30CrMnSiNi2A steel is a high-strength low-alloy steel and it is widely used in the defense industry. Its ductile fracture properties were investigated by using a combined experimental-numerical approach to address the need for assessment of structural integrity. The parameters of the Johnson-Cook constitutive model were obtained through quasi-static and dynamic tensile tests on round bar specimens at different temperatures and relevant finite element method iterations. The effects of strain rate and temperature on fracture were studied. The tensile tests on notched round bar specimens were performed to calibrate the fracture strain in the range of high positive stress triaxiality. The tensile tests on butterfly plates and compression tests on short cylindrical specimens covered the fracture properties in the range of low and negative stress triaxiality. The finite element models were computed and the fracture loci in the space of the effective plastic strain to fracture and the stress triaxiality in a wide range from −1/3 to 1.5 were constructed. The parameters of the Johnson-Cook fracture model and Bao-Wierzbicki fracture model were calibrated. It is shown that stress triaxiality has a significant effect on the fracture of 30CrMnSiNi2A steel and the monotonicity of the fracture loci varies in different stress triaxiality range. The Bao-Wierzbicki model is capable of predicting the fracture patterns of the 30CrMnSiNi2A steel in different stress states.