Let $${\mathcal {M}}$$ be a diffuse von Neumann algebra with a faithful normal semi-finite trace $$\tau $$ , and let E be a symmetric quasi-Banach space. Then for any Orlicz function $$\varphi $$ , we can define the noncommutative Calderon–Lozanovskiĭ spaces $$E_\varphi ({\mathcal {M}})$$ . These spaces share many properties with their classical counterparts. In particular, new multiplication operator spaces and complex interpolation spaces of such spaces are given under a wide range of conditions. Moreover, letting $${\mathcal {A}}$$ be a maximal subdiagonal algebra of $${\mathcal {M}}$$ , we introduce the noncommutative Calderon–Lozanovskiĭ–Hardy spaces $$H^\varphi ({\mathcal {A}})$$ and transfer the recent results of the noncommutative Hardy spaces to the noncommutative Calderon–Lozanovskiĭ–Hardy spaces.