Range Of Elasticity Research Articles

Exploring built environment impacts on transit use – an updated meta-analysis

ABSTRACT The built environment (BE) is widely accepted to influence transit use (TU). Evidence to date suggests the relationship is dependent on many factors which can be difficult to account for in quantitative studies. This creates barriers to transferring research into practice. Considering many studies together can be useful for accounting for more of the factors impacting transit use. Yet, meta-analysis of research measuring these influences was last undertaken in 2010 based on 18 studies. Since then 90 new quantitative studies have been published. These recent studies use improved methodologies and are conducted in more diverse geographies. This paper reports an improved and updated meta-analysis of built environment impacts on transit use. It compares elasticity estimates from research published pre-and post-2010 and explores the impact of new methods and a more diverse geographical representation on findings. Updated meta-elasticities range from <0.01 to 0.26; a similar range to the 2010 study. However, at the individual indicator levels, more recent results are different. Elasticities for urban density, including population, employment and commercial density, have increased significantly in studies published since 2010, as did that of land use mix. However, measures of local access, design and jobs-housing balance decreased in post-2010 studies. These results confirm the small but imprecise relationship between the BE and TU. Results also suggest that while the range of elasticity impacts is relatively consistent, new study methodologies, notably those that control for regional accessibility and self-selection, and the increasing geographical diversity in study applications, is acting to change BE-TU findings at the indicator level. Research setting and context are important to consider when using empirical results to design BE strategies to promote transit use.

Kinematics of Soft Robots by Geometric Computing

Robots fabricated with soft materials can provide higher flexibility and, thus, better safety while interacting in unpredictable situations. However, the usage of soft material makes it challenging to predict the deformation of a continuum body under actuation and, therefore, brings difficulty to the kinematic control of its movement. In this article, we present a geometry-based framework for computing the deformation of soft robots within the range of linear material elasticity. After formulating both manipulators and actuators as geometry elements, deformation can be efficiently computed by solving a constrained optimization problem. Because of its efficiency, forward and inverse kinematics for soft manipulators can be solved by an iterative algorithm with a low computational cost. Meanwhile, components with multiple materials can also be geometrically modeled in our framework with the help of a simple calibration. Numerical and physical experimental tests are conducted on soft manipulators driven by different actuators with large deformation to demonstrate the performance of our approach.

Magnetorheological Gel Mimicking Cervical Ripening as a Potential Model for Evaluating Shear Wave Elastography

The mechanical characteristics of tissue can reflect its biochemical content and, therefore, be a powerful tool in the diagnosis of diseases. Many different methods have been developed for testing the mechanical properties of tissue, such as aspiration, indentation and shear wave elastography. Soft tissues are, however, more complex in behaviour than current commercial tissue-mimicking materials and the models used in measurement methods. Complex behaviours of the tissue include anisotropy and heterogeneous elasticity. The oversimplified models assumed in different measuring methods often neglect the effects of these behaviours, resulting in inaccuracies. The aim of this study was to develop a tissue-mimicking material able to capture the complexity of tissue mechanical behaviour. It will be used to improve mechanical property measuring methods by quantitatively determining how complexities in tissue behaviour affect the measurements made and evaluating the effectiveness of methods designed to overcome it, and will be used to train users for consistency in measurement. The tissue-mimicking material designed in this study focuses on the mechanical properties of the cervix as measured by shear wave elastography. The characteristic behaviours of cervical tissues highlighted are anisotropy, a wide range of elasticity that changes with gestational age and an elasticity gradient across the tissue. Magnetorheological gels were used as their elastic properties can be tuned with the application of magnetic fields. The sample was simulated with the finite-element software COMSOL before being tested by shear wave elastography and the INSTRON universal material testing machine. It had an elasticity range of 6.75–11.06 kPa, which is similar to that of cervical tissue. It was determined that a change in the orientation of the probe with respect to the orientation of anisotropy can cause up to a 30 % increase in measured elasticity. There was a 16% decrease in elasticity across the sample.

Period-Bubbling Transition to Chaos in Thermo-Viscoelastic Fluid Systems

We report a 6D nonlinear dynamical system for thermo-viscoelastic fluid by selecting higher modes of infinite Fourier series of flow quantities. This nonlinear system demonstrates overstable convective motion and some organized structures such as period-bubbling and Arnold tongue-like structures. Studies reveal that the stability of the conduction state does not alter for the new 6D system in comparison with the lowest order 4D system of Khayat [1995] . However, the stabilities of the convective state have some differences. The onset of unsteady convection in the 6D system is delayed for weak elasticity of the fluid. There exists a critical range of fluid elasticity where the 4D system exhibits subcritical Hopf bifurcation while the 6D system shows supercritical Hopf bifurcation, which ensures the increase of the domain of stability. In this range, catastrophic route to chaos occurs in the 4D system, whereas the 6D system exhibits intermittent onset of chaos. Comparing the two-parameter dependent dynamics for the two systems, the chaotic zones enclosed by periodic regions are suppressed in the 6D system, so the flow behaviors become more predictable. Owing to interacting thermal buoyancy and fluid elasticity, both the models exhibit period-bubbling transition to chaos, but the period-bubbling cascade in the 6D model occurs at lower Rayleigh number than the 4D model. The convergence rate of the period-bubbling process slows down compared to usual period-doubling and approaches the square root of the Feigenbaum constant asymptotically.

Nanoparticle elasticity regulates phagocytosis and cancer cell uptake.

The ability of cells to sense external mechanical cues is essential for their adaptation to the surrounding microenvironment. However, how nanoparticle mechanical properties affect cell-nanoparticle interactions remains largely unknown. Here, we synthesized a library of silica nanocapsules (SNCs) with a wide range of elasticity (Young's modulus ranging from 560 kPa to 1.18 GPa), demonstrating the impact of SNC elasticity on SNC interactions with cells. Transmission electron microscopy revealed that the stiff SNCs remained spherical during cellular uptake. The soft SNCs, however, were deformed by forces originating from the specific ligand-receptor interaction and membrane wrapping, which reduced their cellular binding and endocytosis rate. This work demonstrates the crucial role of the elasticity of nanoparticles in modulating their macrophage uptake and receptor-mediated cancer cell uptake, which may shed light on the design of drug delivery vectors with higher efficiency.

Requirements for accurate estimation of shear modulus by magnetic resonance elastography: A computational comparative study

BackgroundMagnetic resonance (MR) elastography is a non-destructive method of measuring biological tissue and is conducive to the early detection of tumors. Researchers usually set different assumptions according to different research objects, then establish and solve wave equations to estimate the shear modulus. Establishing a more reasonable model for a measured object estimates a more accurate shear modulus. Different assumptions of the mathematical model, and the method used to solve the wave equation causes deviation of the estimation. ObjectiveThis study focused on shear modulus deviations caused by differences in calculation methods. The author demonstrated a method to ensure that the measuring range of the selected reconstruction algorithm with selected drive frequency covers the elasticity range of the target tissue. It is hoped to arouse the interest of researchers to introduce new transform domain methods to the field of MR elastography. MethodIn linear, isotropic and local homogeneity assumptions, the typical representative of two different calculation methods are algebraic inversion of the differential equation (AIDE) algorithm and local frequency elastography (LFE) algorithm. To compare the accuracy of these calculation methods, the author adopted a digital phantom that can set the parameter values accurately. It is assumed that the phantom tissue was linear and isotropic, and that the driving wave was sinusoidal. The displacement distribution of waves in the tissue was calculated by the finite element simulation method in two different resolutions with the signal-to-noise ratio (SNR) set to 40 dB and the threshold of relative mean error (RME) no more than 10%. The wavelength-to-pixel-size ratios of the two methods under the setting threshold of RME were compared. ResultsThe lower threshold of wavelength-to-pixel-size ratio for AIDE was close to 10, while that for LFE was nearly 2 (the limitation of Shannon's law) under the setting precision. Thus, the measuring range of the AIDE method was less than that of LFE at the same experimental conditions. ConclusionThe driving frequency selection range of the spatial frequency domain method is wider than that of the spatial domain method. It is worthwhile for researchers to devote more time to introducing new transformation domain method for MR elastography.

Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium

AbstractCardiac patches represent a promising strategy for the treatment of myocardial infarction (MI). Here, an electroconductive cardiac patch that conforms to the mechanics of human myocardium is fabricated. By melt electrospinning writing (MEW), it is possible to fabricate an auxetic patch that can overcome the limited range of elasticity seen in conventional square patch designs. The auxetic patches can accommodate the strains and stresses exhibited by the human myocardium during diastole and systole. It is shown that the geometry of the auxetic patches can be fine‐tuned to reflect anisotropic mechanical properties. The anisotropic ratio of effective stiffness (E1/E2) of the auxetic patches agrees with the directionally‐dependent mechanics of the heart. Furthermore, in situ polymerization of doped‐polypyrrole (PPy) on the auxetic patches confers electroconductive properties close to those reported of human myocardium. This approach demonstrates the potential use of a rational design of PPy‐coated patches for their use as cardiac patches.

Correlations Between Range of Motion and Elasticity of the Coracohumeral Ligament Evaluated With Shear-Wave Elastography.

Range of motion (ROM) in the glenohumeral joint decreases with age in healthy subjects; however, the underlying mechanism remains unclear. The process of aging of the joint capsule, including the coracohumeral ligament (CHL), could affect ROM limitation. This study investigated correlations between elasticity of the CHL, evaluated by means of shear-wave elastography, and age, side dominance, and ROM in healthy individuals. Experimental study. Laboratory. Eighty-four healthy volunteers (39 men and 45 women, mean age: 42.6y) were included. Subjects were divided into 3 age groups: younger (20-39y), middle (40-59y), and older (≥60y) age groups. With participants in the supine position, CHL elasticity in both shoulders was evaluated in both neutral and 30° external rotation, with arms at the sides. ROM, including forward flexion, lateral elevation, external rotation, 90° abduction with external rotation, and hand behind the back were measured with participants in the standing position. The CHL elastic modulus was higher in the older group than in the younger group in the neutral (78.4kPa [SD: 37.1] and 56.6kPa [SD: 31.7], respectively) and 30° external rotation positions (135.5kPa [SD: 63.5] and 71.4kPa [SD: 32.2], respectively). Negative correlations were found between the CHL elastic modulus and ROM in terms of 30° external rotation and both external rotation (R = -.59, P = .02) and 90° abduction with external rotation (R = -.71, P = .003) in the older group, with correlation coefficients increasing with age. Significant correlations were identified between CHL elasticity and ROM in both external rotation and 90° abduction with external rotation with increasing age. Decreased CHL elasticity was strongly associated with decreased shoulder ROM in middle-aged and older individuals.

In Vitro Comparative Study of Dimensional Stability of Three Different Polyvinyl Siloxane Interocclusal Recording Matereials after Storage for Different Time Intervals of 12 Hours, 24 Hours, and 48 Hours

Background: Interocclusal recording materials are generally used in prosthetic dentistry to register the jaw relationship. These materials have a wide range of viscosity, elasticity, and volumetric changes within various material groups. Newer elastomeric interocclusal materials are chemical modifications of elastomers whose comparative properties relevant to clinicians are yet to be studied. Aims: To compare the dimensional change between the polyvinylsiloxane bite registration materials manufactured by different brands within the duration of 12 hours, 24 hours, and 48 hours storage. Methodology: The dimensional changes of the different polyvinylsiloxe bite registration pastes were compared three-dimensionally in different time intervals with the standardised die measurement was 25mm between the vertical lines. Conclusion: Within the limitations of the study, it was found that all 3 interocclusal recording materials NEOSILK, CADBITE, AND O-BITE showed no significant distortion when stored in-vitro for 12 hours. All Materials showed significant distortion when stored in-vitro for 24 hours and 48 hours. All three materials showed more distortion when stored in 48hours compare to 24 hours. Among polyvinyl siloxane interocclusal recording materials NEOSILK showed better dimensional stability when compared with CADBITE and O-BITE when stored in-vitro 24hours and 48hours. Hence we recommend Neosilk bite material for better dimensional stability when compare with other materials.

&lt;p&gt;Shock Waves as a Treatment Modality for Spasticity Reduction and Recovery Improvement in Post-Stroke Adults – Current Evidence and Qualitative Systematic Review&lt;/p&gt;

PurposeThis systematic review examines intervention studies using extracorporeal shock wave therapy (ESWT) application in post-stroke muscle spasticity with particular emphasis on the comparison of two different types of radial (rESWT) and focused shock waves (fESWT).MethodsPubMed, PEDro, Scopus, and EBSCOhost databases were systematically searched. Studies published between the years 2000 and 2019 in the impact factor journals and available in the English full-text version were eligible for inclusion. All qualified articles were classified in terms of their scientific reliability and methodological quality using the PEDro criteria. The PRISMA guidelines were followed and the registration on the PROSPERO database was done.ResultsA total of 17 articles were reviewed of a total sample of 303 patients (age: 57.87±10.45 years and duration of stroke: 40.49±25.63 months) who were treated with ESWT. Recent data confirm both a subjective (spasticity, pain, and functioning) and objective (range of motion, postural control, muscular endurance, muscle tone, and muscle elasticity) improvements for post-stroke spasticity. The mean difference showing clinical improvement was: ∆=34.45% of grade for fESWT and ∆=34.97% for rESWT that gives a slightly better effect of rESWT (∆=0.52%) for spasticity (p<0.05), and ∆=38.83% of angular degrees for fESWT and ∆=32.26% for rESWT that determines the more beneficial effect of fESWT (∆=6.57%) for range of motion (p<0.05), and ∆=18.32% for fESWT and ∆=22.27% for rESWT that gives a slightly better effect of rESWT (∆=3.95%) for alpha motor neuron excitability (p<0.05). The mean PEDro score was 4.70±2.5 points for fESWT and 5.71±2.21 points for rESWT, thus an overall quality of evidence grade of moderate (“fair” for fESWT and “good” for rESWT). Three studies in fESWT and four in rESWT obtained Sackett’s grading system’s highest Level 1 of evidence.ConclusionThe studies affirm the effectiveness of ESWT in reducing muscle spasticity and improving motor recovery after stroke.

Endogenous Longevity and Optimal Tax Progressivity

We study the impact of endogenous longevity on optimal tax progressivity and inequality in an overlapping generations model with skill heterogeneity. Higher tax progressivity decreases both the longevity gap and net income inequality, but at the expense of lower average lifetime and lower aggregate labor supply and income. We find that the welfare-maximizing income tax is less progressive than in the case of exogenous longevity and that the present US income tax should redistribute less. Our result is robust to the empirically observed range of labor supply elasticity and the assumptions of both missing annuity markets and tax deductibility of private health expenditures.

Modified arrowroot starch and glucomannan for preserving physicochemical properties of sweet bread

ABSTRACT Sweet bread is associated with smooth texture and high carbohydrate content, tasty and filling - quality that makes it preferred for snack. The key is in formulating raw material and other components. Commonly, sweet bread has short shelf life. Frozen dough could be the solution to this problem, and glucomannan addition during freezing process should be able to improve its physicochemical characteristics. This research aims to determine the effect of adding modified arrowroot (Maranta arundinacea L.) starch (MAS) as substitution, and glucomannan as frozen dough cryoprotectant toward sweet bread’s physicochemical. Randomized Complete Block Design Factorial (RCBD) was applied, and two factors were studied. The first factor was modified arrowroot starch (0.00%, 3.75%, and 7.50%) and the second was glucomannan (0.0%, 0.5%, and 1.0%). The best result was combination between MAS 3.75% and glucomannan 0.5%, reaching dough expansion volume range of 50% to 60%, bread expansion volume range of 77% to 80%, hardness range of 2 N mm-2 to 3 N mm-2, elasticity range of 88% to 96%, moisture content of 16% to 19%, ash content of 1.4% to 1.7%, fat content of 10% to 15%, protein content of 5%, and carbohydrate content of 51% to 66%. MAS is able to substitute wheat flour in bread production only if it is combined with glucomannan.

Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels.

Synthetic hydrogels with controlled physicochemical matrix properties serve as powerful in vitro tools to dissect cell-extracellular matrix (ECM) interactions that regulate epithelial morphogenesis in 3D microenvironments. In addition, these fully defined matrices overcome the lot-to-lot variability of naturally derived materials and have provided insights into the formation of rudimentary epithelial organs. Therefore, we engineered a fully defined synthetic hydrogel with independent control over proteolytic degradation, mechanical properties, and adhesive ligand type and density to study the impact of ECM properties on epithelial tubulogenesis for inner medullary collecting duct (IMCD) cells. Protease sensitivity of the synthetic material for membrane-type matrix metalloproteinase-1 (MT1-MMP, also known as MMP14) was required for tubulogenesis. Additionally, a defined range of matrix elasticity and presentation of RGD adhesive peptide at a threshold level of 2 mM ligand density were required for epithelial tubulogenesis. Finally, we demonstrated that the engineered hydrogel supported organization of epithelial tubules with a lumen and secreted laminin. This synthetic hydrogel serves as a platform that supports epithelial tubular morphogenetic programs and can be tuned to identify ECM biophysical and biochemical properties required for epithelial tubulogenesis.

Thermomechanical, calorimetric and magnetic properties of a Ni–Ti shape-memory alloy wire

In this work, some physical properties of a commercial Ni–Ti (nitinol) shape-memory alloy with cylindrical geometry (wire) were investigated; the focus was on the thermomechanical, calorimetric and magnetic characterization. By dynamical mechanical analysis, the range of elasticity, the elasticity–viscoelasticity coexistence domain and the domain in which a maximum force is applied were determined for the SMA wire. By using the temperature-modulated differential scanning calorimetry method, a multi-step temperature variation program was applied to the wire with cylindrical geometry, in two stages (heating–cooling) and through the interpretation of heat fluxes (reversible, nonreversible and total), and the phase transitions in the formation of martensite, austenite and rhombohedral phase (R-phase) were identified and correlated with those observed during the thermomechanical study; also, the formation of austenite and martensite was evidenced by the regular differential scanning calorimetry method; by magnetic measurements, it was established that the SMA wire had magnetic properties at room temperature, and the nitinol sample is paramagnetic and linear in the intensity of the magnetizing magnetic field; these results were compared with those previously obtained for the investigation of the nitinol SMA stripe.

Physical and thermophysical properties of a commercial Ni–Ti shape memory alloy strip

Some physical properties like the thermal, thermomechanical, calorimetric, magnetic, and adhesive properties of a commercial shape memory alloy (SMA) with rectangular geometry were studied. Depending on the applied forces, there were identified range of elasticity, the elasticity–viscoelasticity coexistence domain, and the domain in which a maximum force of 18 N is applied, for the SMA strip. The controlled force module, in the tension mode, was used for the determination of the SMA strip elongation at application of the stretching forces from 0 to 13 N, at 30 °C, maintaining each static force value for 3 min. By employing the multi-frequency strain–stress modulus in the tension mode, DMA cyclic heating–cooling measurements were carried out. The measured dynamic mechanical properties for SMA strip were Storage Modulus, Loss Modulus, tanδ, and Stiffness, both at heating and cooling. Thus, the characteristic temperatures of the phase transitions (As, Af, Ms, Mf), of SMA strip were identified. Also, the values of the elasticity modulus (Young’s Modulus) of the SMA strip were calculated at 30 °C. With the DSC Q2000 device, using temperature-modulated differential scanning calorimetry method, a multi-step temperature variation program was applied to the rectangular strip in two stages (heating–cooling). Through the interpretation of heat fluxes (reversible, nonreversible, and total), the phase transitions in the formation of martensite, austenite, and also of the rhombohedral phase (R phase) and moreover enabled for the R phase identification, thermomechanical analysis confirmed the results obtained by classical DSC method. The adherence of some commercial azoic dyes on the rectangular SMA strip, as well as the modification of the surface roughness of the strip after the deposition of the dye, was also studied. By magnetic measurements, it was established that the SMA strip had magnetic properties at room temperature, in which magnetization is the sum of a superparamagnetic contribution and a paramagnetic term, linear in the intensity of the magnetizing magnetic field.

Rheology of Pure Ionic Liquids and Their Complex Fluids: A Review

Ionic liquids (ILs) are liquid salts at ambient or lower temperatures and consist of ions and short-lived ion pairs. They are potential alternatives to toxic, hazardous, highly flammable, and volatile solvents for preparing solutions, dispersions, gels, composites, and polymeric melts. ILs have some very interesting and unique characteristics like good chemical and thermal stability and very low vapor pressures. They have good solvation interactions with a wide range of organic, inorganic, and polymeric compounds. They can enhance colloidal stability and the elasticity range of polymers. ILs are environmental friendly, easily recyclable, and structurally similar to the conventional solvents. For optimal performance, it is necessary to fully understand the rheological properties of ILs and their different systems for academic interests such as understanding the ability of ILs as processing AIDS particularly in film casting, fiber spinning and spraying, comprehension of thermodynamics and dynamics of polymer chains in ILs, analyzing the hydrodynamic volume of dispersed polymer, polymer-ILs interactions, characterizing the viscoelastic properties and nanophase-ILs interactions in nanocomposite systems, analyzing the plasticization efficiency, and the final properties of the composite system. The rheological analysis is also important for industrial purposes particularly for designing processing techniques and suitable operating conditions for IL based systems. The aim of this review is to give an overview of the rheological properties of pure ionic liquids and solutions, dispersions, gels, composites, and melts based on ionic liquids.

One-Pot Synthesis of Unsaturated Polyester Bioelastomer with Controllable Material Curing for Microscale Designs.

Synthetic polyester elastomeric constructs have become increasingly important for a range of healthcare applications, due to tunable soft elastic properties that mimic those of human tissues. A number of these constructs require intricate mechanical design to achieve a tunable material with controllable curing. Here, the synthesis and characterization of poly(itaconate-co-citrate-co-octanediol) (PICO) is presented, which exhibits tunable formation of elastomeric networks through radical crosslinking of itaconate in the polymer backbone of viscous polyester gels. Through variation of reaction times and monomer molar composition, materials with modulation of a wide range of elasticity (36-1476 kPa) are generated, indicating the tunability of materials to specific elastomeric constructs. This correlated with measured rapid and controllable gelation times. As a proof of principle, scaffold support for cardiac tissue patches is developed, which presents visible tissue organization and viability with appropriate elastomeric support from PICO materials. These formulations present potential application in a range of healthcare applications with requirement for elastomeric support with controllable, rapid gelation under mild conditions.

A general and explicit Eshelby-type estimator for evaluating the equivalent stiffness of multiply coated ellipsoidal heterogeneities

The paper presents an efficient estimator for the equivalent stiffness calculation of multiphase ellipsoidal heterogeneities. This estimator is derived from the exact effective stiffness of a generic monofiller composite associated with Eshelby's equivalence principle. It is originally developed for a two-phase ellipsoidal configuration and is subsequently generalized to multiphase heterogeneities via a layer-wise sweeping procedure. The developed estimator has an explicit form, which makes it amenable to computer programming. The performance of the proposed estimator is evaluated by analyzing several numerical examples of spherical compounds and two spheroidal ones spanning a wide range of elasticity contrasts, which are also examined by two other applicable Eshelby-type estimators. To assess the validity of our estimator in two-level homogenization problems, several examples of composite systems reinforced with core-shell inclusions are analyzed using a two-level homogenization scheme in which use is made of the estimator of this study. It is concluded that the presented estimator can be applied to a wide range of multiphase ellipsoidal heterogeneities or limit cases thereof, as well as heterogeneities with radially graded interphases.

Probing and pressing surfaces of hepatitis C virus-like particles

Hepatitis C virus-like particles (VLPs) are being developed as a quadrivalent vaccine candidate, eliciting both humoral and cellular immune responses in animal trials. Biophysical, biomechanical and biochemical properties are important for virus and VLP interactions with host cells and recognition by the immune system. Atomic force microscopy (AFM) is a powerful tool for visualizing surface topographies of cells, bionanoparticles and biomolecules, and for determining biophysical and biomechanical attributes such as size and elasticity. In this work, AFM was used to define morphological and nanomechanical properties of VLPs representing four common genotypes of hepatitis C virus. Significant differences in size of the VLPs were observed, and particles demonstrated a wide range of elasticity. Ordered packing of the core and potentially envelope glycoproteins was observed on the surfaces of the VLPs, but detailed structural characterization was hindered due to intrinsic dynamic fluctuations or AFM probe-induced damage of the VLPs. All VLPs were shown to be glycosylated in a manner similar to native viral particles. Together, the results presented in this study further our understanding of the nanostructure of hepatitis C VLPs, and should influence their uptake as viable vaccine candidates.

Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model.

Synthetic osteoinductive materials that mimic the human osteogenic niche have emerged as ideal candidates to address this area of unmet clinical need. In this study, we evaluated the osteoinductive potential in a rabbit orthotopic model of a magnesium-doped hydroxyapatite/type I collagen ​(MHA/Coll) composite. The composite was fabricated to exhibit a highly fibrous structure of carbonated MHA with 70% (±2.1) porosity and a Ca/P ratio of 1.5 (±0.03) as well as a diverse range of elasticity separated to two distinct stiffness peaks of low (2.35 ​± ​1.16 ​MPa) and higher (9.52 ​± ​2.10 ​MPa) Young's Modulus. Data suggested that these specific compositional and nanomechanical material properties induced the deposition of de novo mineral phase, while modulating the expression of early and late osteogenic marker genes, in a 3D in vitro model using human bone marrow-derived mesenchymal stem cells (hBM-MSCs). When tested in the rabbit orthotopic model, MHA/Col1 scaffold induction of new trabecular bone mass was observed by DynaCT scan, only 2 weeks after implantation. Bone histomorphometry at 6 weeks revealed a significant amount of de novo bone matrix formation. qPCR demonstrated MHA/Coll scaffold full cellularization in vivo and the expression of both osteogenesis-associated genes (Spp1, Sparc, Col1a1, Runx2, Dlx5) as well as hematopoietic (Vcam1, Cd38, Sele, Kdr) and bone marrow stromal cell marker genes (Vim, Itgb1, Alcam). Altogether, these data provide ​evidence of the solid osteoinductive potential of MHA/Coll and its suitability for multiple approaches of bone regeneration.