Abstract

Aim: In this study, we aimed to evaluate the overall and progression-free survival, the radiotherapy process and the early and late adverse effects in patients who underwent radiotherapy (RT) for primary nervous system lymphoma in our clinic.Method: Between January 2010 and September 2019, 16 patients who received radiotherapy due to primary central nervous system lymphoma in our clinic were examined according to their statistically significant differences in terms of survival and side effects.Results: The median disease-free survival of the patients was 6 months, and the median overall survival was 12.5 months. 18.75% of the patients could not receive chemotherapy but only radiotherapy. Radiotherapy doses were range from 2600 to 5000 cGy. When patients were evaluated in terms of radiotherapy dose, field size and chemotherapy, no statistically significant difference in overall survival was detected. Cognitive disorders were observed as the most common late side effects while the most common acute side effects in patients were headaches.Conclusion: In the treatment of primary central nervous system lymphoma, changes in radiotherapy portals and radiotherapy doses can be predicted in patients who received high-dose methotrexate chemotherapy or not. Furthermore, it has been considered that more comprehensive studies are needed to increase the success of treatment and provide standardization in treatment, especially in patients with elderly and comorbid diseases.

Highlights

  • Primary Central Nervous System Lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma type that can be inhabited in the brain, eye, leptomeninx and spinal cord (NHL) [2]

  • Chemotherapy regimens containing high dose methotrexate are frequently used in PCNSL treatment and the likelihood of late side effects due to treatment increases if all Brain Radiotherapy (WBRT) is applied together with chemotherapy regimens containing high dose methotrexate. 40-45 Gy (1.8-2 Gy) WBRT is applied in the presence of progressive disease and/or residence after CT, while 23.4-30 Gy (1.8-2 Gy) WBRT is applied in the presence of complete response

  • The response to radiotherapy of the disease alone is good in cases of WBRT, radiotherapy's contribution to total survival is limited and overall survival is an average of 10-18 months [2]

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Summary

CLINICAL STUDY

Evaluation of the Effectiveness and Side Effects of Radiotherapy in Patients with Primary Nervous System Lymphoma - A Single Center Experience. Timur Koca , Aylin Fidan Korcum , Yasemin Şengün , Melek Gamze Aksu , Mine Genç Radiation Oncology, Akdeniz University, School of Medicine, Antalya, Turkey

INTRODUCTION
MATERİAL AND METHODS
RESULTS
Cognitive Function Impairment
Full Text
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