BackgroundData-driven soft sensor technology is currently an important means for industrial data prediction, addressing the challenge of predicting key quality variables in industrial production processes. Convolutional neural networks (CNN) are widely applied in soft sensor modeling due to their excellent nonlinear modeling and feature extraction capabilities. However, CNN also faces several issues, such as poor robustness to interference and difficulties in extracting features from complex process data. MethodsThis paper introduces a novel CNN model called the Masked Convolutional Transformer Block Deep Residual Shrinkage Network (MCTB-DRSN). Firstly, the Masked Convolutional Transformer Block (MCTB) is utilized to extract features from different positions, thereby enabling the network model to focus more on important information. Secondly, the Global Response Normalization (GRN) layer is incorporated into the Deep Residual Shrinkage Network (DRSN) module, which enhances feature competition among channels. Significant FindingsThis method can provide effective monitoring for chemical production process. Compared with the traditional soft sensor method on the debutanizer column dataset, the results show that the prediction accuracy of this model is significantly improved.