Background: According to the UNODC report in 2013, thirty million men and women globally are imprisoned each year. Prevalenceof infectiousdiseases suchasHIV, hepatitis B&C, TB andother STI inprisons are2-10 timeshigher amongprisonpopulations compared to the rates of general population. Aimed at reducing risky behaviors and incidence of infectious diseases in prisons as well as targeted new educational method named Fission Method of Peer education (FMP) implemented as a cost effective, rapid progressive and extensive coverage method in Iranian prisons Methods & Materials: This interventional studywas performed on HIV education on male prisoners in two blocks of Tehran main complex prison in 2013. One of these blocks went on a 30 day peer training program (FMP) as a case group and other block received routine programs(such as lecture, pamphlet,leaflet, and. . .) of education in prisons (control group). Baseline data collected with pretest from all imprisons in both blocks. The questions were divided into four groups about HIV/AIDS information. After implementation 30 day peer education program in case group, both groups had the post test. Data were analyzed by SPSS software version21 Results: In the case group, post test scores significantly higher than the pre test scores, but in the control group, the difference was not statistically significant (Phi Kramer test). There was a significant proportion of true answer increasing in all 4 question’s groups in the trained inmates: in corrected beliefs questions: p <0.0001, transmission group’s questions: p <0.005, ways of prevention group’s questions: p <0.0001, diagnostic signs questions: p <0.0001). The results obtained strong correlation between levels of education with increasing awareness by this training program method. Thehigher the educational level, the higher change awareness with this method Conclusion: Thisnewpeer educationmethod (FMP) canbe ideal setting to improve HIV/AIDS knowledge of inmates. Considering that this method is cost effective, spontaneous and ongoing with high transmission power to improve the education of prisoners, so it seems to be the way to educate many infectious diseases like H1N1 Influenza especially in their epidemic outbursts in prisons
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