicted accuracy.

Evaluation of dB/dt amplitudes and sources over the Brazilian region during geomagnetic storms in the 2021–2022 biennium

The rate of change of the geomagnetic field (dB/dt) observed at Earth’s surface has been used as a proxy of geomagnetically induced currents, which are known to be hazardous for grounded technological systems such as high-voltage power grid systems. The dB/dt rates have been well characterized in the high latitude region (≳60°), but much less information is available for the low latitudes to date. To overcome this limitation, we have examined dB/dt rates on the H component of the geomagnetic field as measured by an array of stations operated by the EMBRACE Magnetometer Network in Brazil. The main focus is to characterize dB/dt occurrence at very low latitudes (≲22°) of the Brazilian peculiar territory, whose magnetic measurements are influenced by the equatorial electrojet and the presence of the South Atlantic Magnetic Anomaly (SAMA). The period investigated is from 2021 to 2022, over the ascending phase of the solar cycle 25. The statistical analysis demonstrates that dB/dt peak magnitudes are generally below 0.5 nT/s during magnetic storms, and exhibit a dependence on the solar cycle for the station near the center of the SAMA. However, we obtain for a particular case in 2021 that dB/dt reached 1.35 nT/s in magnitude at the magnetic equator during daytime, which is a significant value even for higher latitudes. A case study of the induced geoelectric fields during this event shows that the conductivity structure beneath two compared sites plays a major role in the amplitude of such fields than dB/dt amplitude. Also, the MLT distributions of dB/dt indicate that ultra-low frequency waves can be a major source of these signals in lower latitudes.

Large eddy simulation of combustion characteristics during dual fuel switching process in gas turbine combustor

The present study aims to investigate the combustion characteristics, fuel switching strategy, and flame stability associated with fuel switching processes in a dual-fuel gas turbine combustor. Specifically, the Large Eddy Simulation method is employed in conjunction with a skeletal chemical reaction mechanism to simulate the fuel switching process. It is revealed that the presence of a local rich combustion zone, formed by an increased accumulation of fuel in the head region, leads to the displacement of the heat release position towards the downstream inner shear layer. Additionally, this condition causes a reduction in the recirculation zone area and a deterioration in the uniformity of fuel blending. Simultaneously, the combustor experiences low-frequency, high-amplitude pressure pulsations, as well as pulsations in the heat release rate. Furthermore, a comparative analysis is conducted to assess the discrepancies among three distinct fuel supply strategies employed during fuel switching. The fast-opening strategy is found to demonstrate superior performance indicators, as it accomplishes filling the combustor performance indicators within 80% of the allocated time due to its lower initial fuel changing rate.

Rapid Changes in Strength and Direction of Earth's Magnetic Field Over the Past 100,000 Years

AbstractPrevious studies of rapid geomagnetic changes have highlighted the most extreme changes in direction and field strength found in paleomagnetic field models over the past 100 ky. Here we study distributions of rates of change in both time and space. Field models based on direct observations provide the most accurate values for rates of change, but their short duration precludes a complete description of field behavior. Broader representation is provided by time‐varying paleofield models, here including GGF100k, GGFSS70, LSMOD.2, CALS10k.2, HFM.OL1.A1, pfm9k.2, and SHAWQ‐iron age although variability across models and lack of temporal and spatial resolution of fine scale variations make direct comparisons difficult. For the paleofield we define rapid changes as exceeding the peak overall value of 0.4° yr−1 for directional changes and 150 nT yr−1 for intensities as established by the gufm1 model spanning 1590–1990 CE. We find that rapid directional changes are associated with low field strength and can spread across all latitudes during such episodes. Distributions of directional rates of change exhibit high skewness for models that include excursions. Rates of change in field intensity exceeding 150 nT yr−1 arise in brief intervals during the Holocene particularly associated with the strong field Levantine Iron Age Anomaly. Around the Laschamp excursion there are also rare localized occurrences of rapid intensity change. Limitations in current models make it difficult to define absolute rates for past changes, but we see that rapid changes are essential field characteristics not observed in the modern field that should nevertheless be regarded as an essential for Earth‐like dynamo simulations.

Differences in Patellofemoral Alignment Between Static and Dynamic Extension Positions in Patients With Patellofemoral Pain.

Considering that patellofemoral pain (PFP) is related to dynamic factors, dynamic extension on 4-dimensional computed tomography (4-DCT) may better reflect the influence of muscles and surrounding soft tissue than static extension. To compare the characteristics of patellofemoral alignment between the static and dynamic knee extension position in patients with PFP and controls via 4-DCT. Cross-sectional study; Level of evidence, 3. Included were 39 knees (25 patients) with PFP and 37 control knees (24 participants). For each knee, an image of the dynamic extension position (a single frame of the knee in full extension [flexion angle of -5° to 0°] selected from 21 frames of continuous images acquired by 4-DCT during active flexion and extension) and an image of the static extension position (acquired using the same equipment with the knee fully extended and the muscles relaxed) were selected. Patellofemoral alignment was evaluated between the dynamic and static extension positions and between the PFP and control groups with the following parameters: patella-patellar tendon angle (P-PTA), Blackburne-Peel ratio, bisect-offset (BO) index, lateral patellar tilt (LPT), and tibial tuberosity-trochlear groove (TT-TG) distance. In both PFP patients and controls, the P-PTA, Blackburne-Peel ratio, and BO index in the static extension position were significantly lower (P < .001 for all), while the LPT and TT-TG distance in the static extension position were significantly higher (P ≤ .034 and P < .001, respectively) compared with values in the dynamic extension position. In the comparison between groups, only P-PTA in the static extension position was significantly different (134.97° ± 4.51° [PFP] vs 137.82° ± 5.63° [control]; P = .027). No difference was found in the rate of change from the static to the dynamic extension position of any parameter between the study groups. The study results revealed significant differences in patellofemoral alignment characteristics between the static and dynamic extension positions of PFP patients and controls. Multiplanar measurements may have a role in subsequent patellofemoral alignment evaluation.

Comparative study of surgical outcomes regarding tear meniscus area and high-order aberrations between two different interventional methods for primary acquired nasolacrimal duct obstruction.

To compare endonasal dacryocystorhinostomy (EN-DCR) with sheath-guided dacryoendoscopic probing and bicanalicular intubation (SG-BCI) by evaluating tear meniscus area (TMA) and total high-order aberrations (HOAs) for primary acquired nasolacrimal duct obstruction (PANDO). We retrospectively reviewed 56 eyes of 42 patients (7 men, 35 women; age, 72.7±13.1 years) who underwent EN-DCR or SG-BCI for PANDO in Toyama University Hospital from February 2020 to June 2022. In the EN-DCR and SG-BCI groups, we measured the patency of the lacrimal passage, preoperative and postoperative TMA, and HOAs of the central 4 mm of the cornea using optical coherence tomography (AS-OCT), six months postoperatively. There was a positive correlation between preoperative TMA and preoperative HOAs in all cases. Postoperative patency of lacrimal passage was 100% in the EN-DCR and 80.8% in the SG-BCI group. There was a significant difference in the number of passages between the two groups (p = 0.01). Preoperative TMA and HOAs showed a significant postoperative decrease in both groups (EN-DCR group: p<0.01, p<0.01, SG-BCI group: p<0.01, p=0.03, respectively). We then calculated the rate of change of preoperative and postoperative TMA and HOAs and compared them between the two groups. The rate of change was significantly higher in the EN-DCR group than that in the SG-BCI group (TMA, p=0.03; HOAs, p=0.02). Although both EN-DCR and SG-BCI are effective for PANDO, our results suggest that EN-DCR is more effective in improving TMA and HOAs.

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia

ObjectiveHypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors are a new class of anti-anemia agents. We retrospectively evaluated the safety and efficacy of HIF-PH inhibitors in patients with heart failure (HF) complicated by anemia associated with chronic kidney disase. HIF-PH inhibitor treatment was initiated in 32 patients with chronic HF complicated by renal anemia and were followed up for 3 months.ResultsHematocrit and hemoglobin levels markedly improved 3 months after HIF-PH inhibitor treatment. However, levels of NT-proBNP, which is an indicator of HF, did not decrease considerably. Based on the rate of change in NT-proBNP, we divided the patients into “responder” and “non-responder” groups. The results showed that considerably more patients had a ferritin level of less than 100 ng/mL in the non-responder group at baseline. There were substantially more patients with TSAT of less than 20% in the non-responder group at 1 month after HIF-PH inhibitor treatment. The cut-off values to maximize the predictive power of ferritin level at baseline and TSAT value at 1 month after treatment were 41.8 ng/ml and 20.75. HIF-PH inhibitor treatment can be expected to be effective for improving both anemia and HF if ferritin≥41.8 ng/ml at baseline or TSAT≥20.75 at 1 month after treatment.

Predictors and timing of hydrocephalus treatment in patients undergoing prenatal versus postnatal surgery for myelomeningocele.

Although hydrocephalus rates have decreased with intrauterine surgery for myelomeningocele (MMC), 40%-85% of children with MMC still go on to develop hydrocephalus. Prenatal ventricle size is known to be associated with later development of hydrocephalus; however, it is not known how prediction measures or timing of hydrocephalus treatment differ between pre- and postnatal surgery for MMC. The goal of this study was to determine anatomical, clinical, and radiological characteristics that are associated with the need for and timing of hydrocephalus treatment in patients with MMC. The authors retrospectively identified patients from Barnes Jewish Hospital or St. Louis Children's Hospital between 2016 and 2021 who were diagnosed with MMC prenatally and underwent either pre- or postnatal repair. Imaging, clinical, and demographic data were examined longitudinally between treatment groups and hydrocephalus outcomes. Fifty-eight patients were included (27 females, 46.6%), with a mean gestational age at birth of 36.8 weeks. Twenty-three patients (39.7%) underwent prenatal surgery. For the overall cohort, the ventricle size at prenatal ultrasound (HR 1.175, 95% CI 1.071-1.290), frontal-occipital horn ratio (FOHR) at birth > 0.50 (HR 3.603, 95% CI 1.488-8.720), and mean rate of change in head circumference (HC) in the first 90 days after birth (> 0.10 cm/day: HR 12.973, 95% CI 4.262-39.486) were identified as predictors of hydrocephalus treatment. The factors associated with hydrocephalus in the prenatal cohort were FOHR at birth > 0.50 (HR 27.828, 95% CI 2.980-259.846) and the rate of change in HC (> 0.10 cm/day: HR 39.414, 95% CI 2.035-763.262). The factors associated with hydrocephalus in the postnatal cohort were prenatal ventricle size (HR 1.126, 95% CI 1.017-1.246) and the mean rate of change in HC (> 0.10 cm/day: HR 24.202, 95% CI 5.119-114.431). FOHR (r = -0.499, p = 0.008) and birth HC (-0.409, p = 0.028) were correlated with time to hydrocephalus across both cohorts. For patients who underwent treatment for hydrocephalus, those in the prenatal surgery group were significantly more likely to develop hydrocephalus after 3 months than those treated with postnatal surgery, although the overall rate of hydrocephalus was significantly higher in the postnatal surgery group (p = 0.018). Clinical and imaging factors associated with hydrocephalus treatment differ between those receiving pre- versus postnatal MMC repair, and while the overall rate of hydrocephalus is lower, those undergoing prenatal repair are more likely to develop hydrocephalus after 3 months of age. This has implications for clinical follow-up timing for patients treated prenatally, who may live at a distance from the treatment site.

Long-term exposure to transportation noise in relation to global cognitive decline and cognitive impairment: Results from a Swedish longitudinal cohort

Background and aimsTransportation noise is an environmental exposure with mounting evidence of adverse health effects. Besides the increased risk of cardiovascular and metabolic diseases, recent studies suggest that long-term noise exposure might accelerate cognitive decline in older age. We examined the association between transportation noise and cognitive function in a cohort of older adults. MethodsThe present study is based on 2594 dementia-free participants aged 60 + years from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K). Global cognition score and CIND (cognitive impairment, no dementia) were assessed with a comprehensive neuropsychological battery at baseline and up to 16 years. Residential transportation noise resulting from road traffic, railway, and aircraft were estimated at the most exposed façade and the time-weighted average exposure was assessed. Linear mixed-effect models were used to assess the effect of long-term traffic noise exposure on the rate of change in global cognition score. Hazard ratios (HRs) and 95 % confidence intervals (CIs) of CIND by transportation noise exposure were obtained with Cox proportional hazard models. ResultsGlobal cognition score decreased at an average rate of −0.041 (95 %CI −0.043, −0.039) per year. Aircraft noise was associated with a 0.007 (per 10 dB Lden; 95 %CI −0.012, −0.001) faster annual rate of decline. Global cognition score seems to be not affected by road traffic and railway noise. During the follow-up, 422 (21 %) participants developed CIND. A 10-dB Lden difference in exposure to aircraft and railway noise was associated with a 16 % (HR 1.16, 95 %CI 0.91, 1.49) and 26 % (HR 1.26, 95 %CI 1.01, 1.56) increased hazard of CIND in the multi-pollutant model, respectively. No association was found for road traffic (HR 1.00, 95 %CI 0.83, 1.21). ConclusionsTransportation noise was linked to cognitive impairment and faster cognitive decline among older adults. Future studies are warranted to confirm our results.

The Impact of Posttreatment Imaging in Peptide Receptor Radionuclide Therapy.

Posttreatment imaging of γ-emissions after peptide receptor radionuclide therapy (PRRT) can be used to perform quantitative dosimetry as well as assessment response using qualitative measures. We aimed to assess the impact of qualitative posttreatment imaging on the management of patients undergoing PRRT. Methods: In this retrospective study, we evaluated 100 patients with advanced well-differentiated neuroendocrine tumors undergoing PRRT, who had posttreatment SPECT/CT imaging at 24 h. First, we evaluated the qualitative assessment of response at each cycle. Then using a chart review, we determined the impact on management from the posttreatment imaging. The changes in management were categorized as major or minor, and the cycles at which these changes occurred were noted. Additionally, tumor grade was also evaluated. Results: Of the 100 sequential patients reviewed, most (80% after cycle 2, 79% after cycle 3, and 73% after cycle 4) showed qualitatively stable disease during PRRT. Management changes were observed in 27% (n = 27) of patients; 78% of those (n = 21) were major, and 30% (n = 9) were minor. Most treatment changes occurred after cycle 2 (33% major, 67% minor) and cycle 3 (62% major, 33% minor). Higher tumor grade correlated with increased rate of changes in management (P = 0.006). Conclusion: In this retrospective study, qualitative analysis of posttreatment SPECT/CT imaging informed changes in management in 27% of patients. Patients with higher-grade tumors had a higher rate of change in management, and most of the management changes occurred after cycles 2 and 3. Incorporating posttreatment imaging into standard PRRT workflows could potentially enhance patient management.