Background: Quarter-life crisis is the anxiety and discomfort the young might experience at the end of their studies and at the beginning of their career. Objectives: Factors related to medical students’ quarter-life crisis were explored in this study. Methods: in the cross-sectional study, 351 medical students (74.6% female, mean of age: 23.79 years, SD: 1.53 years) filled in the online questionnaire that contained Quarter-life Crisis Questionnaire, International Personality Item Pool version of Big Five markers, and questions about different aspects of medical school. Independent t-test, Mann-Whitney U test and linear regression analysis were performed. Results: Women reported higher quarter-life crisis (t = –3.44, p = 0.001, Cohen’s d = 0.42). Higher quarter-life crisis displayed among those students who did not apply to medical university right after high school (U = 2865.5, p = 0.03, Cohen’s d = 0.24). Students who would have not applied to medical school again (t = –7.93, p < 0.001, Cohen’s d = 0.90); would have not encouraged their children to apply to medical school (U = 10414.5, p < 0.001, Cohen’s d = 0.57); were uncertain to finish university (t = 6.68, p< 0.001, Cohen’s d = 0.74) showed higher quarter-life crisis. Students who failed at least one term for academic reason (U = 11809.5, p = 0.04, Cohen’s d = 0.23); did not feel to get proper knowledge to accomplish a medical job (t = –3.90, p < 0.001, Cohen’s d = 0.54); were not satisfied with their grades (U = 11560.5, p = 0.01, Cohen’s d = 0.27) reported higher quarter-life crisis. Students who did not plan to work in a clinical field and patient care (t =–5.974, p = 0.00, Cohen’s d = 0.93); wanted to work abroad in the future (U = 12931.5, p = 0.00; Cohen’s d =0.27) had higher quarter-life crisis. Personality traits, such as extraversion (β = –0.20, p < 0.001), conscientiousness (β = –0.10, p = 0.01) were significant negative, neuroticism significant positive predictor of quarter-life crisis (β = 0.61, p < 0.001). Conclusion: The explored variables might be indicators of quarter-life crisis, and can be the basis of university counseling, when medical students’ quarter-life crisis and emerging adulthood is in focus.
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