Abstract
Summary and Conclusions 1.Metabolic and respiratory acidosis lowered the intraocular pressure of albino rabbits. 2.Metabolic alkalosis did not affect the intraocular pressure. 3.The reduction in intraocular pressure due to carbonic anhydrase inhibition (injection of acetazolamide) was additive to prior reduction by metabolic or respiratory acidosis. 4.The normal effect of acetazolamide in reducing intraocular pressure was diminished by prior induction of metabolic alkalosis. 5.These data are consistent with the hypothesis that there is a bicarbonate (or hydroxyl) accumulating system in the formation of rabbit aqueous humor, partially dependent on carbonic anhydrase. University of Florida
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