Randomized Control Group Design Research Articles

The Effect of Mindfulness-based Cognitive Therapy on Anxiety and Resilience of the School Going Early Adolescents with Anxiety

Background: The increasing mental health problems of Indian adolescents are of great concern but child-health mental service is in a nascent stage. Anxiety is the most common psychological problem found in school-going children. The psychological intervention for this high-risk population at an early stage of adolescence can prevent mental health problems. Aim: The study aimed to assess the applicability and effectiveness of mindfulness-based cognitive therapy (MBCT) on resilience and anxiety of early school-going adolescents with anxiety. Method: This study used pre, post, and follow-up with a randomized control group design. Out of 200 samples screened by Preliminary Identification Performa and Clinical Interview Schedule (PI&CI), General Health Questionnaire-12 (GHQ-12), Spence Children’s Anxiety Scale (SCAS), and Brief Psychiatry Rating Scale (BPRS-C), 72 samples aged between 10 to 14 were included in the final study and grouped into two equal groups through a simple randomized method. Psychological intervention based on mindfulness (PIBM) group with N = 36 received 12 sessions of mindfulness-based intervention (MBCT-C) but only 33 completed up to follow-up. Only N = 32 in Treatment Waiting List (TWL) group completed three assessments who received parental counseling about anxiety. The outcome measures were Child and Adolescent Mindfulness Measure (CAMM), SCAS, Bharathiar University Resilience Scale (BURS). Result: The findings suggested that the PIBM group significantly improved in mindfulness and resilience, and anxiety symptoms were reduced. The effect size observed is strong and the post hoc t-test showed significant change in variables in every assessment duration. The TWL group did not have significant change. Thus MBCT-C is an applicable and effective intervention for a early school-going adolescent with anxiety.

Newborn care

A neonate is also called a newborn. Aim: To assess the effectiveness of simulation training on knowledge and practice regarding newborn care among staff nurses. Research design: A quasi experimental non randomized control group design was used. Sampling and sampling technique: Sixty staff nurses each in experimental and control group a were selected by non probability purposive sampling for the study in Rohilkhand Medical college hospital and Varunarjun Medical College Hospital. Knowledge and practice was assessed by using structured knowledge questionnaire and practice checklist.. The intervention included the simulation training of neonatal resuscitation and teaching on immediate and routine newborn care. Results and findings: The study findings revealed that the mean post-test knowledge score was higher i.e. (31.66±1.71) than the mean pretest knowledge score i.e. (20.68 ±4.68) in the experimental group. It revealed that the mean post-test practice score was higher i.e.( 24.71±0.45) than the mean pretest practice score i.e. (21.03 ±1.30) in the experimental group. Data revealed that the mean experimental group knowledge score was higher (31.66±1.17) than the mean control group knowledge score (26.03 ± 3.66). The difference was found to be statistically significant at p=0.05 level of significance.

The Effect of S.A.Q Training on a Number of Physical Picks for Futsal Players' Youth

The research aims to reveal the differences in a number of physical variables for the experimental group players between the pre and post-tests. Also, it shows the differences in a number of physical variables for the control group players between the pre and post-tests. Moreover, the differences in a number of physical variables between the experimental and control groups in the post-test. The researchers used the experimental method for its convenience to the research nature, and the experiment was carried out on a sample of (20) players from Andalusia Youth Forum with ages (under 19) years, (4) players were excluded from the research sample, (2) players for the exploratory experience and (2) players were excluded for being goalkeepers. Homogeneity was achieved in the variables: age, height, weight and training age; and parity between the two research groups in the physical and skill variables that were determined by the specialists. An experimental design called the pre- and post-test randomized control group design was adopted. The researchers used the following statistical methods: the arithmetic mean, standard deviation, skew coefficient, coefficient of variation, percentage, T test for related samples, and T-test for independent samples. The data were statistically handled using the (SPSS) program to obtain the arithmetic mean, standard deviation, coefficient of variation, skew coefficient, T-test for related samples and T-test for independent samples. The researchers concluded that the (S.A.Q) style exercises carried out by the experimental group achieved an improvement in all the physical and skill variables by comparing the results of all the pre and post variables of the experimental group players. In addition, the experimental group that carried out the S.A.Q style exercises achieved better progress than the control group in all physical and skill variables by comparing the results of

Occupational health intervention for work-life balance and burnout management amongteachers in rural communities.

This study examined the efficacy of the occupational health model of rational emotive behavioral on work-life balance (WLB) and burnout management (BOM) amongpublic school teachers. The study was a pretest-posttest randomized control group design. The participants were 141 teachers in rural communities in Enugu state Nigeria drawn with emphasis on inclusion criteria. Two instruments were used for the data. Data were analyzed using repeated measure analysis of variance. The result showed that rational emotive occupational health coaching (REOHC) led to a significant increase in the management of WLBand burnout among teachers compared to their counterparts in the control group. At the follow-up stage, REOHC proved to be effective over a period of 3 months. REOHC is a therapeutic intervention strategy that is valid and reliable over time in the management of WLB and BOM amongteachers. The researchers are optimistic that the extension of REOHC to other related social and psychological-based self-defeating belief by social workers, psychologists, counselors, and employers of labors can enhance their productivity and emotionality in the home and workplace.

An Investigation of The Effect of Block-Based Programming and Unplugged Coding Activities on Fifth Graders’ Computational Thinking Skills, Self-Efficacy and Academic Performance

This paper investigated the effect of block-based programming and unplugged coding teaching activities on fifth graders’ computational thinking skills, self-efficacy, and academic performance. The teaching activities were conducted within the scope of the “Problem-Solving and Programming” unit of the Information Technologies and Software (ITS) course. The sample consisted of 82 fifth graders of three public middle schools in the academic year of 2020-2021. Participants were recruited using random sampling. The study adopted an embedded mixed design. The quantitative stage employed a pretest-posttest randomized control group design, while the qualitative staged employed a case study. Quantitative data were collected using the Computational Thinking Self-efficacy Scale (CTSES), the International Informatics and Computational Thinking Activity Task Test (IICTATT), and a Computational Thinking Performance Test (CTPT) developed by the researcher. Qualitative data were collected using a semi-structured interview questionnaire. The quantitative data were analyzed using the Kruskal Wallis H, paired sample t-test, and ANCOVA test on the Statistical Package for Social Sciences (SPSS). The qualitative data were analyzed inductively using MAXQDA. There was no significant difference in CTSES scores between groups. Experimental 2 had higher IICTATT and CTPT scores than Experimental-1 and control groups. The qualitative findings were grouped into seven categories.

Use of local kelor (moringa oleifera) leaves powder from West Nusa Tenggara to increase the neutrophile cell phagocyte index and its function on rats with PEM infected by staphylococcus aureus

Indonesia is reportedly ranked third in the prevalence of acute malnutrition in the Asia Pacific. Protein Energy Malnutrition (PEM) has a high prevalence in the West Nusa Tenggara (NTB) Province with over600 cases reported by the Health Department from January to October 2015, especially among children under five of which 31 cases led to death. Meanwhile, the nutrition status is accurately determined through blood biochemical and hematology tests. The Neutrophil index is an important biomarker in combating infectious agents, such as Staphylococcus aureus which is often the cause of contagious diseases. Individuals suffering from Protein-Energy Malnutrition are most vulnerable to these types of infections. Fortunately, kelor (Moringaoleifera) has been found to have nutritious contents, especially protein and iron (Fe), but its potential has not been extensively explored in the West Nusa Tenggara. This study aims to confirm the effect of the local kelor (Moringa oleifera) leaves powder in increasing the Innate Immune Response of sample rats with Protein Energy Malnutrition (PEM). A post-test randomized control group design was used with 20 rats grouped into five with a period of 56 days.

THE INFLUENCE OF THE PROBLEM SOLVING MODEL WITH SCIENTIFIC LITERACY ON STUDENTS' COMPETENCE ON GLOBAL WARMING MATERIAL AT SMP NEGERI 29 PADANG

Learning that is still teacher-centered makes students less active in solving problems and finds ideas in learning so as to make students' competencies low. With the low competency of business students, the business that can be done is by applying a problem solving model with scientific literacy. This model is in accordance with the demands of the 2013 curriculum which requires students to be active in learning. The purpose of this study is to describe the effect of the literacy problem solving model on the subject of Global Warming on the competence of students in SMP Negeri 29 Padang. This type of research is a Quasi Experiment with a randomized control group design posttest only design. The population is all eighth grade students of SMP Negeri 29 Padang in the academic year 2019/2020. The instrument used was a posttest question for knowledge competence, observation sheet for attitude competency and product assessment sheet for skills competency. For this research hypothesis was tested using t-test. The results of data analysis obtained are normally distributed and homogeneous data. It can be concluded that the hypothesis is accepted and there is a significant influence in the application of problem solving models with scientific literacy to students' competencies in global warming material at SMP Negeri 29 Padang.

Chlorhexidine and honey: Mouthwash liquids in reducing halitosis of stroke patients

This research aimed to assess the effectiveness of honey and chlorhexidine in reducing halitosis of stroke patients. Pretest–posttest randomized control group design was used to obtain the data in 102 patients at RSUD Dr. Soedarso. The present study compared the effectiveness of different mouthwash liquids; chlorhexidine and honey. The data were analyzed using univariate and bivariate analysis. Most of the halitosis cases were observed in male patients at the age of >54 years old. The mean halitosis score of the patients before treatment was 4 (estimated by using Tanita Breath Checker). After the treatment, both chlorhexidine and honey showed a positive result in reducing halitosis. The average Halitosis score before treatment in the chlorhexidine group was 4 and changed into 1.5 post-treatment. In honey group, the mean Halitosis score before treatment was 4 and changed into 1 after treatment. The average score of halitosis in the group treated with chlorhexidine and in a group treated with honey was not really significant. In the chlorhexidine group, the average score was 2.377 while in the honey group, the average score was 2.277. It meant that both liquids have a similar impact in reducing halitosis. Honey and chlorhexidine are effective in reducing halitosis. Moreover, honey was better in improving halitosis in stroke patients compared to chlorhexidine.

PENGARUH SENAM HAMIL BIRTH BALL DENGAN MUATAN EDUKASI PERSIAPAN PERSALINAN TERHADAP KECEMASAN IBU HAMIL

During pregnancy, there is an imbalance of the hormones estrogen and progesterone which causes physical and psychological changes. A common psychological change during pregnancy is anxiety. Pregnant women who experience anxiety during pregnancy will increase the risk not only to the mother but also to the baby. One of the efforts to overcome the anxiety of pregnant women is to do pregnancy exercises use birth ball and education of childbirth preparation. This study aims to analize the effect of pregnancy exercise use birth ball and education of child birth preparation on pregnant women anxiety. This research method use quasi experimental with non randomized pretest-posttest control group design. Subject is divided into two groups, intervention and control with total sample 34 respondens. Anxiety of pregnant women assessment using Zung Self-Rating Anxiety Scale (ZSRAS). Statistical test using Mann Whitney test with p value p=0,000 showed differences between intervention group and control group p<0,05, there is a significant decrease in anxiety scores in the intervention group compared to the control group. Conclusion of this study is pregnancy exercises use birth ball and education of childbirth preparation reduces anxiety in pregnant women.

The Effect of Otago Exercise Program on Walking Speed and Fall Risk in Elderly Women

Introduction: Elderly has a slower walking speed and an increased risk of falling. Decreased muscle mass and strength contribute to decreasing the ability to produce strength and accuracy responses to maintain balance and reduce walking speed. The Otago exercise program is a fall prevention exercise program for the elderly consist of lower limb strengthening exercises and balance exercises. This study aims to find the effects of eight weeks Otago exercise program on walking speed and risk of falling. Methods: This research is pre and post-test randomized control group design. Twenty-six elderly women in nursing homes age 60 years old or more who meet inclusion criteria, divide into 2 groups, with thirteen subjects in each group. The intervention group performed the Otago exercise program 3 times a week for 8 weeks and the control group had no intervention. Ten meters walking test (10-mWT) is used to assess the walking speed and a timed up and go test (TUG) is used to assess fall risk. Walking speed and fall risk were assessed before and after the intervention. Results: The results of this study showed that 8 weeks Otago exercise program significantly increase walking speed as assessed by the 10-mWT test from 0.67?0.16 m/sec to 0.79?0.19 m/sec (p<0.05) and significantly decreased the risk of falling by TUG test 14.99+2.82 sec to 14.00+2.93 (p<0.05) but not in the control group. Conclusion: The Otago exercise program for 8 weeks increased walking speed and decreased the risk of falling in elderly women.

Efektivitas Penggunaan E-Modul Pada Mata Kuliah Statistika Di Program Studi Pendidikan Teknik Bangunan Fakultas Teknik Universitas Negeri Jakarta

This research aims to find out the effectiveness of the use of e-modules in statistics courses in the Building Engineering Education Study Program of The State University of Jakarta which is seen through learning outcomes. The method used is Quasi Experimental with the form The Randomized Control Group Design. The sample in this study is an affordable sample, namely students who take statistics courses in the 114th semester of 2020/2021. In this study, the sample was divided into two, namely the group given treatment in the form of learning using the teaching materials e-module statistics as an experimental class and the other group using conventional teaching materials as a control class. Data collection is carried out using test instruments of learning outcomes that will be given in experimental classes and control classes. The results showed that the average learning outcome score for the experimental class was 68.79 and for the control class the average score was 55.47. In the test t using the independent sample test technique, the results of = 4,354 = 1,999. The analysis also showed a significant (2-tailed) rate of 0.000 &lt; 0.05. Based on these results, it can be concluded that the e-module statistics effectively has a positive impact on the learning outcomes of students of the Building Engineering Education Study Program of The State University of Jakarta.

IMPLEMENTATION OF MURDER TYPE COOPERATIVE LEARNING MODEL IN BIOLOGY LEARNING

The purpose of this study was to determine the learning outcomes of students by applying the MURDER type cooperative learning model at MTsN Sijunjung. This type of research is a quasi-experimental research with a randomized control group design post-test only design. The instrument used was a test of learning outcomes, by compiling tests, validation tests, trials, and item analysis. Data analysis techniques are the normality tests, homogeneity tests, and hypothesis tests. The results showed differences in the average value, standard deviation, and variance of the experimental class and the control class. The results showed that the research hypothesis was accepted. In conclusion, the learning outcomes in the experimental class with the MURDER type cooperative learning model are better than the control class (normal).

PENGARUH MODEL QUANTUM LEARNING DISERTAI SPEED TEST TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS VII SMP NEGERI 1 VII KOTO SUNGAI SARIAK

The purpose of this research to know the effect of Quantum Learning disertai Speed Test toward result of students mathematic at the seven Grade of SMPN 1 VII Koto Sungai Sariak. This research is pre-experimental study with research design randomized control group only design. The population in this research is the students of class VII SMPN 1 VII Koto Sungai Sariak. Sampling using random sampling technique with class VII7 as experiment class and VII6 as control class. The result of this research is the result of cognitive. Based on the final test, the mean score of experimental class was 74 and the control class was 67. The result of t- test tcalculate was 2.29 and ttable was 1.66 with a=0,05 and dk=54. Therefore tcalculate &gt; ttable means H0 denied and H1 accepted. So, it was concluded that there is an influence of the Quantum Learning with Speed Test toward the result of students’ mathematic at the seven grade of SMPN 1 VII koto Sungai Sariak.

Etlingera elatior (Jack) R.M, Sm Containing Diet Normalizes Some Metabolic Syndrome Markers due to High-fat High-fructose Diet in Wistar Rats

Background: Etlingera elatior (Ee) contains phytochemical compounds that are rich in antioxidants, which may reduce several biochemical markers of metabolic syndrome (MetS). Objective: We aimed to study the effect of fresh Etlingera elatior (FEe) and steamed Etlingera elatior (SEe) as a part of rat diet on body weight, serum lipid, and malondialdehyde (MDA) level in Wistar rats with MetS induced by a high-fat, high-fructose diet. Methods: Our research was a true experimental randomized control group design with pre- and post-test. A total of 24 male Wistar rats were divided randomly into the following four groups: 1) Control, fed standard rat diet during the whole duration of the study, 2) HFFr-Sd, fed high-fat high- -fructose (HFFr) diet for 29 days, followed by 29 days of the standard diet, 3) HFFr-FEe, fed HFFr diet for 29 days, followed by 29 days of a standard diet containing 33.3% FEe, and 4) HFFr-SEe, fed HFFr diet for 29 days, followed by 29 days of a standard diet containing 33.3% SEe. The HFFr diet was given at 15 g/day along with fructose drink (20% pure fructose) at 100 ml/day. The diets in each group after the MetS induction period are referred to as intervention diets. Data at the end of HFFr (pre) and intervention diets (post) were analyzed by paired t-test. The data among groups were analyzed by one-way analysis of variance followed by post hoc test. Results: HFFr diet for 29 days induced MetS in Wistar rats fulfilling the criteria of obesity (Lee Index), hypertriglyceridemia, and decreased high-density lipoprotein cholesterol (HDL-C). Also, there was a significant increase in serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and MDA level (p &lt; 0.05). Feeding a diet containing FEe or SEe can significantly reduce body weight, serum triglyceride, total cholesterol, LDL-C, and MDA, and increase HDL-C levels (p &lt; 0.05). The effect of FEe was more pronounced in ameliorating body weight and lipid profile than SEe. Conclusion: Fresh Ee and Steamed Ee can ameliorate obesity, dyslipidemia, and oxidative stress in MetS Wistar rats induced by a high-fat, high-fructose diet. It suggests that dietary Ee accounting for one-third of daily standard diet can assist in normalizing some MetS markers in rats.

Melatonin prevented the elevation of leukocyte count and the decreased of hematocrit levels in burn-induced Wistar Rats

Background: Burns are commonly caused by thermal injuries that are often encountered in everyday life. Burns may cause tissue damage and tissue infection. Melatonin, a hormone that acts as an antioxidant and anti-inflammatory, can be used as a supportive therapy in patients with burns by preventing excess tissue damage, decreasing inflammatory response, and preventing extreme leukocyte increase. The study aims to investigate the effects of melatonin supplementation on leukocyte count and hematocrit levels in male Wistar rats with burns injury.Method: This was an experimental animal study with randomized control group design. A total of twelve healthy male Wistar rats were randomized and divided into two groups. All Wistar rats were induced with 30% burns injuries area. The melatonin group was intraperitoneally administered with melatonin at 0, 8, and 16 hours after treatment, while the control group was administered with placebo (aquadest) with similar method. Leukocyte count and hematocrit levels were measured by taking retroorbital venous blood at 0, 3, and 24 hours after treatment. Data were analyzed with Paired t-Test, Independent t-Test, Mann-Whitney, or Wilcoxon test depend on their normality.Results: There was a higher leukocyte count in control group compared to melatonin group at 3 hours after treatment (T3) (p=0.050), but not at 0 hours after treatment (T0) and at 24 hours after treatment (T24) (p&gt;0.05). There was increased leukocyte count in both melatonin and control groups in T3 in comparison with T0, however the increment was steeper in control group compared to melatonin group. There were no significant differences in hematocrit levels between the melatonin and control groups in T0, T3, and T24 (p&gt;0.05). There was a steeper increased hematocrit levels in the control group than the melatonin group after T24, although it was not statistically significant.Conclusion: Melatonin might have role in preventing a steeper rise of leukocyte count and hematocrit levels in burns injury. If confirmed by further studies, melatonin might be potential for adjuvant management in burns.

INFLUENCE OF JIGSAW MODEL WHICH COMBINED WITH PAPER OPERAND IDEA TECHNIQUE FOR SENIOR HIGH SCHOOL STUDENTS

The research is based on the problems in SMAN 4 Padang, the low learning competency of students. Learning competency is an ability that must be possessed by students to know what they have mastered during learning. In this study aims to observe the influence of the aplication of the jigsaw cooperative learning model combined with the paper operand technique of ideas on the learning competencies of students in class X MIA SMAN 4 Padang in the acedemic year 2019/2020. Forms of this study was Quasi Experimental Design with design Randomized Control Group Posttest Only Design. The population in this study were all students in grade X MIA SMAN 4 Padang. Sampling using purposive sampling. The data collection technique of learning outcomes using posttest and documentation. Learning outcomes data were analyzed by normality-test, f-test and t-test. The results showed that the average value learning competency experimental class is greater than the control class.

The effectiveness of Aloe vera peel extract on the reproductive status of streptozotocin-induced diabetic rats

Diabetes mellitus is a disorder in glucose metabolism that can cause complications in the reproductive organs. Aloe vera is a medicinal plant that has been widely used as an antidiabetic. The research objective was to analyze Aloe vera peel extract’s effect on motility, sperm concentration, and testosterone levels in diabetic rats. The study design was a post-test-only randomized control group design consisting of a diabetes control group (DM) and a group with peel extract at a dose of 200 mg (PE1) and 400 mg/kg body weight (PE2) for 4 weeks. Rats were diabetic with glucose levels > 200 mg/dl after 72 hours of induction of streptozotocin 65 mg/kg BW. Data in the form of motility, sperm concentration, and testosterone levels were analyzed using ANOVA and LSD tests. The results showed a significant increase in the motility of the PEI and PE2 groups compared to DM. Testosterone concentrations and levels were significantly increased in the PE1 and PE2 groups compared to controls. The conclusion that can be stated is that the peel extract of Aloe vera can increase motility, sperm concentration, and testosterone levels of diabetic rats.

Impact of cognitive behavioural play therapy on social anxiety among school children with stuttering deficit: A cluster randomised trial with three months follow-up.

Background:Stuttering is a speech deficit which is characterized by obstruction of speech eloquence and verbal expression in addition to involuntary flow of air during communication. School children with communication deficit often experience social anxiety in their immediate environment. Currently, reports show that a good number of children with communication deficits are prone to social maladjustment due to their being socially inept. And this has significantly affected their thought pattern, social behaviours and emotional responses. In view of this, we examined the impact of cognitive behavioural play therapy in reducing social anxiety among school children with stuttering.Method:This is a pretest-posttest randomized control group design. Participants were 178schoolchildren in inclusive schools in South east Nigeria. Participants in the intervention group were treated using cognitive behavioural play therapy programme (CBPT). Participants in the waitlist control group were only assessed at three points of assessment. Data analyses were completed using repeated measures ANOVA.Results:The results show that cognitive behavioural play therapy is beneficial in decreasing schoolchildren's social anxiety scores. The intervention equally showed the considerable impacts on the children when exposed to cognitive behavioural play programme at different times of assessment compared to waitlisted control group.Conclusion:It is concluded that CBPT is a long-term psychotherapeutic programme that has significant impacts in reducing social anxiety among children with stuttering. This study makes a leading contribution on the limited scholarship focusing on the impact of CBPT on social anxiety of special population with stuttering deficits in developing countries.

Melatonin prevented the increased serum lactate levels and the reduced hemoglobin levels in burn-induced Wistar rats

Background: Burns are the most common and devastating form of trauma yet constitute a common cause of morbidity worldwide. Complications of burns such as sepsis and tissue hypoperfusion may increase serum lactate and reduce hemoglobin. Measuring lactate levels has been proven to be a useful predictive marker of hypoperfusion and sepsis in patients with burns. Melatonin which acts as an anti-inflammatory and antioxidant, has been proposed to be used as pharmacological adjuvant in patients with burns, reducing oxidative damage. The study aims to investigate the effects of melatonin supplementation on serum lactate and hemoglobin levels in burn-induced male Wistar rats.Method: This was an experimental animal study with randomized control group design. All samples (n=12 male Wistar rats) were randomized and divided into two groups. Each rat was exposed to a hot metal rod for 10 seconds to induce 30% burns injury. Rats in the control group were administered with placebo (aquadest), while rats in the experimental group were administered with melatonin intraperitoneally at 0, 8, and 16 hours after burns injury. Blood samples were collected from the retro-orbital sinuses at 0, 3, and 24 hours after treatment. Data were statistically analyzed using Paired t-Test, Independent t-Test Mann-Whitney Rank Test and Wilcoxon test.Results: There were no significant differences in lactate and hemoglobin levels between melatonin group and control group 0 hours after treatment (T0), 3 hours after treatment (T3), and 24 hours after treatment (T24) (p&gt;0.05). There were increased lactate levels and decreased hemoglobin levels in both melatonin and control groups, however the increment of lactate and the decrement of hemoglobin were steeper in control group compared to melatonin group. There were higher serum lactate increments and higher hemoglobin decrement at 24 hours (∆T0–T24) in control compared to melatonin group (p&lt;0.05).Conclusion: Melatonin might prevent dramatic rise of serum lactate levels and decrease of hemoglobin levels until 24 hours after treatment in burns injury. If confirmed by further studies, melatonin might have a role as adjuvant therapy in burns.

Efek Hepatoprotektif Bit Merah (Beta vulgaris L) Organik terhadap Abnormalitas Faal Hepar Akibat Paparan Pestisida

Pesticide exposure causes hepatic parenchymal cell damage and impaired hepatic membrane permeability. Organic red beets contain high levels of flavonoids, betanin, and polyphenols. The phytochemical compounds in beetroot are anti-inflammatory, antioxidant, and antihepatotoxicity. The purpose of this study was to determine the hepatoprotective effect of organic beetroot (Beta vulgaris L) on hepar physiological abnormalities due to exposure to pesticides. This type of research is an experiment with Post Test Only Randomized Control Group Design. The study population was male Wistar rats aged 2-3 months with a weight of 150-200g. The sampling technique was randomly assigned to 30 rats were divided into 6 groups. Beetroot ethanol extract intake and pesticide exposure were observed for 14 days. Liver physiological abnormalities were measured based on the levels of the enzyme cholinesterase, Gamma GT, SGOT, and SGPT. Measurement of enzymes using the IFCC method, using Stardust MC15 and Humalyzer spectrophotometer. Data analysis using Anova test. There was a hepar physiological abnormality after pesticide exposure which was indicated by a significant decrease in the cholinesterase enzyme (p-value=0,000) and a significant increase in the Gamma GT, SGOT, and SGPT enzymes (p-value=0,000). The intake of organic beetroot ethanol extract (Beta vulgaris L) significantly increased the cholinesterase enzyme back (p-value=0,000) and significantly decreased the Gamma GT, SGOT, and SGPT enzymes (p-value=0,000), approaching normal levels at a dose of 400mg/kgBW. Organic red beetroot (Beta vulgaris L) has a hepatoprotective effect on hepar physiological abnormalities due to exposure to pesticides.