The need for sustainable production, efficient use of resources, energy efficiency and reduction in CO2 emission are currently the main drivers that are transforming the European process industry besides Industry 4.0. Since the potential of industrial symbiosis (IS) and energy efficiency (EE) about environmental, economic and social issues has been discovered, the interest in them is gradually increasing. The funding and investments for IS and EE are highly encouraged by the European Commission, while more and more policies as well as research and innovation (R&I) activities are initiated to promote European industry’s advancement towards a circular economy and CO2 neutrality. The aim is to maintain the competitiveness and economic progress of the industry. The key to build a competitive and sustainable European manufacturing industry is to create a competent, highly qualified workforce that is capable of handling the new business models coming with IS and EE requirements and digital technologies. We can generate this by identifying the skills needs and upskilling and reskilling the current workforce accordingly by delivering the suitable training programmes. Therefore, this work identifies the most critical skills needs related to IS and EE for six different energy-intensive sectors (steel, ceramic, water, cement, chemical and minerals) in Europe. The effect of the digital transformation on the skills needs is as well discussed. The identified skills are aimed to be included in vocational education and training (VET), tertiary education and other kinds of training curricula. We also identify the cross-sectoral most representative job profiles linked with EE and IS in these sectors and demonstrate the methodology for the selection process. Furthermore, we present a key tool for identifying the most significant current and future skills requirements. Also, we define the critical skill gaps of the European process industry using this tool. Once the skill gaps are defined, they can be reduced by delivering well-developed continuous trainings. We also link our work to the respectable ESCO, the European Classification of skills, competences, qualifications and occupations, to attain a common ground with other studies and frameworks, minimise the complexity and contribute to their work. Our work is developed to be an academic and industrial guideline to prepare well-developed training programmes to deliver the needed skills.