The morphology of the contact surface between cast-in-place engineering structures and soil is generally random. Previous research focusing on the shear mechanical properties of soil-concrete interfaces has predominantly concentrated on the role of interface roughness by constructing regular concrete surface types, largely neglecting the potential impact of the roughness morphology (i.e., the morphology of the concrete surface). In this study, concrete blocks with the same interface roughness and different roughness morphologies were constructed based on the sand-cone method, including random rough surface, triangular groove surface, rectangular groove surface, trapezoid groove surface, and semicircular groove surface. A series of direct shear tests were conducted on the rough and smooth sand-concrete interfaces, as well as on natural sand. Through these tests, we examined the shear mechanical behavior and strength of the sand-concrete interfaces, and analyzed the underlying shear mechanisms. The results showed that: (i) the interface morphology had little effect on the variation in the shear stress-displacement curve of sand-concrete interfaces, and it had a significant influence on the shear strength of the interfaces; (ii) under the same normal stress, the shear strength of the sand-concrete interfaces with a random rough surface was the greatest, followed by the triangular groove surface, while the shear strength of the rectangular groove surface proved the lowest; (iii) the shear strength of the sand-concrete interfaces with the same roughness was affected by the size of the contact area between the concrete plane and the sand, that is, a larger contact area correlated with a decrease in shear strength. It can be concluded that the shear strength value of a sand-concrete surface with the triangular groove is the closest to the shear strength of a random rough interface. By gaining a deep understanding of the effects of different contact surface morphologies on shear strength and shear behavior, significant insights can be provided for optimizing engineering design and enhancing engineering performance.