Interpolation theory for complex polynomials is well understood. In the non-commutative quaternionic setting, the polynomials can be evaluated “on the left” and “on the right”. If the interpolation problem involves interpolation conditions of the same (left or right) type, the results are very much similar to the complex case: a consistent problem has a unique solution of a low degree (less than the number of interpolation conditions imposed), and the solution set of the homogeneous problem is an ideal in the ring H[z]. The problem containing both “left” and “right” interpolation conditions is quite different: there may exist infinitely many low-degree solutions and the solution set of the homogeneous problem is a quasi-ideal in H[z].