Introduction: Raoultella planticola is an uncommon pathogen rarely associated with clinical infections. Previous studies showed that most R. planticola isolates were sensitive to cephalosporins, aminoglycosides, fluoroquinolones and carbapenems, and no extensively drug‐resistant (XDR) strains have been reported. Case presentation: In this study, an XDR R. planticola strain, RP01, was isolated from a Chinese patient with multiple chronic diseases. Antimicrobial susceptibility testing showed that RP01 was resistant to almost all clinically available antibiotics except tigecycline. PCR and sequencing revealed the presence of blaNDM‐1 , encoding a metallo‐β‐lactamase with hydrolysing activity against carbapenems. Further genomic sequencing and ResFinder analysis identified 20 resistance genes, encoding resistance to β‐lactams, aminoglycosides, sulfonamides, tetracycline, fluoroquinolones, trimethoprim and fosfomycin. Conclusion: These results described the ability of the rare pathogen R. planticola to acquire multiple resistance genes.