Background: Work-related musculoskeletal disorders (WMSDs) are one of the most important factors for occupational injuries and disabilities, with the back injuries being the most common work-related injuries in different industries in many developing countries. Objectives: The objectives of the present study were determination of the prevalence of WMSDs symptoms, identification of major risk factors associated with WMSDs symptoms and ergonomics interventions to reduce these disorders. Patients and Methods: This follow-up and interventional study was carried out in a lead mine. Forty persons participated in this study. The Nordic musculoskeletal questionnaire was used to study the prevalence of WMSDs and the quick exposure check (QEC) method was used to assess the physical exposure to risks. Ultimately, data was analyzed using McNamar’s and Cochran’s tests by SPSS version 11 software. Results: The results revealed that the highest prevalence of musculoskeletal disorders was reported in lower back (57.5%) and knees (50%) during the 12 months prior to the study. After ergonomics interventions, significant reductions in WMSDs were observed at the time of follow-up. According to Cochran’s test, significant differences between the pre, four and nine months after the intervention in lower back and knee were observed (P < 0.005). Conclusions: Consistent reductions were observed for all WMSDs disorders at the ninth month of the follow-up. It can be inferred that the use of practical and low-cost methods of engineering and administrative interventions together and monitoring the proper implementation of these interventions during a long time may achieve desired results in reducing musculoskeletal disorders in small scale and poor industries in developing countries.