Rabbit Aqueous Humor Research Articles

The Effect of Carbonic Anhydrase Inhibition on Intraocular Pressure of Rabbits with Different Blood CO2 Equilibria : In the Anterior Chamber in Cats and Dogs

Summary and Conclusions 1.Metabolic and respiratory acidosis lowered the intraocular pressure of albino rabbits. 2.Metabolic alkalosis did not affect the intraocular pressure. 3.The reduction in intraocular pressure due to carbonic anhydrase inhibition (injection of acetazolamide) was additive to prior reduction by metabolic or respiratory acidosis. 4.The normal effect of acetazolamide in reducing intraocular pressure was diminished by prior induction of metabolic alkalosis. 5.These data are consistent with the hypothesis that there is a bicarbonate (or hydroxyl) accumulating system in the formation of rabbit aqueous humor, partially dependent on carbonic anhydrase. University of Florida

Failure of Carbonic Anhydrase Inhibition by Acetnazolamide to Alter Tonicity of the Aqueous Hiumour1

Summary.The carbonic anhydrase inhibitor acetazolamide affects the production of aqueous humour in rabbits without changing the steady state osmotic pressure gradient between aqueous and plasma.

Tetracycline and chloramphenicol studies on rabbit and human eyes.

It has been observed that those antibiotics which penetrate into the spinal fluid through the so-called blood-brain barrier also penetrate into the eye through the blood-aqueous barrier. Recent reports in the literature have indicated that tetracycline penetrates into the spinal fluid in animals1and in humans.2 As no other report concerning the intraocular penetration of tetracycline has been published up to this time, we considered it of value to determine the degree of penetration of this antibiotic into the aqueous humor of rabbits and human beings. It was considered of importance to use human as well as rabbit eyes, for there have been very few reports on the intraocular penetration of antibiotics into human eyes, the supposition having been that rabbit eyes were very similar to human eyes in this respect. Various modes of administration and dosage schedules were utilized. Also, a small number of assays were performed

Penetration of Magnamycin into the Aqueous Humor of Rabbits

Penetration of Magnamycin into the Aqueous Humor of Rabbits

Study on Penetration of Cysteine and Cystine into the Aqueous Humor of Rabbits and its Relation to Early X-Irradiation Effects on the Eye

Study on Penetration of Cysteine and Cystine into the Aqueous Humor of Rabbits and its Relation to Early X-Irradiation Effects on the Eye

Dehydroascorbic Acid—Ascorbic Acid in the Aqueous Humor of Rabbits

Dehydroascorbic Acid—Ascorbic Acid in the Aqueous Humor of Rabbits

Cocaine Recovery from Rabbit and Cat Aqueous Humor

In 1930 the statement was made “At present there is no method sufficiently delicate to determine quantitatively the amount of cocaine present in the anterior chamber as it arrives from the conjunctival sac after clinical instillation.”1Recently, a method2 was developed whereby cocaine can be quantitatively recovered from body fluids. The essential features of this method follow:To the deproteinized fluid supposedly containing cocaine, is added 1 cc. of a 1% solution of phosphomolybdic acid in normal sulphuric acid. After mixing and centrifuging, the precipitate is washed with water which, after another centrifuging, is decanted and discarded. One cc. of N/5 sulphuric acid, 1 cc. of 2% aqueous solution of hydroquinone, and after shaking, 1 cc. of carbonate-sulphite solution are successively added to the precipitate. This develops a color which is read in the Duboscq microcolorimeter against a standard prepared by adding the above reagents to 1 cc. of a solution of approximately equal alkaloid content.With ...