The flexible optical fiber sensor serves as a prototype for highly sensitive photonic skin flexible sensors (PSFS) with rapid response times, facilitating the development of advanced wearable healthcare devices. Future bionic skin sensors, tailored for wearable devices focusing on health monitoring and robotics applications, will necessitate the incorporation of optical systems. In this work, PSFS based on weak coupling structure is proposed for the first time. This structure comprises a fiber optic sensor with weak coupling as the core sensing node, and the sensing material is hydrophilic and flexible sodium polyacrylate (SPA). The SPA combines the high sensitivity of PSFS with excellent biocompatibility, enabling both static and dynamic sensing measurements for physical parameters such as humidity and temperature. Leveraging the strain amplification effect of the single-mode tapered fiber and the unique fiber structure, the material's sensitivity to relative humidity (RH) is significantly enhanced, reaching 0.19 dB/%RH. Furthermore, the temperature response demonstrates exceptional sensitivity (0.29 dB/℃) within the range of human skin surface temperatures (30–48℃). Remarkably, the sensor has a significant response time of 128 ms. This research proposes a novel approach for constructing highly sensitive and versatile PSFS, which is critical for health care monitoring.