Radiation Portals Research Articles

Microwave heating based on two rotary waveguides to improve efficiency and uniformity by gradient descent method

This study aims to improve the efficiency and uniformity of microwave heating based on a rotary radiation structure. This study’s steps are summarized as follows. First, using the finite element method in a simulation model, two radiation ports revolve on their axes and heat the material. Second, the heating efficiency at different angles is analyzed to find efficient angles of radiation ports. Finally, to improve the uniformity of material with high efficiency, we use the gradient descent method in machine learning to optimize the heating time at selected angles. An experimental system is established for this research and the simulation results are verified by experiments, showing that this research has an obvious superiority and efficiency and uniformity of the material have improved compared to traditional heating results without angle selection and optimization of the heating time. What is more, influences of material with different shapes, positions and materials have also been discussed.

Functional and biochemical changes in the thyroid gland following exposure to therapeutic doses of external beam radiotherapy in the head-and-neck cancer patients.

Majority of the head-and-neck cancers are locoregionally advanced at the time of diagnosis. Hence, radiotherapy (RT) portals will invariably cover the whole neck and thus, the thyroid gland which may lead to its dysfunction. The purpose of this study is to identify the functional and biochemical changes in the thyroid gland following RT to the neck using single-photon emission computed tomography-computed tomography (SPECT-CT) and thyroid function tests (TFTs). In this prospective study, 45 patients of the head-and-neck cancer, receiving RT with or without chemotherapy were investigated. Baseline TFTs and thyroid scans (on SPECT-CT) were done, and the same were repeated at the completion of RT, at 3 and 6 months. All patients received a minimum of 30 Gy to the whole neck. Baseline TFTs and thyroid scans were normal. None of them developed hypothyroidism clinical or subclinical (C/S) at the completion of RT. Six patients developed hypothyroidism (four subclinical, two clinical) at 3 months of the completion of treatment. At 6 months of follow-up 14 patients (31.1%) developed hypothyroidism (ten subclinical, four clinical) with P≤ 0.01. All patients having clinical or subclinical hypothyroidism had decreased uptake on thyroid scan. Patients having decreased uptake on thyroid scan only, with normal TFTs and no symptoms of hypothyroidism were zero at the completion of RT, 1 at 3 months follow-up, and seven at 6 months follow-up. Hypothyroidism (C/S) is an under-recognized but significant complication of therapeutic doses of RT to the neck. In our study, we recognized hypothyroidism as early as 3 months following the completion of RT. Hence, tests to evaluate functional and biochemical changes in the thyroid gland should be instituted as early as 3 months following RT.

Abstract P4-12-29: Utility of surface guide radiation therapy (SGRT) in radiation therapy for breast cancer

Abstract Purpose: Radiation therapy has been shown to be a highly effective treatment for breast cancer. Historically, patient setup for daily treatment has required a set of permanent tattoos. However, due to a variety of reasons, it may be hard to align patients to these marks and the marks can also cause distress in many patients. National Comprehensive Cancer Network’s (NCCN) radiation therapy guidelines recommend weekly radiation ports films; however, many centers perform daily image guidance using x-rays for breast treatments prior to radiation delivery, increasing both radiation dose and treatment time. Surface Guided Radiation Therapy (SGRT) is a technique which is being adopted by radiation therapy centers to aid in patient’s setup and treatment delivery accuracy. SGRT is safe and non-invasive, using visible light to compare the patient’s skin surface in the treatment room to the planned treatment position with sub-millimeter accuracy. SGRT can also automatically signal for the treatment delivery system to pause radiation if the patient moves out of the desired position. The aim of this study was to evaluate the AlignRT (Vision RT, Ltd, London, United Kingdom) SGRT system for patient setup accuracy in comparison to a 3-point tattoo setup and daily KV pair imaging. Methods: A total of 20 breast cancer patients (600 radiation fractions) were setup using a 3-point tattoo technique and then positioned using AlignRT. Inter-fraction positions were analyzed between all three techniques, namely tattoo, AlignRT and kV imaging. In addition, the AlignRT system was used to evaluate that patient’s position during breath hold. This deep inspiration breath hold (DIBH) technique is designed to provide cardiac sparing during left breast radiotherapy. Results: Using 3-point tattoo setup, an average magnitude of 5.7±3 mm error from isocenter was measured, compared to 2.4±1 mm using surface guidance. Statistically significant 3d shift vectors were found between patient setup using 3-point tattoo and SGRT techniques, however between SGRT and daily KV imaging 3d shift vectors were not statistically significant. AlignRT based DIBH showed the distance between the heart and chest-wall at the mid tangential beam level, based on weekly port films, to be within 2±1 mm of the planned level. Conclusion: SGRT has been shown to improve the accuracy of patient setup compared to 3-point tattoos and is comparable to daily KV imaging for isocentric setup. SGRT can be used in clinics to reduce the frequency of KV imaging and therefore additional radiation exposure. SGRT can also remove setup tattoo requirements which are placed during simulation which provide a permanent reminder to patients of their cancer and treatment. SGRT has also been demonstrated to ensure adequate and reproducible breath hold for DIBH left sided breast treatments. Citation Format: Snehal Desai. Utility of surface guide radiation therapy (SGRT) in radiation therapy for breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P4-12-29.

Evaluation of The Effectiveness and Side Effects of Radiotherapy in Patients With Primary Nervous System Lymphoma. A Single Center Experience

Aim: In this study, we aimed to evaluate the overall and progression-free survival, the radiotherapy process and the early and late adverse effects in patients who underwent radiotherapy (RT) for primary nervous system lymphoma in our clinic.Method: Between January 2010 and September 2019, 16 patients who received radiotherapy due to primary central nervous system lymphoma in our clinic were examined according to their statistically significant differences in terms of survival and side effects.Results: The median disease-free survival of the patients was 6 months, and the median overall survival was 12.5 months. 18.75% of the patients could not receive chemotherapy but only radiotherapy. Radiotherapy doses were range from 2600 to 5000 cGy. When patients were evaluated in terms of radiotherapy dose, field size and chemotherapy, no statistically significant difference in overall survival was detected. Cognitive disorders were observed as the most common late side effects while the most common acute side effects in patients were headaches.Conclusion: In the treatment of primary central nervous system lymphoma, changes in radiotherapy portals and radiotherapy doses can be predicted in patients who received high-dose methotrexate chemotherapy or not. Furthermore, it has been considered that more comprehensive studies are needed to increase the success of treatment and provide standardization in treatment, especially in patients with elderly and comorbid diseases.

New Configuration of Microstrip Patch Antenna Arrays

            A new configuration of a Microstrip patch antenna array is presented in this paper. The array is arranged in such a way that only one patch placed in the E-plane and four patches are placed in the H-plane. This is to make the antenna provide a dual band performance and increase the gain. The feeding network utilized in the array is based on the step-loaded matching structure in order to maintain good matching impedance between the input port and the radiation (out) ports. The antenna array is simulated using the Computer Simulation Technology (CST) Microwave Studio. The gain of the first frequency band, which has the center frequency 4.35 GHz, is 8 dBi, while the second band is 5.8 dBi at the center frequency 9.8 GHz. Due to simplicity and high gain, the antenna array is of interest of many high gain and long distance applications such as point-to-point communication systems.         

Evaluation of adequacy of conventional radiotherapy fields based on bony landmarks in cervical cancer patients using contrast enhanced computed tomography scan- A regional cancer centre experience

Evaluation of adequacy of conventional radiotherapy fields based on bony landmarks in cervical cancer patients using contrast enhanced computed tomography scan- A regional cancer centre experience - IJOGR- Print ISSN No: - 2394-2746 Online ISSN No:- 2394-2754 Article DOI No:- 10.18231/j.ijogr.2019.068, Indian Journal o

OTHR-15. PATIENTS WITH LIMITED STAGE SMALL CELL LUNG CANCER THAT RECUR WITH ISOLATED BRAIN METASTASES HAVE PROLONGED SURVIVAL

INTRODUCTION: Small cell lung cancer (SCLC) frequently metastasizes to the brain. In patients with limited-stage disease (disease confined to one radiation portal), the incidence of brain metastasis after 3 years is 50–60%. We reviewed patients with SCLC and hypothesized that isolated brain recurrence has a unique natural history. METHODS: 471 adult SCLC patients seen at University Hospitals Case Medical Center from 1998 to 2014 were screened. Patients were separated by those with isolated brain metastases and those with other patterns of metastasis. Demographic data including age, race, sex, smoking history and clinical data such as TNM classification, stage, treatment, and time to relapse and death were collected. Median overall survival (mOS) and progression free survival (mPFS) were compared using log-rank tests and Kaplan-Meier plots were constructed. In a separate cohort of metastatic SCLC we examined differences in next generation sequencing (NGS) of targeted exomes between primary and metastatic sites including the brain. RESULTS: 281 extensive-stage patients and 40 limited-stage patients were included. 12% (30/281) of the extensive-stage patients and 25% (10/40) of limited-stage patients had isolated brain metastases. Patients with limited-stage disease who developed isolated brain metastases had significantly improved mOS as compared to those who developed other sites of metastasis (OS = 38.7 months vs. 20.2 months, p=0.033). Furthermore, mPFS for limited-stage patients with isolated brain metastases was improved compared to other patterns of metastases (PFS = 17.9 months vs. 10.1 months, p = 0.03). NGS demonstrated that NOTCH1 mutations were infrequent in biopsies from all metastatic sites but were common in primary lung tumors. CONCLUSION: In our single center review, patients with limited-stage SCLC who recurred only in the brain had improved survival as compared to those who had other patterns of metastases. Our initial work demonstrates differences in oncogenic gene mutations between the metastatic and primary tumors.

Feasibility of Cascadable Plasmonic Full Adder

The concept and configuration of a plasmonic cascadable full adder are proposed, whose logic operation is carried out by interference of surface plasmons and whose circuits are formed only with single- and multiple-mode plasmonic waveguides. This full adder is fabricated by patterning a SiO2 film deposited on a metal film using complementary metal-oxide-semiconductor-compatible processes except for the material of metal. The redundant surface plasmons present after interference are drained from the waveguides by forming radiation ports, and metal bumps are formed in the circuits to prevent stray light recoupling with the waveguides. The logic operation of the circuits is numerically confirmed by the three-dimensional finite-difference time domain method, and the difference in surface plasmon intensity between logic level “0” and “1” is numerically estimated to be 1.5 dB even for the worst case. These simulations were experimentally confirmed for some input signal patterns using scanning near-field microscopy, and the surface plasmon intensity distributions monitored coincide well with those simulated.

Fertility preservation in female cancer patients: current knowledge and future perspectives.

Protecting fertility in the presence of cancer has become highly significant, as the desire to give birth to a child is increasingly postponed to later in life, and long-term survival with cancer has increased. A variety of fertility-preserving methods have been developed. To find them, we performed a literature search in Medline using the key words "female fertility preservation in cancer" in December 2017. A total of 2381 different publications were found. After screening the abstracts 78 publications in English, French, or German language had been assessed as relevant (17 dealing with medical approaches, six with surgical approaches, 15 with oocyte cryopreservation, 11 with ovarian tissue cryopreservation and 29 were review articles). In general, there are medical (non-surgical) and surgical approaches. Medical approaches comprise administration of GnRH-analogues during gonad toxic oncologic treatment, and cryopreservation of oocytes after ovarian stimulation. Surgical approaches comprise traditional methods of organ-saving surgery and ovarian transposition outside of the radiation portal as well as ovary cryopreservation as standard. It is important to inquire about a prospective desire to have children with premenopausal women with cancer and comprehensively explain the fertility conserving methods available. Every premenopausal woman with cancer should be counseled about the methods of fertility protection currently available at a multiprofessional center.

Utility of Molecular Imaging with 2-Deoxy-2-[Fluorine-18] Fluoro-DGlucose Positron Emission Tomography (18F-FDG PET) for Small Cell Lung Cancer (SCLC): A Radiation Oncology Perspective.

Although accounting for a relatively small proportion of all lung cancers, small cell lung cancer (SCLC) remains to be a global health concern with grim prognosis. Radiotherapy (RT) plays a central role in SCLC management either as a curative or palliative therapeutic strategy. There has been considerable progress in RT of SCLC, thanks to improved imaging techniques leading to accurate target localization for precise delivery of RT. Positron emission tomography (PET) is increasingly used in oncology practice as a non-invasive molecular imaging modality. Herein, we review the utility of molecular imaging with 2-deoxy-2-[fluorine-18] fluoro-Dglucose PET (18F-FDG PET) for SCLC from a radiation oncology perspective. There has been extensive research on the utility of PET for SCLC in terms of improved staging, restaging, treatment designation, patient selection for curative/palliative intent, target localization, response assessment, detection of residual/recurrent disease, and prediction of treatment outcomes. PET provides useful functional information as a non-invasive molecular imaging modality and may be exploited to improve the management of patients with SCLC. Incorporation of PET/CT in staging of patients with SCLC may aid in optimal treatment allocation for an improved therapeutic ratio. From a radiation oncology perspective, combination of functional and anatomical data provided by integrated PET/CT improves discrimination between atelectasis and tumor, and assists in the designation of RT portals with its high accuracy to detect intrathoracic tumor and nodal disease. Utility of molecular imaging for SCLC should be further investigated in prospective randomized trials to acquire a higher level of evidence for future potential applications of PET.

Radiation-Associated Chronic Dysphagia Assessment by Flexible Endoscopic Evaluation of Swallowing (FEES) in Head and Neck Cancer Patients: Swallowing-Related Structures and Radiation Dose-Volume Effect.

We aimed to restore dose-volume parameters of swallowing-related structures (SRSs) by evaluating long-term swallowing dysfunctions after radiotherapy (RT) in head and neck cancer patients (HNCPs). Head and neck cancer patients whose pharyngeal region was involved in RT portal and treated with definitive RT/chemoradiotherapy (CRT) were included in the analyses. Patients underwent objective swallowing assessment by flexible endoscopic evaluation of swallowing (FEES). Volumes of SRSs that received 55 Gy (V55) (mean dose [Dmean]) were evaluated according to the dose-volume histograms of each patient. For every SRS, optimal dose-volume cut-off values were determined by receiver operating characteristic curve analysis. Fifty-five patients at a median 20 months (range, 12-26 months) after their treatments were evaluated. There was a strong negative correlation between FEES scores and dose-volume parameters of SRS ( r ⩽ -0.5, P < .0001). According to our results, middle pharyngeal constrictor (MPC) and inferior pharyngeal constrictor (IPC) had a Dmean > 57 Gy, base of tongue (BOT) Dmean > 50 Gy, supraglottic larynx (SGL) and glottic larynx (GL) Dmean > 55 Gy, and cervical esophagus (CE) Dmean > 45 Gy. MPC V55 > 70%, IPC V55 > 50%, BOT V55 > 65%, CE V55 > 40%, and SGL and GL V55 > 50% were significant predictors for dysphagia. It was found that dysphagia correlates strongly with dose-volume parameters of SRSs. IPC, SGL, and CE were found to be structures significantly associated with dysphagia.

Immortal Time Bias in Post-Operative Radiation Studies Utilizing the National Cancer Data Base

Studies employing large observational oncology databases, such as the National Cancer Database (NCDB), are appearing with increasing frequency in the oncology literature. Immortal time bias is a well described and often overlooked type of confounding selection bias that may give the illusion of treatment effectiveness in time to event (survival) analyses via marked alterations in effect sizes (i.e. hazard ratios). ‘Immortal time’ may arise during observational study design when follow-up incorporates a period of time where either death or the measured study outcome cannot occur. Bias in immortal time can occur in analyses designed to evaluate the impact of a specific intervention that calculates overall survival (OS) from time of diagnosis (in contrast to time of treatment), and in study designs that do not account for the time to receipt of adjuvant therapies (e.g. postoperative radiation therapy or PORT). Given the increase in NCDB analyses being used to evaluate the impact of PORT, we sought to examine how often-published studies accounted for time dependent confounders. We performed a PUBMED search using the terms: ‘NCDB,’ ‘National Cancer Data Base,’ ‘postoperative radiation,’ and ‘adjuvant radiation therapy,’ published between 2015-2018. Inclusion for review involved all manuscripts where PORT (with or without chemotherapy) was delivered to any disease site as a comparative arm within the study. This led to review of 42 publications. We specifically assessed how OS was defined and whether any statistical metrics were used to account for potential immortal time bias in the receipt of PORT via landmark analyses or adjusted hazard ratios. Of the 42 publications reviewed, OS was not defined in 8 (19%) studies, was determined from date of diagnosis in 20 (47.6%), from date of treatment start date in 8(19%), or from diagnosis with a one month landmark time in 6 (14.2%). There was no landmark analysis, sequential landmark definition, or an adjusted cox model with a clear time dependent definition in 31 studies (73.8%) when accounting for time to PORT. Amongst the 11 studies that did a landmark analysis, 9 of them (81.8%) had a landmark time with rationale that was not clearly defined. Among the manuscripts analyzed, PORT was concluded to be beneficial in 38 studies (90.4%). Immortal time bias may obscure the effect size (usually via overestimating HR) of PORT as an adjuvant therapy and affect the validity of NCDB hypothesis generating studies. The NCDB has many strengths with its power to generate valid research questions, but its inherent biases require rigorous statistical methods to help validate conclusions. Studies assessing PORT are encouraged to measure OS from treatment start date and perform sequential landmark analyses to help quantify PORT effect size and mitigate this common confounder.

Impact of Radiation Therapy on Scleroderma and Cancer Outcomes in Scleroderma Patients With Breast Cancer.

We examined systemic sclerosis (SSc) patients with breast cancer to identify the prevalence of radiation complications and to examine outcomes in SSc patients who received radiation therapy as part of their cancer treatment. Patients with SSc and breast cancer were identified from the Johns Hopkins and University of Pittsburgh Scleroderma Center databases. We examined whether erythema, blistering, ulceration, or thickening of the skin developed in the radiation therapy port. Changes in modified Rodnan skin thickness score (mRSS) and forced vital capacity percent predicted (FVC%) at 12 and 24 months post-cancer diagnosis were compared between patients who did and those who did not receive radiation therapy. A total of 43 of 116 breast cancer patients at Johns Hopkins and 26 of 37 patients at the University of Pittsburgh received breast radiation therapy. At Johns Hopkins, 4 of 30 (13.3%) patients with available data developed erythema, none had blistering, 1 of 30 (3.3%) developed ulceration, and 15 of 31 (48.4%) had skin thickening in the radiation port. At the University of Pittsburgh, 7 of 11 patients (63.6%) with available data developed erythema, 2 of 11 (18.2%) had blistering, none developed ulceration, and 6 of 11 (54.6%) had skin thickening in the radiation port. In a limited sample, there were no significant changes in the mRSS or FVC% between patients who did and those who did not receive radiation therapy. These data suggest that radiation injury causing local tissue fibrosis is not inevitable in SSc patients with breast cancer, occurring in approximately 50% of patients without evidence of lung or generalized skin disease flare. Therefore, the use of radiation therapy for breast cancer is considered an option based on the informed patient's preference.

Dynamic numerical recipes to improve detection schemes for the interdiction of radioactive shipment

Radiation Portal Monitors (RPM) acquire sequential measurements of gamma activity that can be modeled as a sequence of Poisson distributed random numbers. These series can be analyzed with Statistical Process Control (SPC) methods to trigger alarms when the statistical distribution of the ambient dose during a transit changes. Some usual SPC methods have been compared and modified to narrow the time required to bound an alarm. Both the probabilities of detection and the Average Run Length (ARL) are used and fitted to curves to benchmark the SPC methods, which are ranked as: SR, EWMA, CUSUM, SPRT, FLR, and Shewhart.

Complications of Radiotherapy and Radiosurgery in the Brain and Spine.

To recognize the main complications of radiation therapy and stereotactic radiosurgery in the brain and spine, and to highlight the imaging findings to improve the diagnostic process and treatment planning.

Cranial Cavernous Malformations: Natural History and Treatment.

Cavernous malformations (CMs), also known as cavernous angiomas or cavernomas, are low-flow vascular malformations of the brain and spinal cord that consist of clusters of dilated sinusoidal channels lined with endothelial cells that do not exhibit intervening tight junctions. The involved blood vessels lack muscular and elastic layers, and blood at various stages of thrombosis and organization often fills the thin-walled vascular caverns. CMs are grossly distinct from adjacent brain and have a lobulated appearance sometimes likened to a mulberry, with a characteristic dark red or purple color. Hemosiderin and gliosis often surround CMs of the brain and spinal cord; no neural tissue is present inside the lesion. Except for developmental venous anomalies (DVAs) present in ≈33% of CMs,1 no abnormal vascularity is typically seen on digital subtraction angiography, leading CMs to be termed cryptic or occult vascular malformations (Figure 1). Multiple small hemorrhage events lead to a pathognomonic popcorn appearance on magnetic resonance (MR) imaging because of hemosiderin staining from blood products of various ages. Calcifications may be present on computed tomographic imaging (Figure 2). Figure 1. A 48-year-old woman presented with headaches. A , Magnetic resonance imaging of the brain with T2-weighted imaging demonstrated a 1.1-cm lesion in the cerebellar vermis with mixed signal intensity. B – D , Susceptibility-weighted imaging demonstrated hemosiderin within the lesion’s core and a developmental venous anomaly associated with the cavernous malformation (arrowheads). Figure 2. A 28-year-old woman presented with partial seizures without secondary generalization. A , Noncontrast computed tomography of the head demonstrated a 1.4-cm right posterior cingulate hyperdensity, with evidence of mild hemorrhage and calcification. Magnetic resonance imaging of the brain demonstrated the cavernous malformation to have a core of mixed signal intensity, heterogeneous enhancement, and a rim of hemosiderin consistent with a cavernous malformation, as evidenced on ( B ) susceptibility-weighted imaging, ( C ) T2-weighted …

OTA Test Method for Receiver Sensitivity of Mobile Communication Base Station Based on the Conduction Method

The paper carries out test towards the mobile communication base station antenna radiation port over the air (OTA), analyzes the interference generated by antenna, and tests the single input and single output OTA with conduction method. The conduction-based test firstly checks the reversed interference generated at the base station radio frequency port as well as the antenna interface parameters, then uses channel simulator to replace the empty port wireless environment to simulate the wireless circumstance of base station communication, including reversed interference and multi-path signal, next measures the receiving sensitivity of the base station radio frequency port, and finally figures out the antenna radiation port sensitivity level. The results reveal when compared with normally used far-field test method, the conduction-based test has low uncertainty but accurate outcome.

A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors.

Lymphopenia is a common accompaniment of multimodal cancer therapy. As the most radiosensitive cells of the hematopoietic system, lymphocytes residing within or circulating through a radiation portal are frequently depleted by radiation therapy. The recognition that radiation-induced reduction of circulating lymphocyte counts and eventual lymphocyte infiltration of tumors have a tangible impact on overall survival outcomes has revived the interest in understanding the causes of treatment-associated lymphopenia and developing strategies to predict, prevent and ameliorate this well-documented phenomenon. In this systematic review, we have performed a comprehensive search of the literature to elucidate the studies that document a correlation between radiation-associated lymphopenia and survival outcomes in solid malignancies. We also summarize potential unifying paradigms that account for radiation-induced lymphopenia across studies and lay the groundwork for attempting to explain and/or counter this phenomenon.

Accurate identification of whispering gallery mode patterns of gyrotron with stabilized electro-optic imaging system

The precise field pattern measurement and analysis of a typical whispering gallery mode excited in a gyrotron are important to understand the interaction physics of the gyrotron. We precisely analyzed the characteristic of a whispering gallery mode, rotating TE6,2 mode, by a photonic-assisted W-band (75–110 GHz) electro-optic imaging measurement system. The whispering gallery mode in the W-band region diverges fast in free space as it propagates from the radiation port. Therefore, scanning the field patterns of a device-under-test should be performed as close as possible to identify the device's characteristics. We successfully accomplished visualizing highly accurate field patterns of a rotating and mixed whispering gallery mode based on the measured electric field magnitude and phase by using dual optical fiber-scale electro-optic (EO) probes. We observed the distorted fields when the typical open-ended waveguide and a general EO probe were used in the extremely near-field zone, whereas a very precise f...

A Dual Linearly Polarized End-Fire Antenna Array for the 5G Applications

A dual linearly polarized antenna array with end-fire radiation of the 60-GHz band is proposed by combining two types of magneto-electric dipoles (ME-dipole), which operate in vertical polarization (V-pol) and horizontal polarization (H-pol), respectively. Based on the substrate integrated waveguide structure, two kinds of ME-dipole are placed closely by sharing the same metallic post wall between them, achieving an element space of 0.77λ0. Besides, mutual coupling between the close elements is numerically analyzed and then suppressed by making modifications to the antenna structure. The proposed dual-polarized element achieves bandwidths of 26% and 32% (|S11| <; -14 dB) for the V-pol and H-pol, respectively. A 1×8 element array is designed, fabricated, and measured. Good agreement is achieved between the measurement and simulation. For the V-pol excitation, a bandwidth of 21% is obtained and gain is up to 16.1 dB. For the H-pol excitation, the bandwidth is 18% and peak gain is 15.1 dB. Radiation patterns are stable over the operating frequencies with cross polarizations below -30 dB for both polarizations. The port isolation is very high above 45 dB. With all these advantages of dual polarization, end-fire radiation, stable gain, and high port isolation, the proposed array is a potential candidate for the future 5G applications.