Rapidly Disintegrating Research Articles

Preparation of Rapidly Disintegrating Glipizide Tablets by Surface Solid Dispersion through Superdisintegrants

The objective of this investigation was to enhance the dissolution of glipizide using solid dispersions containing different superdisintegrants and to prepare rapidly disintegrating glipizide tablets with rapid absorption through the oral cavity by direct compression of the prepared solid dispersion. Primojel, Ac-Di-Sol and Kollidon CL were used as superdisintegrants. These excipients were used in different ratios and by using solvent evaporation method, rapidly disintegrating glipizide tablets were prepared by direct compression of the prepared solid dispersion, as well as, by camphor sublimation method aiming for more enhancing of tablet disintegration. Glipizide loaded with Kollidon CL showed the best dissolution properties compared to the other tested excipients. The physical properties of all the prepared GZ tablet formulations were found to be acceptable according to USP/NF2002. Kollidon CL containing formulations showed the most rapid disintegration time values reaching one second in tablets prepared by camphor sublimation method. The most effective formula in decreasing the blood glucose level was that containing glipizide loaded with Kollidon CL, with significant difference from the physically mixed ingredients or the pure GZ powder depending on Student’s T-test for area above the blood glucose level.